It is said that in the 17th century, a Spanish count came to Lima, the capital of Peru, with his beloved wife. Unfortunately, his wife contracted malaria and was cared for by an Indian girl. Seeing that her condition was getting worse, the Indian girl decided to treat her secretly. Everything the Indian girl did was secretly watched by the count. The count believed that the Indian girl wanted to murder his wife and wanted to punish her, so she had no choice but to tell the secret of the "Cinchona Tree". After his wife recovered, the Spanish count returned to Europe with the bark.
Later, Swedish scientist Rinaius conducted careful research on the bark of this plant and extracted its active ingredient, which he named "quinine". "Quinine" means bark in Peruvian language.
Artemisinin is extracted from Artemisia annua, for which Tu Youyou also won the Nobel Prize in Medicine. Ancient people have known about using Artemisia annua to treat malaria for a long time. As for the specific dynasty when it started, Li Zhiyun is not sure.
Li Zhiyun walked up to Dr. Jia and said in a slower tone: "Doctor Jia, I shouldn't be angry at you. Please forgive me." Dr. Jia quickly waved his hands and said: "No, no, Jia is incompetent and deserves to be scolded. Don't blame me." Your Highness." Li Zhiyun paused for a moment and said, "Doctor Jia, why don't you use Qinghao to treat my second brother's illness?"
"Qinghao?" Doctor Jia looked at him in surprise, "Your Highness also knows medical skills?"
"Don't worry about this. I just ask you, do you know that Artemisia annua can treat malaria?"
Dr. Jia shook his head blankly and said, "Jia doesn't know." Li Zhiyun didn't know whether it was because there were no records in medical books at this time or because Dr. Jia was ignorant. Just when he was about to say something else, Doctor Jia suddenly slapped his forehead and shouted: "By the way, Jia has remembered. Your Highness, please wait a moment."
After that, Dr. Jia walked out and came back after a while, holding a book in his hand. He lived next door and had apparently gone back to get medical books. Doctor Jia handed the book to Li Zhiyun and said, "Your Highness, the prescription for treating malaria with Artemisia annua you just mentioned is in this book."
Li Zhiyun took it and took a look. It was "Elbow Preparation for Emergency Prescriptions" written by Ge Hong of the Eastern Jin Dynasty. The so-called "post-cubital" means that it can be hung on the elbow for easy portability, similar to later clinical practical manuals. This book looks brand new, unlike the one in the medicine cabinet, which is dog-eared at the edges. It seems that Dr. Jia is not very interested in this book "Emergency Prescriptions".
This book is as thick as a brick, and Li Zhiyun doesn't have time to look through it page by page. He handed the book back to the other party and said, "Where is it? Find it and I'll take a look." Doctor Jia took the book back, flipped through it for a while, then handed it to him and said, "It's right here." Li Zhiyun took it and took it. Look, sure enough, it says "Prescription for treating malaria caused by cold and heat": soak a handful of Artemisia annua with two liters of water, wring out the juice and drink it all.
After Li Zhiyun looked at it, he said, "Doctor Jia, since you know there is this prescription, why don't you use it?" Dr. Jia hesitated for a moment and said, "Your Highness, you don't know. This Ge Hong is a Taoist priest who makes alchemy, not a medical doctor. Furthermore, he There are many fallacies in his prescriptions, and Jia generally does not use them. If your highness does not believe it, please read on. He listed more than a dozen prescriptions for treating malaria, most of which are absurd."
After hearing this, Li Zhiyun looked down and saw the writing on the book: On the other side, kneel down toward the sunrise and pour ink into both ears. On the other hand, catch a spider and swallow it with rice. On the other hand, find a soybean and cut it in half, write the sun and month on it, and then eat it facing the sun. And so on, there are many weird recipes later.
After Li Zhiyun finished reading, Zhang Zheng took the book and read it, and said: "Your Majesty, what Dr. Jia said is right, are the prescriptions written by this man named Ge reliable? The King of Qin has a rich body, so don't do it." You used the wrong recipe." If Li Zhiyun is not a time traveler, then he must be like Zhang Zheng in thinking that the recipe recorded in Ge Hong's book is not reliable at all. But he knew that no matter how absurd Ge Hong's other prescriptions were, it was absolutely true that Artemisia annua could cure malaria!
Li Zhiyun estimated that Ge Hong must have written all the prescriptions he collected from the people into the book, and it was inevitable that there would be mixed results. However, Artemisia annua is definitely a timeless remedy for treating malaria. It is said that artemisinin has saved millions of lives in Africa, and that is in the presence of quinine. It can be seen how effective artemisinin is in treating malaria.
As Li Zhiyun repeatedly assured that there would be no problem, Dr. Jia finally relented and said, "Since His Highness insists on using this recipe, let's give it a try. Artemisia annua is edible and has the effect of clearing away heat and detoxifying. Even if it cannot cure malaria, Miasma, there’s no harm in it.”
"Does Doctor Jia recognize Artemisia annua?" Li Zhiyun asked worriedly.
After hearing this, Dr. Jia smiled and said: "This is what Jia eats. There is no plant or plant that can be used as medicine that Jia doesn't know. This Artemisia annua is not a rare thing, and it is not difficult to find. There are many in this area." There might be some on the mountain, so Jia immediately took people up the mountain to collect them."
Doctor Jia took one of his soldiers to collect Artemisia annua from a nearby mountain, carrying bamboo on his back. In less than half an hour, the two of them gathered the Artemisia annua.
Li Zhiyun took a look and saw that Artemisia annua was a very common green plant, about one foot tall with long and narrow leaves. Doctor Jia followed the recipe in Ge Hong's book, soaked it in twice as much water, squeezed it to extract the juice, and then gave it to his second brother to take it all at once.
However, after the second brother took several doses of medicine, his condition still showed no improvement and he was still unconscious.
How is this going? Li Zhiyun felt confused and suspicious. He looked at Dr. Jia suspiciously and said, "Is what you picked back artemisia annua?" Dr. Jia patted his chest and assured him that it was absolutely correct. He was afraid that Li Zhiyun wouldn't believe it, so he specially called in a few villagers. During their spare time, the villagers often go to the mountains to collect medicinal materials and sell them to drug stores in the city to supplement their family income. Therefore, they know a lot of medicinal herbs. After the villagers saw the plant, they all said it was Artemisia annua.
Li Zhiyun was dejected and had nothing to say for a moment. Although Dr. Jia didn't say anything, his face clearly said: How is it? Did I say that before? However, as a doctor, it is not a glorious thing for him if he cannot cure the patient. Therefore, Dr. Jia returned to his house, took out a lot of medical books, and read through them, hoping to find a specific formula for treating malaria.
In the battle of Qianshuiyuan, due to the incompetence of Liu Wenjing and Yin Kaishan, the Tang army suffered an unprecedented defeat, losing 70,000 to 80,000 troops. Generals Murong Luo'er, Li Anyuan, and Liu Hongji were all killed in battle. Xue Ju then sent his troops to conquer Gaocheng City, then collected the corpses of Tang soldiers and built a high platform to promote martial arts. After Liu Wenjing and Yin Kaishan led the defeated soldiers and fled back to Chang'an, they were all dismissed by Li Yuan.
Gaocheng City. Xue Ju was sitting in the hall, where many civil and military ministers were neatly lined up. Xue Ju looked majestically on everyone's faces and shouted loudly: "Where is the prince?" Xue Rengao stood up, cupped his fists and said: "Abba, my son is here!"
"Did Li Shimin catch him?"
"Not yet. Abba, I have searched the entire Gao'an City, but I still haven't caught Li Shimin. I think he has escaped."
"What?" Xue Ju stared and said, "Where did he escape to?"
"It's not clear yet," Xue Rengao said, "But don't worry, Abba, Erchen has already blocked all the roads leading to Chang'an. Even if he had wings, he would not be able to escape back to Chang'an. Erchen guessed that he might just hide. Somewhere nearby.”
"Okay then." Xue Ju ordered, "Prince, you immediately send out a large team of people to search for Li Shimin. You must catch him. If you want to see him alive, you will see his body if he dies!"
"My son, I obey!"
At night, Li Zhiyun sat in front of his second brother's bed, refusing to go back to his room to sleep. The second brother has been in a coma and has not had any water or rice for several days. His originally handsome face has been tortured and haggard by the disease.
Li Zhiyun felt like he was in a dream. He simply couldn't believe that the dying patient in front of him was Li Shimin, the powerful British leader in history. It seems that human life is really too fragile. Whether it is a commoner or a hero who dominates the situation, they are all equally small and insignificant in the face of the power of nature.
The second brother's illness is getting worse and worse, and his life is losing little by little, but Dr. Jia is helpless. Li Zhiyun doesn't know how to deal with this situation. He only knew that he could not watch his second brother die of illness. The unification of the Tang Dynasty depends on the second brother, and the prosperous age of the Tang Dynasty created by the second brother must not disappear from history.
According to the news from the scouts, Xue Ju has sent troops to block all roads leading to Chang'an. They are temporarily unable to return to Chang'an and can only hide in this small mountain village. However, there is no famous doctor or good medicine here, and the second brother's illness cannot be delayed. Li Zhiyun felt that he had been pushed to the edge of the cliff.
Li Zhiyun thought of Artemisia annua again. There is no doubt that artemisinin is a specific drug for treating malaria. Otherwise, Tu Youyou would not have won the Nobel Prize in Medicine. However, when Artemisia annua was used on the second brother, why did it have no effect at all? Li Zhiyun even began to wonder if his second brother was suffering from malaria. However, as soon as this idea came up, he quickly rejected it.
Although Li Zhiyun did not know medical skills, judging from the symptoms of his second brother's illness, it was undoubtedly malaria. Besides, no matter how bad Dr. Jia's medical skills are, he can't even figure out what disease his second brother has, right?
Li Zhiyun seems to have heard before that malaria is the most serious infectious disease in human history. The death toll it causes far exceeds that of smallpox, plague and even the Black Death. It can be listed as one of the three major diseases faced by mankind along with cardiovascular disease and cancer. disease. He heard from Dr. Jia that malaria can be divided into many types. What kind of disease does the second brother have, and there is no cure?
