Kunming City, Sanqing Headquarters.
At nine o'clock in the evening, on the path by the river, several figures were stretching their bodies, spreading their legs, and running panting.
Xue Shen is also one of them, but he is a bit older, over 30, runs slower and can last for a shorter time.
After running three to five hundred meters, he had to stop and rest for a while. His chest heaved violently and he gasped for air. His lungs felt as if they had been torn apart by a ferocious beast, which was extremely uncomfortable.
[An app that has been running stably for many years, comparable to the old book-chasing tool, used by all old bookworms.
"The problem has been discovered, so how to solve it?"
"When running, the body needs a lot of oxygen to support muscle movement. This demand is fixed and cannot be changed. It can only be improved from other variables."
"It is known that my cardiopulmonary function is fixed. Unless the gene mutates and turns into shark lung, there is not much room for improvement. And if I want to adjust the breathing frequency to improve it, I have to seek help from a kinesiology expert. The process is too cumbersome and time-consuming. It’s been too long.”
"So, assuming the volume of gas inhaled in one deep breath remains the same, how can we increase the oxygen content?"
"There seem to be two ways. One is to increase the oxygen content of the gas. I remember that there was a portable oxygen bottle. I want to see if I can buy one and wear it when running. It should be able to increase the oxygen intake."
However, when Xue Shen remembered the scene where he was holding an oxygen bottle and taking a big gulp of oxygen while running.
Another image emerged in his mind.
Several colleagues gathered around, looking at me strangely, looking up and down with malicious eyes, and making bursts of ridicule.
"Hey, Director Xue is only in his early 30s, why is he so weak?"
"Hahaha, you even carry an oxygen bottle when running at night. Isn't this too exaggerated, Xue Bo?"
"That's right, you are a bit premature. Look at this 70-year-old man dancing in the square for half an hour without blushing or out of breath."
"Breaking oxygen? Are we moving to a 5,000-meter plateau overnight?"
"Hahaha~"
More and more colleagues gathered around me, and their laughter became more and more arrogant.
Even Mr. Wei was alarmed and cast a suspicious look.
"Xiao Xue, are you in such bad shape? You're too tired. You should pay attention to rest."
"You don't have to worry about work. I think your teammate Xiao Zhou is quite capable. Why don't you leave it to him first and you can go home and rest for half a year?"
"What? Are you in good health? Then why are you taking oxygen while running? Is there any illness you are hiding from me?"
Such a scene of social death instantly made Xue Shen's body tremble and he immediately gave up the idea of taking oxygen in public.
"No, if you want to take oxygen, you can only take it in advance and then run, otherwise you will definitely be laughed at by your colleagues."
"But it's useless to inhale beforehand. Hemoglobin's ability to carry oxygen is limited."
"Unless..." His eyes suddenly lit up and he stood up abruptly.
"Unless I can find a nanoparticle that has an oxygen-carrying capacity that far exceeds that of hemoglobin, even daily breathing can provide sufficient oxygen to meet the oxygen needs of muscle tissue, so that my body will never feel tired again."
"This is a once and for all solution!"
"And I'm very tall. You can't tell from my appearance at all. My colleagues will only think that my physical fitness is great, awesome plus."
I thought of myself running so fast on the runway, riding so fast, leaving only an elegant and lake-shaped figure behind.
Colleagues were left far behind and could only exclaim in surprises and cast admiring looks.
Xue Shen suddenly felt itchy, wishing he could research this magical nanoparticle right away and give himself a tube on the spot.
"Fortunately, nanoparticles are my research field, and there are many substances with strong oxygen-carrying capabilities. If I study them carefully, it shouldn't be too difficult."
He turned on the computer with excitement and began to study relevant literature.
After this research, I was instantly fascinated.
Time flies, the sky outside the window gradually darkens, and the lights in the room automatically turn on.
"After reading the information for a day, I learned a lot."
"Research on biomimetic nanomaterials for oxygen transport in the body is now quite popular in the industry. I read a lot of literature and finally got a clue."
Xue Shen stood up from the computer, stretched slowly, came to the window, looked far into the distance, and fell into deep thought.
The blood of the human body is very hard, not only transporting various components necessary for the body, but also transporting a large amount of oxygen required for survival.
After all, the human body obtains the energy necessary for the body through redox reactions, and oxygen is the lifeline of the human body.
Carefully designed red blood cells exist for the task of "transporting oxygen."
In order to achieve maximum efficiency, red blood cells discard all components of traditional cells and are composed almost entirely of hemoglobin.
A red blood cell contains 250,000 hemoglobin molecules. Each hemoglobin with a diameter of 5.5 nanometers has four card positions and can accurately carry four oxygen molecules.
In essence, red blood cells are like containers that carry oxygen inside and transport it to various parts of the body.
It does not use oxygen itself, but instead uses glucose to meet its energy needs.
However, hemoglobin also has a shortcoming, that is, it prefers carbon monoxide much more than oxygen.
If carbon monoxide is present, the hemoglobin will load it up like a passenger on a rush-hour train, leaving the oxygen on the platform, which is why carbon monoxide suffocates people to death.
At the same time, red blood cells use nitric oxide as a signaling molecule, which basically determines how much blood is distributed to which parts as the body's needs change at different times.
For example, after a meal, sufficient blood is provided to the stomach to aid digestion, so generally the brain will feel sleepy after a meal, which is caused by insufficient blood supply to the brain.
At normal altitudes, red blood cells occupy 40% of the blood volume. This large and regularly operating system can meet the body's oxygen needs under normal circumstances.
Of course, under abnormal circumstances, some accidents will definitely happen.
For example, if you go to a high-altitude area, your body will work overtime like a factory, producing a large number of red blood cells and increasing the oxygen-carrying capacity of the blood.
In this way, after staying at the plateau for a period of time, the proportion of red blood cells in the body will increase by about half.
Such a high red blood cell content causes the blood to become thick and sluggish, causing the heart's pumping pressure to increase dramatically. The lips begin to turn purple, and the fingers become as thick as mallets, leading to a special disease.
But once you move to a lower altitude, the problem disappears.
Of course, there are more problems such as excessive exercise leading to lactic acid accumulation.
The lack of red blood cells leads to insufficient oxygen supply in the body and is also the main cause of anemia.
If a nanoparticle with a stronger oxygen transport capacity than red blood cells could be produced, it could be introduced into the body in a short period of time when a large amount of oxygen is urgently needed, and then excreted through metabolism after use.
Not only can it solve the problem of insufficient oxygen during exercise and reduce the damage caused by anaerobic exercise, it can also treat some altitude sickness.
Even if it can be used for a long time, it can also be used to treat anemia.
Thinking of this, Xue Shen's eyes suddenly lit up.
When he started studying this, it was mainly for personal interest, but he didn't think much about it.
However, if you can not only solve personal problems, you can also treat more patients.
Wouldn’t it be possible to bundle personal interests and company interests together?
In other words, you can use it for public and private purposes, and use the company's projects to benefit yourself. By the way, you can also benefit patients and make a lot of money.
For all three parties, it was a fruitful harvest, and it was simply a win.
This may be the happiness of being a scientist.
Xue Shen thought triumphantly and made a quick decision in his heart.
He quickly returned to the computer, his hands flew on the keyboard, and he quickly wrote a simple project report.
"Feasibility Report on a Biomimetic Nanomaterial for Oxygen Transport in the Body"
I wrote a lot and submitted it.
"Okay, just wait for the boss to approve it in a few days and then we can start it."
"This is a small project. There are already many research results in academia, but there are no products that can be commercialized yet."
"I don't have any big projects now anyway, so why not study this carefully? The prospects are still very broad."
"The most important thing is, if there are any research results, I can be the first
Enjoy, nay, try it out. "
When Xue Shen thought of this, he couldn't help but raise the corners of his mouth and laughed.
He turned off his computer, prepared to go to the cafeteria to eat, and then went back to continue his research.
However, just after taking two steps, the familiar soreness hit me again.
"Damn it, why aren't you feeling better yet? No, it's too uncomfortable. We need to work harder on the project."
Xue Shen limped out of the office while cursing.
The next day, after a night's rest, he finally felt better.
My waist is no longer sore, my legs are no longer painful, but my thighs are still a little sore and numb.
But it's not a big problem. If you take another day's rest, you will definitely be able to recover completely.
After my routine work in the morning, I suddenly received a system prompt in my mailbox.
"Your project application request has been approved, please check as soon as possible."
Xue Shen was immediately delighted: "The boss approved it so quickly? This speed is amazing."
Although he felt that this project was definitely fine and would not be rejected, Wei Kang's speed still exceeded his expectations.
After taking a look at the approval, he found that his boss was very approving of his idea, and he couldn't help but smile.
"Great. The next step is to select a few materials and then simulate and optimize them on the computer."
"When the results come out, we will conduct experiments to verify and see if there are any gains."
"There are many types of specific nano-oxygen carrier materials. In this regard, hemoglobin-based oxygen carriers and perfluorinated compound-based oxygen carriers are two of the more popular types."
"Hemoglobin oxygen carriers have two disadvantages. One is that it contains heme molecules, which can cause auto-oxidative damage to the body. The two hemoglobin and oxygen molecules are reversibly chemically combined, so they cannot release all dissolved oxygen to surrounding tissues. The oxygen delivery efficiency is relatively Low."
"In comparison, perfluorinated compounds and oxygen are simply physically dissolved. With the same amount of dissolved oxygen, the oxygen released is 4 times higher than that of hemoglobin. Therefore, its ability to carry and release oxygen is very superior, and its tissue compatibility and safety are also good. It has high clinical potential."
"Perfluorocarbons are a good choice. The hydrogen atoms are partially replaced by fluorine atoms. They are very chemically inert and relatively safe. The dissolved oxygen content is about 40-50vol%. Under the same oxygen partial pressure, the oxygen-carrying capacity is that of water. 20-25 times that of plasma."
"In addition, it also has the ability to dissolve carbon dioxide and can take away the carbon dioxide produced by aerobic respiration of tissue cells and the waste products produced by metabolism."
"Currently, this substance does not have much clinical application. It is mainly used in blood substitutes, organ preservation perfusion fluids, etc. There are still great development prospects."
"Of course, 20 times the oxygen-carrying capacity is still not enough. The molecular formula and nanostructure must be greatly improved, and the preparation method of the nanoemulsion must also be carefully designed to adapt to industrial mass production."
Xue Shen looked at the screen attentively, immersed himself in it, and entered a state of total selflessness.
