Sanqing Headquarters, Nano Laboratory.
At midnight, the lights on the entire floor were turned off.
In the darkness and silence, only one room was still brightly lit.
Xue Shen was standing in front of the workbench, staring nervously at the instruments in front of him, as if waiting for something.
Five minutes later, the machine buzzed and flashed green.
A plastic bottle below was quickly filled with a colorless, odorless and transparent liquid.
He picked it up carefully, with a smile on his face.
"Finally, this is the result of my three months of research, perfluorocarbon globin nanoemulsion."
"A spiked version of artificial blood."
During these months of research, he painstakingly improved the structure of perfluorocarbon and created a new molecule with a high oxygen carrying capacity.
Not only that, he also combined this molecule with globin to achieve the effect of transporting oxygen in human blood.
Human hemoglobin is mainly composed of globin and heme.
Among them, heme is similar to a compartment and is used to store and exchange oxygen molecules.
Globin is like a coupler connecting the train's power system and carriages, tightly binding the oxygen-laden hemoglobin together for efficient oxygen transportation.
However, unlike the long flat structure train in reality, this oxygen-carrying train is transported in liquid, so it has an efficient three-dimensional space folding structure.
It is like a honeycomb, with a dense hole structure. Oxygen molecules are densely embedded in the recessed heme from the inside out. They are tightly bundled together by globin and transported throughout the body in the blood.
Globin is like a diligent blood coachman, with large space, strong ability, and very hardworking and uncomplaining.
Naturally, Xue Shen would not let go of such a ready-made worker.
So we took advantage of the function of globin, replaced the heme with a perfluorocarbon compound molecule, and also improved the structure from a tetramer to a hexamer, making it more efficient and more space efficient.
Under such transformation, the same size has more perfect performance.
The new oxygen-carrying protein has a higher and faster ability to bind oxygen, and can also quickly release oxygen under designated circumstances, and can transport oxygen in the blood in the most efficient manner.
One nanoparticle can carry 9 billion oxygen molecules and carbon dioxide molecules, 200 times the amount carried by ordinary red blood cells.
It is also safe and non-toxic. It can be naturally decomposed in the human body within 24 hours and excreted from the body without causing any damage to the human body.
The speed of blood oxygen exchange and transmission determines the speed of human physiological reaction. The use of this kind of nano artificial blood will bring powerful explosive power and endurance to the human body.
And this is also the result Xue Shen wants.
He carefully held the jar of nano-artificial blood in his hand, and he couldn't help but feel excited and excited.
I can’t wait to take a tube for myself right away and experience the feeling of flying.
Obviously, this is impossible.
Without animal testing, the perfect performance parameters are nothing more than paper data.
Even for safety reasons, he had to conduct a few experiments on mice to verify the results.
Xue Shen first injected pure oxygen into the nano-artificial blood solution to fully combine with oxygen molecules.
Then he found a squeaking white mouse, took out a syringe, and injected 1 ml of nano-artificial blood into the mouse's blood vessels.
Finally, he dropped the mice into a sealed glass tank filled with water and began to record the survival time of the mice.
"Generally speaking, if a mouse holds its breath for more than 1 minute, it will suffer from hypoxia and suffocation, and if it takes more than 3 minutes, it will definitely die."
"Let me see, how long can this mouse hold its breath after using nano blood?"
Xue Shen stared at the mouse in the sink through the glass and waited patiently.
The little white mouse fell into the water and panicked at first, choking several times.
Then it calmed down and floated in the water with its legs spread out, its long tail hanging down to the bottom of the tank, perhaps giving up the struggle.
"For more than 3 minutes, the mice did not appear to be asphyxiated or hypoxic."
Xue Shen suddenly became energetic and moved closer to observe carefully.
There was still nothing abnormal about the white mouse, its limbs remained motionless, only its eyes moved from time to time.
Xue Shen was very satisfied: "It's very good. I have been holding my breath for 5 minutes and there is no hypoxic reaction."
In this way, time passed slowly.
It wasn't until half an hour later that the mouse suddenly started struggling in the water.
It desperately pushed up the glass lid, its mouth opened wide, and its limbs waved convulsively.
The water flow was agitated, and gradually, the mouse's limbs became stiff and eventually lost its life.
"In an underwater environment, a 25g white mouse will die in 36 minutes without supplemental oxygen."
Xue Shen frowned and thought: "The survival time has been extended by about 12 times, which is quite impressive."
"The time a human can hold his breath underwater is about the same as that of a mouse. Death will occur in 5 minutes. If nano blood is injected, the breath holding time should be converted into one hour."
"But the mice were too small, and the total blood volume was less than 2 ml. I directly gave 1 ml of nano-blood, which is equivalent to half of the blood."
"If it were a human, the total blood volume would be 4 liters. There is no way to transfuse too much nano-blood, and the effect would be greatly reduced."
"However, the unit density of nanoparticles can be increased, so that even if 300 ml is infused, it can greatly increase the oxygen-carrying capacity of the blood."
"In addition, the hypoxic underwater environment is different from the normal environment. If you are on land, people will continue to breathe, and these nanoparticles will form a long-term oxygen transport cycle, giving people a strong oxygen-carrying capacity."
"So if it's not used for diving, but used for running, it will definitely be awesome."
Xue Shen couldn't help but smile proudly when he thought of this.
"The next step is to conduct experiments on large mammals."
“Once the safety of nano-blood is verified, we can try it on ourselves.”
Thinking of this, his heart suddenly became excited and his breathing became a little rapid.
The next day, he excitedly found a miniature pig and prepared to conduct experiments.
This pig has a very pink nose and ears. It is as big as a cat and weighs only 5 kilograms. It is a very good drug experiment subject.
Put the piglet into a sealed box and pump the air out.
Soon, the pig had difficulty breathing due to severe lack of oxygen. It lay directly on the bottom of the box, gasping for air.
The originally pink nose turned pale, and the limbs became cold.
Seeing that the piglet was about to suffocate to death.
Xue Shen quickly opened the box, inserted a thick needle into the pig's blood vessel with precision, and injected all 20 ml of nano-blood into it in one breath.
The effects were almost immediate, with piglets that were severely hypoxic seeing improved oxygen levels after receiving the injection.
The color of the skin changed from pale to pink due to lack of oxygen, and the body temperature returned to normal.
"Sure enough, it also has miraculous effects on large mammals." Xue Shen looked at this scene and was instantly overjoyed.
"It seems that nanoblood can be injected into the human body through blood transfusion, thus having extremely powerful oxygen-carrying capacity."
He clenched his fists excitedly and waved them in the air a few times.
Then, his expression became serious.
“Once the safety of nanoblood has been confirmed, it’s time to move on to the next step.”
"It's time to give yourself a shot."
However, for theoretical safety, he still waited another day.
The next day, blood tests on the piglets revealed that the nanoparticles injected yesterday had been decomposed and excreted, and could not be detected in urine or blood.
Xue Shen finally felt relieved.
He prepared syringes of different sizes and planned to test them on himself in order from the smallest to the largest.
First, he gave himself a hypodermic injection to see if it would cause allergies.
Logically speaking, nanoparticles should be very safe, but don’t be afraid of 10,000, just be afraid of the unexpected.
All necessary precautions must be taken.
In this way, 0.1 ml of nano-blood is injected into the subcutaneous tissue of the wrist, forming a small mound, like a mosquito bag.
After a few seconds, the mosquito pack gradually disappeared.
"No abnormal reaction." Xue Shen showed a satisfied smile.
Next, he formulated rigorous and detailed experiments.
In the first week, a certain amount of nano-blood is injected before get off work every day, in order:
1ml, 5ml, 10ml, 20ml, 50ml, 80ml, 100ml.
Then I went for a run and ran 5 kilometers along the river bank, which took about 30 minutes.
During this period, the smart watch will faithfully record his physical changes.
By running this for a week, we can obtain human experimental data on nano-blood within 100 ml.
Moreover, the amount can be increased from small to large, the safety is controllable, and there will not be too much risk.
In the second week, it will be the same running, but the amount of nano blood injected will gradually increase.
The plan will continue until the blood transfusion is 300 ml, and any more will not be appropriate.
In this way, through daily recording, the most suitable injection amount can be obtained.
The best dose that allows him to sprint at full strength for 15 minutes without fatigue during night running, and still be energetic and vigorous.
On the first day, because the injection dose was small and he secretly administered it to himself, he could not ask medical students for help.
So he applied for a sample of the company's mini syringe pump.
It is said to be a syringe pump, but it is actually more like a pen.
Just inject the liquid into the disposable needle at the tail, aim the pen tip at the vein, and press the button on the scale to accurately inject the required liquid into the body.
This thing is very convenient to use, and Xue Shen knows how to use it as soon as he gets started.
He pressed it without letting go, and with a few swish, the scale showed that 1ml of nano-blood was injected into the vein.
The whole process was like being bitten by a bug, without any pain.
With a gentle press, the injection was completed before any reaction occurred.
Of course, this is mainly due to the small amount, which was only pressed for one second.
If it is 5ml or 10ml, you need to press for longer, and a large amount of liquid is injected into the blood vessels, and it is impossible to feel nothing at all.
After the injection, Xue Shen felt nothing abnormal.
He had already put on his running shoes, so he went to the river as usual, warmed up his body a little, and started jogging.
During this period, he ran two or three times a week, so now he is not as tired when running. After his body gets used to the intensity, he can basically recover the next day.
After several rounds of short rests, I finally finished the entire distance in about 30 minutes.
The familiar sweating profusely and body aches were all over again, no different from usual.
This time Xue Shen roared happily, washed up and fell asleep.
The next day, 5ml.
Everything is business as usual.
On the third day, 10ml.
Everything is business as usual.
On the fourth day, 20ml.
Running was the same as before, but he didn't know if it was an illusion. He felt that the soreness after running was not that strong.
On the fifth day, 50ml.
This time, Xue Shen finally had a clear feeling.
He felt that after running, his breathing became longer and smoother, and he was no longer as out of breath as before.
Even the rest time in between has been shortened.
After running 5 kilometers, although I was still sweating, I was not so tired. It seemed that I still had enough energy left to run for a while.
At the moment, he didn't want to fight, and returned to the dormitory as usual to wash up and rest.
However, when I woke up the next day, my body's soreness and fatigue were somewhat relieved.
Xue Shen truthfully recorded his physical data and feelings, feeling a surge of joy in his heart.
On the sixth day, 80ml.
This night run was more relaxed than the previous few days.
He ran the same 5 kilometers in one go without needing to rest in the middle.
At the end, although I was still panting, it felt like a normal deep breath without any discomfort in my lungs.
I recall when I first started running, my lungs hurt as if they were being torn apart after running a few hundred meters.
Xue Shen instantly felt like he was in another world.
The next day, the pain in my body disappeared. Only when I pressed hard on the muscles in my legs would there be a dull pain.
If you don't touch it, you basically don't feel anything.
On the seventh day, 100ml of nanoblood was injected into the body through intravenous drip.
A strong expectation suddenly arose in Xue Shen's heart.
He couldn't wait to get to the track by the river, stretched his limbs, and was ready to run.
There are also three or five colleagues standing on the track next to them, all in their early twenties, warming up.
A familiar colleague greeted him warmly.
"Xue Bo, you are running again today. I see that you have been running every day recently. Why are you suddenly so interested?"
Xue Shen smiled and waved his hand: "I can't help it. I'm getting older. People in their early 30s should take care of their bodies. I'm too lazy to go to the gym, so this is the best way. I'll run away now. See you later."
After saying hello, he exerted force on his soles, moved his legs, and his whole body shot out like an arrow from a string.
Seeing his back quickly disappearing into the distance, the smile on the colleague's face froze instantly.
On the runway, several other colleagues exclaimed.
"Wow, you run so fast!"
"It seems to be Xue Bo. I didn't expect him to be so good at running even though he's sitting in an office."
"No, is there anyone who can run so fast at night? Aren't you afraid of having a heart attack?"
"It's very explosive, but it will probably slow down soon."
"I bet he won't last long. He will run for a minute or two before resting."
"Come on, let's run too."
However, what is surprising is that after they ran behind for at least five or six minutes, Xue Shen was still nowhere to be seen in front of them.
The unconvinced people began to run at full speed, each one of them panting like an ox and sweating profusely.
Finally, after running for another seven or eight minutes, I saw the figure jogging at a steady speed in the distance.
Several people glanced at each other and were about to use their legs to catch up.
But I heard a person suddenly let out a scream and fell on the spot: "Ah, my leg is cramped~"
"No way, it's so miserable. Hurry, help him to the chair and massage his leg muscles."
Several people hurriedly helped their colleagues aside.
After finally getting rid of the cramped muscles, another five or six minutes passed.
Just about to get up and run again.
Suddenly, Xue Shen ran over from a distance with a leisurely expression, waving his hands and saying hello warmly.
"Hey, why don't you run away? Young people, you have to start running!"
"How can you sit still at this age?"
"Keep running, I'll wait for you in front!"
Xue Shen shouted while exerting force on the soles of his feet, whizzing past like a whirlwind, gradually going away.
A few people were left looking at each other on the roadside.
In this way, after running 5 kilometers in one breath, he came to a chair on the side of the road and sat down without changing his expression or heart.
At this moment, he felt a little hesitant.
After this long run, it seems that I still have some energy left, so I am considering whether to run a few more kilometers.
Do you want to make the experiment more difficult? Otherwise, the limit value cannot be measured.
Just as I was thinking this, suddenly, a voice sounded in my ears.
"Xue Bo, you are so amazing. You can run for five kilometers without losing breath."
"Have you ever considered running a marathon?"
(End of chapter)
