Mr. Xia declined politely. Although Fang Hanmin was a little embarrassed, he didn't care too much. After all, Lao Xia's qualifications were there. He was old, approaching retirement, and couldn't stand the fatigue of traveling on business. These were all facts. For such an old man, Qualified leader, Fang Hanmin certainly cannot do anything reluctantly.
Let Lao Xia come forward to contact the design unit, mainly because he has dealt with the design agency and is familiar with the routines and rules. In addition, Lao Xia is the chief engineer of the Red Star Pharmaceutical Factory. Fang Hanmin feels that if he comes to contact the design department, he can be influenced by it. The other party's attention will help speed up the design progress. Now, Lao Xia refuses to accept this task and chooses to stand aside, so Fang Hanmin has to find someone else.
Sitting at his desk, Fang Hanmin went through the familiar middle-level leaders in his mind, but found no suitable person to contact the pharmaceutical design unit, so he called the head of the human resources department, Hou, and asked him to check the personnel files and look at the entire factory. Among department-level cadres, who are scientific and technological personnel majoring in engineering?
An hour later, Section Chief Hou reported the results to Fang Hanmin. There were more than ten scientific and technical personnel with engineering majors in the whole factory, but only one qualified. "This person's name is Xu Hui. As far as I know, He is now the deputy director of the Technology Center."
Upon hearing this name, Fang Hanmin was very familiar with it, "Yes, Xu Hui is one of the two deputy directors of our technology center. He is also the head of the catalyst preparation and recovery treatment section. I didn't expect that he studied engineering."
"It is recorded in the file that he majored in chemical engineering at university."
"Great! It's him."
The next morning, Fang Hanmin talked to Xu Hui and asked him to serve as director of the generic drug production project preparation office.
Xu Hui is the second college graduate after the resumption of the college entrance examination. He is a few years older than Fang Hanmin. Although he majored in engineering, he is introverted and not good at dealing with outsiders. He feels that he is now in a corner, managing catalyst preparation and The recycling and processing section is very good. "Director Fang, I'm afraid I'm not qualified to be the director of the preparation office."
"Isn't your major in chemical engineering? You used to be a technician in a workshop and independently managed the catalyst section. Now you are preparing to build an industrialized production line for generic drugs. I think it is most appropriate for you to be responsible for the preparatory work."
"But, I can't make decisions!" Xu Hui told the truth.
"The preparation process has not yet reached the decision-making stage. You only need to contact the design department, achieve seamless connection with them, and provide the design unit with all the information they need. Based on your professional background, this work is suitable for It shouldn’t be too difficult for you.”
"You mean, I'm mainly responsible for dealing with the design department?"
“In the preparatory phase, that’s the main thing to do.”
Xu Hui majored in chemical engineering. During the graduation project process, under the leadership of their teacher, they practiced in a large design institute for most of the semester and completed their graduation project there. After knowing the content of the work in the preparatory stage, he dispelled all doubts, "I majored in engineering. I was asked to do things within the scope of my major. I finally found a job that matched my major!"
After accepting the task, Xu Hui became the director of the Preparatory Office for the Construction of Generic Drug Production Lines, but the catalyst section of the technology center was leaderless. This involved the preparation and recycling of palladium carbon catalysts. Fang Hanmin did not dare to be careless. He approached Jiao Tiehui and asked the chief of the Labor Discipline Inspection Office to solve the problem. Liu went back to work as the section chief of the catalyst section.
In terms of personal relationships, Jiao Tiehui was Fang Hanmin's best friend at the Red Star Pharmaceutical Factory. However, when Fang Hanmin wanted to use his right-hand man, Jiao Tiehui was still a little resistant, "Liu is a key member of the Labor Discipline Inspection Office. You transfer him?" If I leave, I won’t be able to do my job in the future!”
Fang Hanmin disagreed, "Look at this, you are the director of the Labor Discipline Inspection Office. Even if Da Liu is your right-hand man, will you be unable to work without him?"
Jiao Tiehui hurriedly explained, "No, no, no, I mean, there are thousands of people in the whole factory. Without the backbone of Da Liu, we will definitely not be able to take care of it!"
"If you don't have enough manpower, you can choose more people. Among the employees you are familiar with, as long as there is someone who is decent, fair, and upright, just say hello to the Human Resources Department and transfer him to your office. I know you are with We have worked together with Liu for a long time, and you have a tacit understanding. However, the catalyst section of the technical center needs managers. Da Liu once served as a team leader there, but now there is a lack of a section leader. I think there is no more suitable candidate than him. For the sake of work, you You have to endure the pain and give up your love!"
Jiao Tiehui was originally very supportive of Fang Hanmin's work, but because the incident happened so suddenly, he couldn't accept it mentally, so he became resistant. After Fang Hanmin explained the truth clearly, he blamed himself, "Hey, why are you reluctant to give up? , We are all employees of Red Star Pharmaceutical Factory, no matter who we are, we must put the overall situation first, not to mention Da Liu, even if I need to do anything, I will absolutely obey the leadership arrangements."
"I'm just telling you, how can you, the most sensible person, be so upset? Tell Liu and ask him to report to his new post as soon as possible."
...
After several inquiries, Guo Peng and others learned that a manufacturer specializing in the production of test equipment in other provinces had the test equipment they needed. In order to rush for time, Fang Hanmin asked them to send people from the research group to buy the equipment as soon as possible.
Guo Peng and others did not dare to neglect, and sent two staff members from the research team, who returned four days later carrying the test equipment.
Fang Hanmin went to the laboratory to guide the installation and debugging of the new test equipment. Because the previous tests were all operated under normal pressure, in order to eliminate the nervousness of the research team staff about the pressure operation, when they were ready, Fang Hanmin personally demonstrated. As the temperature rose, The reading of the pressure gauge also changed. When the pressure reached about two kilograms, he decisively stopped heating and allowed the test device to continue running.
After various indicators stabilized, Fang Hanmin asked the staff of the research team to work with him to pay close attention to the test operation and make detailed records of the test process.
For several days, Fang Hanmin continuously demonstrated the operation under conditions of pressure of three kilograms, four kilograms and five kilograms, and the staff of the research team basically mastered the operation essentials.
Fang Hanmin handed over the test to Guo Peng and others and asked them to repeat the stability test under these conditions. "Director Fang, doesn't the test pressure need to be increased further?"
"It is not difficult to see from the test results of these tests that pressure does have an impact on the generation of trans isomers, but when the pressure exceeds three kilograms, this effect becomes less obvious. Therefore, I think there is no need to further improve the system. Pressure, after all, the higher the pressure, the greater the accompanying safety risks, and the benefits brought by further increasing the pressure are not proportional to the risks faced."
The test results show that within the pressure range of three kilograms, the trans isomer decreases as the pressure increases. This phenomenon shows that the system pressure is indeed conducive to inhibiting the formation of trans isomers. Although the pressure exceeds three kilograms, this kind of The effect is not obvious, but it also confirms Fang Hanmin's speculation to a certain extent.
The synthesis reaction was carried out under a pressure of three kilograms, and the obtained generic drug contained only one percent trans isomer. Compared with the original result, this was reduced by one percent. This is an exciting discovery!
A series of subsequent stability tests achieved basically consistent results. Through these efforts, the first technical node to be improved proposed by Fang Hanmin was further optimized.
Since then, under the guidance of Fang Hanmin, the research team has found more reasonable process conditions in optical resolution and phenylethylamine recovery tests, which not only saved 3% of the amount of resolving agent, but also improved the recovery rate of the resolving agent. 99% increased to 99.8%.
After optimizing the process technology of the three nodes, through calculation, compared with the original test results, the production cost was reduced by 15%. This result was even beyond Fang Hanmin's expectation. At least the results obtained from the laboratory can be It shows that he envisioned making generic drugs into a drug that has significant curative effect, extremely low side effects, and is of high quality and low price. This goal has been achieved! ...
The laboratory development of the generic drug project is finally over. After a busy year, all the staff of the research team can finally breathe a sigh of relief! However, Guo Peng and other scientific and technical personnel cannot rest for a moment. In addition to having a large amount of data to sort out, they also have to write a test summary report, which is a must-do after each project.
Preparatory work for the construction of the production line is progressing steadily. With the efforts of Xu Hui, director of the Preparatory Office, the design institute has completed the basic design on time. However, before the engineering design was carried out, the design institute and Hongxing Pharmaceutical Factory had serious differences in design fees. .
The reason is that Fang Hanmin proposed that future generic drug production workshops should be designed and constructed in accordance with GMP standards. However, the Provincial Pharmaceutical Design Institute believed that this requirement was too advanced and the design department needed to spend more energy and time familiar with the relevant specifications. Therefore, they proposed The design fee will be increased by 50% on the original basis.
"Are these people at the design institute still being unreasonable? Isn't it just to design a GMP workshop? They suddenly increased the design fee by 50%. It's a money grab!" After listening to Xu Hui's report, Fang Hanmin immediately became angry. .
"Director Fang, the GMP standard workshop is a new thing in the domestic pharmaceutical industry, and the design institute is relatively unfamiliar. I estimate that they need to refer to a lot of foreign materials and learn a lot of new knowledge during the design process, and may need to spend more energy and time. "Because Xu Hui was also exposed to GMP for the first time, he expressed his understanding of the design institute's requirements.
Fang Hanmin disagrees with this. In the 21st century that time travelers have experienced, GMP has already become the standard for the pharmaceutical industry. Those standards come from the World Health Organization and are open to all countries. Regardless of design or production management, GMP standards are followed one by one. Just do it according to the requirements, and there is no need to spend too much extra energy.
However, Fang Hanmin is a reasonable person after all. He partially agrees with Xu Hui's statement that it does take some time to get familiar with a new thing, but increasing the design fee by 50% is absolutely unacceptable! "You tell the design institute that Red Star Pharmaceutical Factory can accept a maximum increase of 5% in the design fee and an extension of one month, otherwise there is no need to discuss it!"
Xu Hui is an honest man. He has never dealt with the outside world before. He feels that the gap between the two sides is too big. Even if he conveys Fang Hanmin's intention to the design institute now, the other party will not agree. "Director Fang, how about you personally come forward to talk to the design institute?" Have an interview with people from the hospital to see if you can convince them?"
Fang Hanmin thought for a while, "Well, it's time to meet with the other party. You invite people from the design institute to the Red Star Pharmaceutical Factory, and I will interview them."
"Okay, I'll call and invite them soon. In addition, I think we should continue to cooperate with the design institute, because they have already completed the basic design. If we find another design agency, the preliminary work will be in vain."
