“ALS can be cured!!!”
This news is like a virus, spreading rapidly among people with ALS.
At first, the patients couldn't believe it, thinking it was a rumor hyped by some self-media.
It's not like this has never happened before. Patients naively thought that their diseases could be cured, and happily went to ask the doctor, but it turned out that their joy was in vain.
We have heard "Wolf Crying" a lot, and everyone has become accustomed to letting the bullets fly for a while before seeing any news.
However, when the first batch of patients participating in the clinical trial, Ma Jun and Wang Ping, exposed their test results one by one and came forward to speak out.
Almost instantly, everyone believed it.
As a result, Sanqing's customer service hotline was overwhelmed.
It also attracted the attention of the media and continued to top the trending searches.
It’s so popular, it’s all about it, especially stem cell therapy, which sounds very mysterious.
Suddenly all kinds of random speculations were flying everywhere.
It is said that Sanqing extracts stem cells from the baby's umbilical cord.
It is said that Sanqing buys placenta and squeezes stem cells.
There is also talk of Sanqing cloning human embryo slices to extract stem cells.
It is even said that Sanqing bought a large number of dead babies and refined the stem cells, which is why the treatment effect is so good.
These rumors are mixed in various self-media popularizations about ALS. They are true and false and hard to guard against, fooling a large number of netizens.
The Sanqing officials were forced to issue an announcement to refute the rumors.
"Our company's first-phase clinical trial of stem cell treatment for ALS is progressing smoothly and achieving good results."
"The 25 patients with stages I to III ALS who participated in the treatment have all had their conditions under control and have restored their ability to take care of themselves and walk normally."
"The laboratory uses the patient's own oral mucosal cells, which undergo multiple rounds of differentiation into neural stem cells, are injected intrathecally into the spinal cord, and finally differentiate into neuron cells to achieve the therapeutic effect."
"Currently, this therapy is only suitable for patients in the early and middle stages. Clinical treatment has not yet been carried out for patients with advanced stages. The quota for the second phase of clinical trials is now being actively opened. Everyone is welcome to sign up on the Longtu app."
"According to regulations, new treatments must undergo phase three clinical verification before they can be approved for marketing. The specific time is not yet known, so please be patient. Thank you for your attention!"
At the end of the announcement, a link to a paper published in the journal Life was thoughtfully attached.
At this moment, the self-media suddenly shut down.
They opened the paper at the speed of light, but were lost in the vast sea of professional words and experimental data. They were at a loss for a while and could only wait for the popular science from experts to learn from it.
After all, Sanqing officials personally said that the patients' own somatic cells were used and had nothing to do with human placenta. They couldn't forcefully spread rumors to avoid being thrown rotten eggs by readers and ruining their reputation.
But the paper is too professional, and these science illiterate people really can’t understand it. They don’t know where to start if they want to make it up.
You can recognize these words and phrases individually, but put them together and it's like reading a book from heaven. You can only stare and be blinded!
On the other hand, the science popularizers on Station B immediately ushered in a carnival.
Many uploaders have received higher education, and at least their high school biology knowledge has not been eliminated. It is not difficult for them to learn information about stem cells.
The hosts of Up worked overtime overnight and produced popular science videos one after another, which kept the audience hooked.
Also learned more about ALS and stem cell therapy.
Thanks to the publicity of the Ice Bucket Challenge and the living celebrity case of Hawking.
ALS has a huge reputation among the people. Not only is everyone aware of it, many people have heard of this disease more or less.
Even movies and TV dramas have kept pace with the times. The protagonists no longer suffer from leukemia and congenital heart disease, nor do they become vegetative, because all these diseases can be cured.
There were not many terminal illnesses left for the directors, so they rummaged through the boxes and finally found the trump card of ALS.
Not only is it famous, there are various celebrity platforms, and there is also natural ice bucket challenge publicity, and it is really a terminal disease that humans cannot overcome.
So they all pressed on the heads of the protagonists.
But only halfway through the show, I heard the sad news that ALS can be cured.
The directors were as if they had been struck by lightning on a sunny day. They were so shocked that their faces turned pale and they could not help but howl in their hearts.
At this time, all the terminal diseases were dealt with by Sanqing. In their poor brains, there was really no terminal disease that could be arranged for the protagonist.
Not to mention the terminal illness crisis in film and television dramas, netizens are rejoicing at the moment and are discussing it enthusiastically online.
"It's great. Finally there is a treatment drug. I hope it can be launched soon and relieve the pain of many patients and families."
"In just a few decades of life, being healthy, able to eat, drink, and run is the greatest wealth and happiness."
"Every time I see these terminally ill patients, I feel less anxious. At least I have health."
"Unfreeze life with love, Sanqing, you are awesome!"
"I give Sanqing a thumbs up and hope that people suffering from Alzheimer's disease can thaw out as soon as possible."
"My mother died from this disease. It was only three years from diagnosis to death. It would have been better if this medicine had been available earlier."
"My father, too, passed away after being ill for five years. Although he can no longer use this medicine, I will burn incense sticks for him and tell him the good news."
"My brother is like this too. He can't take care of himself, and his family takes care of him. But now that he knows the news, he has already applied for a clinical trial quota. I wish him good luck."
"Every time I see reports about ALS, it reminds me of my mother. She passed away three years ago. I really miss her."
"My dad died from this disease. It was so painful. First, he couldn't move his hands, then his feet, and finally his respiratory tract. Slowly, he couldn't even speak. He was so shriveled that only skin and bones were left. ”
"Hey, my nephew also has the same disease. He is 11 years old. He was diagnosed when he was more than 1 year old. Now he can be treated. It seems that God has finally shown his power."
"This disease is very scary. I don't know the cause of it. There is no warning when it attacks. One of my leaders was a soldier before and was always in good health. Suddenly I felt unwell. Then I was diagnosed with ALS. I survived. He left after a year, only 45 years old."
"A small part of it is hereditary, and the cause of the disease is unknown for most people. In fact, the drug Sanqing only treats the symptoms but not the root cause, but it is already the best treatment drug."
"Under what circumstances does ALS occur? Modern medicine still needs to continue to study to find out what the cause is, so that it can be completely cured."
"Looking at the paper given by Sanqing, the disease is under control. As long as it is discovered and treated early, it can be delayed forever. If nothing else, at least my life is saved. Maybe I can be like Hawking, who will be delayed for three or four years." ten years."
"There is no greater good than benefiting the common people."
"I hope there will be more reports and popular science like this in the future, and less celebrity searches and gossip."
"It's great. Before I knew it, medicine has become so advanced that people with chronic and rare diseases can live with dignity."
"I have a question. Now that early-stage ALS can be treated, what about late-stage patients? Should they just wait to die?"
"It's hard to say. At present, we can only delay the deterioration of the disease, but we cannot reverse the disease that has already worsened."
"With Sanqing's research and development speed, it should be able to treat late-stage patients soon."
"I hope patients with late-stage ALS can get out of their predicament as soon as possible."
"Come on Sanqing, it will definitely work. We can see the light."
"There are too many terminal diseases in the world. I hope that one day, with technological breakthroughs, there will be no terminal diseases in the world!"
"Have all the five major terminal diseases in the world been conquered by the Sanqing?"
"Cancer, AIDS, leukemia, ALS, and rheumatoid disease. The first four can be treated. Leukemia is still a type of cancer. After all, rheumatoid is the only one left."
"Is rheumatoid disease considered a terminal disease? I feel like many of my relatives have this disease."
"This is an autoimmune disease, and it's actually scarier than you think."
"Terminal diseases refer to difficult and complicated diseases that cannot be effectively treated without specific drugs. It does not mean that a high mortality rate is considered a terminal disease."
"That's it, that's pretty much it. I hope Sanqing will continue its efforts to get rid of rheumatoid and completely eradicate human terminal diseases."
"Wake up upstairs, Sanqing is a pharmaceutical company, not a wishing fountain."
"To be honest, there is only one terminal disease left in mankind now, and that is the disease of poverty."
"Heartbreaking, but true."
"It's me. Although I look healthy on the surface, my body beneath the skin has long been riddled with disease."
"Damn it, if Sanqing can cure this terminal disease, I'm willing to treat Mr. Wei as my ancestor."
"Don't put so much pressure on Mr. Wei. This disease cannot be solved by him alone. It still depends on everyone's efforts."
"Indeed, this depends on the consciousness of the people. You can only strive for a good life by yourself, and you cannot count on charity from others."
****
Sanqing Headquarters, Neuroscience Laboratory.
Chen Yiqing looked at the nerve cell tissue slices under the camera, frowned deeply, and murmured to himself.
“Experiments on rats have shown that stem cell therapy is highly effective in treating acute spinal cord injuries, but is less effective in treating complete spinal cord injuries.”
"Most paralyzed patients have complete spinal cord injuries. Their vertebrae have severe fractures, dislocations or penetrating injuries, which all lead to transverse rupture of the spinal cord."
"The process of repairing a spinal cord injury is like building a bridge between two sides of a river. The difficulty varies depending on the situation."
"In ordinary spinal cord injuries, after nerve rupture, the distance between them is like the two banks of a stream, very close to each other."
"In this case, even if there is no stem cell filling, the nerve cells can repair themselves spontaneously, and they can cross it with one foot and connect them together with force."
"For slightly more severe spinal cord injuries, the distance between the severed nerves is like a river that is more than ten meters or dozens of meters wide. It is very difficult to connect them together by relying on their own repair power alone."
"At this time, the number of the body's own neural stem cells is very small, and the axons that grow cannot connect to the other side."
"But the river is not wide and the water is relatively shallow, so stem cells can be transplanted to solve this problem and build a bridge connecting the two banks."
"The transplanted neural stem cells can differentiate into glial cells, just like filling the bridge piers in a shallow river. Then the neuron cells are like the steel bars of the bridge, growing axons to connect each other, thereby retransmitting information to the other side."
"However, when the spinal cord injury is particularly severe, such as in patients with high-level paraplegia, their spinal cord has been completely severed in some places."
"Neurons need to grow to several millimeters in order to be connected together. A few millimeters may seem short, but for cells at the micron level, it is a natural chasm, and there is a lot of scar tissue in the middle, which acts as a physical barrier and blocks the spinal cord. of healing.”
"Just like a big river, there are hundreds of meters wide between the two banks, and the current is very fast. Just transplanting neural stem cells can no longer build a bridge for people to cross."
"What should I do in this situation?"
Chen Yiqing stood up suddenly, paced back and forth in the laboratory, thinking hard, his brows furrowed into the character "Chuan", but he still couldn't figure out the solution.
"Bridge, build bridge, build road..." These words kept repeating in his mouth, and they almost turned into a mantra.
Suddenly, he thought of the widest river in China, the Yangtze River, and the Yangtze River Bridge he had seen before. There was a bang in his mind, and a flash of light flashed through his mind like an electric current.
"That's right, build a bridge! Even on a river as wide as the Yangtze River, which is thousands of meters wide, humans can build a bridge of more than 6,000 meters to connect both sides of the river. The connection of a few millimeters between nerves is naturally not a problem."
"I was mistaken before. Building a bridge cannot only use stem cells, but also requires the use of other ingredients."
"A neuron can grow from the brain to the spinal cord. It grows for many years to form countless axons and establish a nerve network throughout the body."
"Now it is broken and shrunken. The gap in the middle cannot be completely filled by transplanting some neural stem cells."
"Not to mention that neuronal growth usually occurs in a radial pattern, spreading outward from a central point and is very free and unguided."
"The transplanted neural stem cells can easily grow and grow to other places. They cannot accurately form a straight line and accurately connect the two broken ends."
"It would be a stroke of luck to allow it to grow freely into a fixed position."
"However, I can build a larger and longer neural scaffold, connect the two ends of the damaged nerve, and then put neural stem cells in the scaffold and let them grow in one direction, and it will be effective."
"In this way, we can artificially build a bridge to connect the two sides of the Taiwan Strait and allow nerve signals to flow unimpeded."
After figuring this out, Chen Yiqing was immediately excited.
"Such a neural scaffold must be a hollow 3D structure, and the design must be very sophisticated to guide the regenerated neurons in the correct direction and reconnect the damaged ends of the spinal cord."
"Artificial nerve scaffolds are like bridges, helping neurons regenerate and bridging the gap between the two."
"In this way, even paralyzed patients can recover."
"It's just that the material for this bracket is hard to find."
"To have extremely high biocompatibility, it is best to replace the extracellular matrix to provide support and guidance for the correct growth of neurons."
"Which is better, collagen material or high molecular polymer material?"
"What kind of thermal stability and mechanical structure should it have?"
Chen Yiqing searched in his limited knowledge base of materials science, and felt a faint sadness in his heart.
“I don’t know much about these advanced materials!”
"By the way, Nano Lab, I have to cooperate with them!"
He slapped his thigh suddenly and walked out with bright eyes.
