"Shocking! A major breakthrough in xenogeneic organ transplantation!"
"Can you imagine that a human heart is beating inside such a macaque?"
"And this human heart actually grew out of a pig?"
"Looking at this scene, do you feel that humans finally have an endless supply of organs for transplantation?"
"According to the latest reports in the industry, the R&D team of Sanqing Group achieved a historic breakthrough and successfully planted human organs in genetically modified pigs and transplanted them into macaque monkeys."
"Viewers, please follow my footsteps and enter the Kunming Animal Experiment Center."
"Here, the reporter will reveal to you the mystery of the world's first human-pig chimera animal experiment..."
On an ordinary working day, when people turn on the TV or mobile phone and see such a breaking news, everyone is shocked.
"Holy shit, isn't it? There are human organs growing on pigs?"
"Really? Is today April 1st?"
"Honey, come out and see God!"
“Is this news I can watch for free?”
"In addition to eating meat, pigs can also be used for this purpose. I really can't think of it."
"Here, I can't believe this happened here. I didn't expect it to be reality?"
“Reality is truly 10,000 times stranger than man’s wildest imagination.”
"Am I the only one who wonders what should some people who dislike dirty pork do?"
"Haha, don't worry, if I get a terminal disease and the organs from the pig can save my life, I will never despise it. I will definitely find a good land to bury it, so that it can rest in peace and enjoy the treatment of ancestors."
"Upstairs, have you ever thought that pigs may not want to be buried? It's a waste of land resources and not environmentally friendly."
"What, are you a pork tapeworm? Do you know what pigs think?"
"Everyone, please stop arguing and get down to business. If human organs can be grown on pigs, that would be great. Not only will the number of organ transplants increase, but the price will also drop."
"The problem is that the high price of organ transplantation has nothing to do with the organ. The organ itself is free. What's more expensive is the surgery and the anti-rejection drugs."
"I know a little bit about genome research. If the news is true, then there will be no need to take rejection drugs for organ transplantation in the future, because the organ in the pig must have been cultivated with the patient's own cells, otherwise it would have been lost. significance."
"Wouldn't it be more expensive? After all, no manufacturer will cultivate organs for us for free."
"But if you think about it, saving the cost of anti-rejection drugs will still be a huge expense after taking it for decades."
"Will it have any impact on my poor income of 3,000 yuan a month? I can't afford it anyway."
"Stop, stop, stop, have you grasped the wrong point? Is the pain point of organ transplantation the price? Is it a good donor? The biggest problem is not being able to wait for a matching organ. If there is a suitable organ, the price is actually Not the biggest problem.”
"What, did the poor people above get expelled from the hospital? Will you help me pay for the transplant cost of hundreds of thousands?"
"If you don't have money, you can first use artificial organs. Although it is a little more troublesome, it is cheap and can save lives. Technologies such as artificial hearts and artificial kidneys have already begun to be used clinically. There should be no problem in living ten or twenty years longer."
"I also think that the price of organs grown from pigs must be sky-high, because it seems very troublesome and requires senior research and development personnel to take action. Moreover, it is a customized organ for a certain patient, so the initial success rate will not be very high. .”
"Actually, this doesn't require very senior R&D personnel. Biological Dog said that as long as the technology is mature, an undergraduate can do it."
"It's great. The era of mass organ transplantation has arrived. Human beings no longer need to be afraid of disease. Living a long life is no longer a dream."
"Haha, it's just a thing for the rich. The poor should just wait to die."
"Is that Mr. Wei's trumpet upstairs? The price hasn't come out yet, and you've already made a conclusion."
"You are overthinking it. We have just finished the animal experiments. The reporters didn't even say whether it can be implemented on humans. They are already arguing about whether it is expensive or not."
"Maybe it will take ten years to realize it, so what a fuss."
Just as domestic netizens were discussing it, the news also spread overseas.
The video of the transplanted monkey instantly exceeded one million views in the media, and is still soaring.
Overseas netizens were also shocked without any surprise, but because they had more categories, their reactions varied.
Most Western netizens reacted in the same way, marveling at Sanqing's miraculous biotechnology and expressing envy and jealousy towards the Chinese patients.
"Faq, I must be dazzled to see such magical news in my lifetime."
"The Chinese are simply devils, and of course I mean this as a compliment. They actually came up with such a brilliant idea to grow human organs from pigs, thereby completely solving the problem of insufficient donors for organ transplants."
"I am a vegetarian. When I saw this news, I immediately fell into deep thought. If I face a life crisis and need organs from pigs to save my life, whether to kill or not to kill is a question."
"Hey, man, I'm sure you're going to make the double-standard decision to save your own dog's life."
"Isn't this nonsense? But I will still insist on being a vegetarian. I can save a pig."
"Oh my god, this method is comparable to the hand of God."
Even Mabuse jumped out excitedly and gave a lot of praise.
"I have long said that the 21st century is the century of biology, and Sanqing is the greatest business company of this century."
"This time, they have completely conquered disease and death. As long as the human body is clinically successful, I declare that from now on, I will be Mr. Wei's most loyal believer."
Of course, there are also some discordant voices mixed in with the turbulent public sentiment.
Mainly from animal protection organizations, they expressed strong protest against Sanqing's inhumane medical experiments on macaques. Some activists even went to the entrance of Sanqing's overseas branch to demonstrate.
In addition to these people, some religious figures were also greatly affected, but they strangely remained silent.
As for the academic community at home and abroad, experts and scholars are shocked and are also silently waiting for the follow-up.
Because they understand that Sanqing’s clinical trials will never stop at animal experiments.
Since the monkey organ transplant operation was so successful, the next step of human clinical trials is not far away.
Once human clinical trials are successful, Sanqing will open a new era of organ transplantation.
There are millions of patients around the world waiting for organ transplants every year, which will be a huge market.
This is not one of those patients who can just get a box of pills from the pharmacy and be cured.
If every patient can obtain a tailor-made healthy organ, the time and energy spent in the entire process will not be a small amount.
Xenogeneic organ transplantation will become a very refined field. Even with the power of Sanqing and one family, it will be difficult to monopolize all patients in the world, and there will inevitably be an exchange of interests.
Even if Sanqing leaked some cake crumbs from between his fingers, it would be enough for them to eat and drink.
After thinking about this clearly, some clever biologists were already trying new research ideas based on the key information revealed in the news.
After all, the opportunity to cross the river by touching Sanqing is one that cannot be missed.
****
Kunming City, First People's Hospital, Dean's Office.
"Dean Fang, is there really no other way?"
Huang Qin leaned back on the sofa, with an expression of disappointment and helplessness on his face.
Dean Fang spread his hands and said with a wry smile: "It's very difficult for us to find brain-dead patients for human experiments on xenogeneic organ transplantation."
"Your xenotransplantation is too advanced. There is no domestic precedent to follow. Due to biosafety issues, it cannot be directly used on patients who need organ transplants. It can only be conducted on human subjects with brain-dead patients in accordance with international practice."
"Brain death is a standard proposed by the medical community to determine a person's death. It is relatively scientific, but the country has not yet adopted it in judicial practice."
"There is currently no legislation on brain death in our country. In judicial practice, the criteria for determining death are heart, pulse cessation, and breathing cessation."
"So even if there are brain-dead patients in the hospital, even if they sign a body donation agreement, they can only donate their organs, and they cannot use them for clinical experiments."
"As for patients who are actually legally deemed dead, their organs have failed and their blood has stopped flowing. They definitely do not meet your requirements for clinical experiments. They can only be donated to medical schools to serve as anatomy teachers."
"So this situation is quite difficult, and our hospital really has no solution."
He shook his head and couldn't help but sigh: "I never thought that such a major historical breakthrough would be stuck in the human clinical stage."
"We can only blame it on the fact that our research in this area was too backward in the past and we have not forced the relevant departments to enact legislation. Now you have made such a big step all of a sudden, and the regulations cannot keep up with the changes in the actual situation."
"Actually, I also understand the above regulations," Huang Qin sighed and said, "After all, primates and pigs cannot be directly equated with humans. Even if there is only 1% genetic difference, the experimental results cannot be directly equated with human clinical trials. result."
"No matter how many and good the experimental results on monkeys are, they can only be used for reference and cannot be used directly. If it were me, I would not agree rashly."
“However, without clinical-level safety and effectiveness studies conducted directly in humans, how can we prove true ‘safe and effective’?”
"Isn't this a paradox? Animal experiments cannot prove the safety and effectiveness of human experiments? But it cannot be directly used in human clinical trials, so where can we prove the safety required for human clinical trials?"
"If we can't go to the clinic, no matter how much we invest, what's the point?"
Speaking of this, he couldn't help but feel a little angry, feeling deeply unwilling that the progress of scientific research was hampered by backward medical regulations.
"By the way, Ding Mian, why haven't you spoken? Don't you usually talk a lot? Why are you mute now?"
Seeing Ding Mian, who was silent and staring at the ceiling in deep thought beside him, Huang Qin suddenly became furious.
What time has it been? Do you still have time to get distracted?
Why don't you think of a solution quickly!
He complained silently in his heart, so he patted Ding Mian on the shoulder hard, trying to wake him up from his wandering state.
"Director Ding, did you hear what Dean Fang said? Should we report the current difficulties to the Director General of Health and arrange overseas clinical trials as soon as possible?"
"For example, Eagle Country and some countries in Europe recognize the existence of brain death. Can they recruit brain-dead volunteers? After completing clinical trials and obtaining proof of safety and effectiveness, they can then launch formal human clinical trials in the country?"
"What do you think?"
After Huang Qin finished speaking, he looked at Dean Fang again: "What do you think?
"Is the idea I just thought feasible?"
Dean Fang showed admiration: "Yes, this plan is good and the feasibility is quite high."
"In the gap between animal experiments and clinical practice, brain-dead remains must be used as a transition model."
"This can avoid cross-species disease risks and solve the fundamental problem that xenotransplantation cannot enter the clinical research stage."
"I support you very much. The Cleveland Clinic in Eagle Country has a close relationship with us. As long as we tell them, I believe they will be willing to carry out follow-up clinical cooperation with Sanqing on our behalf."
At this time, a voice suddenly came out, interrupting the conversation between the two.
"Would it be better if we just connected the kidneys to the blood vessels in the legs of brain-dead patients and performed cardiopulmonary bypass dialysis instead of transplanting them?"
"Huh?" Huang Qin turned his head in shock and saw Ding Mian with a deep look on his face.
Before he could react, the other person continued to talk.
"First of all, let's be clear. We are using human kidneys from pigs, which have a very high safety factor. They are not at the same level of safety as pig kidneys."
"Secondly, we only connect the blood vessels and the kidneys are outside the body. This can maintain controllability to the greatest extent. Once any problem occurs, we will immediately cut off the blood vessel connection without causing serious consequences."
"Finally, our connection time will not be long, no more than 48 hours at most. We are just verifying functionality and acute immune rejection to facilitate subsequent improvements."
"In such a short period of time, it will not cause any harm to the body of the brain-dead patient, and there will be no change in appearance. It should be easier for the patient's family to accept it."
"Of course, this is also a transitional plan. After all, it will take several months for overseas clinical arrangements to be completed. We can obtain some detailed clinical data before then. What do you think?"
Dean Fang was stunned for a moment after hearing these words. When Ding Mian finished speaking, he couldn't help but slap his thigh suddenly and let out a cheer.
"Seconds, Xiao Ding, you are still smart. I think this method is feasible and does not violate the regulations. I will try my best to communicate with the family."
"Hey, even if the patient is brain dead, as long as the heartbeat and breathing have not stopped, to the family members, he is still a living person."
"It is very difficult for any family member to accept that their organs should be taken away. This is also human nature."
"However, it's just to connect an organ outside the body to verify the functionality and safety. I don't think the family members will be very opposed to it."
"Of course, subsequent compensation such as medical expenses and the like are unavoidable."
Huang Qin understood instantly and said quickly: "That's no problem. In order to thank the patient for his contribution to medical research, we will bear the life support and medical expenses during the patient's brain death. We will never embarrass the family."
Dean Fang nodded with satisfaction.
"That's fine, don't worry, I'll find you a brain-dead patient as soon as possible."
(End of chapter)
