Saibei University. Chemistry Laboratory!
Zhou Yang has been here for two days, and now his research work has entered the most critical juncture.
Fluoxetine is a 5-HT reuptake inhibitor that can selectively inhibit the reuptake of 5-HT by central neurons, promote transmitter conduction function, invigorate the spirit, improve mood, and produce antidepressant effects.
This drug is very effective in treating depression, and has the characteristics of fast onset, long duration of action, no cardiovascular system effect, and weak anticholinergic effect.
Therefore, since its launch in 1987, it has quickly replaced tricyclic antidepressant drugs.
Although the effect is very good, the preparation method of this drug is very simple, and there are several methods for laboratory preparation alone.
The first method is to first use acetophenone, methylamine hydrochloride, and paraformaldehyde to react with ManniCh to generate 3-methylamino-1-phenylacetone hydrochloride, and then reduce it with potassium borohydride in methanol to prepare 3 -Methylamino-1-phenylpropanol was synthesized into fluoxetine hydrochloride through etherification and salt formation.
The total yield of fluoxetine produced by this method is approximately 41%, which is very impressive.
The second method is to use 3-dimethylamino-1-phenylpropanol as raw material, chlorine it with thionyl chloride, and perform an etherification reaction with p-trifluoromethylphenol to obtain N. Methyl fluoxetine is then subjected to VOn BraUn demethylation reaction with ethyl chloroformate, hydrolysis reaction, and salt formation reaction to generate fluoxetine hydrochloride.
Both the raw materials and the preparation process are relatively simple!
With Zhou Yang's theoretical level and practical ability, preparing this kind of drug is really not a challenge.
The only thing that gave Zhou Yang a headache was that although the chemistry laboratory at Saibei University was the most advanced in the province, it was still lagging behind.
In addition, they are not well maintained, and there are errors in the accuracy of many instruments and equipment. The actual situation is not very good.
Therefore, after arriving at the laboratory yesterday, the first thing Zhou Yang did was not to prepare medicine, but to adjust and calibrate the instruments.
You must know that chemical experiments are like solving math problems. A slight difference can make a huge difference!
Even a dose difference of a few milligrams can produce completely different results.
Therefore, before actually preparing drugs, these instruments and equipment must be calibrated accurately.
However, Zhou Yang's behavior instantly aroused the dissatisfaction of the person in charge of the Chemistry Laboratory of Saibei University.
In his opinion, this young boy, you are here to do an experiment, and you are here to cause trouble!
It’s just that an expert will know if it’s there as soon as he takes action!
After watching Zhou Yang's next operation, he was quickly conquered.
It took half a day for Zhou Yang to calibrate most of the equipment in the laboratory. Only after meeting the standards did he start preparing fluoxetine.
Zhou Yang used the first method, which was more complicated but more effective.
As time passed, Zhou Yang finally breathed a sigh of relief as he watched the 3-methylamino-1-phenylpropanol in the equipment undergo etherification, salt formation, and then condensation into white powder.
This was the first time he prepared medicine after his rebirth. Although he had the blessing of experience in his previous life, it was still somewhat difficult in the current experimental environment.
Fortunately, everything was safe and he succeeded!
The next step is to repeat the previous steps. After all, Lin Wanwan's illness is not serious and the amount needed is not small.
Normally, when treating depression, fluoxetine is taken orally at 20 mg once a day.
If the condition is serious, it can be gradually increased to 60-80 mg per day as needed.
Based on Zhou Yang's estimate of Lin Wanwan's condition, she would need at least two months of medication to alleviate her condition. If she wanted to recover, she would have to take medication for at least half a year to a year.
And he obviously can't come often to prepare this kind of medicine for her, so if he has the chance, he will make more.
Three days later, when Zhou Yang came out of the laboratory, he had successfully prepared 10 grams of fluoxetine, which is 10,000 mg.
According to Lin Wanwan's situation, it would be enough for her to last for a year and a half.
And in order to make it easier for her to take it, Zhou Yang combined the fluoxetine with other drugs to make hundreds of "metalgin"-sized tablets.
Although he didn't know whether these pills could cure Lin Wanwan's illness, Zhou Yang tried his best.
As for the rest, it can only depend on Lin Wanwan's own luck!
In addition, before leaving, Zhou Yang had also written a letter to Lin Wanwan's family.
In the letter, Zhou Yang briefly described Lin Wanwan's experiences over the years and her current situation, hoping that her parents and relatives could take care of her for a while.
Zhou Yang had personally experienced Lin Wanwan's case and knew that Chen Jin had been asking Lin's father and mother for money through various means over the years, and he succeeded every time.
This shows that Father Lin and Mother Lin love Lin Wanwan and will definitely come after knowing what happened to her.
I also hope that with the company and care of her parents and family, she can get better!
.......
The preparation of fluoxetine was finally completed, so Zhou Yang planned to stay in Qingcheng for one more day before returning to Yunshan County.
In addition to preparing special medicine for Lin Wanwan, he also had another task when he came to Qingcheng this time, which was to purchase the equipment needed for the biogas digester.
After all, the biogas digester cannot be used directly after it is built. It needs to be transported through pipelines and then subjected to secondary treatment.
For example, biogas power generation requires a biogas generator!
Whether it’s plastic pipes or biogas generators, Yunshan County doesn’t have them, and Ning City also has a lot of problems.
Now that he has arrived in the provincial capital, Zhou Yang plans to purchase all these things back.
But Zhou Yang was not very familiar with Qingcheng!
More importantly, in this era, it is not possible to buy what you need with money.
Many supplies are in short supply, so you need to get a note from someone above.
Even some things cannot be printed on paper and must be customized from the manufacturer.
Not only is it expensive, but you often have to wait several months.
After thinking again and again, Zhou Yang could only turn to Yang Yunzhao for help. After all, he was the department head of Saibei University, and he had the right to purchase some equipment and instruments.
In the past few days, Yang Yunzhao organized teachers in the department to conduct a detailed review of the seven textbooks translated by Zhou Yang.
All the teachers and professors thought that Zhou Yang's translation skills were very high, so they decided to compile a chemistry textbook suitable for Saibei University students based on the contents of these textbooks and the current level of students.
However, these matters are all handled by professionals and do not require the director Yang Yunzhao to do it himself.
After hearing Zhou Yang's request, Yang Yunzhao naturally would not refuse.
In his eyes, Zhou Yang is a real precious talent!
Being able to translate seven textbooks within one month, not only the translation speed is fast, but the quality is also very high.
No matter where such people are placed, they are top elites who need to be attracted by scientific research institutions.
And they have only finished translating the textbooks for freshman students, and there are still textbooks for sophomores, juniors, and seniors waiting to be translated.
In addition, the school’s revolutionary committee director (principal) also said that in addition to their chemistry department, the physics department, mathematics department, architecture department, and biology department also have a large number of professional books waiting to be translated.
All in all, Zhou Yang has been well served!
Therefore, Yang Yunzhao did not refuse Zhou Yang's request and fully cooperated with him.
With Yang Yunzhao's help, Zhou Yang's task of purchasing materials went smoothly, and he bought them all quickly.
Afterwards, Zhou Yang was ready to return!
PS: The second chapter has been delivered, and the third chapter is still being written. It will be posted in the afternoon!
