Someone said back then that Chinese and Western cultures eventually went their separate ways because the East produced porcelain and the West produced glass. After the glass was ground, containers that could be quantified appeared and a large-scale killing microscope entered the crowd. Of course, this is also a family talk.
However, the development of microscopes has allowed doctors to understand more about gadgets.
"As we all know, the current mainstream view in academic circles is that the structure of DNA is helical, but the actual structure changes due to movement. After tuberculosis cells are killed by a series of drugs such as isoniazid and rifampicin, the structure of the remaining bacterial DNA Changes have occurred. At this time, its results have changed.
From a stable helical structure to a more stable G4 structure, it is first a G-tetrad plane (G-tetrad) formed by hydrogen bonds between 4 G bases on the same DNA single strand. When such a quadruplex plane appears repeatedly, a G-quadruplex will be formed. In the middle of the plane, there is usually a cation (mostly potassium ion) to help stabilize the structure...."
When Zhang Fan said this, the experts and scientists in the venue instantly turned the quiet venue into a buzzing mode. Someone in the venue raised their hands. Everyone was not interested in Zhang Fan's new statement. Doubtful, but surprised, surprised that Zhang Fan could now clearly state the changed structure.
Zhang Fan nodded slightly and pointed to a female scholar with a beautiful face who was obviously an Oriental.
How to describe the structural change of NDA that Zhang Fan calls, it is probably a piece of paper that is partially burned but not completely carbonized. If it is completely carbonized, this is the so-called organic change, directly changing from paper to carbon. In the past Drugs that can treat paper have completely lost their effectiveness as drugs.
Drug-resistant nodules are the intermediate product between paper and carbon. This product is the most troublesome. It is more stable than paper and more unstable than carbon. The selectivity of drugs is a huge challenge for doctors. Maybe the medicine that was effective the day before becomes ineffective again overnight.
"Swordsman Special Zhang, is the G4 structure you call a simulation or is it actually developed in tuberculosis bacteria?"
Zhang Fan originally thought that this girl was a Chinese, but when he stood up and spoke, Zhang Fan felt that she was from the country of meatballs. Some people boasted that they could tell the difference between Chinese, meatballs, and stick people at a glance. Zhang Fan felt that she was from the country of meatballs. This is bragging. If there wasn't a Rendanhu on his lips and a small pillow on his back, Zhang Fan really wouldn't be able to tell the difference.
Hearing the woman's question, Zhang Fan hesitated for a moment, but still gave a positive reply: "In the tea element laboratory, we have already observed this structure."
The woman hurriedly asked, "Why haven't I seen anyone from the Tea Research Laboratory publish any papers on this topic?"
Damn it, I kindly asked you to stand up and ask a question, but you actually said, "This question is not part of today's report."
"Swordsman Special, can you simulate this structure?" Another white-haired beauty stood up and asked.
There is such a strange phenomenon in the medical field. Among young experts, there are more female experts than male experts. Not only China, but also other countries are similar. Of course, if you insist on talking about a piece of cloth on your head, there will be no way to talk about it.
But after entering middle age or entering the top expert group, there are many more male experts than female experts.
The simplest ones, such as obstetrics and gynecology, there are a lot of female doctors in outstanding universities and so on. But after entering the academician level, there are many more male academicians. I don’t know why.
Zhang Fan nodded, "Okay!"
Then, Zhang Fan turned around, picked up the pen and started writing on the blackboard.
The first is the simulation state, which is the so-called hydrogen-bonded carbon-based chemical structure. Zhang Fan explained it while writing.
"You said he was a surgeon, why did he jump into the tuberculosis pit? Look at his familiarity. Some people said at the beginning that he had embezzled other people's scientific research results, and then under his influence, the person involved did not dare to stand up. Come out and speak.
If you look at people's current level, can this be drawn by someone who has appropriated other people's scientific research results? "
"It's too good. Even the best of us have nowhere to go." Although he said this, he saw that the experts from all over the world were as quiet as elementary school students in class. The Chinese infectious disease experts who came with him still felt a little bit. Proud.
On this stage, Chinese people have been missing for too long, and now there is finally a Chinese voice.
Once Zhang Fan started writing on the blackboard, he completely entered a mode of talking to himself. There is a joke on the Internet that the eyes of liberal arts students are like looking at lovers, while the eyes of science students are like looking at fools.
Normally, Zhang Fan is not too obvious, but once he enters the serious mode, his eyes look like they are looking at a fool.
But as Zhang Fan wrote more and more, everyone began to get confused. Why is there an extra hydrogen bond here? Telomere G4 helps protect the DNA at the ends of chromosomes, but can it also inhibit the activity of telomerase?
When WHO officials saw it, they immediately began to contact the leaders of the Chinese ministry, "Can this report be opened as a video conference so that more experts in this field can come in and discuss it?"
"This is related to the knowledge protection of our country's scholars, and haven't Golden Retrievers been making unbridled accusations about our health? I think we can let go until these bad accusations are completely eliminated, but we cannot allow Golden Retriever experts to participate."
The leaders of the department have finally toughened up. Although they had quarreled in the past, they could never check and balance Golden Retriever. Moreover, they had a group of younger brothers who really wanted to defeat many with a small number.
It's okay now. If he doesn't seize this opportunity to counterattack today, his leadership position will be regarded as a family inheritance.
"We support China!"
"We also support China!"
In the venue, a group of Gallic chicken brothers first directly stood on the side of China. To be honest, they really want tea medicine to enter their country at a cheaper price. On the land of Africa, because of AIDS, There was malaria and tuberculosis, and more people died than in the war.
Seeing the leaders of the Chinese Ministry pretending to be reserved, representatives from Golden Retriever and European countries gritted their teeth, "I retract my remarks against China on tuberculosis and apologize. China is a country with the responsibility of a great power... ..."
When the leader of the ministry heard that the golden retriever bowed his head, his nose turned into rosacea with joy, and the red color was particularly conspicuous. "Okay, after all, we are also a responsible big country, we can open up, and we can have video conferencing."
When the video was connected, mainly laboratories in developed countries were connected.
"Director, this model is consistent with the structure and properties of drug-resistant tuberculosis."
"Their tuberculosis drugs are designed based on this model, but where are the nodes? It seems that they are moving faster than us." In the golden retriever's laboratory, a group of people looked at the screen where one person kept writing. Painting.
Not only golden retrievers, but all laboratories above the standard in developed countries in Europe and the United States are watching this meeting.
"With the new structure of DNA, can we say that other bacteria or cells have similar structures?"
"This structure is not evolved, but can be said to be induced by chemical drugs. It is not naturally formed, but can this structure be induced in animal cells?"
The discussion was intense and no one now doubts the correctness of this model.
"I just don't know where their node is. They are so lucky."
After the tuberculosis drug was developed, after several rounds of research, no papers or academic reports were published in China.
Then adhering to China's tradition of using one generation, developing one generation, and designing one generation, the tuberculosis drugs on Chasu's side have entered the third generation. Chasu Hospital applied to the country to start selling tuberculosis drugs abroad.
That's why we have today's report.
Of course, this report is just to tell you a principle. The general meaning is to come and take a look. There is gold in the Sahara Desert. You see, this gold is what I dug in the Sahara Desert, but in which part of the desert was it dug? , I'm sorry, this has nothing to do with today's report.
In the venue, I want to mention
A group of people asked. After Zhang Fan finished writing, he stood quietly in front of the blackboard, "It's really beautiful, isn't it?"
A group of people didn't know whether Zhang Fan was talking about the beautiful blackboard writing or the beautiful tuberculosis structure. But now this is the key. Whatever Zhang Fan says is right now.
"Tuberculosis drugs from China must be imported!"
"We must import tuberculosis drugs from China!"
"Find a way to import tuberculosis drugs from China!"
One of Zhang Fan’s reports directly made the pharmaceutical factory in the Hi-tech Zone of Chasu smile crookedly. The previous clinical phase III did not meet European and American standards and did not meet the Golden Retriever’s FDA.
Now, they have compromised on China's tuberculosis drugs. Not only did they compromise, but they also had to use the standards of teasin and the drug standards of teasin in the field of tuberculosis.
"It's so expensive? A box costs twenty dollars?"
At Chasu Hospital, Ouyang looked at the price list in surprise.
In a series of research and development at Chasu Hospital, tuberculosis drugs are the most expensive, but the most expensive ones are also tuberculosis drugs. After the drugs were turned over to the state, not to mention the covert subsidies, the overt subsidies allowed the tea hospital's scientific research to just recover its costs.
At first, Ouyang thought that was all, as long as he didn't lose anything, but now he woke up and things changed!
"Except for a small portion of free support for African countries, the prices for other countries are the same."
Xiao Chen reported to Ouyang with a smile.
The Chinese government can laugh out loud now, because every box of tuberculosis drugs earns them one dollar. Although it doesn't look like much, it's a big deal.
"It's a good sign, it's a good sign. We must do a good job in service and guarantee work, and we must seize the opportunity to let Chasu Hospital produce more leading products. Next year our Chasu City will hit the frontier's economic leader city!"
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