"25 minutes!"
"The transplanted kidney produced urine within 25 minutes after blood reperfusion."
The surgeon in charge stared at the baboon's urine bag, his eyes gleaming, and he shouted excitedly.
In an instant, everyone turned their attention.
The urine bag that was originally empty was now half filled with orange liquid.
This liquid, which seemed somewhat disgusting to ordinary people, was so pleasing to the eyes of everyone present, more charming than the most beautiful flowers.
Everyone stared at the urine bag with an intoxicated smile.
"Hahaha, it finally worked." Du Biao touched his chin, Lao Huai couldn't help but feel happy.
"There has been no acute rejection reaction for half an hour, which shows that the immune suppression is very successful. It depends on how long you can live after transplantation."
Huang Qin also breathed a sigh of relief, feeling that he was one step closer to final success.
"For xenogeneic organ transplantation, an international consensus has been established to enter clinical trials. After testing on non-human primates, the survival rate is more than 6 months, and the continuous success rate reaches 60%."
Dean Liu has done relevant homework and is familiar with various standards, he said cheerfully.
"Didn't you prepare 6 pigs? As long as 4 of them survive for more than half a year, they will meet clinical standards."
"There are two of them with a fault tolerance rate. I feel that the probability is quite high."
The chief surgeon also nodded in agreement: "For xenogeneic organ transplantation, the kidney is the most ideal organ. You have done the right thing by choosing to start with the kidney."
"Because unlike the heart, if something goes wrong, the kidneys can be removed and the patient can undergo dialysis."
"There is only one heart. If something goes wrong, it may not be possible to save."
"In addition, the success rate of islet transplantation is also very high. At present, the baboon's immune system has not rejected the pig organ, and there has been no massive bleeding after transplantation. It can be seen that all functions are normal."
"It will be fully tested later to see if the transplanted organ has been damaged in the short term, and the insulin levels in the baboon's body will be checked."
"In the next few days, we will closely monitor this baboon and pay attention to its survival time. All test results will be notified to you as soon as possible."
"However, the absence of acute rejection, which is a good thing, does not mean that chronic rejection will not occur."
At the end, the surgeon expressed a certain degree of concern.
"What is not known is whether the baboon's immune system will attack the transplanted organ months later, and whether the organ will continue to function by then is also unknown."
Huang Qin said thoughtfully: "What you said makes sense. I hope the baboon can survive longer."
"There are already ready-made examples of pancreatic islets abroad. After transplanting gene-knockout pig islets, monkeys survived for a year and improved their diabetes."
"So I'm not worried about this. I just hope that the complications of kidney transplantation can be reduced."
"Hahaha~" Du Biao laughed at the side: "The success of the operation is already a great joy. As for how long he will survive, it is not something we should think about now. We just have to wait and see what happens."
"If I remember correctly, this is the first multi-organ xenotransplantation operation in China."
"This is big news that broke the record. We have to celebrate it and publicize our achievements."
"That's right, teacher, I'll leave this to you. Call the reporters back later and give it a good publicity."
Huang Qin nodded, and then gave instructions to the eight students behind him who were as silent as chickens.
"You will take turns to stay here these days, carefully observe the baboon's post-operative condition, and record them one by one. The more detailed the better."
"knew!"
The students all responded in unison, with uncontrollable joy on their young faces.
Fortunately, they knew that this was not a laboratory, but a serious operating room, so they all stopped jumping for joy.
The success of this transplantation operation shows that the genetic modification of pigs is very successful.
As long as the baboon's survival time and postoperative conditions are recorded, this experiment will come to a perfect end.
If it survives for more than 6 months, it will not only break the record, but directly create a miracle.
A student in his 20s with limited life experience has never seen such a big scene.
At this moment, each of them felt as if they had taken ten pounds of chicken blood, their hearts were beating fast, and adrenaline was being secreted crazily.
As soon as he heard the instructions from his senior brother, he acted like a robot and immediately agreed.
After Du Biao and Huang Qin left together, they took turns staying in the operating room and breeding room to observe the baboons after xenotransplantation.
****
"On the first day after surgery, both kidneys excreted approximately 900ml of urine."
"The baboons' serum creatinine, which is excreted in the urine through the kidneys, began to slowly decline, and the transplanted kidney began to function."
"On the third day after surgery, the baboon's fasting blood sugar level dropped significantly, and endogenous insulin secretion was detected in the body, which greatly enhanced blood sugar control."
"On the 5th day after surgery, a biopsy of the left kidney was performed, and the renal tubules and glomeruli were normal."
"There was no endothelial injury, fibrin thrombus, or evidence of immune rejection."
"Daily blood sample analysis showed negative for endogenous viruses in pigs."
"This means that no porcine virus derivatives that should not be present were detected in the baboon's blood."
"At the same time, since there are no signs of immune rejection yet, the dose of immunosuppressants has also begun to be gradually reduced."
"So far, the baboon that received xenogeneic organ transplantation has survived for 7 days in good health."
"Although chronic immune rejection cannot be ruled out, there should be no problem for this baboon to survive in a short period of time."
Huang Qin read the report on the computer line by line, and stared at the picture of the lively baboon on the screen for a long time before he started laughing.
"Teacher, it seems that our xenotransplantation experiment was really successful this time."
"When doing scientific research, you must remember to guard against arrogance and impetuosity. This is the first step. It is nothing if a baboon can live for 7 days. It is only if it can live for 70 days. Only if it can live for 700 days can it truly achieve the goal."
Du Biao stood behind him, looking at the data on the screen, and he felt deeply relieved.
He originally wanted to give a habitual warning, but seeing the eldest disciple smiling so happily, he just gave a small reminder, and then they laughed happily together.
"But everyone did a good job this time, and my old face also got the credit."
"If the baboon is still alive in two months, you can write a paper of your own and publish it in Nature or Life without any problem."
Thinking of this, Du Biao suddenly became excited. This was a top journal. He finally had a top journal paper in his name. Who would dare to call him Professor Buffalo in the future?
As long as this paper is published, he can give him a slap in the face and knock back all the clamor of the trolls on the Internet.
Besides, how can we evaluate outstanding students without top-ranking papers?
Once he appears on the cover of the top issue as the corresponding author, there will be no suspense in this year's Outstanding Youth selection.
The more Du Biao thought about it, the more excited he became. He smiled from ear to ear, and the nasolabial folds on his face stretched a lot.
"That's right, I will write a first draft during this time. When the subsequent data comes out, I will put it in together and refine it before publishing it."
Huang Qin said casually, crackling in his hands as he created a new word document.
"Report on early organ transplantation of kidneys and islets in 36 genetically modified pigs"
Corresponding author: Du Biao
Author: Huang Qin
He paused briefly and quickly added the names of eight other students after his own name.
Du Biao looked at this scene and nodded secretly in his heart. Xiao Huang is really a good person. For such an important paper, everyone has a share in it, regardless of whether the students are close or close, and regardless of the level of contribution.
As the only student who successfully cultivated genetic pig embryos, Xiao Gao gained the status of second author.
Although the second author is not as valuable as the first author, his recognition is still relatively high, especially the top journal paper, which is of great significance to him.
Not only can it be awarded, but it can also be counted as his research results.
Considering the prospects in the field of xenotransplantation and his high degree of participation in the project, he is likely to become a unique talent after graduation.
As for other students, even if the embryo cultivation fails, they have no important contribution to the project.
But there is still hard work without credit, and getting the right to author three, four, or even nine papers is what it should be.
However, the level of contribution is definitely not as high as that of the previous people, and the recognition received is also relatively limited.
But considering that among this group of students, the worst one has published five SCI/CSCD papers, which has fully satisfied the graduation requirements for graduate students.
Du Biao couldn't help but consider another practical issue.
He pondered for a moment, then spoke carefully.
"Xiao Huang, when your paper is published, it should be time to research 3."
"That's right." Huang Qin said casually while writing down his thoughts.
"Then have you ever considered graduating early?"
"Huh?" Huang Qin suddenly turned around and looked at his mentor, his eyes widening.
Du Biao thought he didn't understand, so he explained in detail.
"You see, you have completed all the courses and your grades are very good."
"The research direction was determined within half a year of the first year of graduate school. After the second year of graduate school, I finished writing the first draft of the thesis and completed the graduation assessment requirements."
“In the second half of this year, when I am in my third year of graduate school, I will publish my thesis and then complete the graduation thesis defense at the end of the year.”
"You can graduate directly."
Speaking of this, he couldn't help but sigh.
"In two and a half years, you will be able to graduate with a Ph.D. I have never taught such students in my life."
"You have already published a paper before others have decided on a research direction. You have completed your graduation defense while others are still learning to do experiments. You have already made world-class research results while others are still worrying about the topic of thesis."
"Xiao Gao and the others call you Senior Brother, and you really deserve this title."
"From now on, you will be the senior brother of our department. When the junior brothers and sisters enter their work, you will have to take more care of them."
Huang Qin asked in surprise after hearing what the teacher said.
"Well, haven't I been a direct blogger for five years?"
"You can graduate so early?"
"Isn't there a minimum number of years to graduate?"
Du Biao said angrily: "People's Ph.D. degrees are all delayed. Those who can graduate early are already outstanding students."
"Others graduated a year and a half ahead of schedule, but there is no one like you."
"But there's nothing you can do about it. You're too capable. A doctorate degree is not a job contract. You have to work for five years. Once you meet the graduation requirements, you can graduate."
"I'm not the kind of tutor who exploits students. How could I prevent you from graduating?"
"Actually, it's not legal to get a PhD in 2 and a half years. A direct PhD requires at least 4 years, but you are not an ordinary person."
"You can replace me as a doctoral supervisor, why are you still pretending to be a student in school? Is it fun?"
"If you really don't want to graduate, that's fine. Just stay on campus and be a good student for two more years."
Huang Qin was happy when he heard this and nodded repeatedly.
"I was wrong. It was because the teachers taught me well and gave me enough respect and freedom that I had room to express myself freely and was able to graduate early."
"Don't worry, when the junior brothers and sisters graduate, I will definitely protect them."
"If you want to work in Sanqing, you can do it. If you want to work in other laboratories, I will highly recommend it."
Du Biao thought for a while and added.
"Actually, although you graduated in two and a half years, you only completed the thesis defense. You have to wait a few months to get your degree certificate and graduation certificate. It is estimated that it will take almost three years to get them."
"The main thing is that you have written several doctoral theses before and now. Your scientific research level is already at the level of a doctorate."
"In this way, the biggest problem in obtaining a doctorate title, the requirement for a thesis, will be easily solved. So it is not an exception for you alone."
"I remember that there was a Nobel Prize winner named Axelrod abroad. His work had been fruitful for many years, but in order to establish his own business, he had to obtain a Doctor of Science title."
"So he went to study for a doctorate at the age of 42, just like you, working and studying at the same time."
"But he studied for a master's degree while working before and published many doctoral-level papers, so he completed his doctoral studies in only one year."
"If you calculate it this way, it's almost the same as him. It takes two years to graduate with a master's degree and one year to graduate with a doctorate. Overall, it's very reasonable."
Huang Qin was stunned for a while when he heard this: "Why do scientists need to have a doctorate title if they set up a new branch?"
Du Biao coughed lightly and gave him a meaningful look.
"Since you asked, let me tell you that this is almost the default rule in academia."
"For scientific research institutions, you must have a doctorate title to become the head of a laboratory."
"The professional titles in colleges and universities are similar. For example, if you want to be a professor, doctoral supervisor, or outstanding student, you must have a final degree, that is, a doctorate."
"Of course, there is no such requirement for the industry. If the company is willing to hire a master's or bachelor's degree to be the person in charge of R&D, that is also the boss's own business."
Huang Qin couldn't help but blurt out: "Isn't this discrimination based on academic qualifications?"
As soon as he finished speaking, he laughed awkwardly: "Teacher, I said the wrong thing."
Du Biao chuckled: "You are also a doctor now, so you don't want to say that."
"In short, for people like you who are pursuing academic pursuits, it is better to get a doctorate."
"Sanqing has secured such good conditions for you to study directly. I think it also encourages you to learn and improve."
"I understand, I understand, I just said it casually."
Huang Qin chuckled, feeling a little more grateful to Xue Shen in his heart.
If Xue Shen's unintentional words hadn't aroused his ambition to make progress, he would never have thought of studying for a Ph.D.
Even such a promising xenogeneic organ transplantation project is due to Xue Shen's help.
"I'll have to treat Lao Xue to a big dinner later and thank him properly." He secretly made up his mind.
"If he gets a terminal disease in the future and needs an organ transplant or something, I will definitely give him a comprehensive treatment as soon as possible."
"The whole set of pig hearts, pig lungs, pig livers, and pig kidneys will be arranged for him. He can transplant whichever one he wants."
(End of chapter)
