Pasteur continued his research and experiments.
He artificially reduced the immunogenicity of the highly immunogenic Bacillus anthracis and inoculated it into sheep, and then proved that the sheep vaccinated with Bacillus anthracis would not contract the disease again.
Rabies virus cannot be isolated and cultured like bacteria.
Pasteur confirmed that the pathogenic microorganisms that cause rabies are present in the brain tissue or spinal cord of diseased animals.
He chose rabbit brain for passage.
to obtain attenuated strains.
Then a live vaccine was successfully made!
With the development of immunology and microbiology, vaccines were truly defined.
Vaccines are automatic immune preparations used to prevent infectious diseases made from pathogenic microorganisms and their metabolites through artificial attenuation, inactivation or genetic engineering.
Based on this approach, numerous vaccines have been developed.
After thirteen years and two hundred and thirteen generations of continuous culture on the culture medium, the attenuated BCG vaccine and the attenuated live vaccine made by heating and inactivating Vibrio cholerae were obtained.
With the development of the discipline, traditional classic vaccine varieties have been further transformed, and recombinant genetic engineering has given great technical support, and recombinant gene vaccines have emerged.
The most popular vaccines in modern times are nucleic acid vaccines.
Nucleic acid vaccines transport the vaccine to human cells through carriers, instructing the cells to produce immune active ingredients. The cells spit out the active ingredients, stimulating the human body to obtain corresponding immunity, so that they will not cause disease.
Nucleic acid vaccines can even transfect food cells.
For example, a hepatitis B virus nucleic acid vaccine is inserted into the genome of tomato cells, and eating tomatoes is equivalent to being vaccinated.
As immunological research continues to deepen, humans have more expectations for vaccines.
Researchers don't just hope that the vaccine will just cure the disease.
It is also hoped that it can prevent the progression of the disease or treat the disease by inducing a specific immune response.
...
In the bedroom.
Zhu Yuanzhang and others listened to Su Xuan talk about how to inoculate healthy calves with vaccinia vaccine, how to collect and preserve the vaccine, and how to cultivate attenuated virus strains.
Sun Shouzhen's eyes became brighter and brighter.
It's like opening the door to a new world.
He didn't expect that there was such a method of "fighting poison with poison" to treat patients.
Zhu Yuanzhang and others were stunned after hearing this.
"Dr. Su, what is the 'virus' I just told you about?"
Zhu Biao, who was standing behind Zhu Yuanzhang, couldn't help but ask.
He had just been wondering for a long time.
He had never heard the word "virus" before, and there was no such word in the books he had read.
Su Xuan explained: "A virus is a tiny, non-cellular organism."
Zhu Biao:?
Zhu Yuanzhang:?
Queen Ma:?
Sun Shouzhen:?
All the doctors:?
I don't know why, but they always feel that they are not very talented and knowledgeable in front of Su Xuan, because they only half understand and half understand most of what Su Xuan said.
Sun Shouzhen has been studying medicine for decades and has seen countless medical techniques.
He can also be considered an expert.
But in front of the "new theory" proposed by Su Xuan, he felt ashamed.
"Tiny, non-cellular organisms?"
Zhu Biao pondered Su Xuan's words carefully.
Zhu Yuanzhang and others also frowned.
Su Xuan thought for a while and explained in the most concise words: "Just think of it as a 'virus' that can make people sick. Bean disease is also a kind of 'virus'."
He did not explain microscopic cells, microorganisms, bacteria, and viruses to Zhu Yuanzhang and others in detail.
This knowledge is too advanced.
Even in modern times, these were only discovered in the past hundred years.
If you tell them too many complicated things at once, I'm afraid their brain CPU will be overloaded and strike.
At this time, everyone looked at Su Xuan differently.
Zhu Yuanzhang sounded emotional.
"Doctor Su is so knowledgeable."
"None of the doctors in my hospital are as good as you."
"Doctor Su is willing to serve as the Chancellor."
All the civil doctors took a breath of air and were shocked, then looked at Su Xuan with envious eyes.
The Prime Minister of Taiyuan Hospital is only under the orders of Taiyuan Hospital and is equivalent to the second-in-command of Taiyuan Hospital.
The assistant hospital order is in charge of affairs related to Tai Hospital.
And Yuan Cheng is from the fifth rank.
If Su Xuanruo serves as the Prime Minister of the Imperial Hospital, he is one person below countless others in the Imperial Hospital. All the doctors in the Imperial Hospital must obey him.
Sun Shouzhen, the imperial eunuch, had no objections to Zhu Yuanzhang's reward for Su Xuan.
If it weren't for Su Xuan's lack of qualifications.
I'm afraid Sun Shouzhen wants to give up his official position as the imperial magistrate to him.
Su Xuan's medical skills far surpassed his.
Medical knowledge is even more advanced.
If Zhu Yuanzhang and others were still here, he would want to worship Su Xuan as his teacher now and learn medical skills from Su Xuan.
"Thank you, Your Majesty."
On the surface, Su Xuan accepted the appointment with neither humility nor arrogance, but he was happy in his heart.
He now has an official position.
Eating public meals.
There is a backer behind it.
No matter what era, relying on the public is always the right choice.
And the official position from the fifth rank is already very high.
The deputy Qianhu of Jinyiwei who will be established in the future will only be from the fifth rank, and the bachelors of the future Ming Dynasty cabinet will only be from the fifth rank.
The fact that he had such a high position when he first entered the court would probably make countless people jealous.
"Order of the Sun Academy."
"We order you to assist Su Yuan Cheng in promoting cowpox. We will prevent the people of Ming Dynasty from suffering from bean disease."
"This is huge."
"It concerns the future of Ming Dynasty."
"You must not neglect it."
Zhu Yuanzhang ordered with a majestic face.
Sun Shouzhen knelt down to accept the order, "Yes! I will certainly live up to your majesty's trust and assist Su Yuan Cheng in completing his mission!"
Su Xuan looked at this scene.
Sun Shouzhen, who was wearing a cyan and white pheasant official robe, was kneeling on the ground with his hands clasped in fists, while Zhu Yuanzhang, wearing a bright yellow dragon robe, was sitting on a chair, overlooking Sun Shouzhen.
This scene made Su Xuan feel a little dazed.
Only at this moment did he truly feel that he had really arrived in the Ming Dynasty.
The fifteenth year of Hongwu.
At this point in time, a lot of things will happen.
Jinyiwei is about to be founded.
The Battle of Yunnan during the Ming Dynasty.
The prototype of the Ming Dynasty cabinet was formed.
And Tuogu Si Timur in the north may soon ascend to the throne of the Northern Yuan Dynasty.
King Zhu Shu of Qi is about to go to Qingzhou to join the feudal clan.
Queen Ma passed away.
...
"However, if I promote vaccination, there will be earth-shaking changes tomorrow, right?"
Su Xuan thought.
There are records in history that an unusually large-scale smallpox plague occurred during the Jiajing period of the Ming Dynasty.
History books say:
"In the spring of the Jiawu year in Jiajing, pox was prevalent, and eighty-nine people died from the disease."
This incident led to the promotion of vaccination.
The method of smelling acne originated in Taiping County, Ningguo Prefecture during the Longqing Period of the Ming Dynasty, and spread throughout the world.
And now Su Xuan is promoting vaccination.
I am afraid that the future large-scale smallpox plague during the Jiajing period will be eliminated as a result.
"I have done a great deed, right? I saved millions of people in the Ming Dynasty in advance. If this is considered a meritorious deed, it can be said to be a great achievement."
Su Xuan muttered to himself.
Zhu Xiongying's bean disease was cured by Su Xuan.
The heads of many private doctors and imperial doctors were saved.
This incident can be considered peaceful.
A low-key carriage drove slowly out of the palace.
inside the carriage.
Su Xuan opened the curtains and looked outside. There were small vendors on both sides of the road. There were not many people. The common people wore coarse linen clothes and had sallow complexions. The smell of earth, the fragrance of food, and the noisy conversations filled Su Xuan's mind. of the five senses.
【Ding! 】
[Rescue Zhu Xiongying, mission accomplished! 】
[Reward for divine medical skills! 】
