There are many methods in the drug testing process of drug development, but they must all be complied with, including control, balance, randomization and repeatability.
There are many jokes here, such as this repeatability. At that time, a certain university wanted to upgrade, but the number of experiments was not enough, so it opportunistically opened a certain Chinese journal and started to copy. As a result, the experiment was replicated, but the data was not reproducible at all.
As for control, there is a quite classic experiment here. In the early years, many big guys promoted trace elements. For example, a certain big guy from Golden Retriever added vitamins to complementary foods. Another example is the selenium-containing rice from China in recent years.
Various people in white coats came out to speak out, as if if you don’t eat this rice, you will be stunted and your IQ will be insufficient.
In fact, this selenium experiment was conducted by scientists in the 1960s. A team of about 500 people was recruited. 250 experimenters added extra selenium and 250 ate a normal diet without adding additional selenium.
As a result, the experiment was originally supposed to last for 7 years, but by the third year it could no longer be continued. There was no change in the control group, and there was no change at all whether they ate additional selenium-rich elements or not. Why can't it be done anymore? The boss who paid for it saw that this experiment can't be done. If it continues, it won't be easy to brag about it in the future!
In fact, unless some areas that are particularly deficient in selenium need additional supplements, there is no need to deliberately supplement them in normal areas, unless you have a lot of money.
As for the TB drug experiment of tea element, there is no way to conduct a double-blind experiment and can only choose a controlled experiment.
Thousands of tuberculosis patients require thousands of normal drug testers. Tea element is inherently deficient in this aspect.
For example, in big cities, not to mention other overt and covert markets, first of all, a medical school can find many medical students. But tea element is not good, because if you are not a medical student, you will easily become panic first if you don’t know whether to popularize science or not.
"Zhang Yuan, there are not enough people!" Lao Chen blocked Zhang Fan in the operating room. Lao Chen rarely entered the operating room. This was because he was forced to do so by a group of old men, so he rushed to the operating room.
"You think of a way, you are such a big dean, can't you even handle this little thing?"
"My dean, you can't let me mobilize the troops. This won't work. When we are short of blood, we look for the troops. Even when the hospital is moved, we look for the troops, but this won't work."
"Hey!" Zhang Fan looked worried. Although there were usually a lot of people on Chasu Street, it was really hard to find such a large number of drug testers.
First, you must be healthy, second, you must be able to listen to and understand popular science, and third, you must take certain risks.
So, this is difficult.
Suddenly, Zhang Fan thought of a way, and then looked at Old Chen with suspicious eyes. Old Chen's innocent expression was like a fox with a chicken butt hanging from the corner of his mouth, insisting that he didn't steal the chicken.
The state has regulations on the treatment of drug testers. Adverse drug reactions and the like must be notified. If an accident occurs, the hospital must bear the cost of treatment.
In addition to these, there are also fixed expenses and subsidies for nutrition and transportation expenses. The one-time cost is about one thousand yuan.
Although many drugs are tested on animals, there are still risks in this stuff. Many big cities have drug dealers who specialize in making a fortune, and they can form a business just like extra actors.
Tea Su can't find anyone, so we have to rely on the government. To be honest, this matter can only be done by Zhang Fan or Ouyang. Others really can't get it. No wonder Lao Chen pretends to be crazy and acts like a fool.
After Zhang Fan changed his clothes, he drove to the Chasu Government.
Under the clear blue sky, the Cruiser slid into the gate of the Chasu Government like a fish, particularly conspicuous. If we put it in the past, a car like Zhang Fan's would have been too ordinary in the border government.
Once a leader, he was the king of the desert, but now he can no longer do it, the Cruiser has turned into a cheetah, and the four circles have turned into red flags. It’s hard to find a sunny day, and this year the weather has been better.
The government boss stood by the window and basked in the sun while looking at the factories that had been built on the land, especially the modern enterprises in the high-tech zone, which made the leaders feel that this was the country that I had built.
Finally, I saw Zhang Fan's Cruiser from the corner of my eye. This car was so easy to recognize. It was the only Cruiser with a red plate, and on the window there were a row of people from the province to the city, from the city to the county level. The pass card is so colorful that people who don’t know it think it is a United Nations car.
"It's bad. It's definitely not good. Whoever leaked the news about me will be chased after I walked into the office. You must find out who it is."
The government boss was very angry. It was not that he was afraid of meeting Zhang Fan or Ouyang, but that he was afraid that Ouyang would come to ask for the debt. I heard that the Chasu Government went to the capital this time, and Ouyang seemed to have been commended by the general manager himself.
This guy was arrogant, domineering and unreasonable before, but now he is probably even more powerful.
"You're not here to collect debts, are you?" the director of the office next to him replied. After finishing his reply, he wanted to slap himself.
If you say this thing correctly, there will be no reward. If you say it wrong, when Ouyang leaves, the boss will probably vent his anger on his long mouth.
Why!
After a while, the boss of Chasu saw Zhang Fan's smiling face, and Zhang Fan was the only one. The boss breathed a sigh of relief. He really wasn't here to ask for a debt. If he was here to ask for a debt, it wouldn't be Zhang Fan.
"Make tea for Zhang Yuan, don't make green tea, just Tieguanyin, Zhang Yuan likes to drink it." Mr. Cha Su said to the office director with a big smile. The office director smiled and greeted Zhang Fan. Really, it was as if he was wearing a pair of angled gauguins for a grand occasion. Every step he took was painful, and he had to put a thick smile on his face.
Zhang Fan politely waited for the tea to be brewed, then took out two small gadgets from his handbag, "This is a gift I brought to the leader in the capital. It's not valuable. It's just a thought."
When Zhang Fan took out the gift, Boss Chasu's face turned pale. It wasn't that he was afraid of how thick Zhang Fan's gadget was, but because he believed that Zhang Fan was telling the truth. Just because he believed the truth. , he is afraid.
When had these two guys from Cha Su given gifts? They wished they could give them gifts themselves. This guy rarely comes to give gifts today, which is definitely not a good thing.
The boss quickly pushed it with both hands, "It doesn't matter whether it's valuable or not. We can't violate the rules. No, no."
"It's worthless, it's worthless!"
"Don't say it's not valuable. Even if it's valuable, it won't work. It really won't work."
The two of them are like aunties on the street.
In the end, Zhang Fan still didn't take it out. Zhang Fan actually had a reason to say it. If you want it, I will say it. If you don't want it, I will say it. Seeing that the leader was facing a formidable enemy, he put the souvenirs he ordered from Xiangshan. In the handbag.
Zhang Fan looked at the office director, meaning the boss doesn't want you to have one? The office director's face changed. He kept asking Zhang Fan to drink tea.
When Zhang Fan saw it, he became rude.
The moment he sat down, Zhang Fan seemed to hear a voice:
Shh!
"After the committee of our Tea Su Hospital held a meeting to study, we decided to distribute dividends to relevant pharmaceutical companies at the end of next year. After all, we will make money this year."
As soon as he said this, if the dean of the Clinical School of Suzhou University was here, he would definitely be ready to curse, you little bastard, you actually stole the teacher.
When the boss of Chasu heard that he wanted to share the dividends, he felt happy, and then when he heard about the end of next year, he felt disappointed and broke his heart.
"Can we distribute it a little earlier, for example, at the end of this year? After all, we want to show everyone the contribution of Chasu Hospital."
Zhang Fan will definitely not agree to pay dividends this year. The dividends at the end of next year are probably just to get the fish to take the bait.
Zhang Fan looked embarrassed, "It's too late to pay dividends this year, but it's okay to pay it earlier, but it's probably the middle of next year. It would be embarrassing to pay it earlier."
"Hey!" Boss Chasu knew at a glance that Zhang Fan didn't really want to pay dividends, so he didn't want to take the fight.
"If you don't give me any benefits, don't let me continue to do it."
Zhang Fan looked at it and sighed in his heart, "It's so true that all the talents in China are gathered within the system."
When the dean said this, Zhang Fan's heart skipped a beat, but the man opposite him had been trying to get Zhang Fan to implement it early. As for the rest, he would not take the bait at all.
"I originally wanted to pay the dividends earlier, but..." Zhang Fan was interrupted mid-sentence.
The leader seemed to suddenly remember something very important and wanted to get up and leave immediately.
"Director Yang, do you have another important meeting? Why don't you ask the room chief to come over and talk to Zhang Yuan?"
"This guy wants to run away!"
Zhang Fan quickly said: "How about letting the European Academy come too?"
"It's not necessary, it's not necessary. There are still a few minutes. Let's hurry up. You are a great expert. The hospital can't do it without you. I can't waste your time. Let's keep the story short."
When the leader saw it, his brows were furrowed as if they were being struck by a knife, and he thought to himself: "It's so difficult! Why is it so difficult to deal with?"
"That's right, the people who tested the medicine..."
Listening to Zhang Fan's words, the leader's face turned green, red, and white, and his hands trembled.
Don’t I owe you some money? Are you such a bully?
"Those who are subsidized, those who are subsidized, one thousand yuan per round."
"Five thousand!"
"Uh, let..." Zhang Fan originally wanted to let Ouyang do the talking, but then he thought, he couldn't always use Ouyang to scare people. If you scare people, they won't be afraid anymore.
"Leader, five thousand is really not enough. I make the decision. One thousand and one, no more!"
"Four thousand, otherwise there is no need to discuss it. Your hospital is no longer under the leadership of Cha Su, so don't scare me. The government still owes the bank hundreds of millions."
After struggling for a long time, seeing that Zhang Fan really couldn't take it out, he put the price at 1,500 and went out. Zhang Fan got into the car while singing.
To be honest, the leader is smart enough, but not only is he not familiar with the medical field, but he also probably doesn't have much idea about money.
After fooling the leader with his professional knowledge for the first time, Zhang Fan felt quite proud. Really, this sense of accomplishment was no less than the feeling of passing the professional examination.
