"Wasn't the patient well before I went on vacation? Why did he suddenly get hospital flu?"
Jian Jian Yun's voice became sharp, and his tone was full of anxiety.
"The patient is over 60 years old and had a craniotomy for cerebral hemorrhage. Logically speaking, he should be almost recovered in the past half month. How could he have nosocomial pneumonia?"
“What are the results of the sputum culture?”
"MRSA! Haha, it's really a typical nosocomial infection."
"At least five hospitalized patients are infected? That's really serious."
"The ICU organized a hospital-wide discussion and has initially formulated a set of anti-infection treatment plans?"
"Thank God. Unfortunately, I am currently in isolation and cannot be of much help. I hope that when I go back, my condition will be completely under control."
After hanging up the phone, Jian Jianyun frowned, his face suddenly filled with sadness.
Wei Kang asked curiously: "What's wrong? From what you called just now, it sounds like you have hospital flu?"
Jian Jianyun immediately vomited her bitterness: "Yes, it seems that a girl was sent to a local hospital for infusion treatment by her parents because of a cold and cough. Later, not only did her condition not improve, but it also worsened."
"So he was sent to our hospital for treatment. He was not diagnosed with MRSA at first, but instead infected other patients in the ICU."
"Later, the condition never improved. I did a sputum culture and was diagnosed with MRSA. By this time, it was already too late."
"My patient stayed well in the ward, but his family members wandered around the hospital and brought germs from the ICU to the patient. Then he got pneumonia and was sent directly to the ICU. It was an unforeseen disaster."
"I was going to be discharged from the hospital soon, but what happened is that I am now lying in the ICU not knowing whether I will live or die."
"It is estimated that all the treatment costs will have to be paid by the hospital. Now I am worried that the patient will not be saved because he is over 60 years old, has underlying diseases, and just had surgery. His body is really weak and his immunity is completely weak."
"Except for that girl, several other patients were infected in our hospital. If they were not rescued, it would be a serious medical accident. There is really no way to explain it to their families."
"This is really difficult to handle." Wei Kang's face became serious.
Nosocomial infections are infections acquired by patients in hospitals and are currently a headache for the medical community in various countries.
Because non-compliance with disinfection procedures, poor management and other man-made disasters are the main causes of most nosocomial infections, the industry regards this as a shame for the medical profession.
The cumulative incidence of nosocomial infections in foreign hospitals has remained at 4%, while the figure in domestic hospitals is about 8%. In any case, it is a relatively high number, and every occurrence will bring a lot of additional pain to the patient.
Nosocomial infections are mainly caused by some superbugs that are resistant to common antibiotics. These superbugs include Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus ( MRSA), Acinetobacter baumannii, etc.
Among them, MRSA is the most famous. Pneumonia caused by this bacteria is often very serious. It will initially show flu symptoms, and then the patient will rapidly deteriorate until respiratory failure.
Data shows that the 48-hour survival rate of patients infected with MRSA is only 63%. If more than 50% of patients do not receive timely treatment, they will die within an average of 4 days after the onset of symptoms. It can be described as extremely vicious and dangerous.
Wei Kang asked with concern: "How effective is the antibiotic program?"
Jian Jian Yun shook his head and sighed: "I don't know either. All I know now is that the patient is lying in the ICU, and his life or death is uncertain. There are three younger patients who may be able to survive, but it's hard to say for my patient."
"The plan the ICU used for the girl was intravenous infusion of vancomycin, but this antibiotic is very toxic to the kidneys. My patient may not be able to tolerate this adverse reaction, so I will consider using linezolid for treatment."
"But you know, these antibiotics have serious side effects. Excessive use can be harmful to the body, but if you don't use other antibiotics, there is very little choice. Alas~"
Wei Kang couldn't help but feel worried when he saw her sighing.
Suddenly, something moved in his mind, and he remembered Sanqing's new project.
Nanopills are simply a tailor-made solution for this situation.
So, he immediately put forward constructive suggestions.
"Honey, actually, for the current situation in your hospital, Sanqing has a special nano-robot technology that may be used."
"This project has completed animal experiments, and the results are very significant. In a mouse model of acute Pseudomonas aeruginosa-infected pneumonia, the nanopills significantly reduced the bacterial load and greatly reduced the animal's mortality."
"The same remarkable effect was achieved in a mouse model of sepsis infected by Acinetobacter baumannii."
"More importantly, this new method uses only a very small amount of antibiotics during the entire treatment process, which can be said to pave the way for the development of nanorobots to treat bacterial infections in the human body."
Jian Jianyun's eyes widened in surprise and he exclaimed.
"Really? Wow, hubby, you are amazing, you can actually develop such a powerful thing."
"Just wait, I'll call Director Cui in the ICU right now," Jian Jianyun dialed the phone and asked, "How long will it take for this nano pill to be ready?"
Wei Kang mused: "The first clinical phase has been tried on healthy people and did not cause any adverse reactions. In the following clinical phase two trials, some patients will be recruited to try the drug."
"If I remember correctly, the company has prepared finished products for the common superbugs, just waiting to be used on patients."
"MRSA is the most common superbug. Even if it is made temporarily, it only takes 6-8 hours to mount the required antibiotic molecules on the nanoparticles."
"That's great." The worry on Jian Jian Yun's face disappeared, and he instantly became extremely excited.
Wei Kang also took out his mobile phone: "I will immediately ask the people in the nano laboratory to be ready to support the hospital at any time."
****
Kunming First People's Hospital.
Director Cui of the ICU was looking at the five patients in the ward, racking his brains to think of treatment plans.
Among them, a high school student named Xiaofang was the one who had been infected for the longest time. After 20 days of treatment, she has improved.
There are also two younger patients whose conditions have remained stable under antibiotic treatment and have not continued to worsen.
As for the remaining two patients, one has had chronic lung disease for more than ten years and has been in the hospital for a long time. His body has become resistant to many antibiotics.
Another man, who was in his 60s, had just undergone major surgery and his body's immunity was at its weakest when he was infected by the worst infection, a superbug.
Director Cui looked at the condition of these two people and was so helpless that he almost shed tears in an instant.
"Fortunately, these young patients have much better physical fitness and stronger immune systems, so they should be able to survive."
"It depends on the fate of the other two." He murmured to himself and slowly shook his head.
On the hospital bed in front of him, a teenage girl was lying, her childish face showing a hint of pain, obviously suffering from severe pain.
Xiaofang is a high school student in Kunming City. In the impression of most of her classmates, she is a girl who studies seriously and has good grades.
At the end of December, as the final exam was approaching, she stayed up several nights in a row in order to review and prepare for the exam.
As a result, the body immediately became exhausted. Not only was the whole body aching and weak, but also symptoms of fever appeared.
At first, she thought she had just a common cold and that she would get better soon as long as she drank more water and rested.
As a result, after lying at home for two days over the weekend, not only did it not improve, but it got worse and worse. I coughed continuously and my body temperature once reached 40 degrees Celsius.
In this case, her parents were also anxious and took her to a hospital near her home for treatment.
After a series of infusions to reduce fever, my condition went up and down, but my cough never stopped.
Three days later, Xiaofang developed a high fever again, and a CT scan showed small patches of inflammation in her lungs, which meant that her lungs were obviously infected.
The doctor immediately arranged for her to be hospitalized.
Unexpectedly, less than half a day after being admitted to the hospital, Xiaofang's condition deteriorated rapidly, with symptoms of chest tightness and shortness of breath, oxygen saturation gradually declining, and even respiratory failure.
The doctor continued to increase her oxygen intake, but she still felt out of breath and her chest was so tight that she was almost suffocating.
My parents made a prompt decision and transferred directly to the First People's Hospital, the best tertiary hospital in Kunming.
After arriving at the hospital for expert consultation, he was immediately transferred to ICU for treatment.
Various first aid measures were arranged immediately, including ventilator-assisted ventilation, lung CT review, sputum culture, blood culture and other specimen cultures, and none was left behind.
At first, the hospital did not think about nosocomial infection, but within a few days of assessing the condition and determining the treatment plan, patients in other beds in the ICU also developed similar symptoms.
At the same time, Xiaofang's condition continued to deteriorate. Not only was she on a ventilator, but she also continued to have a high fever. The partial pressure of oxygen in her body barely reached the standard. As for both lungs, almost all of them were consolidated, and the inflammation indicators were very high.
If the condition continues to worsen, I am afraid that I will need ECMO (extracorporeal membrane oxygenation machine), which is the so-called artificial lung.
In just one week, a healthy and lively young girl turned into a dying girl.
Director Cui of the ICU suddenly realized that Xiaofang's infection might not be an ordinary virus or bacteria.
At this time, the sputum culture results also came out. It turned out that she was infected with the super bacteria MRSA, and the blood culture also showed that Gram-positive cocci were cultured.
The ICU immediately organized a hospital-wide discussion and initially formulated an anti-infection treatment plan for positive bacteria and hospital-acquired infections.
Fortunately, Xiaofang's drug sensitivity test showed that vancomycin is effective.
The ICU immediately gave her an intravenous drip of vancomycin and carried out all-round suppression of MRSA.
In the following days, Xiaofang's fever peak slowly and steadily dropped, and the support of the ventilator also slowly decreased.
However, other patients also broke out at this time.
A total of five patients were diagnosed with MRSA, and all were treated together.
Soon, the vicious nature of MRSA was exposed.
Complications followed one after another, including pneumothorax and massive airway bleeding, all of which started a crazy counterattack in the patient's body.
Soldiers came to stop them, and water came to cover them. In the rounds of MRSA battles, Xiaofang's condition gradually stabilized.
Her body temperature slowly returned to normal, and the ventilator support was gradually reduced to an offline level.
What is even more gratifying is that other important organs in her body were checked one by one, and no signs of MRSA infection were found. All infections were only concentrated in the lungs.
All this shows that Xiaofang is gradually recovering.
A few days later, her tracheal intubation was removed. Although she was still weak, her condition had stabilized and she was transferred to the general ward not long after.
It is expected that he will be discharged from the hospital in another week.
For her, these days were like a long nightmare, and she finally recovered and woke up.
But for all the medical staff in the ICU, this battle that cannot be relaxed at all times is far from reaching the moment of victory.
Xiaofang was the first patient to recover. In addition to her, two other young patients also recovered after receiving antibiotic treatment.
Fortunately, none of the three of them had any sequelae. They only needed to rest for a period of time before they could regain their health.
This is undoubtedly a good thing. Young people's bodies are still much more resilient after all.
But for the remaining two patients, getting rid of the pain was much more difficult.
Not only did these two people have very serious lung infections, but after a week of treatment, their white blood cells and other indicators did not drop significantly, and their lung CT images showed no signs of improvement. There was still a lot of thick sputum in the airways, and they needed instruments to aspirate sputum every day.
These signs all indicate that infectious diseases have not been effectively controlled.
Such results will occur when superbugs encounter elderly patients, critically ill patients, weak immune systems, and patients who have been treated with broad-spectrum antibiotics for a long time.
The condition will be difficult to control and even life-threatening.
Because MRSA is multi-resistant to many antibiotics, if the bacteria cannot be controlled and are allowed to continue to develop, when the superbug infection spreads to other parts of the body, it is likely to cause sepsis, eventually leading to organ failure, and thus incurable Death.
Director Cui looked at the treatment results, and his mood instantly became extremely heavy.
"Vancomycin is too nephrotoxic. Tried in small doses, the effect is not good. The effect of linezolid is also average. I can only try teicoplanin for injection. This antibiotic has a relatively long half-life and is resistant to vancomycin." Bacteria have a certain inhibitory effect.”
"If that still doesn't work, we will try injectable tigecycline and daptomycin one by one."
"It's just that, as a result, various antibiotics are used in turn, and the doses used are quite small. I don't know if the patient can hold on."
He hesitated for a while and finally decided on a treatment plan.
At this moment, the phone suddenly rang.
"What, Sanqing's nano pills?"
"It can accurately deliver antibiotics into the body and achieve very significant effects. At the same time, the dosage is greatly reduced, and adverse reactions are almost negligible."
"Such a good thing is only being brought out now?"
"Oh, it turns out that human clinical trials have just started, so it's okay."
"Okay, I will formulate a new antibiotic treatment plan immediately, and then you will bring the corresponding nano pills as soon as possible."
The moment he hung up the phone, Director Cui's eyes lit up, he was refreshed, and the sadness disappeared from his face.
