Zhu Jun's account on Station B has millions of fans, and he is also considered a quite influential Up master in the game area.
Although he does not live broadcast every day, it is actually rare for him to disappear for a week like this.
Many fans who missed him left messages on the space to ask about his current situation.
Until this day, the account @口强王之 Zhujun suddenly released a new video.
The person who appeared in the picture was not Zhu Jun, but a man in his thirties with a face that was somewhat similar to him.
As soon as he came up, he introduced himself, told all about Zhu Jun's condition, and also showed a video of Zhu Jun unconscious in the ICU.
"Hello everyone, I am Zhu Ming, Zhu Jun's brother. Zhu Jun is seriously ill and in a coma. I will speak on his behalf."
"Four days ago, Zhu Jun suffered from liver and kidney damage due to a urinary tract infection. His platelet index was very low and he was severely comatose. He has been lying in the ICU intensive care unit."
"We don't need donations and we are not short of money. We just ask for a more professional team of doctors to come to the No. 1 Hospital of Zhejiang Medical University in Hangzhou for offline treatment, because his current physical condition cannot be transferred to other cities."
"We need experts in infectious diseases, hepatology, nephrology, or intensive care."
"I haven't slept a wink for several days, and my mother fainted from crying. Everyone is on the verge of collapse."
"I temporarily asked Zhu Jun's up friend to help make this video. I am still accompanying him in the hospital, and I am also trying to find a treatment plan everywhere."
"It's an urgent matter, and human lives are at stake. I hope everyone will forward it and help spread the word."
“I’m willing to spend any amount of money just to find better experts and treatment options.”
“If you can help, please leave your contact information in the comment area, thank you very much.”
As soon as the video "I am in coma and rescued, please help me find an expert to save my life" was released, fans were shocked.
They forwarded it one after another to express their wishes.
"I'm crying. I hope he recovers soon."
"Good people live a long life and will get better."
"I have been following Up Master for several years. His optimism and bravery have inspired me. He has gone through many low points in life. Ji Ren has his own destiny, and he will be fine."
"Come on, young man! I have a classmate who is a doctor. Let me help you ask."
After Zhu Ming released the video, he also called many local media for help.
When the media reports were also published on the Internet, it caused an instant sensation.
After reading Zhu Jun's deeds, netizens were very sympathetic and helped to retweet the post and tag many well-known medical Vs.
The medical Vs lived up to expectations and gave their own interpretations, saying they would consult experts in the industry, and also conducted a wave of science popularization to the public.
Huang Yaoshi: "Paralyzed patients and bedridden elderly people have low immunity due to year-round catheterization, which will inevitably lead to urinary tract infections and other diseases. In this case, it is mostly caused by opportunistic pathogens, such as Escherichia coli, which Lebsiella, Pseudomonas aeruginosa, etc. It is recommended to take cephalosporin antibiotics for anti-infection treatment under the guidance of a doctor.”
Dr. Lilac: "Looking at the patient's condition, he has already been admitted to the ICU. It must be very serious. I am not a professional infectious disease doctor, so I can only help forward it. I hope that experts in the industry can stand up and give professional treatment plans."
Know the trick: "Urinary tract infection belongs to the category of 'lead syndrome' in traditional Chinese medicine. It is mostly caused by infection with damp-heat evil. Damp-heat is accumulated in the bladder and travels to the kidneys and bladder. It consumes healthy energy and causes damage to the spleen and kidneys, leading to Deficiency of righteousness and attachment of evil. If the blood meridians of the kidneys and bladder are damaged, it may lead to blood not flowing through the menstrual flow and causing hematuria. As the spleen and kidney qi are deficient for a long time, the defense will not be solid, and it is easy to be infected with external evils, which will relapse and worsen the condition. I Here are a few symptomatic Chinese medicine prescriptions, which can help the patient to recuperate his body after he is rescued."
Although the medical influencers are enthusiastic in giving advice, netizens seem to be unappreciative of some people.
Especially after he came up with a few Chinese medicine prescriptions, he immediately attracted a lot of ridicule.
"To be honest, traditional Chinese medicine should not treat a disease like high paraplegia."
"Some people may not know that many liver and kidney injuries are caused by taking traditional Chinese medicine."
"Haha, Chinese medicine is everywhere. Just come here if you smell it. Western medicine is so powerful, why can't it cure high-level paraplegia? Even a urinary tract infection can't be cured? Why do you have the nerve to ask for help from the Internet?"
"At least the patient is still hanging on for his life in the ICU. If he drinks a dose of traditional Chinese medicine and immediately dies, that would mean that the world is not functioning properly."
"This question must be viewed dialectically. How will you know if it is useful if you don't try it?"
"Once again, there is no difference between Western medicine and Chinese medicine. They are all modern medicine. Can you understand the basic common sense before we start arguing?"
Almost instantly, TCM hackers and TCM fans started going back and forth, engaging in a high-intensity battle, which completely distorted the topic.
Just when Zhu Ming launched the entire network to find experts.
Hangzhou, First Hospital of Zhejiang Medical University.
In a spacious conference room, the directors of the Department of Infectious Diseases, ICU, Hepatology Department, Nephrology Department, Cardiology Department, etc. are all gathered together at this moment for expert consultation.
Dr. Zhao explained Zhu Jun's case, then sat down and waited quietly.
The director of the Nephrology Department pondered and said: "The acidosis caused by the patient's kidney damage has been treated with sodium bicarbonate, and diuretics have also been used to treat edema. However, this treats the symptoms rather than the root cause. It still depends on the underlying disease. to continue taking the medication.”
The director of the ICU rubbed his face and said with a tired look: "I have issued critical illness notices twice, and I have rescued him every time. I have tried my best."
"If it continues to worsen, it is very likely that in addition to the kidneys, other organs in the body will also fail. By then, there will really be nothing left to do."
Hearing this, everyone looked at the director of the infectious disease department.
The director of the Department of Infectious Diseases smiled bitterly and said: "Basically, except for a few antibiotics that are seriously harmful to the liver and kidneys, all other available antibiotics have been used, but with little effect. It can be seen that the patient's Pseudomonas aeruginosa is very drug-resistant. .”
"Honestly, I don't have any good ideas."
Having said this, he showed a trace of hesitation and said: "How about we try polymyxin? See if it can curb the super bacteria in the patient."
The director of the nephrology department hesitated for a moment and flatly refused: "No, it's too dangerous. This antibiotic is very toxic to the kidneys."
The director of the infectious disease department was still making the final struggle: "What if it is used in small doses multiple times?"
The director of the nephrology department asked with a straight face: "How small is a small dose? Antibiotics are usually intravenous drip or intravenous injection. Adults need to inject 100-200 mg 8 hours a day. The dose is already very small. No matter how small it is, it can still be effective." Does it work? Don’t forget that the patient I just rescued was sent away by you again before he could live for a few hours. "
The director of the infectious disease department suddenly fell silent.
The director of the ICU suddenly interrupted and asked: "Have you ever figured out what is the cause of drug resistance?"
The director of the infectious disease department took out his mobile phone and explained: "We are conducting genetic testing on the Pseudomonas aeruginosa extracted from the patient's body. It is estimated that the results will be out soon."
The call was quickly connected, and he asked a few questions, his expression becoming solemn.
After hanging up the phone, he looked around and slowly said: "After PCR sequencing of Pseudomonas aeruginosa in the patient's body, the NDM-1 resistance gene was detected on the coding plasmid, which is resistant to all β-lactam antibiotics. Medicinal properties.”
He paused for a moment and added: "This resistance gene has even produced resistance to another last-line antibiotic, carbapenem antibiotics."
"The only option we have left now is polymyxin, not only that, but also in combination with antibacterial inhibitors."
The whole place fell into silence, everyone knew what this meant.
Previously, everyone speculated that Pseudomonas aeruginosa must have some genetic mutation that makes it resistant to so many antibiotics.
However, when the truth was finally revealed, everyone still felt a sense of despair.
There are a wide range of β-lactam antibiotics, including penicillins and their derivatives, cephalosporins, monoamide rings, carbapenems and penemase inhibitors, etc., which are the most widely used antibacterial drugs. one type.
NDM-1 is a new super-resistant gene discovered by scientists, encoding a new drug-resistant enzyme that can break down most antibiotics and render them ineffective.
Not only that, it can spread quickly between different bacterial populations.
Pseudomonas aeruginosa itself can change the permeability of the cell membrane and prevent the entry of penicillins. With resistance genes, it can even take the initiative to hydrolyze penicillins, cephalosporins and other drugs with hydrolase.
In other words, except for the two or three drugs called antibiotics as the last line of defense, there are no drugs available.
The director of the infectious disease department pondered for a moment, as if he had made up his mind, and said resolutely: "In this case, the only option is to use polymyxin, preferably in combination with a bacteriostatic agent like tigecycline."
The director of the liver department suddenly turned dark: "Although tigecycline can overcome tetracycline resistance caused by bacterial efflux and ribosome protection, it is the last resort for patients with multi-drug-resistant Gram-negative bacterial infections, but it It’s very toxic to the liver.”
The director of the infectious disease department smiled: "So the patient's liver is counting on you."
The director of the liver department and the director of the nephrology department looked at each other at the same time, both wanting to cry.
At this time, the ICU director's phone rang. He hurried out for a minute and then rushed back.
He looked happy and said loudly to everyone: "An acquaintance just contacted me and provided a solution. Not only can it reduce the dosage of the medicine, reduce the damage to the liver and kidneys, but it can also enhance the efficacy of the medicine."
Everyone looked at him, waiting for his answer.
The director of the ICU was overjoyed and said: "The person who called me was the director of the ICU of Kunming First People's Hospital. He has considerable experience in nosocomial infections caused by super bacteria. After seeing this incident on the Internet and in WeChat Moments, he immediately I called..."
"Tell the important point!"
Everyone roared in unison.
The director of the ICU felt a hint of coldness in the eyes of his colleagues, immediately shrank his neck and said.
"Sanqing's nanopills, a powerful drug delivery tool at the nanoscale, can reduce the dose of antibiotics to one thousandth and deliver it directly to the lesion, reducing losses during the body's metabolic process, so it can maintain the same The effect while greatly reducing toxicity to the liver and kidneys, as well as other adverse reactions.”
"At present, this pill has just entered the third phase of clinical trials. We need to contact Sanqing Group as soon as possible to apply to participate in clinical trials."
“With nanopills, you can use them in combination with polymyxin and tigecycline. The former is effective against drug-resistant Pseudomonas aeruginosa, and the latter can inhibit bacterial resistance and will definitely save the patient. "
As soon as he finished speaking, the director of the nephrology department clapped his hands: "Wonderful, if it is one thousandth of a dose, the dosage has been reduced sharply from 100 mg to 0.1 mg, and the toxicity to the patient is basically negligible. It really accomplishes multiple things with one stone!”
The director of the liver department also nodded approvingly. Generally, for intravenous infusion, the dosage of antibiotics is around a few grams, and it should be within 8 hours. Only in this way can the drug concentration in the body be maintained and the bactericidal effect can be achieved.
At the same time, most antibiotics are excreted from the liver and kidneys. A large dose will be very toxic and accompanied by other adverse reactions.
If it can be reduced from the gram level to the milligram level and the content of the drug in the body can be maintained, the effect will be self-evident to the patient.
Although the dosage of polymyxin is not that large, only 100 mg, but it can be reduced to less than 1 mg, and all worries will disappear.
The director of the infectious disease department immediately stood up and urged: "Since there is such a good thing, what are you waiting for? Hurry up and call the people in Sanqing. I remember that when our hospital used to buy equipment, there seemed to be a medical representative from Sanqing. Come over."
The director of the ICU stood up and walked towards the door: "Yes, I will contact you right away. Just wait for my good news."
****
Due to the emergency, Xue Shen rushed to Hangzhou with nano pills that night.
Dr. Zhao enthusiastically took him to the intensive care unit.
"Sanqing actually sent someone here so quickly. I'm really grateful."
Xue Shen opened the refrigerator in his hand, pointed to the two syringes with a faint green color inside, and asked: "Do you have polymyxin and tigecycline for injection here?"
Dr. Zhao nodded in surprise: "Yes, why, don't you have these two antibiotics here?"
Xue Shen spread his hands and said: "We have made some improvements to the process of nano-pills. Now we only need to inject antibiotic injections into the solution of nano-pills. The nano-polymers on the green algae can combine with the drug molecules in a few minutes, and the It’s mounted on a pill.”
“In this way, we don’t need to prepare in advance in the laboratory and mount the antibiotics on the nanopills in advance, and we can completely prepare them on site.
"Of course, the dosages of different drugs must be properly formulated to achieve saturation and meet the maximum loading effect."
Dr. Zhao was dumbfounded and couldn't help but admire the magic of nano-pills.
"There is such a magical pill. It is indeed produced by Sanqing."
Soon, the nurse brought two bottles of medicine, one was polymyxin B sulfate for injection, and the other was tigecycline for injection, both in 50 mg specifications.
Dr. Zhao hesitated for a moment and asked, "What should I do with this? It seems that the dose is a bit too much."
Xue Shen smiled: "First take a part, about a few milligrams, and then inject the solution. After the nanopill absorbs the drug molecules and reaches saturation, it will not continue."
Dr. Zhao suddenly realized: "So this is really convenient."
He carefully extracted a small amount of the drugs from the two injections, and then injected them into a nanopill solution.
Xue Shen shook the two syringes vigorously, and saw that the liquid became turbid, and then quickly returned to clear, except for some precipitates that were barely visible to the naked eye at the bottom.
Dr. Zhao opened his eyes wide and looked at it for a while before asking: "Is this okay?"
"Yes, you lead the way."
Xue Shen put the syringe into the refrigerator again, picked it up, and followed Dr. Zhao to the ICU ward.
Several department directors have gathered around the patient's bed, waiting for treatment.
The expressions on their faces were originally a little anxious, but after seeing Xue Shen, they instantly turned into bright smiles.
Xue Shen took out the nano-pill injection and handed it to the ICU director at the signal of everyone.
He could see that the other party looked quite excited, as if he had been looking forward to this moment for a long time.
The ICU director took a careful look at the injection in his hand and reluctantly looked away.
At this moment, Zhu Jun still had a high fever and was lying unconscious on the hospital bed.
The entire ward was very quiet, with only the beeping of the monitor and the occasional gurgling of the ventilator.
After the nurse disinfected, the ICU director took a deep breath.
Under everyone's nervous gaze, two nano-pill solutions were injected into the patient's veins one after another.
(End of chapter)
