Just when Zhang Fan and his group were on the plane.
The Lancet published a heavyweight paper on intestinal tumors.
And it was published by Chasu Hospital. The papers published before are important, but they are not big inventions.
Either a small new discovery or an innovation in surgical technology.
This kind of paper is just the accumulation of a lot of accumulation. It is helpful for the appointment of doctors, but it has not been raised enough to attract the attention of people outside the non-hepatobiliary disciplines.
But the intestinal tumor paper published this time is different.
Wanziguo and Chasu have been cooperating for almost a year.
From the beginning of the cooperation, Wanzi Country first called for patients from their own country. In the first wave, the Chasu people were shocked because they found that suddenly there were many people bowing on the street.
Colon cancer is the third most common cancer in the world. Moreover, it is particularly common in Maruko Country. I don’t know whether it is a genetic problem or a problem of eating too much sashimi. Even the Yuan capital of their country has this problem.
It is said that there is a joke that one year the prime minister of the Maruko Country gave a report to their emperor. As a result, the two-hour report required seven or eight trips to the bathroom.
The emperor was also curious, thinking that the prime minister was interested in their toilet.
Therefore, when Wanziguo saw Zhang Fan's skill in intestinal surgery, he began to cooperate vigorously with Chasu Hospital.
I originally wanted to seduce Zhang Fan to Maru Zi Kingdom, but the generation born in the 1980s grew up playing Zhang Ga over and over again during the holidays. They are definitely not the same as the one who plays chess. .
It is impossible to go to Maruko Country.
Therefore, Maruko Country can only cooperate with Chasu Hospital.
But in medical research, what’s expensive is actually not what’s in the laboratory.
It’s the funding for clinical trials.
For example, a new drug needs to be developed.
When this thing was developed, its target was cardiovascular disease.
First there were live animal experiments, and then there were dissection experiments.
But animals cannot communicate with people while playing, they can only observe target organs.
As a result, when it comes to the human body, the cardiovascular function is too ordinary.
But the doctors unexpectedly discovered that this thing was actually effective on the third leg.
To be honest, if it had not been effective on the third leg, Weiwei probably would have died in the first round of clinical trials.
These early trials and R&D are not the most expensive.
What is often more expensive is entering the clinical trial phase. Many new drugs die in this area.
This kind of test first requires a large number of specimens, and these specimens are people, so many pharmaceutical companies go to Sange to do clinical trials.
It's not that the third brother's clinical trials are awesome, but that his medicine is cheap.
Hundreds of millions or even billions of research and development expenses are actually spent on several rounds of clinical trials.
Therefore, it is too expensive for Wanzi Country to bring patients here. Then he encouraged patients from Outer Mongolia to come over.
For a moment, after the bowing, another group of Meng people wearing similar but different clothes appeared on the streets of Chasu.
When the elderly man took a look, he thought, "Aren't these the descendants of our herdsmen hundreds of years ago?"
To be honest, anyway, the Mongolian people in China say that they are the ones with the golden color, and the group outside were all herded by them in the past.
After a lot of investment, we finally saw results.
Colon cancer is easy to develop and metastasize, and its mortality rate is extremely high.
This time, the team working together between Chasu and Wanziguo finally discovered a factor that causes colon cancer to metastasize.
The scariest thing about cancer is not its growth rate. According to the current level of surgery, no matter how fast you grow, as long as it is not an important organ, it can actually be cut or embolized.
But the scary thing about this thing is that it has long legs, and it can run and be contagious.
It is particularly scary when it spreads. The first way is lymphatic metastasis. Lymph is originally the immune system. Once it is destroyed by cancer, the body will directly be affected.
Therefore, when the doctor looks, touches, or listens, he or she will feel the lymph. Especially when the doctor touches your buns, this is not to be a hooligan, but to see if your lymph nodes are swollen.
Of course, there are scum too.
Also, it spreads from blood vessels. Where there is flesh, there are blood vessels. Once it enters the blood vessels, the chance of surgery is gone. Radiation and drugs can only be used to kill the poison. The usual outcome is that the cancer is not killed, and the drugs and radiation Kill the person first.
The third type of direct invasion, such as why surgery for rectal cancer is so scary, is because rectal cancer directly invades nearby organs.
For example, the male prostate, urethra, female genitals and uterus share the levator ani muscle, surrounding skin, and bladder.
Therefore, radical surgery for rectal cancer is quite scary, as it is equivalent to digging out all the organs near the chrysanthemum.
In this kind of surgery, the chrysanthemum looks like a sunflower as big as a basin. Then all these organs are dug out, and the intestines are directly visible.
The last one is just like dandelions, planted. When cancer cells mature, they can swim around in the body like dandelion seeds and settle wherever they land.
But what is the reason that allows cancer factors to escape and metastasize?
The trouble is, the causes of metastasis vary among different cancers.
This time, the team from Chasu and Wanziguo discovered the cause of colon cancer metastasis.
Creatine!
Creatine is not only a catalytic enzyme for energy conversion in mammals. Also an energy buffer.
To put it simply, for example, your wife caught you eating secretly, and then you started lying, your brain was running at high speed, and as a result, you didn’t have enough ATP, which is equivalent to the human body’s gasoline.
This stuff is not easy to produce and preserve, so it is often stored in the form of fat. Everyone says it is good when it is stored, but once it is used, this stuff will still decompose, so when the energy is insufficient.
When the brain is about to shut down, creatine takes its place.
For example, many weightlifting enthusiasts do it in order to make their muscles bigger or to make a turtle shell appear on their belly.
Just supplement with creatine.
Tea Su Hospital found this time that for normal people, creatine is good.
However, patients with colon cancer have found that creatine also has a bad side.
This thing can promote cancer metastasis by activating the single-stage spindle to cause the Smad2/3 signaling pathway.
To put it bluntly, cancer cells were originally eating leek boxes in the colon. As a result, creatine is too cheap or has too much energy. It shows its ability to open a gap between the intestines and other organs, allowing colon cancer to escape. 's highway.
It's that simple.
What are you afraid of about disease? What you are afraid of is not knowing the mechanism, not knowing what this thing is all about.
For example, SARS back then was so scary because we couldn't figure out what it was.
But once discovered, there is always a way.
Although colon cancer has not discovered why it appears, we have discovered how it spreads.
Although this cannot completely eliminate colon cancer, this discovery is quite powerful.
If the way it escapes can be cut off, then even if colon cancer occurs, it will still be a lamb to be slaughtered. If it disobeys a little bit, the doctor can cut out the diseased intestine for you.
Therefore, this discovery is quite impressive. It can be said that once a creatine drug is developed that inhibits the impact of colon cancer, colon cancer will be directly limited to the colon.
After the successful experiment of the Chasu and Wanzi teams, conflicts broke out between the two sides.
This is the so-called whether sharing the same wealth can lead to shared wealth.
What Wanzi Country means is that they are the main force in the experiment.
Even the money for the test tubes was paid by them.
Of course, on Cha Su's side, Ren Li and others can't let go.
After arguing all morning, both parties finally compromised.
Because there are many teams researching this thing all over the world, you must publish your paper as soon as possible after success, otherwise the paper will be espionage and given to other teams, and it will be too late to cry.
Then, the first author is a professor from Wanziguo, but the strange thing is that the corresponding author is Zhang Fan, yes, Zhang Fan.
Because there is no top colon expert or scholar here. But it was impossible to let go, so Zhang Fan was asked to step forward.
Moreover, because the early stage of the surgery relied directly on Zhang Fan, although Zhang Fan played a small role in the experiment, without Zhang Fan's early accurate separation of cancer, they would not be able to study it.
Therefore, Zhang Fan became the corresponding author.
In fact, when it comes to papers, the first author is often very important, but the corresponding author is not bad either.
The first author is often the main force of the experiment and the experimenter from beginning to end.
As for the corresponding author, he often comes up with the idea, and may or may not participate in the experiment. Therefore, the corresponding author is usually the teacher or mentor of the first author.
However, he must be responsible for the experimental results and thesis. It's okay to win an award, but if there is a problem with the paper, the journal will contact not the first author, but the corresponding author.
The only one left with more weight is the second author.
The rest, third, fourth, fifth and sixth, are actually members of the atmosphere group.
After the paper was published, everyone from Johnson & Johnson to Roche, Pfizer, and Novartis started to pay attention to it.
In the past, some research and development equipment focused on Tea Su, but now it is different. Zhang Fan and Tea Su Hospital have been directly included in the pool of scholars they focus on.
After the paper was published, GlaxoSmithKline in Mishima learned that Zhang Fan was coming to Mishima. They didn't pay much attention to it originally.
Because people are not very prominent in the research and development of drugs for the liver.
But its respiratory, gastrointestinal, metabolic and anti-tumor aspects can directly represent the highest pharmaceutical level today.
So, when I saw the new discovery of tea and meatball country. They started to pay attention.
The head office directly began to contact the Royal Hospital to inquire about Zhang Fan's itinerary.
Moreover, be prepared to spend a lot of effort to publicize Zhang Fan.
Enterprises do not show any blood or swords.
But the hospital in Mishima didn’t see it that way.
"You are saying that Dr. Zhang Fan of Tea Su is suspected of fraud. It is incredible that a liver and gallbladder expert can publish a world-class colon paper."
"Yes! You can actually become the corresponding author, and the first author is a famous colon professor from Wanzi Country!"
In the Royal Hospital, the director and professor of the Hepatobiliary Department looked at the newly published paper together.
"Expand the number of participants in the speech. Let gastrointestinal experts also participate." The director of the Royal Hospital said directly.
"But if Zhang Fan really makes a lie, will it affect our reputation?"
"No, no, no, if he faked it and was discovered by our hospital, it will give us more honor."
"Okay! Do you need to invite people from other countries?"
"Does our Great Three Islands Empire still need experts from other countries?"
Professor Royal said proudly.
