It's not that Fang Hanmin is too modest. Without the support of the old factory director, not only would he not be able to turn his vision into reality, it would even be difficult for him to gain a foothold in the Red Star Pharmaceutical Factory.
Even after the insistence of the old factory director, Fang Hanmin took the position of director of Red Star Pharmaceutical Factory. Faced with the collective resistance of senior scientific and technological personnel, it was a group of young scientific and technical personnel who gave Fang Hanmin great support and made him formulate The plan was gradually implemented.
Although what Fang Hanmin said was true, Director Lin pointed out the crux of the problem, "Director Fang, I admit that the support of the old leaders and young scientific and technical personnel is indispensable to you. However, I feel that all this is based on Based on your previous contributions, have you ever thought that if you had not made achievements that impressed the leaders before, would the old factory director support you unreservedly?"
Fang Hanmin said frankly: "At the beginning, the second workshop where I worked had a lot of problems. If it was not solved, it might have to close down. When neither the workshop nor the factory-level technical department could come up with a solution, someone suggested to the workshop leader. , let me give it a try, and through hard work, I solved several technical problems in the workshop one by one. That incident attracted the attention of the factory leaders, and later, I was transferred to the technical department of the factory."
Although Fang Hanmin made it easy, Director Lin had been engaged in pharmaceutical technology research and development for half his life. Even if he did not understand the specific situation, he felt that things were not that simple. Technical problems that could not be solved by the workshop and factory-level technical departments were suddenly solved by Fang Hanmin. , this is simply incredible! He couldn't help but murmur in his heart, what kind of deity did this Factory Director Fang in front of him come to earth?
Director Lin believes that even though Fang Hanmin graduated from a prestigious domestic university with a Ph.D., he spent most of his Ph.D. studies on basic theoretical study and research. In addition to solid theoretical knowledge, solving technical problems in actual production is also inseparable. Rich practical experience. With Fang Hanmin's age and qualifications, where did he accumulate so much practical experience?
Thinking of this, Director Lin couldn't help but ask: "Director Fang, let me take a guess, do you have a PhD in pharmaceutical sciences from a prestigious university?"
Fang Hanmin smiled calmly, "Director Lin should know that Ph.D. graduates from prestigious universities are either assigned to national research units, or they are higher up than national agencies, or provincial institutions, or at least they stay in school as teachers and continue to engage in research. Ours It would be great if local state-owned enterprises in municipal-level cities that farm land can be assigned a few undergraduate students!"
"So, Director Fang is a college student who graduated from which prestigious school?"
Fang Hanmin is a little embarrassed every time he faces this question, but he has become accustomed to it and has already prepared a fixed answer. "I am very ashamed. I have no academic qualifications and am just a high school graduate."
Director Lin was shocked again, "What? A high school graduate with no academic qualifications? What about your knowledge of pharmaceutical technology...?"
"Haha, Director Lin, don't be surprised. All my knowledge of pharmaceutical technology was acquired through self-study. Some people say that interest is the best teacher. I was born interested in pharmaceutical technology, and I have been interested in it ever since I started working. I studied hard and mastered some knowledge of modern pharmaceutical technology."
Although Fang Hanmin's explanation sounded reasonable, Director Lin was still skeptical. After all, he not only had a background in this field, but also had been engaged in drug synthesis research for more than twenty years. As far as he knew how difficult this science was, he It is simply a fantasy to think that a high school graduate without specialized training in theory and practice can master systematic knowledge of modern pharmaceutical technology through self-study!
Lao Lin tried his best to calm down his emotions, but he still looked very confused, "To be honest, this is the first time I have heard of a miracle like what happened to Factory Director Fang, and it completely subverted my understanding."
"Director Lin, we feel as incredible as you do, but what happened is right around us, and it is a fact that we have seen with our own eyes!"
"Not only did we learn a lot of theoretical knowledge from Factory Director Fang that we had never learned in school, but his ability to solve practical problems opened our eyes even more."
Fang Hanmin did not comment on the remarks of the three subordinates. Director Lin looked at him with an exaggerated expression, "Director Fang, you also opened my eyes!"
Unknowingly, it was one o'clock in the afternoon. In order not to delay Director Lin's ride, Fang Hanmin raised his glass and once again suggested wishing him a good journey! After the wine party, Fang Hanmin and his party took Lao Lin to the train station and watched him check in and enter the station before returning to the unit.
...
Although initial results have been achieved, and the generic drug has also been registered by the regulatory authorities, according to Fang Hanmin’s plan, the exploratory trials of the generic drug research team of the technology center are still ongoing, with the aim of finding better process conditions. , ultimately eliminating the optical isomers in the synthetic products.
According to Fang Hanmin's instructions, the research team further conducted repeated tests on various conditions. The obtained racemate was analyzed and tested. The best test results showed that the cis isomer (active ingredient) accounted for 95%, and the trans isomer accounted for 95%. Formula isomers (harmful components) account for 5%.
"Is it necessary to continue the trial?" Guo Peng, deputy director of the technology center and leader of the generic drug project, wanted to end the project as soon as possible.
After analyzing the test process and results, Fang Hanmin felt that the synthesis test had been done in sufficient detail. Continuing the test would only be a waste of resources and would not have much impact on the results. However, the separation test of optical isomers still needs to be continued.
"Director Fang, in the best sets of test results, the trans isomer only accounts for 5%, and the active ingredients are as high as 95%. How meaningful is it to continue to separate and purify?" Guo Peng didn't quite understand Fang Hanmin's thoughts. .
"As far as I know, the toxic and side effects of the active ingredients of this generic drug we developed are minimal. The toxicity of the trans isomer accounts for 98% of the drug. If the trans isomer is not separated, the drug will not be officially After it is produced and put on the market, how do you explain it to prescribers? Is it worthy of the patients who take this drug?" Fang Hanmin asked.
"The trans isomer only accounts for 5% of the total. Even if its side effects account for 98% of the entire drug, it is not very harmful. Are we making too big a fuss about this issue?"
Unexpectedly, Guo Peng would say such words. Fang Hanmin put down the information at hand and looked at him very seriously, "Drugs are used to treat diseases and save people. As the development and production unit of this drug, if we treat drugs with your attitude It’s irresponsible to the patient to have toxic and side effects!”
"Director Fang, I think you take the problem too seriously! There are many drugs used clinically now. As long as they can cure the disease, who cares about the side effects, whether the prescriber or the patient?"
"What you said is true, but you cannot use existing problems as a shield for half-hearted work. We are developers and producers of pharmaceutical products. If we cannot minimize the side effects of drugs from the source, what can prescribers and patients do?" What method? Moreover, most of the drugs currently used clinically are old products many years ago. The generic drugs we are developing now are new products that have only been used clinically in the past ten years. The upgrading of drugs, in addition to improving The therapeutic efficacy must also reduce the toxic and side effects to be meaningful." Fang Hanmin said sincerely.
As a doctor of pharmaceutical sciences from Oxford University in the 21st century, the time traveler knows that the toxic and side effects of many similar drugs in previous lives have been greatly reduced. Even century-old drugs like aspirin, through continuous improvements in process technology, have become less effective both clinically and for the public. For daily medication, the old dosage forms have long been eliminated, and enteric-coated sustained-release tablets that have no irritating effect on the gastrointestinal tract are commonly used.
Guo Peng's perfunctory attitude towards the side effects of drugs made Fang Hanmin doubt his professionalism. However, not only did he not realize the seriousness of the problem, he was rather complacent. "There is a folk saying, 'It's the medicine that makes up for the three points.'" Poison', according to the proportion of the trans isomer in the synthetic product, I estimated that not to mention three points of poison, not even one point. Therefore, I think the toxic and side effects of our generic drug are already very low Got it!"
A common mantra among the people actually became Guo Peng's excuse for not paying attention to the toxicity of drugs. This statement made Fang Hanmin dumbfounded, but he could not tolerate this attitude!
"Guo Peng, as scientific and technical personnel engaged in drug development, first of all, your understanding is wrong! The saying that medicine is three parts poison has been around since ancient times, but it was part of the experience of our ancestors who lacked scientific and technological knowledge. Talking about it without scientific basis can be said to be helpless. In addition, we have used modern scientific and technological knowledge and have found the source of drug toxicity through experiments. Why not do our best to find ways to remove this toxicity from drugs? This This is the responsibility of pharmaceutical science and technology workers!”
Seeing Fang Hanmin's heartbroken look, Guo Peng knew that his remarks had disappointed his leader, "Director Fang, I just said it casually, don't take it seriously."
"Just talking? Guo Peng, you are the deputy director of the technology center and the leader of the generic drug research group. If you have a muddling-through work attitude, will others be more negative? You know, the technology center is responsible for implementing science and technology The arduous task of development planning, if there is no pragmatic and truth-seeking scientific spirit, how can we carry out future work? Have you thought about these issues? "
"Director Fang, your words are a bit exaggerated. My views on the side effects of drugs have nothing to do with my work attitude and will definitely not affect the specific implementation of the science and technology development plan. In fact, I do not deliberately ignore the side effects of drugs. I will develop it now." For this generic drug, you require 5% of the trans isomer to be completely separated. I think the technology is too difficult, and the existing equipment in the laboratory does not meet that condition."
After listening to Guo Peng’s defense, Fang Hanmin also felt that his words were a bit harsh. We should be more tolerant and understanding towards young people. Being too demanding may be counterproductive. “I hope I’m overthinking it, but I really hope you take it seriously.” The toxic and side effects of drugs. As for the separation and purification tests of active ingredients in generic drugs, they must continue. The existing instruments and equipment in the laboratory cannot meet the requirements. Then you can see what kind of instruments and equipment need to be added. Give me a list. , I will solve the remaining problems."
A few days later, Guo Peng presented a purchase list of new test equipment to Fang Hanmin. After reading it, he pointed to a set of equipment in the list and asked Guo Peng: "How much do you think this equipment can improve the separation effect?" ?”
"It should be able to increase by one or two percent."
Fang Hanmin said very calmly: "First of all, no one can say whether this equipment can improve the separation effect by 12%; in addition, even if it can achieve this effect, there is still a certain gap from the ideal goal."
"I think this solution has the hope of further improving the separation effect. Apart from this solution, I have no other way." It seems that Guo Peng has tried his best.
After thinking for a moment, Fang Hanmin relaxed his frown and said, "I think it is necessary to use a brand-new process and equipment. Let's do it in one step."
"One step to get it right? Director Fang, I don't understand what you mean."
