"The first batch of clinical trial results have come out."
Ding Mian held a document in his hand, raised it high in the air, and walked into Xue Shen's office excitedly.
Just as he was about to continue, he saw another person sitting in the office.
This is a young man in his twenties, about the same age as himself, sitting at his desk with an honest smile on his face, which makes people feel close to him.
Ding Mian immediately got stuck, forced out a smile and said, "There are others here, you go ahead and I'll come back later."
"No, no, we are all our own people." Xue Shen quickly stood up and enthusiastically pushed him down on another chair.
"This is my roommate Huang Qin, the head of the Animal and Plant Laboratory. He's getting off work soon. He came over to meet me for dinner and we started chatting. You are all my buddies. It's rare that we meet, so let's get to know each other."
Huang Qin immediately gave a thumbs up, looking like a nymphomaniac meeting a fan, with a smile on his face.
"You are the God Ding that Brother Xue often talks about. I have admired you for a long time. I have longed for a big shot like you who is good at scientific research, handsome, and so young and promising. I must meet you today." Please ask for advice and get some academic spirit."
Hearing what he said, Ding Mian felt happy and humbly said: "No, I actually heard Brother Xue mention you. He said that you are the most diligent person he has ever seen. You really live up to your name. admire."
The two talked about each other's business, and soon hit it off immediately. They hooked up with each other and were passionate, as if they were brothers who had known each other for many years.
"Ahem," Xue Shen coughed twice and reminded, "Don't just talk about it. What's going on with the clinical trial results you just mentioned?"
"Oh, this, the experimental results are very gratifying. Let me read you some data." Ding Mian opened the document in his hand and started reading.
"56 patients with acute renal failure from three medical institutions participated in the clinical trial and conducted a comparative test between the artificial kidney and conventional dialysis."
"Sixteen of the patients only received conventional continuous dialysis. Six of them died due to various complications. Eight of them still developed chronic renal failure despite timely treatment. Only two of them completely recovered."
"Eighteen patients received 72 hours of artificial kidney treatment. Except for one elderly man who died of serious illness, the others have improved, switched to routine treatment, and were quickly cured and discharged."
"The remaining 22 patients had acute renal failure caused by uremia. They received artificial kidney treatment for a month. Their creatinine levels dropped by about 100, and there was no death."
"As for the long-term dialysis effect of the artificial kidney, we have to continue to see, but it should not be higher than the 20% annual mortality rate of conventional dialysis."
He glanced at Huang Qin, and considering that the other person might not know much about artificial kidneys, he explained thoughtfully.
"An important cause of death in routine dialysis is that the long interval between weekend dialysis, water and sodium retention, and the accumulation of toxins and blood potassium in the body increase accordingly, leading to acute sudden death."
"In addition, the toxins in uremia include water-soluble small molecule toxins, medium molecule toxins and protein-bound toxins. Conventional dialysis mainly uses the principles of diffusion and convection to remove metabolic waste, harmful substances and excess water, which can effectively remove low molecular weight and even medium molecule toxins. Molecular toxins, but cannot effectively remove protein-bound toxins, and long-term use accumulates a lot of toxins in the body, which is also a reason for the high chronic mortality rate.”
"Our artificial kidney uses biological renal tubular cells to achieve most of the functions of real kidneys. It can remove medium molecules and protein-bound toxins more efficiently, improve patients' quality of life, and greatly reduce mortality."
"After the blood filtration membrane is optimized, as long as it is replaced in time, there will be no hemolysis or thrombosis."
"If all uremia patients use artificial kidney dialysis, I estimate that the mortality rate can be reduced to one-tenth, from 20% to 2% per year, which will greatly extend the patient's life."
"Of course, this is just a guess on my part, and everything will have to be verified in subsequent phase III clinical trials."
Ding Mian finished speaking in one breath, and Huang Qin was the first to applaud.
"God Ding deserves to be God Ding, he's so awesome!"
Ding Mian chuckled and asked curiously: "Brother, you are doing research on animals and plants, what exactly are you studying?"
Huang Qin thought for a while and said: "Mainly doing various gene editing of animals and plants, most of which are cooperation with external research institutes, institutions and companies. We provide genetic technology, they provide samples, and then carry out subsequent cultivation. If you have any needs, please give us feedback and we will improve.”
"That's about it. Actually, this is not a serious laboratory, it's a small department affiliated with the biology laboratory."
Having said this, he blinked with an ambiguous expression and smiled.
"Our laboratory has a farm affiliated with it, which is not far away. It has genetically modified pigs, cattle, sheep, chickens, ducks, etc., so if you want to have a toothpaste, let me know. I have a lot of fresh products here. "
Xue Shen on the side suddenly understood and laughed: "I understand, I understand. Your reputation as the canteen manager has long been known to me."
Ding Mian nodded and asked, "Is that devilish muscle pig in our cafeteria a product of your farm?"
Huang Qin thought that the other party liked the meat and wanted to get some pieces of it for him, so he rolled his eyes and patted his chest.
"Brother, do you like this too? You have a good eye and I will tell you the truth. This is our most popular product. We just launched a batch and only half a box was sold. I still have some stock over there. I can pick it out for you. A few pieces..."
Ding Mian interrupted him and said, "No, I would like to ask how far your gene editing technology has progressed in pigs? Can you knock out the kidney development genes of pig embryos?"
Huang Qin was stunned for a moment, his brain was a little down, and he spoke after a while.
"Currently, retroviruses in pigs can only be cut out through gene editing technology. This is already a great progress."
"I know that if the virus is not removed, transplanting pig hearts into humans will cause new infectious diseases. Indeed, this work has removed a big obstacle to transplanting pig organs into humans." Ding Mian was convinced. Nod.
Huang Qin suddenly became excited: "I knew you were knowledgeable. Gene-edited pigs are actually one of my research and development directions. My idea is to use the latest gene-editing technology to transform pig genes to produce pigs that can match humans. Compatible organs.”
"Pigs themselves are food for humans, so as a source of organ transplants, there are certainly no ethical issues. Pigs have a large number of litters, a short gestation period, and the size of their organs is very close to that of humans. From all aspects, it is very Excellent source of organs.”
"Many examples have confirmed that pig parts can be successfully used in humans and are highly biocompatible."
"Of course, there are still many obstacles if pig organs are directly transplanted into humans, but the main problems are immune rejection, which can be solved through gene editing technology."
"I have also conducted some research on the pig genome in the past two years. The main purpose is to knock out some genes in pig cells that easily trigger rejection by the human immune system, and then cultivate them to see if I can cultivate cells that can be transplanted. Pig organs.”
"However, research in this area is still a bit difficult, and I may not be able to do it alone..."
Before he finished speaking, Ding Mian held his hand tightly, and two gleams of light shot out from his eyes.
"Brother Qin, your research is on xenogeneic organ transplantation. It coincides with my research direction."
"Excuse me, has your research on the pig genome produced any results?"
Huang Qin quietly retracted his hand and said with a dry smile: "Yes, there are, but I am studying the immune system genes of pigs, as well as the genes for meat quality and growth. I have not studied the kidneys in depth."
"But don't worry, the Academy of Agricultural Sciences is currently at the forefront of research in this area. They have released the pig genome map. If you want to study kidney genes, there is no problem."
Ding Mian looked at him steadily: "But I want you to study pig kidneys, what do you think?"
"Huh?" Huang Qin was stunned again and hesitated: "I am working and studying for a PhD at the same time. I am quite busy. I have to set aside time to study this..."
Xue Shen suddenly slapped him hard, winked, and said, "Qin, have you chosen your doctoral thesis topic?"
Huang Qin scratched his head and said subconsciously: "I haven't thought about it yet. It's still early. I've just finished my first year of graduate school, so I can't think of a doctoral thesis. Besides, I have to discuss this with my supervisor."
Xue Shen said decisively: "Listen to me, you should choose the topic of pig organ transplantation. It is absolutely high-end, absolutely cutting-edge, can produce great results, and..."
He pointed at Ding Mian, showed a sly smile, and said: "If you want to study this topic, don't you have ready-made labor? No, I mean partners?"
Huang Qin's eyes widened instantly. He looked at Ding Mian and then at Xue Shen, and his voice trembled: "Brother, is this okay?"
Ding Mian was already deep in thought. He was a little frustrated because the bioartificial kidney could not be implanted into the human body last time. He had been thinking about continuing his research to solve the problem of transplanting the artificial kidney into the human body.
Today Huang Qin talked about pig xenogeneic organ transplantation, and it was like a spark that instantly ignited a brainstorm in his mind.
He was now completely immersed in his own world, talking to himself and starting to dance.
"President Wei said it well, either don't do it, or do something big and solve the problem completely."
"Since the problem of tubular death in artificial kidneys cannot be solved, then we can directly create a kidney and transplant it into the human body."
"You are right. Editing and knocking out pig genes is no longer a big problem."
"The complete genetic map of pigs is also available. We can completely compare pig genes with human genes, and then gradually modify certain pig genes, such as immune genes, into human genes."
"If we can knock out the immune genes in pigs that are different from those in humans, we can solve the problem of biocompatibility between pigs and humans, and there will be no more heterogeneous immunity and infection after transplantation."
"Theoretically, this step is not too difficult. The company's genetic laboratory can completely accomplish it."
"But this is only the first step."
"The second step is to continue to use gene editing technology to knock out the kidney or heart, whatever, the development genes of any organ in the pig. Whichever one is easier to knock out first."
"What do we get? We get a pig born without kidneys."
"Of course, this pig with congenital dysplasia is still just an innocent blastocyst. At this time, we can continue to the final step."
"Then, when everything is ready, we inject human stem cells into the blastocyst that lacks kidney development genes and let it mature."
"Then, when the pig develops into an embryo, its kidneys will be completely developed from human stem cells."
"In the six months between the pig's growth and slaughter, a human kidney will mature in its body, waiting to be harvested."
"If this method of 'organ transplantation' can be successful, not only kidneys and hearts, but also other human organs besides the brain can be produced by pigs."
"Absolutely a wonderful birth of a child. Bravo!"
With a strange cry, Ding Mian ended this exciting speech. When he looked at Huang Qin and Xue Shen excitedly, he saw the other party looking at him with strange eyes.
Ding Mian touched his cheek: "What's wrong? Is there something on my face?"
Xue Shen looked at him with a worried look on his face, hesitating to speak: "Xiao Ding, are you having fun again?"
The expression on Huang Qin's face was very complicated. He looked fascinated for a while, and then frowned and gritted his teeth, as if there was a fierce struggle deep in his heart.
After a while, he said: "Ding Shen, your ideal is very beautiful, but if you want to realize it, I'm afraid it won't be possible for a few years."
Ding Mian said in surprise: "Didn't I make it very clear? There are three steps in total, and each step has a specific research direction? Isn't this realistic enough? It's as simple as putting an elephant in the refrigerator. "
He looked at Huang Qin with strange eyes: "As for time, that's not a big problem. It will definitely take a few years to get it done. Are you still afraid that Mr. Wei will default on your debt and not give you money?"
Huang Qin smiled bitterly and said, "But if I choose this as my PhD topic, I'm afraid I won't be able to graduate within ten years."
"That's right, that's definitely not possible." Ding Mian suddenly realized, he shook his head and said extremely seriously.
"Then we have to hurry up. We must not delay it for too long. Ten years is definitely not enough. I think two or three years should be enough."
"Huh?" Huang Qin was completely stunned. He grabbed Ding Mian and wanted to roar twice to wake him up.
Before I could speak.
Xue Shen spoke from the side.
He pinched his throat and said leisurely.
"Qin, if this project really comes to fruition, you will be a giant in the field of xenogeneic organ transplantation. Academicians will have to give you up when they see you. Think about it for yourself. Are you choosing a crappy topic to write a paper on? Or do you want to be a stud and become a great master who creates a new world?"
"This..." Huang Qin swallowed a large mouthful of saliva with difficulty, grabbed Ding Mian's hands, and shrank back.
He patted Ding Mian's shoulder gently and smiled innocently: "Ding Shen, why is there dust on your shirt? Come on, let me pat it for you."
"Since God Ding is so confident, I, Old Huang, am not a courageous coward."
"I was the only one who studied this before. I'm used to working alone. Now that Ding Shen has joined me, I think I can definitely make it happen."
"We are joining forces. I can handle everything about pigs, and you can handle everything about stem cells. What do you think?"
Ding Mian raised the corners of his mouth, clenched his hands into fists and stretched them out.
Although Huang Qin was a little confused, he followed suit and stretched out his fist.
The two fists touched lightly in the air and then retracted immediately.
Ding Mian then showed a bright smile: "Hello, teammate."
(End of chapter)
