“In addition to improvements in size and speed, our new generation bio-3D printer has also greatly improved its printing accuracy. It is ten times more precise than the previous generation product and can print more delicate organs. Tissue. For example, some nerve tissue like hair, capillary tissue, etc.
Improved printing accuracy can increase the activity of organ tissues and improve their own functions. For example, some capillary nerve tissues that were discarded in the past can now be printed out. This can make these organs and tissues more similar to real organs and tissues, and therefore easier to survive. "
At this point, Qin Ziheng paused, and then continued to introduce to everyone: "In addition to improvements in printing, we have also made great improvements in the storage of cell consumables and the preservation technology of printed organs and tissues. .
In the past, the tissue cells cultivated by these clones were stored in a container, so it was easy for the cells to accumulate and interfere with each other.
Therefore, these cells are prone to damage and death. When printing, these dead cells are mixed inside, which will cause the death of some cells inside the printed tissue, affecting the activity and function of the organ tissue, and may even affect the survival of these tissues after transplantation.
In addition to the storage of these cells, we have also improved our technology in organ and tissue preservation. This allows the printed organs and tissues to be stored for a longer period of time and maintain high activity. "
After listening to Qin Ziheng's introduction, Zhang Jun couldn't help but ask: "So how long will it take to print these tubular arterial tissues this time?"
Hearing Zhang Jun's question, Qin Ziheng said with a smile: "In fact, it only takes a day for us to print, which is about ten hours. But we need to extract relevant tissue cells from the patient, then clone them, and select High-quality clones are cultured out and then printed, so it takes about a week.”
Zhang Jun nodded after hearing this, and then looked at the printing screen on the screen and couldn't help but ask: "What is this printing?"
"Haha, we are trying to print the human eyeball. Although the eyeball tissue is small, it is very complex, so it is very troublesome to print it. And it is very difficult to print an organ with a large proportion of liquid.
So we're trying to print it out, but it's been unsuccessful. "
After hearing Qin Ziheng's words, everyone couldn't help but look at the printed screen on the screen. More than half of the eyeball on the screen has been printed out. The outline of the eyeball can be seen clearly, but it is not complete.
What are these next to the eyeballs? Lin Wei couldn't help but become curious when she saw this.
Qin Ziheng replied: "The umbilical cord next to it is the artificial placenta. Simply put, it is the organ tissue that provides nutrition for the printed eyeball tissue. Because the printing time is relatively long, in order to maintain the activity of the entire organ tissue, we will print additional The umbilical cord comes out of this organ tissue and then provides it with nutrients.
In this way, the vitality of the organ tissue can be kept to the greatest extent, and the status of the printed organ tissue can be detected by analyzing the nutrient cycle consumption, so as to determine whether the printed organ tissue is successful. "
How difficult is it to print eyeball tissue? Zhang Jun couldn't help asking after seeing this.
Qin Ziheng immediately answered after hearing this: "The main ones are the printing of the retina and optic nerve, and the printing of the front cornea and iris. At present, we can already print the cornea, but there are still some problems in the printing of the iris and retina optic nerve. We are currently trying to gradually overcome these problems.”
Oh, can the cornea be printed out? Have you verified it? Wu Hao couldn't help but smile and asked. He knew about this experimental project, but he didn't expect that they would progress so quickly, and they could actually print corneas.
Qin Ziheng smiled and nodded: "It has been verified that we have successfully printed the corneas of mice, pigs and monkeys, and performed living transplants. Experimental tests after transplantation have shown that the recovery of these corneas is in good condition without any excretion. Abnormal reaction. And the vision of these animals returned to normal without any abnormalities.
We are currently further verifying this technology, and are preparing materials, applying for phase I clinical trials, and starting to screen relevant clinical volunteers. "
The risks of clinical trials must be controlled to ensure safety before they can be conducted. Don’t be so obsessed with progress that you neglect quality and safety. Wu Hao couldn't help but give instructions after hearing the words.
Upon hearing Wu Hao's instructions, Qin Ziheng immediately nodded and responded: "Don't worry, we have been strictly abiding by the rules you set for us.
Moreover, the safety of clinical trials of this technology can be guaranteed. On the one hand, the cells required for printing come from the patients themselves, so there will be no rejection reactions. On the other hand, this is just an ordinary corneal transplant surgery. The technology is very mature, so the risk is relatively low.
Finally, in terms of the screening of clinical trial volunteers, we generally screen those volunteers who have strong intentions and meet the physical conditions, so as to ensure the safety of the entire Phase I clinical trial.
Only after the first phase of clinical trials is successfully completed and the test results meet the requirements, we will conduct subsequent phase 2 and 3 clinical trials and expand the scope of volunteers participating in clinical trials to various groups of people. "
After hearing Qin Ziheng's words, Wu Hao nodded with relief, and then said to the other party and everyone: "Currently, there are many patients who are blind due to corneal diseases, and there are probably nearly 10 million patients suffering from blindness.
Compared with current allogeneic cornea transplantation and artificial cornea, our 3D bioprinted cornea is safer and more reliable. It is a complete human cornea tissue, no different from a real cornea, and can completely cure those caused by corneal loss or disease. causing blindness in patients.
Therefore, this will be a huge market, and if we can successfully put this technology into the market, it will bring us huge benefits beyond imagination.
In addition to the profits, we are also saving tens of millions of blind patients. This honor and this harvest are incomparable to anything else. "
At this point, Wu Hao told Qin Ziheng: "Come on, keep working hard, and strive to successfully implement this technology. I will also introduce this technology and your team in detail at this year's annual product and technology launch conference. For the whole world to know.”
(End of chapter)
