Xie Tianyin held his mobile phone and looked at the enthusiastic speeches of the group members, with a smile on his lips.
With the vigorous promotion of him and several branch supervisors, the trial run of Rh-negative artificial blood in Jiangnan area was very successful.
In order to popularize artificial blood as soon as possible, the group of friends rushed to participate in clinical trials for free.
The number of "help" calls he's received this week has dropped significantly.
In the past, we would receive at least ten requests for blood donation every day. In addition to a series of tasks such as verifying information and recruiting volunteers, we would have to make at least nearly 200 phone calls a day.
But today, until the afternoon, he had not received any call from the hospital.
In the group that used to be filled with donation messages, everyone was discussing another matter.
"I just returned from a clinical trial. As a healthy person, I never imagined that one day I would also receive a blood transfusion."
"It's such a magical experience. I just donated 2 units of blood a month ago, and I feel like I've regained a little bit of my blood after participating in the trial."
"I transfused 50ml of artificial blood, and there were no adverse reactions."
"I donated blood not long ago, so I received a unit of artificial red blood cells. The feeling of weakness after donating blood disappeared."
"Actually, this is not a bad thing. It is actually good for the body. It is said that athletes will draw out their own blood during training, save it, and then reinfuse it before the competition. This can increase the number of red blood cells, allow the body to transport more oxygen, and enhance endurance and athletic ability. Get good grades.”
"Haha, I didn't expect that I would also experience the effects of blood stimulants."
"Pfft, I'm just one suspension away from the game, and I have a complete set of operations."
"There are a lot of growth factors and other things in the plasma. I heard that there are rich people in Eagle Country who spend millions of dollars to regularly replace their whole body blood with the blood of young people when they get older, so as to stay young."
"When I get older, will I be able to do this? But I guess I can only afford artificial blood."
"It is safe to use industrial products like artificial blood. At least there are no infectious diseases such as hepatitis."
"The number of people in Phase I and Phase II clinical trials is not too large. I went there too late and didn't sign up. It seems I can only wait until Phase III trials are opened."
"In fact, clinical trials are not as scary as what is said on the Internet. I now go for a review every two weeks to see if there are any adverse reactions."
"You still have to pay attention. During the physical examination, I saw someone had an allergic reaction and a rash on their wrists when they were injected subcutaneously."
"This is what happens with whole blood. There are too many components in plasma and it's too complex. If you replace it with red blood cells or platelets, there shouldn't be much of a problem."
"By the way, did you know? Xinhua Hospital's bloody head was picked up in one pot."
"No wonder, when I went to prepare blood last week, I saw that all the blood heads had disappeared."
"It is said that he refused to refund the patient's deposit, and then he was reported and immediately went to the police."
"You deserve it. It's so expensive. It's like a steamed bun with human blood."
"Thank God, these dirty guys are finally gone. Every time I go to donate blood, I always feel like fish on the chopping board, waiting for someone to bid at any time."
"By the way, if someone has artificial blood in the future, do we still need to donate blood for free?"
As soon as this question came up, everyone fell silent.
Everyone originally came together to donate blood to help each other. So if there is no need to donate blood in the future, is it still necessary for this organization to exist?
"@集团主, you are the one who pushed this matter forward, do you have any opinion?" Someone started @xietianyin.
Xie Tianyin chuckled. He had already anticipated this day, so he discussed the matter with the Provincial Blood Center.
After thinking about the words, Xie Tianyin slowly started typing.
"In fact, the free blood donation policy will not be abolished."
"Artificial blood is currently in limited quantity and has not yet been officially mass-produced. It can only be trialled in the Jiangnan area."
"It may be several years before we can meet the needs of the whole country."
"Hai City now uses thousands of units of blood every day. If it were extended to the whole country, it would be an astronomical figure."
"Therefore, I estimate that artificial blood and free blood donation will run in parallel for a long time."
"If you have used artificial blood, you will know that the price of artificial blood is still quite expensive. According to the market price, one unit may cost thousands of yuan. If it is separated blood components, such as suspended red blood cells, the price It will be more expensive.”
"Free blood only requires a cost, which is mainly the cost of collection, testing, separation, and transportation. Under the above subsidies, a unit of 200ml is about over 200, which is much cheaper."
"So artificial blood can only be used for acute blood transfusions and large amounts of surgical blood. The problem of blood shortage must be solved first."
"For some people with limited financial conditions, they can donate blood for free on weekdays, and they can also ask their family members to donate blood when needed. In this way, they can obtain cheap and free blood with a blood donation certificate."
"In general, the two policies will run in parallel for a period of time, which will not only solve the problem of blood shortage and combat illegal blood trading, but also keep people enthusiastic about donating blood for free."
"When the cost of artificial blood is completely reduced, we will then consider whether to cancel the free blood donation system."
After reading his explanation, the group of friends all agreed, and they immediately expressed their opinions and started discussing.
"I agree with the group owner and the blood bank. Free blood donation is actually a good policy. It can be regarded as mutual aid for us at the bottom. However, the promotion and implementation are not good. As a result, not many people responded, and the blood was not enough. It’s better to keep it.”
"Free blood donation is a public welfare act, and artificial blood is a market act. Each has its own advantages and can completely complement each other."
"Artificial blood is indeed relatively expensive. It may be affordable for serious surgery, but it is difficult for patients with blood diseases who require long-term blood transfusions to afford it."
"Enterprises have to make money when developing artificial blood. They cannot provide it to patients for free. Even the blood we donate for free requires a series of costs to collect, transport and store. Not to mention artificial blood, dual regulations are the most realistic solution. .”
"I still plan to donate blood once a year. I'm used to doing it, and I'm still a little uncomfortable if I stop."
"In the past, we donated blood to people who had difficulty using blood. Now we donate to poor patients to make their life easier. It's all a donation of love, there is no difference."
"Love brings us together. Saving others is also saving ourselves."
"Fortunately, no one will ever die from lack of blood again."
"This is the meaning of our Rare Blood Type Alliance's existence."
****
Sanqing Headquarters, Factory Building No. 018, Biopharmaceutical Zone.
Ding Mian shuttled between the stainless steel culture tanks with a serious expression, giving instructions to the employees beside him from time to time.
"The temperature of the culture environment must be strictly set at 37°C without any deviation. You can add some fresh culture medium every 3-4 days."
"It should be noted that the density of stem cells must be high to increase their value quickly. If the number is still small after 3 days of culture, it means the condition is not good. At this time, the density should be increased, and then the culture should be continued for one or two days, depending on the situation."
"Hematopoietic stem cells are suitable for growing in an environment with an acidic pH. Do not change the culture medium frequently. The nutrient solution must be strictly quantitative. If the condition is not good, add more. The more acidic the conditions, the greater the density of the stem cells, and the better they will grow. .Be careful, prefer acid to alkali.”
"The effect of the nutrient solution I debugged last time was not very good, and the value increase was not fast enough. The proportions of LIF, β-mercaptoethanol, and L-glutamine were a little wrong. I revised it again. When you prepare the next batch, press This is the ratio."
"Stem cells are relatively sensitive and easily susceptible to external stimulation. When changing the culture medium, it takes about a week to adapt. After adapting, it is best not to change it at will."
"Yes, yes." The production line supervisor held a notebook in his hand and quickly recorded all the operating steps and precautions, and asked a few questions from time to time.
"Theoretically, the entire production process is very complete, and the output is calculated strictly according to the schedule, so there won't be any big problems."
"After the artificial blood was completely cultured, it was filled into blood bags in batches of 400ml each, and then samples were taken for routine blood tests. Everything was very normal. The test results for bacteria and viruses were also negative, and the transaminase tests were normal. .”
"Well, good job." Ding Mian nodded in approval while checking the inspection report.
"At present, this production line can already meet the demand for Rh-negative blood. But if we want to supply the country's blood demand, it is far from enough."
After the inspection, Ding Mian shook his head and sighed.
The production line supervisor smiled bitterly and said: "How can we do that? Our biopharmaceutical area factory is already tight, so it would be nice to have one for artificial blood. Even if all the equipment is put in, I estimate there will only be six production lines."
Ding Mian smiled: "Anyway, if the production line of this factory is completed, my task will be completed. Then it will be your job to find an outsourcer."
“So I tried my best to fix all the operating procedures and data and make it into a fool-like operation manual. In this way, the operators only need to operate the equipment step by step. When they become proficient, they can copy this set of copies to any product. on-line."
"Yes, you are right." The production line supervisor flipped through the thick notebook and nodded repeatedly.
There were several operators behind him, all holding small notebooks and carefully recording everything.
The production process of artificial blood is very complicated, and they do not have much experience. They can only practice as much as possible to become familiar with the entire operation process, especially the preparation of culture media and nutrient solutions, which is a technical job that requires extra care to complete.
Generally speaking, from a practical perspective, the more complex the components of the culture medium, the more comprehensive the functions will be, the more convenient it will be to use, and the easier it will be to raise stem cells.
The culture media used for hematopoietic stem cells are all purchased products and contain a variety of growth factors that promote cell proliferation. However, you still need to add some ingredients according to your own conditions to prepare the most perfect culture medium.
"In fact, after we find the optimal ratio, we can customize the culture medium and nutrient solution according to needs. This can be used immediately after thawing, which is convenient and fast, greatly reducing operating links, improving production efficiency, and saving valuable time."
The production line supervisor made a suggestion. If production is to be outsourced in the future, it is obvious that the preparation of these culture media will also need to be carefully optimized and customized by suppliers.
Ding Mian nodded: "That's natural."
"I heard that the pilot program for rare blood types in the Yangtze River Delta was very successful. Will there be no need to donate blood for free in the future?" someone said excitedly.
Ding Mian shook his head and said, "It's not that easy. We have just started."
Another employee curled his lips and said: "I feel that donating blood for free is of no use. No matter whether the blood donation is free or not, you still have to pay when you use it. It's better to just spend money to buy it."
"Naive." Ding Mian sneered: "In Eagle Country, free blood donation and paid blood donation coexist. Do you know where the blood product companies have the most blood collection points?"
"I don't know." Everyone shook their heads.
"Slums. Many poor people donate plasma twice a week and can get more than 300 US dollars a month. They can get 900 US dollars for their first blood donation, so they all rely on this. Of course, some vain people also rely on selling blood to make a living. credit card."
“The place with the second largest number of blood collection points is on the border between Eagle Country and Cactus Country. 90% of the donors are from Cactus Country, because the cost of one donation is higher than their weekly salary, and this is their only source of income. "
Ding Mian gushed: "This is pitiful enough, but what is even more terrifying is the safety hazard of paid blood donation. Do you know why Sakura Country changed from paid blood donation to unpaid blood donation?"
Everyone shook their heads again.
"When the Ambassador of Eagle Country encountered an accident in Sakura Country, he suffered from massive bleeding and needed a blood transfusion, so he directly took more than a thousand milliliters of blood from the blood bank for transfusion. Not long after, he was found to have hepatitis, as well as other messy infections, such as HIV, anyway. He died a few months later.”
"He passed away peacefully, but the people of Sakura Country were not peaceful. All the citizens were completely shocked because they found out that their blood bank contained a bunch of mines, which were full of bacteria, viruses and various hidden dangers. Even the ambassador was deceived. Dead, let alone ordinary people."
"So we worked together from top to bottom and finally launched the free blood donation event, which is how we achieved the current results."
"So, paid blood donation is definitely a dead end. Only free blood donation can save the blood shortage."
"Of course, now that artificial blood is available, it is a more reasonable solution to do both in parallel."
"It can be expected that when artificial blood is mass-produced and rolled out across the country, it will inevitably trigger a social change."
Everyone nodded, their eyes full of admiration, and said, "Dr. Ding still knows better."
****
Just when the artificial blood project was progressing steadily.
Wei Kang received a call from the space center.
The time for the rocket launch has been determined and is scheduled for December 30.
Starting from January 1st, he and Jian Lianyun will spend three days on the space station, and then return with the original spacecraft.
Since the two have already received three spaceflight trainings, the last round is just around the corner.
On December 15th, the last 14 days of training before the rocket launch will officially begin.
(End of chapter)
