"With pox vaccination, tens of millions of people in the Ming Dynasty will be safe!"
“Vaccination is a bold approach, but it just works.”
Everyone in the palace was full of praise for the variolation technique.
Su Xuan curled his lips when he heard what they said, "If you promote the use of the first three types of variola vaccination, it will not save people, but harm them."
Everyone's expressions changed drastically.
Sun Shouzhen humbly asked for advice, "What does Doctor Su mean by this?"
Su Xuandao:
"The first three types of variolation are too dangerous and are unsafe treatments."
"The acne dressing method is relatively primitive, has a low success rate and is highly dangerous. This is why this method has not been implemented and is rarely used."
"The acne pulp method uses fresh acne pulp from children to cause acne, which is harmful to the patient. Many patients are unwilling to accept it, so this method is rarely used."
"With the dry seedling method, if the amount of acne scab powder is not properly controlled, it will have a huge impact on the patient. The amount of powder used is difficult for ordinary doctors to control. In addition, the seedlings irritate the nasal mucosa and increase nasal mucus, which often washes away the acne and results in increased nasal discharge. It is ineffective, so this method is not feasible.”
There is a lot of knowledge in variola vaccination, and these were summarized by predecessors. Su Xuan just told Zhu Yuanzhang and others the experiences summarized by predecessors.
“Wouldn’t it be impossible to promote variolation?”
Zhu Yuanzhang was greatly disappointed.
If the variola vaccination technology could be promoted, it would benefit millions of people in the Ming Dynasty. However, according to what Su Xuan said, it seems that variola vaccination has various problems and cannot be promoted.
"No."
"Vaccination can still be promoted."
"But what needs to be promoted is the fourth water vaccine method of variolation."
"The water seedling method is to take 20 to 30 acne scabs, grind them into fine powder, mix them with three to five drops of purified water or human milk, mix well, spread them into thin sheets with new cotton, wrap the water seedlings inside, and knead them into jujube cores. Like this, tie it with a thread, stuff it into your nostril, and take it out after six hours."
"This method is the most effective among the variola vaccination methods."
"It can achieve the purpose of preventing bean diseases."
"Even if you get sick."
"It can also alleviate the condition and avoid critical illness."
"In addition, the bean scab used in vaccination is called 'shimiao'."
"It is an artificial method to infect the vaccinator with bean disease once."
"This 'Shimiao' is very dangerous."
"It is necessary to choose bean scabs with 'mild seedling properties' as seedlings. Such seedlings are called 'mature seedlings'. Their toxicity is weakened and they are safer after inoculation. The longer the seedlings are passed on, the better. The longer they are passed on, the clearer the potency will be. Artificial The more you become familiar with the practice, the fire poison will be eliminated, the essence will remain alone, and you will be completely safe and trouble-free."
Sun Shouzhen and the other doctors listened carefully and memorized these important points in their hearts.
Su Xuan is probably the only one who knows this wonderful method of preventing bean diseases. If they don't memorize the method now, they may miss their only opportunity.
"This method is harmless and can be promoted."
Su Xuan said emphatically.
"Very good!!"
Zhu Yuanzhang touched his palms and smiled.
He didn't care what method he used, as long as it could prevent millions of people in the Ming Dynasty from suffering from bean disease.
That's a good way.
"Doctor Sun, we order you to help Dr. Su promote that water seedling method!"
"We must let all the people of Ming Dynasty be vaccinated!"
Zhu Yuanzhang's face was solemn, and he was sitting on the pear wood chair, but it was as if he were sitting on an imperial chair, exuding invisible majesty.
"yes....."
Sun Shouzhen wanted to agree.
"Your Majesty, please be slow."
Su Xuan interrupted the two of them.
Zhu Yuanzhang and others looked at him one after another.
"Your Majesty, although the water vaccine method in variola vaccination is a good choice to prevent bean disease."
"But there are better ways to prevent bean disease."
Su Xuan said.
Zhu Yuanzhang and others were stunned.
Is there a better way?
They thought that the water seedling method was a perfect way to prevent bean disease, but Su Xuan actually said that there was a better way.
Zhu Yuanzhang took a deep breath, his eyes were deep, and he whispered:
"Doctor Su has really brought us a lot of surprises."
"The so-called better way."
"Why?"
"Vaccinium Technique."
Su Xuan spit out four words.
The technology of cowpox was discovered by Jenner, a country doctor in England. Jenner had also been vaccinated with variola when he was a child. Later, during his medical practice, he discovered that people who had had cowpox would not get smallpox.
Jenner was inspired to realize that cowpox might have made them resistant to smallpox.
He started experimenting.
A cowpox-stricken milkmaid's hand was inoculated with a little pox slurry on the arm of an eight-year-old boy who did not suffer from smallpox, and cowpox developed at the site of inoculation.
Six weeks later, Jenner inoculated the boy with smallpox, and the boy was fine.
Then he tried again and again.
It was later confirmed that cowpox can prevent smallpox!
Then the cowpox method was introduced to my country by Portuguese traders in Macau.
Cowpox is safer than variola.
Chinese people also use cowpox for this reason.
The vaccinia vaccine is safe and reliable and will not cause human-to-human transmission after vaccination.
As soon as it came out.
Soon it was widely used around the world.
In 1979, the World Health Organization announced that smallpox was eradicated from the earth!
This is the first time in human history that we have won the battle against an infectious disease!
Su Xuan told Zhu Yuanzhang and others about the safety and reliability of cowpox. Zhu Yuanzhang and others did not expect that cowpox could have such an effect.
There are three types of vaccines administered by cowpox vaccination.
Liquid vaccinia.
Freeze-dried vaccinia.
Chicken embryo group vaccinia.
Liquid vaccinia vaccine is made by inoculating vaccinia virus into the skin of healthy calves and collecting soy milk.
Freeze-dried vaccinia vaccine is made from ordinary vaccinia vaccine under vacuum and minus 18-20 degrees Celsius.
Chicken embryo vaccinia is made by inoculating chicken embryo tissue cells with vaccinia virus and has the same immune effect as cowpox vaccine.
With the technology of the Ming Dynasty, only liquid vaccinia could be used. The conditions required by the other two methods were too harsh. In addition, the effectiveness of liquid vaccinia decreased rapidly at room temperature and needed to be stored at low temperatures.
Zhu Yuanzhang and others were dumbfounded.
Liquid vaccinia?
Virus?
A bunch of novel vocabulary popped out of Su Xuan's mouth.
They could barely hold back.
If these words are single, they understand the meaning, but if they are combined, they do not know the meaning.
Anyway.
They understood that cowpox prevented bean disease.
And cowpox is the best way to prevent bean disease.
Su Xuan looked at Zhu Yuanzhang and others who were confused after hearing this, and was thinking about another thing.
Variola to cowpox.
Let mankind open the box of vaccines!
After the successful application of cowpox technology, scientists began to study why cowpox could fight smallpox.
In the 1850s, chemist Louis Pasteur established the relationship between disease and germs.
The discovery of specific microbial pathogens that cause specific diseases.
When bacteria grow on artificial culture media for a long time, their toxicity will weaken.
But the immunogenicity is still there!
