As one of the top hospitals in the country, West China Hospital received the fastest response from Sanqing to its request to conduct clinical trials.
In the past, Sanqing conducted clinical phase 1 and 2 trials in Kunming City, and only conducted phase 3 clinical trials in hospitals in other provinces.
But this time, due to a severe shortage of artificial blood vessels and demand exceeding supply, the company received special approval from superior authorities to conduct Phase III clinical trials in key cities across the country in advance.
A few days later, medical representatives arrived at West China Hospital with a five-member research team.
In the spacious conference room, doctors from various departments gathered together and looked curiously at the three refrigerators placed on the table.
With a "click", the refrigerators were opened one after another, revealing the neatly arranged artificial blood vessels inside.
The research team leader looked around, smiled slightly, took one out of each box, and began to display them individually.
"These three boxes contain three specifications of artificial blood vessels. They are large-diameter artificial blood vessels above 1 cm, medium-diameter artificial blood vessels of 6-8 mm, and small-diameter artificial blood vessels below 6 mm."
"It is well known that large-diameter artificial blood vessels are suitable for arterial large vessel replacement, and medium-diameter artificial blood vessels are suitable for vascular bypass grafting and the establishment of dialysis vascular channels. However, so far, no small-diameter artificial blood vessels have been launched."
"Sanqing's small-diameter artificial blood vessel not only fills the domestic research and development gap, but is also the world's first clinically successful product. It will be widely used in peripheral blood vessel replacement, cardiac bypass, and arteriovenous insufficiency surgery."
"Because large and medium-diameter artificial blood vessels have been used in total aortic replacement, the treatment effect is very good, and it can completely replace competing products. This is our clinical trial report."
"As for small-diameter blood vessels, we have optimized the production materials and added anticoagulant coatings to enhance the strength and toughness of the blood vessels and achieve long-term anti-thrombotic effects."
"Animal experiments show that the long-term effects are also very good. After 16 weeks of safety and effectiveness experiments, the replacement artificial blood vessels were 100% unobstructed. No blood clots were seen after the operation. Many indicators are better than imported products."
"We also have a wide range of models, ranging from 1 mm to 36 mm, and we can even accept customization of special sizes, lengths, and specifications. It can be said that all calibers are available. You just need to make a request, and we will definitely do it. Try to be satisfied.”
"I didn't bring many samples this time, only common models. These are some of our technical parameters and clinical data. Please check them out."
After hearing the introduction, the doctors were immediately excited and applauded.
There were bursts of applause in the conference room.
As for the directors of cardiac surgery, hematology, urology and other departments, they all reached out to pick up the samples and observed them carefully.
As they watched, they whispered, exchanging their opinions, and then passed them on to the doctors around them.
"It looks really good and feels good."
"This is a small-diameter blood vessel of 3 mm. It's really thin. It's the first time I've seen such a small blood vessel. It's exactly like a vein."
"Tsk tsk, there are still 1 millimeter of blood vessels. This is just a show off."
"When it goes on the market, McVie and Terumo's faces will be swollen."
"Haha, if you dare to run out of stock, you will have to bear the consequences of customers looking for substitutes."
"Haha, now I no longer have to worry about being out of stock. I can't wait to use it for surgery."
"I have a patient who needs heart bypass surgery, but his vascular condition is not good. I am worried about the surgical plan. Maybe I can switch the patient to this one."
"The patients in the dialysis room can be saved." Dr. Tang carefully held a 3 mm artificial blood vessel and felt the high bionic feel that was almost the same as human blood vessels. He was trembling with excitement.
Half an hour later, the sample was passed around among everyone and returned to the refrigerator again.
The director of cardiac surgery stood up quickly and couldn't hide his excitement and said: "I have several patients who need thoracic artery replacement, and they are all waiting for the artificial blood vessels to arrive. Now I have finally scheduled their operations. .”
The director of the Department of Urology clenched his hands into fists and pounded the table excitedly: "There are many elderly people in the dialysis room. Some of them have been undergoing dialysis for more than ten years. The blood vessels have long been tattered and closed internally. They are in need of your artificial intelligence." Blood vessels."
The director of the hematology department leaned back and urged in a good mood: "Hey, you two are so anxious, so what are we waiting for? Let's get started quickly."
"Hahaha~" Everyone looked at each other and smiled, and the conference room was filled with happy air.
After the meeting, people from Sanqing went to do clinical preparations, and everyone else went back to their respective departments.
Seeing that it was getting late, Dr. Tang followed behind and walked towards the Nephrology Department.
Passing by the dialysis center from a distance, he glanced at the door, suddenly his heart moved, and he turned around and walked in.
The dialysis room is still so quiet, like a silent battlefield, and every bed tells the story of the tenacity of life.
Only nurses kept walking between the beds, monitoring the operation of the machines and observing the conditions of the patients.
Dialysis patients have pale faces, swollen bodies, and dry and cracked lips. Some of them are staring at the ceiling in a daze, while others are resting with their eyes closed, silently waiting for the passage of time.
When the kidneys lose their drainage function, they cannot urinate in small amounts many times. The urine output every two days must be removed all at once during four hours of dialysis.
Every time you are dehydrated, it means that the whole body's blood flows out of the body one after another and enters the dialysis machine. The filter separates toxins and water and then discharges them, and the remaining blood returns to the body.
Every circulation of blood, from filling to contraction and then filling again, is a severe test for the blood vessels and the heart.
The greater the intake of water, the more likely it is for blood pressure to fluctuate at high peaks, and the greater the possibility of reactions such as general weakness, hypotension, muscle cramps, and heart failure after dialysis.
The water and electrolytes in the body are in a state of disorder for a long time, and various toxins such as creatinine and uremia are accumulated in the body for a long time, which makes dialysis patients more likely to be thirsty.
They have to control water when they are thirsty, which makes them lose the joy of drinking water forever.
Everyone must start living a prudent life for the rest of their lives. The water level cannot exceed 3% in one day and 5% in two days. An adult man cannot drink more than 3 kilograms of water in 2 days.
3 kilograms of water is only about 6 bottles of common mineral water, which also includes the water in the morning, lunch and evening meals.
There is water in rice, vegetables, and fruits, and you also need to drink water when taking medicine. Apart from these, you can only drink one bottle of mineral water every day. If you are not careful, you will overdose.
As a result, dialysis patients are thirsty for a long time. They spend the rest of their lives like travelers who have lost their water bladders, walking in the vast desert, thirsty but unable to drink water.
This feeling does not make people go crazy like when an addiction occurs, but is more like a small and continuous torture of the spirit, like holding a soft knife to slowly and persistently cut the flesh.
What's even more cruel is that for hemodialysis, you have to go to the hospital for 4 hours every day or two and lie motionless on the bed, which greatly limits your freedom.
As a result, most patients can no longer go to school and work normally, and are reduced to the margins of society at a young age. From being the hope and mainstay of the family, they suddenly become a burden and burden.
Dialysis is like an invisible rope tying the patient, leaving him with neither health, nor freedom, nor hope.
Dr. Tang looked at the beds one by one, his eyes falling on the familiar and numb faces, and his originally happy mood instantly turned into depression.
It took him a while before he returned to normal, walked to the middle of the patients, raised his hand, patted it three times, and said in a loud voice.
"Hello everyone, I am Old Tang from the Department of Nephrology. Many of you are my patients. Today I want to bring you good news."
The patients' eyes flickered and focused on him, each one full of curiosity and expectation.
"Remember what I said? I once said, don't be depressed, embrace reality and always be hopeful for the future."
"Society is changing rapidly now, and technology is changing rapidly every day. As long as we continue to develop, miracles will happen to you sooner or later."
"Of course, miracles are not built in one day, but happen slowly, from quantitative changes to qualitative changes."
"The same is true in medicine. The last time I brought you good news was the availability of drugs to treat chronic nephritis. Now less than a year later, I have brought you another good news."
"Sanqing Group has successfully developed a small-diameter artificial blood vessel, which can replace your own blood vessels and treat arteriovenous insufficiency. The third phase clinical trial is now being carried out in our hospital."
"Those of you who are older, those who often suffer from blood clots, and those who have used artificial blood vessels for internal incompetence can go to the clinical building next to the inpatient department and apply for clinical trials to use their artificial blood vessels."
"Don't be afraid of trouble. The test is free and does not cost a penny, but it will make your blood vessel access smoother and less likely to cause blood clots."
The more Dr. Tang talked, the more excited he became: "Believe me, everyone should apply for clinical trials tomorrow."
"This is the quantitative change brought about by technology. I hope that the good news I will bring you next time will be a miracle that uremia can be completely cured."
The patients looked at me and I looked at you. They were a little stunned at first, but they immediately came to their senses and became extremely happy.
They couldn't sit up, so they could only lie on the bed one by one, asking questions.
A smile appeared on Dr. Tang's face and he patiently answered his questions.
The patients' fatigue was swept away, and their bodies seemed to have miraculously temporarily gained strength. Their voices became louder and louder, and their faces became radiant.
The noise inside attracted the attention of people waiting for dialysis outside. Many people stood at the door and kept looking inside.
There were also many acquaintances here, who instantly recognized Dr. Tang and flocked to his side.
Doctor Tang smiled broadly, waved to them, and spoke with great enthusiasm.
"Tell you good news"
****
West China Hospital is not the only hospital to start phase III clinical trials in advance.
Well-known tertiary hospitals in first- and second-tier cities such as Yangcheng, Jingcheng, Haishi, and Shacheng have also taken action.
They have all had in-depth clinical cooperation with Sanqing before. As long as the superior department allows it, Sanqing will naturally want it.
Soon, the news that Sanqing successfully developed a small-diameter artificial blood vessel to solve international problems and fill the industrial gap became overwhelming and spread everywhere.
However, unlike the large-diameter artificial blood vessels that shocked netizens across the country, this time it was industry insiders who were shocked.
Domestic equipment manufacturers were very excited, and everyone was smiling from ear to ear.
Because this shows a new development direction for artificial blood vessels, biomaterials are undoubtedly more suitable and more promising than the old polyester materials.
Especially the upstream polyester materials have always been monopolized by foreign manufacturers. It is difficult for domestic manufacturers to break through the patent blockade and develop new materials on their own.
Now, Sanqing has pointed them in the direction of biological protein materials and confirmed its feasibility.
Then they can be followers, work in this direction, and develop new materials.
Maybe the effect is not as outstanding as that of Sanqing, but if you can take the cost-effective route and form a ladder bidding, you will still be very profitable.
You can even be the OEM or supplier of Sanqing. As long as you are in this industry chain, you can make more or less money.
After all, the demand for 40,000 artificial blood vessels every year will only increase in the future. Sanqing will definitely not be able to swallow it all by itself. It will produce them all by itself and share the profits with many friends.
In the past, these tens of thousands of artificial blood vessels were imported, and they could not even drink a sip of soup.
Now that artificial blood vessels have broken the monopoly and been completely localized, it means that everyone can have a meal at the table.
They can get a small piece of this freshly baked cake no matter what, which is much better than before when they could only stare at it.
In sharp contrast to the carnival of domestic manufacturers, Terumo and McVie were heartbroken.
Faced with this situation, they were all at a loss and completely unable to deal with it.
A new factory has not restored production capacity for 5 years after opening, and another was directly knocked down by an iron fist due to quality problems.
Both companies acted recklessly and brought their own faults. They have been at an advantage for a long time, which made them slack and made various mistakes. They gave up the market to themselves. They really can't blame others.
What annoys them even more is that the flagship products of these two companies are large and medium-caliber artificial blood vessels.
They couldn't handle the small-diameter blood vessels, so they could only look at the news about Sanqing, gritting their teeth with hatred, and feeling helpless and furious.
Sanqing has developed large- and medium-caliber artificial blood vessels this time, which has already completed a double kill for these two companies.
Once the small-diameter blood vessels below 6 mm come out, it will be a sure-fire outcome.
Everyone in the industry knows that when Sanqing's artificial blood vessels are launched, the entire industry will be completely reshuffled and a wave of bloodbath will be completed.
The imported blood vessels in the domestic market are completely finished, and it is only a matter of time before they are replaced by Sanqing.
As for the overseas market, it may be based on three pillars at the beginning. Slowly, when Sanqing's small-diameter blood vessels become more powerful, domestic sales will drive the overseas market. In just a few years, Sanqing will complete its counterattack and become the leading artificial blood vessel company. throne.
"In a few years, when Sanqing also occupies more than 50% of the market in multiple fields and achieves a monopoly, what a beautiful and spectacular landscape it will be."
Wei Kang was sitting in the office, imagining this scene, and the corners of his mouth couldn't help but raise.
(End of chapter)
