May Day coincides with the weekend. I originally had three days off because I was thinking about the generic drug synthesis trial being carried out by the research team of the Technology Center. After breakfast on the third day, Fang Hanmin had to go to work.
After knowing his thoughts, Song Yuping teased: "As a factory director, you are busy with work, so you can give up the wedding leave that the policy gives you, but you must also dedicate the May Day holiday. If your work attitude is not the national model worker, the superior organization I really feel wronged to you."
The resentment of the newlywed wife was obvious, but Fang Hanmin really wanted to know the progress of the experiment in the past two days, even if he came back after understanding the situation, so he said with a playful smile: "Yuping, it's broad daylight, you don't need me to accompany you, right? You can watch at home Read a book, I’ll be back as soon as I go.”
"Hey, it seems like no one cares about your company. Go if you want. No one will stop you. It's your business when you come back. It has nothing to do with me." Knowing that Fang Hanmin had made up his mind, Song Yuping simply decided to do something that had nothing to do with her. But her resentment has not gone away.
"You can't say that. Why does my business have nothing to do with you? But I will be back in a moment. Calm down and smile for ten years. You will look better when you smile."
In Song Yuping's impression, Fang Hanmin never made people happy, but his last words made her laugh, "Go ahead, I don't care when you want to come back."
With Song Yuping's half-truth and half-truth permission, Fang Hanmin suddenly kissed her on the cheek, "Thank you, madam! I won't keep you waiting too long."
...
Because Fang Hanmin had not been seen for two consecutive days, colleagues in the research team thought he was on vacation at home. When he appeared in the technology center laboratory, colleagues were surprised, "Director Fang, why are you here?"
"Oh, I have some personal matters that have been dealt with in the past two days. Let me take a look at the test results from the day before yesterday and yesterday."
Guo Peng handed the two-day test records and test results to Fang Hanmin, "The results are similar to what you expected, and the sample content is also up. However, colleagues from the testing agency reported to me that on the spectrum, the main peaks of the sample seem to be two The peaks overlapped, and when the melting point was determined, it was found that the melting point of the sample was two degrees wider than the melting point range given in the literature."
Fang Hanmin casually looked at the test records and carefully analyzed the sample test data. "Judging from the test data alone, the results are not bad. The main peaks on the graph overlap, and the melting point range does not match the literature value. What is going on?"
"The people at the testing center couldn't explain it clearly, and I don't know the reason either," Guo Peng said frankly.
"You guys continue working, I'll go to the testing center to look at the spectrum."
After leaving the laboratory, Fang Hanmin turned around and went to the analysis and testing center. He asked the staff to bring up the test spectra of yesterday and the day before yesterday. After careful identification, he found that the main peak of the sample was indeed not smooth enough. He asked the person in charge of the analysis center next to him. : "Wang Gong, do you think this small piece of bulge is the main peak of another component?"
"The main peak of the sample should be very smooth. In this case, I don't think it can be ruled out that it is the main peak of another component."
"In other words, these two peaks are too close and overlap in the spectrum? Have you changed the detection conditions to try to separate them?"
"I think the main peaks of the two components overlapped. We changed several detection conditions, but failed to separate them. In addition, the melting point range of the sample is wider than the literature value, which is not normal."
"How is it possible that there are two ingredients? And the boiling points are so close. What impact will this have on the efficacy of generic drugs?"
With the test results in front of him, Fang Hanmin had to admit this fact, but he couldn't figure out which link had the problem.
After leaving the analysis and testing center with great doubts, Fang Hanmin rode his bicycle and went around the main positions and departments of the factory to see if they were operating normally.
There is a three-day holiday on May Day. If it is not for a wedding, as the leader of the whole factory, Fang Hanmin must be on duty in the factory. He did not enter the factory yesterday and the day before yesterday. In addition to thinking about the test results of the technical center, he is also concerned about the operation of all departments in the factory. Condition.
Fang Hanmin felt relieved when he saw that the administrative agencies were safe and sound and the production units were operating normally. He returned to the research group of the Technology Center again and discussed his views on the test results of these batches of test samples with Guo Peng and others, "The sample spectra are indeed abnormal. I suspect that the main peaks of the two components overlap. "
"How is it possible? Where did the two ingredients come from?" Guo Peng and others found it difficult to understand.
"There is nothing impossible. According to the analysis of the spectrum, there are two components. As for where the second main component comes from, I can't tell at the moment."
After discussing with Guo Peng and other technical staff for a while, no one could explain the reason. Fang Hanmin made some explanations to Guo Peng and left the research group.
When Fang Hanmin returned home, it was already 1:30 in the afternoon. After entering the house, he found Song Yuping sitting on the edge of the bed reading a book. The food on the table remained untouched and had lost its heat, as if it had been placed on the table for a long time.
Knowing that he came back late, Fang Hanmin took the initiative to speak: "Yuping, the food is cold, why don't you eat?"
"If you don't come back, can I eat it?"
Knowing that he was in the wrong, Fang Hanmin quickly apologized, "I went around all the major departments in the factory and wasted some time. I came back late. I'm sorry!"
"Okay, it's good to know that you can go home. I'm afraid that you will regard the factory as your home and forget about this home one day." Song Yuping said coldly.
Sitting down next to Song Yuping, Fang Hanmin put his hand on her shoulder and said affectionately: "With such a beautiful wife waiting at home, I can never forget home no matter how busy I am."
"Let's go! What time is it? Are you still hungry?" Song Yuping pushed him.
"Don't tell me, I'm really hungry."
"The food has been cold for a long time. I'm going to heat it up and get ready to eat."
After a while, Song Yuping put the hot food back on the table, and Fang Hanmin set out the bowls and chopsticks. During the meal, Song Yuping talked about marriage leave, "The education department stipulates that older young people have ten days of marriage leave, which is different from you. I won’t waste a day and will take all ten days of wedding leave.”
"That's the benefit you should enjoy. You were tired from preparing for the wedding some time ago, so you just have a good rest at home for a few days."
"What I mean is that we have officially married and started a family. I want to use my wedding leave to go back to my hometown to meet my parents and family members, and to inform them about our marriage so that they don't worry about it. Thinking about it."
"Go back to your hometown?" Fang Hanmin thought for a moment, "We are newlyweds. What will your parents and family think if I don't accompany you when you go back to your parents' home, or if I don't pick you up in a few days?"
"You don't have time, don't care what they think."
"Oh, we have already made them unhappy by not going back to our hometown to get married. Do you think it's appropriate if we continue to ignore their feelings?"
"What do you think we should do? A son marrying a wife or a daughter getting married is an honest matter. We can't keep both parents in the dark, right?"
Fang Hanmin nodded in agreement, "It's time to let both parents know, but it's obviously not appropriate for you to go back by yourself, and I don't have time to go back with you. Otherwise..., Yuping, let's not go back for the time being. Let's give it to both parties." Write a letter to your parents to inform them?”
Song Yuping smiled and said, "You have planned this for a long time, right? I remember you said before that you didn't want to go back to your hometown to get married. You just need to inform your parents and family after the wedding."
"As you can see, I am so busy all day long that I don't have time to go back to my hometown to deal with those scenes? In addition, I really don't like the customs and habits of my hometown. Let me tell you, we are getting married in the city, which is an advantage for you. , if you go back to your hometown to get married, on the wedding night, those people in the village who are making wedding arrangements will have to torment you. I can’t bear to let those people in the village tease such a charming and beautiful daughter-in-law. Why, are you willing to be tormented by those guys? " After saying that, Fang Hanmin showed a smirk.
Song Yuping rolled her eyes at him, "Nonsense! Who is willing? I just remind you not to forget the due procedures."
"Then it's settled, neither of us will go back for the time being. You can write a letter to both parents and explain the situation."
"It's okay for me to write a letter for you, but have you ever thought about it? Your parents have been very angry because we didn't go back to our hometown to get married. We will inform them of the situation after the wedding. If I write it for you, they won't even have your handwritten letter. We can’t even see each other, what do you think they will think?”
"This... I didn't think about it." Fang Hanmin felt that his idea just now was indeed inappropriate. "Yuping, you are right to remind me. I should write the letter to my parents myself."
...
More than ten years have passed since the first test in the second workshop. Fang Hanmin has made more than 20 process modifications and innovations for Hongxing Pharmaceutical Factory. Basically, he has not encountered too many technical difficulties. Mastering common-sense pharmaceutical science and technology knowledge can solve all technical problems. However, in this trial of imitation of a patented drug, two almost overlapping main peaks were found in the test spectrum of the sample obtained. This phenomenon troubled Fang Hanmin.
The cause of this phenomenon must be found as soon as possible, otherwise, the goal of continuing the test will not be clear. Fortunately, the traveler has a very profound academic background. Combining the basic theories of pharmaceutical technology mastered by the traveler, Fang Hanmin carefully analyzed the sample spectrum. He believed that the two overlapping main peaks on the spectrum may be the target product and its counterpart. isomer.
"Enantiomers?" The scientific and technical personnel of the research team, including Guo Peng, are relatively unfamiliar with this term. Some have never heard of it, and some have only heard this term mentioned by teachers in relevant majors during college, but they have little impression of it.
"Yes, it is also called a mirror image isomer, or a chiral molecule." Fang Hanmin tried to speak more plainly.
After giving a more detailed explanation and vivid metaphor, the technical staff of the research team still vaguely understand this concept. Fang Hanmin thinks this is not a big problem. After all, the most important task at the moment is to find the generation pair as soon as possible. The causes of enantiomers and how to separate and purify enantiomers and target products.
Through analysis, Fang Hanmin believed that the product generated during the synthesis process of this drug was a mixture of enantiomers. However, he did not know whether the original patent did not discover it or deliberately concealed it. The corresponding patent specification did not mention this. This situation, therefore, Fang Hanmin had never thought about this before.
Enantiomers are divided into left-handed and right-handed isomers. The mixture of equal amounts of left-handed and right-handed isomers is called the so-called racemate. Although most of the physical and chemical properties of the two isomers are exactly the same, their There is an essential difference in biological activity. Is the L-isomer or the D-isomer the active ingredient of the drug? Or are both isomers active ingredients in drugs? To answer these questions, Fang Hanmin believes that there is still a lot of work to be done.
I thought it would be relatively easy to imitate patented drugs, but now it seems that it is not as simple as imagined.
