Su He and the Wang brothers have decided that Wang Bonuo will go south to buy sweet potatoes in the near future.
When he was about to leave, Wang Wenjun suddenly said.
"Commander Su, I have made a major discovery about the cowpox vaccine, but I have no way to test the effectiveness of the vaccine."
Su He didn't expect the surprise to come so quickly.
This is how Wang Jijun found a cow with cowpox.
“This matter is easy to handle, there are many death row inmates and reform-through-labor prisoners in the prison.
Dangerous experiments, conducted directly on death row prisoners.
Less dangerous experiments are conducted on labor reform prisoners.
I'll give you a thousand death row prisoners and 10,000 reform-through-labor prisoners.
This quantity is sufficient to verify the safety and effectiveness of the vaccinia vaccine. "
Su He quickly met Wang Jijun's request and taught him the controlled experiment method.
…
December 8th.
Su He just came back from the dock.
Wang Bonuo was very active. He agreed to go to Fujian to buy sweet potatoes and immediately organized manpower.
It only took him more than two days to set off again.
Su He asked Su Changsheng to send some people to follow him to develop an intelligence network in the south.
…
December 20th.
As soon as Su He walked from the back house to Wenhua Hall, he saw Su Wuniu wandering around the door of Wenhua Hall.
Su Wuniu was wearing official uniform and his face was full of energy.
As the Minister of Works, he was in charge of craftsmen and engineering.
When Su Wuniu saw Su He, he immediately came over.
“Su He, I have completed the craftsman grading work.
According to your requirements, there are nine levels of workers in total.
A first-level craftsman apprentice and a ninth-level craftsman can be called a master craftsman. These people are so powerful. "
Su He stopped and gave serious instructions: "Uncle Wuniu, you must pay attention to the treatment of craftsmen.
More work, more reward.
Competent people must have high remuneration. "
“That’s for sure, I used to be a craftsman, and I know how hard it is for craftsmen.
Major factories have been basically completed, and their scale is much larger than the factories in Dashanguan.
Especially the craftsmen you pardoned, all of them have unique skills. "
Su Wuniu wanted to continue talking and introduce the situation of the factory to Su He.
Su Que trotted over and said: "Commander Su, Wang Jijun informed me that he has made vaccinia vaccine. Preliminary experiments have shown very good results."
"Uncle Wuniu, I have important things to do. We can talk about the factory later."
After Su He finished speaking, he immediately rushed to the closed cattle farm.
Wang Jijun searched for cows infected with cowpox in cattle farms to test the effect of cow bean vaccine.
Not far from Wang's Medical Center in Beicheng, there is a large house where soldiers stand guard.
Wang Wenjun was already waiting at the door of the house. She saw Su He arriving in a donkey cart.
With a smile on her face, she immediately said after seeing Su He:
"I succeeded and have produced a vaccinia vaccine that has basically no side effects."
Su He approached the house. There were many cows inside.
The cows had severe acne on their bellies.
These cows all had cowpox.
Wang Wenjun introduced her process of developing vaccinia vaccine.
“After learning about the cowpox vaccine from you, I bought a lot of cows and wanted to find cows with cowpox.
This process was very difficult, and I couldn’t find a suitable cow for a long time.
Until I met a cow that had just given birth to a calf.
I noticed that the cow was in pain when the calf was suckling.
The cow's belly was covered with acne, and some had ulcerated.
The shape and progression of acne are very similar to smallpox.
I think this is cowpox. The cowpox vaccine is cultivated using the same method of cultivating vaccinia.
The cultured cowpox vaccine was tested on prisoners and it was very safe.
I vaccinated 10,000 people and not a single death occurred.
The most serious phenomenon was that only a dozen people had high fevers. "
Su He knew that the cowpox vaccine was safe and basically not fatal to humans.
Elderly people with weak immunity rarely die if they are directly infected with the cowpox virus.
What's more, after many rounds of cultivation, the toxicity of the cowpox vaccine has been weakened.
Su He said with satisfaction: "It's named cowpox vaccine.
If you don't know if there is smallpox nearby, it would be a good idea to test whether the cowpox vaccine is effective against smallpox. "
“I’ve done this experiment and it really protects against smallpox.
The success rate was 100%, and among the 10,000 prisoners, not a single one contracted smallpox. "
Wang Wenjun said proudly.
"There's smallpox here."
Su He shouted so loudly that his voice broke.
He looked at the house and asked with some concern: "Is it safe inside the house?"
Wang Wenjun looked at Su He's scared look.
She laughed and said: "Don't worry! This is just a place where cowpox vaccine is cultivated, there is no smallpox.
The prisoner suffering from smallpox was in the innermost house.
They are kept in strict isolation.
It was guarded by guys who had been vaccinated against pox, and except for me, no one was allowed in or out.
I need to wash myself thoroughly in the bath when I come in or out.
As for smallpox, I am a doctor and I must know its dangers better than you. "
Su He asked Wang Jijun to use prisoners to test the safety of the cowpox vaccine.
Unexpectedly, she went so far as to directly perform smallpox immunity experiments on these people.
Let them try to catch smallpox and test the effectiveness of the cowpox vaccine.
"Where did you get the smallpox virus? Are the experimental results accurate?" Su He asked.
Don't be careless about this matter. The spread of smallpox virus is a fatal matter.
"Don't worry! You told me about the experimental control, and I will conduct the experiment exactly according to this method."
Wang Wenjun carefully explained to Su He the experiments she conducted.
In order to cultivate human pox vaccine, Wang's Medical Center retained some serum from the pox of smallpox patients.
Very few medical clinics dare to keep these things.
But everyone at Wang's Medical Center has been vaccinated against variola, so they are not afraid of these things at all.
Wang Wenjun gave death row prisoners and reform-through-labor prisoners who were vaccinated with cowpox vaccine, and vaccinated smallpox patient serum.
After many experiments, no one who received the cowpox vaccine developed symptoms of smallpox.
There are a thousand people on death row, and almost all of them have symptoms.
Three hundred and sixty-five prisoners died directly from smallpox.
After Su He heard this, he recognized the effectiveness of the smallpox vaccine.
There are 10,000 prisoners in the labor camp, all of whom are immune to the smallpox virus.
This amount of data can fully prove the effectiveness of the vaccinia vaccine.
"How is the production of cowpox vaccine? Is it convenient to vaccinate?" Su He asked.
Wang Wenjun happily replied: "The cowpox vaccine has a very high output and is very cheap to make, so ordinary people can be vaccinated.
The vaccination process is very convenient, and even ordinary people without medical skills can do it after simple training. "
Suhe is preparing to promote cowpox vaccine in the Guards Brigade.
Confirm the safety of the vaccine before promoting vaccinia vaccine to the people.
Wang Wenjun quickly organized a group of people to take the cowpox vaccine and go to the Guards Brigade barracks.
On the way, Su He saw what the cowpox vaccine looked like.
They are vaccinia virus slurries in porcelain bottles.
This is the original solution of vaccinia virus, a live virus that has been screened and has very low side effects on humans.
It is definitely not as effective as future vaccines.
But as long as it successfully infects the human body and makes people immune to the smallpox virus, there is no problem at all.
Su He personally explained the safety and effects of cowpox vaccine to the soldiers.
Li Dazhuang, commander of the Guards Brigade, took the lead in vaccination with cowpox vaccine.
The soldiers did not resist and lined up to have the doctor vaccinate them with cowpox vaccine.
