Suzhou University, Sanqing Branch.
"Haha, Xiao Du, come in quickly, I'm looking for you for something."
In the dean's office, Du Biao was warmly welcomed as soon as he showed up.
Dean Lu's enthusiasm made him instantly flattered.
"Dean, what do you want from me?"
"I heard that the xenogeneic organ transplantation operation in your laboratory was successful?" Dean Lu asked curiously.
"I can't say it was a complete success," Du Biao said with a habitual humility. He suddenly remembered that he was here to announce the good news, and he couldn't be too low-key.
So he quickly said: "We transplanted genetically modified pig kidneys and pancreatic islets into baboons. The survival time is more than a week, which shows that the operation was quite successful."
"The baboon is very healthy so far. There is no acute immune rejection in the body and all physical indicators are normal."
"This is the first multi-organ xenotransplantation operation in China, which is of great significance and has achieved zero breakthrough."
"Even in the field of xenotransplantation in the world, our pigs have the most modified genes, up to 36 types, and they are all perfect, without any mutations or functional abnormalities."
"The success of this operation is enough to prove that our country has reached the international leading level in xenogeneic organ transplantation."
Having said this, Du Biao couldn't help but blush slightly. Fortunately, his current face and eloquence have been completely transformed after being trained in academic conferences. He said these words in one breath without any pause at all.
I heard Dean Lu slapping his thigh fiercely and cheering repeatedly.
"Okay, okay, okay. With such impressive results, applying for Distinguished Young Scholars is a good thing."
"It seems that the school is really going to support you this time."
Du Biao was immediately delighted: "Dean, you, you are also optimistic about me?"
Dean Lu's face became solemn and he said, "Don't forget that I usually like to make jokes with you, but this time I am really optimistic about your project."
"Xiao Du, I don't know whether I should praise you for your determination or your good luck."
"The field you chose is really unpopular and has no competitors at all."
"No one has studied this before you, and there are some big names in this field, but compared with foreign countries, the results are still a bit behind."
"Besides, he is older, and he is directly looking for academicians. There is no conflict with you at all, but there are broad prospects for cooperation."
"When I say this, you go back and think about it yourself."
"Research on xenogeneic organ transplantation, I remember that it started to become popular after the first clinical case of pig heart transplantation into humans abroad. Previously, it was all about non-primate clinical research, and it has not yet been applied to humans."
"You are really lucky. As soon as you become popular, you will produce results."
"Not only is this area very popular now, it's also extremely hot. According to my gossip, it's even on the Ministry of Science's focus list."
"Your current research can be considered as filling the clinical gap in non-primate research in China. Not only is it multi-organ transplantation, it also modifies 36 genes, which can be regarded as solving some of the problems of immune rejection and biosafety."
"I went back for a meeting yesterday, and Academician Meng asked about your project."
Du Biao was shocked: "Ah, what did Academician Meng say?"
"As you know, we have nine academicians at Suzhou University, mainly concentrated in two areas, half of which are in the fields of medicine and biology, and the other half in the field of nanomaterials."
"Now the four medical academicians are very interested in your project."
"That's why I said, you have great hopes for Shen Jieqing this year."
Dean Lu said with a smile: "Has the paper been published? This is very important. I guess your paper must be published in a formal publication, so the hard conditions are met."
Du Biao was a little embarrassed: "It hasn't been published yet. I just wrote the first draft and am waiting for the survival data of the baboons."
Dean Lu waved his hand: "It's okay, it's still early."
"Your monkeys only need to survive for more than 40 days."
Du Biao nodded, and then asked curiously: "Why is it 40 days? Is there anything special about it?"
At the same time, I was thinking, should I terminate the experiment after 40 days? Or should we keep the baboons alive?
Dean Lu shook his head, a smile slowly appeared on his face.
"Because the big guy who does xenotransplantation also did pig kidney transplantation, but the recipient monkey only survived for 38 days. As long as you surpass him, you will be considered an innovative breakthrough. Hahaha~"
Du Biao couldn't help but smile: "Then this shouldn't be difficult. I'm very confident in the baboon's vitality. It must survive for more than three months."
"Yeah, that's even better. It's directly leading the world." Dean Lu laughed heartily.
"The school told me privately that you have been put on the list."
"Hurry up and write the PPT of your speech. Remember to be concise and concise. Don't write thirty or forty pages. The judges won't have time to listen to you talk so much. Just write a dozen pages, put the paper on it, and explain the project clearly."
"Yeah, I understand, I'm already writing." Du Biao was secretly happy and nodded quickly.
"That's good." Dean Lu taught earnestly, without any secrets.
"Don't worry, if it were another topic, a layman might not be able to understand it, but for your topic, even a primary school student can understand it, let alone those academicians and outstanding students."
"Anyway, your meal is now on the table. For the rest, just remember to draw more cakes. The bigger the cakes, the better. Those old guys are all doing this."
As Dean Lu talked, he couldn't help but fall into memories.
"When I went to the meeting, those guys asked me what I was talking about. Yes, they asked very few about the specific details of the project, so they caught me asking..."
"What is the biological significance of your project?"
“Are there any underlying medical issues solved?”
"A lot of the papers you published and the work you did were about hot issues. The articles are good-looking, but what human problems have they fundamentally solved?"
The more Dean Lu talked, the angrier he became: "Ah, these questions may seem high-minded, but they are actually all bullshit."
"I was asked about it on the spot, and I was almost dumbfounded."
"Fortunately, I am smart and have a strong foundation in biology. I quoted a lot of information on the spot and quoted classics. From biology to anthropology, and then to philosophy, I finally fooled these old men."
Hearing these words, Du Biao became more and more frightened: "Huh? Are all the judges asking this kind of question? Then I have to write it down quickly."
He groped around on his body and found that he didn't have a notebook with him. He quickly took out his mobile phone, opened the memo, and wrote down several questions that Dean Lu said one by one.
Dean Lu said so many words in one breath, and felt a little dry. He picked up a glass of water to moisten his throat and continued.
"But your research is different from mine. Illiterate people can make up their minds after reading it."
"You can talk about it in a big way. It not only solves the major medical problem of organ transplant shortage, but also makes a brand-new explanation from the perspective of genomics and biogenetics, in depth and from multiple angles."
"It is of great epoch-making significance for the survival of mankind and the continuation of civilization."
The more Du Biao listened, the more confused he became: "Is my research really so significant?"
"Is it such a great contribution to mankind? Can it even affect the entire human civilization?"
"It doesn't matter how much it means to mankind, but it is very important to tell everyone." Dean Lu made the final decision and made a key summary.
"In short, this ppt is related to your bright future, so you must not be careless."
"You'd better find someone who can write. Make sure to highlight the highlights of your work. After you've finished writing, show it to me and I'll check it for you."
"Also, you'd better send that paper out as soon as possible. Don't delay it too late. The monkey can die at any time, and it won't be far away from those few days."
At the end of the speech, he did not forget to mention Du Biao, and he simply gave it to him.
"I understand, thank you, Yuan Lu. Don't worry, I will never let you and the school down."
Du Biao was confused, but he wrote them down one by one and nodded firmly.
It was just a ppt, but Du Biao still had a certain degree of confidence in his document writing ability.
Now that the school has made it clear that it will support him in his promotion, there is a high chance that he will be selected as an outstanding student.
This is how judging hats is, it depends not only on the judges' own abilities, but also on the connections behind them and the support of the platform.
When all three are combined, losing is unlikely.
His application has been submitted a long time ago, and it contains the research work to be carried out, which is mainly focused on xenogeneic organ transplantation, including solving a series of problems in human clinical aspects. It is absolutely very innovative in China.
Applications for outstanding youths are all processed through work units.
The academic committee of the unit will select the merit list, and then the unit will sign the recommendation and submit the materials to the corresponding science department.
Therefore, the platform and the power of the big guys behind it play a decisive role.
Suzhou University has its own academicians, who are also academicians in medicine and biology. In addition, there are more than 30 outstanding young people.
These connections are crucial to him.
Especially in the selection of medicine and biology, connections are all about.
Although the academicians and outstanding young people of the school have to avoid the selection meeting, it is still very easy to say hello to familiar colleagues and exert some influence.
From the tone of the school, it is obvious that the higher-ups are also very interested in the emerging field of xenogeneic organ transplantation and want to train a young academic leader.
Then, there is no other choice except him.
In addition, his academic achievements are indeed outstanding and no one can deny them.
It is still an unpopular track that has just become popular, and there are not many competitors.
It can be said that the right time, the right place, the right people, and everything is taken care of.
If this is not enough to qualify him as an outstanding youth, then he might as well go home and find a piece of tofu and hit him to death.
"That's good. By the way, many students are interested in your research direction this year, and the school has added a lot of student places for you."
"Here is a list of several direct descendants of big bosses who would like to come to you to study for a doctorate."
At the end of the sentence, Dean Lu picked up a document from the table and handed it over.
Du Biao was shocked, knowing that this was the so-called exchange of interests.
He took the list with a heavy heart and scanned the names on it, still having some doubts in his heart.
“How good are these people at doing research?”
"If the ability is really limited, the job of plating scrap iron with gold will not be easy to do."
Dean Lu seemed to see what he was thinking, and smiled and said, "Don't worry, I've checked everything for you."
"There are parallel imports in there, but not many, just one or two. The others are all capable. You just need to train them carefully. Don't worry too much."
"They are also exploring new directions for the big guys. After all, the mainstream research fields are pretty much the same."
"Now that we see such a brand-new virgin land, everyone will be tempted and want to get a foot in the door."
"Even if you don't make any academic achievements, you can still make a lot of money by starting an organ transplant company."
"You just have to be aware of the relationship here."
Du Biao nodded slowly and said nothing more.
He knew in his heart that this was the price he had to pay in order to be recognized as an outstanding youth.
Once you put on your hat and get on the card table, your life will be much better.
Denounce academics, envy academics, understand academics, and then become academics.
At this moment, Du Biao suddenly understood everything.
****
Kunming, Animal Experiment Center.
"What? The baboon is dying?"
"what happened?"
Huang Qin rushed into the breeding room and shouted eagerly.
The breeding room was divided into several large cages separated by fine wire mesh, housing the six baboons who had undergone transplantation operations.
At this moment, in the cage on the left, a baboon was lying on the mat, with its feet in the air, motionless, and looked like it was dying.
"Forty-five days after the kidney transplant, the condition suddenly took a turn for the worse. The left kidney began to stop producing urine and was unable to remove creatinine from the blood. A biopsy of the transplanted kidney revealed necrosis of the glomerular cells in the left kidney and the formation of unexplained micro-thrombosis. .”
Xiao Gao followed closely, explaining in a hurried voice.
"We are still studying this, and it is not yet clear why there is a difference in urine output between the two kidneys, nor why creatinine cannot be cleared."
“One guess is that due to upright walking, the blood pressure of humans and baboons is higher than that of pigs, so the blood vessels of the pig kidney may be damaged by the baboon’s blood pressure after transplantation, causing damage to the vascular endothelium and blockage of the blood vessels, thereby causing thrombosis. "
"In addition, since the immunosuppressants we use are all human drugs, long-term use also has many side effects on baboons, and may cause some damage to kidney function."
"Taken together for various reasons, this baboon will most likely not survive more than a few days."
When Huang Qin heard this, his expression suddenly softened a bit: "That's right, there's nothing we can do about it."
"Xenotransplantation is still a new research, and it is still full of many unknowns waiting for us to answer."
"It seems that more clinical research is needed to solve a series of problems caused by xenotransplantation and truly benefit mankind."
He took one look at the baboon's painful expression and made an immediate decision.
"Since it's hopeless, let's euthanasia it. It's considered a closure and it's in compliance with the regulations."
"By the way, how are the other baboons doing?" he asked as he walked to the other cages.
Seeing this, I couldn't help but frown.
There were 5 baboons left, each with their own abnormalities. Some were slow and listless, and some were grinning and irritable. In short, few of them looked healthy.
"These five are also suffering from certain physical conditions," Xiao Gao rushed over. When he saw the situation, he stopped talking.
"It's okay, tell me everything in detail." Huang Qin comforted: "Scientific research is always full of surprises, and it is impossible to follow the plan completely."
"Even if all the baboons die, it's expected. It's just that we need to delay their death as much as possible, you know."
"As long as the cause of death can be found and the next experiment continues to be improved, the harvest will be huge."
Xiao Gao nodded and explained the situation one by one. (End of chapter)
