In the 21st century, optical dissociation technology has been very mature, and there is more than one specific method. Whether the time traveler was studying for a PhD at Oxford University or later engaged in new drug creation at the RGP Company R&D Center, he was in the laboratory of his previous life. Having personally performed the separation operation of optical isomers, Fang Hanmin is very familiar with this technology.
In fact, when the test results found that the generic drugs contained optical isomers, Fang Hanmin thought of using optical resolution technology for separation and purification. However, he considered that this technology was too advanced and under the current domestic conditions, this technology was not practical in specific applications. There would be many difficulties during the implementation process, so he had to decide to use traditional methods.
However, the test results during this period showed that the traditional process was not suitable for the separation and purification of optical isomers at all, which forced Fang Hanmin to think of optical resolution technology again, which he said was done in one step.
After listening to Fang Hanmin's idea, Guo Peng and several other scientific and technical personnel looked at each other. They felt that although this technology was advanced, it could not be implemented because they had heard the teacher of the relevant course introduce this technology during college, but it was at the forefront of technology and With cutting-edge technology, even in developed countries, optical resolution of optical isomers can only be carried out in extremely high-standard laboratories.
"Director Fang, we have not heard that any unit in China has developed this technology. Do you think there are conditions for implementing optical splitting in our technology center?" Guo Peng was obviously not interested in this because he felt that the technology was too difficult. .
Fang Hanmin did not answer Guo Peng's question directly, but asked: "Have you heard of this technology before?"
“During college, in advanced organic chemistry courses, the teacher briefly introduced the principles of optical resolution technology, but that was cutting-edge technology and we had only heard about it.”
"Oh, you know the technical principle? That will be easier!" Because it was a bit unexpected, Fang Hanmin looked a little excited, "You know, although the amount of trans isomer in the synthetic product is not large, it has very toxic and side effects , in order for this generic drug to benefit the majority of patients, it is necessary for us to separate the trans isomer and eliminate the toxic and side effects of the drug to the greatest extent."
"Director Fang, we understand the importance of this work, and the technical solution you proposed is also very advanced. The key is to separate the trans isomers by optical resolution. Not only is it technically difficult, but also drug research and development institutions nationwide Without the relevant test conditions, our technology center is even less able to carry out optical disassembly tests."
How could Fang Hanmin not know the technical difficulty of optical splitting? However, the time traveler has personally engaged in the actual operation of this technology in his previous life, and he is very familiar with the technical details of optical splitting. However, Guo Peng and others do face huge technical challenges.
The Technical Center of Hongxing Pharmaceutical Factory was built by Fang Hanmin himself. He knew the background of the Technical Center very well. He knew that with the existing hardware facilities of the Technical Center, there were no conditions for carrying out optical separation experiments. Even those large-scale domestic pharmaceutical research companies So far, scientific research institutes have no precedent for carrying out such experiments. On the one hand, it is because the technology is too difficult. On the other hand, the lack of advanced instruments and equipment in the laboratory is also the main reason.
Although Fang Hanmin understands the concerns of Guo Peng and other scientific and technical personnel, he has his own opinion, "It is true that no domestic scientific research institution has put this technology into practice, but what I want to emphasize is that there is a first time for everything, why can't we How about being the first to try something new? As for hardware facilities such as instruments and equipment, although the current conditions are not applicable, we can find ways to solve it."
"Finding a solution? It sounds simple, but how to solve it? Director Fang, do you know how much it costs to purchase those cutting-edge scientific research instruments? The key is that even if you have money, many instruments and equipment may not be available in China!" Guo Peng I've never been optimistic about this.
"Haha, you are so optimistic! Red Star Pharmaceutical Factory does have money, but that money has other uses. The budget for technology development this year has been spent. If you want to purchase new instruments and equipment, the funds have not yet been secured."
"That's it! In that case, why do you have to ask for trouble?" Although Guo Peng and Fang Hanmin have a superior-subordinate relationship, they are peers and have worked together for more than ten years. They have a lot of things in common, so he always talks casually with Fang Hanmin.
"It depends on people. There are indeed many difficulties in carrying out optical splitting experiments, but our goal cannot be changed! Just be prepared, and I will figure out other things."
Guo Peng knew that this was a task given to him by Fang Hanmin. Fang Hanmin was not only the director of the factory, but also technically qualified as Guo Peng's teacher. If he found another reason to treat him negatively, the nature would change.
After thinking for a moment, Guo Peng had no choice but to nod in agreement. ...
Two days later, at about 9 a.m., Director Yuan of the Municipal Industry Bureau was in his office, concentrating on checking the statistics of the first half of the year for the companies under his jurisdiction. Suddenly he heard someone knocking on the door, and he responded casually, "Come in!"
Lao Yuan was slightly surprised when he saw the person who came in through the door, "Hanmin? Why are you here?"
"Old leader, it seems you don't welcome me!"
Lao Yuan stood up and explained quickly: "No, no, no, that's not what I meant. I mean, you are such a busy person, how can you have time to visit me?"
No wonder Director Yuan was surprised. In addition to handling administrative affairs, Fang Hanmin devoted all his energy to technology development. It has been more than half a year since Lao Yuan was transferred to the Municipal Industry Bureau as the top leader. Fang Hanmin only took advantage of the opportunity of a meeting in the Industrial Bureau to visit the old leader. Twice, today is the first time he made a special trip to visit the old leader.
Facing Lao Yuan's doubts, Fang Hanmin said with a smile: "No matter how busy you are, you should take time to visit the old leader. It's been so long, I'm afraid you are too worried!"
Director Yuan said seriously: "Am I that kind of person? Others don't know, and I don't know that you are busy at both ends of the day. How can you have time to take care of these insignificant things?"
"It's just a joke, don't take it seriously. Old leader, I came to see you today. I don't go to the Three Treasures Palace for anything!" Fang Hanmin stopped beating around the bush.
"I'm just saying, if you have nothing to do, can you come to my place? What's the matter? Sit down and talk." In addition to the superior-subordinate relationship, Lao Yuan and Fang Hanmin have been friends for many years. When he was still the director of the Red Star Pharmaceutical Factory, he Don't treat Fang Hanmin as an outsider.
After the two sat down face to face at the coffee table, Fang Hanmin took out a document from his bag and said, "Director Yuan, there is a report here, please take a look."
Lao Yuan took it and read it carefully from beginning to end, then looked at Fang Hanmin, "Hasn't the technical center of the Red Star Pharmaceutical Factory been built a long time ago? A lot of instruments and equipment were also purchased. I remember that the factory-level leadership team held a meeting to discuss this. At the time of the incident, some team members did not agree to spend so much money on scientific research and development, but I made the decision against all opinions. Why do we need to purchase instruments and equipment now? And we still need such a large amount of funds? "
"Old leader, the instruments and equipment we used to have have been fully utilized. The instruments and equipment we plan to purchase now have new uses."
In fact, Fang Hanmin had clearly stated the purpose of the equipment he planned to purchase in his report. In order to impress Director Yuan, he also explained the purpose of the equipment to Lao Yuan in person.
Director Yuan is very familiar with the scientific and technological development plan of Red Star Pharmaceutical Factory, because it was proposed by Fang Hanmin and personally approved by Fang Hanmin when he was the director of Red Star Pharmaceutical Factory. After listening to Fang Hanmin's story, he asked with interest: "So, you have already started to implement the science and technology development plan?"
"Yes, we started the experiment around the Spring Festival."
"Just do what you say, you are such a resolute person! I remember that in your plan, the short-term goal is to copy patented drugs. How far is the trial now?"
"After more than half a year of testing, we have prepared an API in the laboratory that is almost the same as the original patent, and registered it with the regulatory authorities."
Lao Yuan was surprised, "Your trial progress is fast enough! As far as I know, it will be difficult for a generic trial of this difficulty to produce results within one or two years. But Hanmin, since the patented drug has been successfully imitated, why do you still need to How about purchasing such advanced equipment?"
Fang Hanmin told Director Yuan that there are trans-isomers in raw materials that have greater toxic and side effects on the human body. "We applied to purchase these cutting-edge instruments and equipment just to separate the trans-isomers from raw materials."
Director Yuan thought for a while, "Have you conducted anatomical analysis on the same drug produced by a foreign company? Is there such a trans-isomer in the imported drug?"
"We have done an autopsy analysis and found that the same imported drug contains this trans isomer."
"Separating this trans isomer is not only technically difficult, but also requires advanced instruments and equipment. Since you have already done as well as foreign companies, why do you still go forward?"
It seems that most people think that doing more is worse than doing less. The same issue was raised by Guo Peng and others from the Technology Center to Fang Hanmin. Now Director Yuan also said the same. Fang Hanmin had to explain it seriously and he must get the understanding of his superiors. and support, otherwise, if the funds to purchase advanced instruments and equipment are not resolved, nothing can be done.
"Director Yuan, when we imitate patented drugs, we are actually standing on the shoulders of our predecessors. Why can't we do better than them? If we are just satisfied with doing as well as our predecessors, then we will never innovate!"
These few words moved Lao Yuan deeply. He never expected that a person without formal academic qualifications could realize such a profound truth. He originally thought that Fang Hanmin was a self-taught professional technician who only knew how to study technology. It seemed that he had previously Fang Hanmin's understanding is not comprehensive.
"Hanmin, you said it so well! Standing on the shoulders of our predecessors, we should make breakthroughs and innovate! The Red Star Pharmaceutical Factory you led has set an example for the city's industrial enterprises, and they should all learn from Red Star To learn from the pharmaceutical factory, I will ask the department in charge of publicity in the bureau to summarize your experience and promote it to the overall situation in a timely manner." As the top leader of the Municipal Industry Bureau, Lao Yuan hopes that his subordinate companies will be like Red Star Pharmaceutical Factory and rely on innovation to drive corporate development. .
Fang Hanmin has always been low-key and never likes to show off. In addition, the purpose of coming to Lao Yuan today is not to promote the performance of Red Star Pharmaceutical Factory. "Director Yuan, let's summarize the promotion later. What I want to know is, see After receiving this report, when will the bureau grant us the funds to purchase instruments and equipment?”
Lao Yuan scratched his head and felt very embarrassed, "What about this? Oops, you know, this year's budget has been used up. It's October now. Let's wait another three or four months until next year's budget comes out. , things will be easier to handle.”
Fang Hanmin became anxious when he heard that. Regardless of the relationship between his superiors and subordinates, he said anxiously: "Next year's budget will have to wait three or four months? Director Yuan, aren't you trying to pass the buck?"
