Kunming, Infectious Disease Hospital.
In the treatment room, a middle-aged man in his forties sat nervously on a chair with an uneasy expression.
Don't blame him for being so nervous, the formation at the scene was actually a bit scary.
Surrounding him were a dozen doctors in white coats.
Everyone stared at him with burning eyes, looking up and down. Their eyes were like an evil ghost looking at a roast chicken or a pervert looking at a beautiful woman. They were so hot that it was scary.
"The Romance of Fairy Wood"
After a while, the man was stared at, and he looked timidly at the doctor in front of him.
"Director Fu, didn't you ask me to be a volunteer for Sanqing's new drug clinical trial? Where is the drug?"
Director Fu was in his fifties, with some gray hair. He looked kind and friendly. He said with a smile: "Come on, we are waiting for someone, please be patient."
The man's expression suddenly changed, and he said with a mournful face: "Isn't it true that I have recovered from Yang? Or am I suffering from some other terminal disease? You can't hide it from me."
"Don't think too much. It's nothing. Your illness is fine." Director Fu comforted him a few words.
"But when you look at me like this, do you think it's not a good thing?" The man looked like he was about to cry.
"Haha, that's it..." Director Fu was about to speak when suddenly there was a sound of footsteps in the distance.
He suddenly smiled: "It seems that the medicine and people have arrived."
After saying that, he turned around and faced the door.
Soon, Director Fu led a group of five or six people, all wearing white coats, to the patient.
A middle-aged man with a square face and a dignified look glanced at him and asked, "Is this Tester No. 0?"
Director Fu nodded and began to introduce the man's information.
"Director Han, patient No. 0 is 46 years old and has been suffering from AIDS for more than ten years. He has taken almost all anti-AIDS drugs on the market, and many of them have become drug-resistant."
"He is currently taking Duanailing, and the HIV virus in his body is no longer detectable. However, after genetic analysis of some lymph, blood and other tissue cells, it was found that there is a large amount of HIV virus gene pool remaining, making him a very suitable clinical trial subject."
Director Han nodded, smiled at the patient, stopped talking, and stood aside to watch.
Director Fu extended his hand to another strong man and said with a smile on his face: "You are Tang Que of Sanqing Group, I have admired you for a long time."
He looked at the small box in Tang Que's hand and asked curiously: "Is this the gene therapy drug you developed?"
The patient looked at Tang Que's bulging biceps under his white coat with a look of surprise on his face, thinking: "This big guy is actually a scientific researcher? I really can't tell. If it weren't for this white coat, I would have thought he was." Where is the fitness coach from?”
Tang Que smiled and nodded, and handed over the small box in his hand: "The medicine this time is a bit special. It is a non-inactivated biological agent and must be kept refrigerated. I just wanted to see the effect on the patient with my own eyes, so I went with Director Han. coming."
Director Fu took it carefully and felt an icy chill wherever he touched it. He placed it on the table and opened it gently. Ten tubes of injections lay quietly inside.
Everyone took a step forward in an instant, looking at him greedily, showing an expression of great anticipation.
…
This is the world’s first HIV gene drug!
Director Fu picked up a tube of injection, looked at the liquid inside, his eyes became a little drunk, and said excitedly: "The next is the moment to witness history!"
Director Han stared at the genetic potion, his eyes unblinking, showing a trace of longing.
The patient also looked excited at the moment. Although he couldn't understand much, he felt that everything seemed very powerful.
The injections, which need to be refrigerated for transportation and storage, are still placed in such a high-end box. The whole thing looks very high-tech, just like a Hollywood science fiction movie.
He had never seen such a big scene before, so he couldn't help but get excited and eager to try.
"You can start now." The patient couldn't help but urge.
"Haha, why are you so anxious?" Director Fu said with a smile and walked to him.
Sterilize and insert the needle with a single movement, and quickly inject the liquid in the needle into the patient's vein.
The entire process took less than half a minute to complete the treatment.
The patient pressed the cotton ball with his fingers and was still a little dazed: "What? Is this the end? I thought it would take a few hours for so many people to do it."
Director Fu shook his head: "What are you thinking about? It's just like a vaccine. It's just a shot."
He looked at the patient and his eyes became sharp: "However, follow-up observation is the most important."
"You have to stay in the hospital for two weeks this time. You don't need to take medicine, but you have to provide some blood samples and tissue cells every day, and we will conduct tests."
"You don't need to take medicine after you are discharged from the hospital, but remember to come here for a checkup every week."
The patient opened his mouth wide and said in disbelief: "I don't need to take medicine after I'm discharged from the hospital? You know I have AIDS, right? What if it relapses?"
"Haha, it's just to test how long you can stop taking the medicine and still keep the HIV virus clear, so you can't take the medicine."
Tang Que suddenly interrupted: "So after you are discharged from the hospital, you'd better be more conscious and keep in touch with the Centers for Disease Control and Prevention. At the same time, you should also pay attention to propriety in your daily life."
The patient opened his mouth and wanted to refuse, but after thinking about the benefits of trying the medicine, he endured it and said angrily: "Okay, I understand."
Director Fu comforted him: "This is also for your own good. With just one injection of this genetic drug, you can completely cure your AIDS and eliminate future troubles. If the test goes well, you will never need to take medicine again."
When he said this, the patient became happy: "Haha, really? That's great, I can finally get rid of this damn thing called AIDS."
"Okay, I'll give you another check, and then you can go to the ward with the nurse."
Director Fu took matters into his own hands, performed a physical examination on the patient, and said with satisfaction.
The group of people walked out in a grand manner and arrived at a conference room.
Director Han couldn't wait to ask: "How is it? Are you sure?"
"It seems that everything is going well so far. After the patient was injected with the drug, his body temperature rose slightly, but there is no other abnormality. We will not know what the situation is until the blood sample is checked tomorrow." Director Fu said thoughtfully.
"There will be a few more patients coming tomorrow and the day after tomorrow, and there will be more cases. We will record all the patients' reactions in detail."
Tang Que agreed: "Although the cell experiments and animal experiments were very successful, this is the first time it has been used on patients. You must proceed with caution. If there are any adverse reactions, you must notify us in time."
…
Director Han said expectantly: "Great, then I will wait for your good news."
He looked at Tang Que: "Director Tang, Mr. Wei and I have something to discuss. Let's go back together."
Last time Wei Kang told him that the HIV gene drug was successfully developed and that the HIV elimination plan could be upgraded to 2.0. He was so excited that he immediately took the time to rush over and wanted to meet Wei Kang in person to discuss the matter.
They had just met and before they had a chance to talk, they learned that the genetic drug was going to be clinically tested here, and they immediately came over with Tang Que to check it out in person.
Sure enough, he was not disappointed. After seeing the genetic medicine with his own eyes, he was conquered by this seemingly very technical medicine.
It is indeed a genetic drug developed by the Sanqing Group. The appearance alone is very high-end.
With this in mind, he became even more eager for version 2.0 of the HIV Elimination Plan.
Version 1.0 was implemented very smoothly and was a huge success.
Everything went as planned, and the chain of HIV transmission was completely cut off.
The delta is completely gone.
However, how to deal with these existing patients next made him a little embarrassed.
Although they can continue to take medicine, the problem is that this is not something that can be resolved in a short time.
These people have to take medicine until they are old, which may take decades, which is undoubtedly a huge burden on the medical system.
Although it can be converted to medical insurance in a few years and patients can pay part of it themselves, but if they are used to free medicine delivery, it will inevitably not arouse opposition from patients.
And what should I do if drug resistance develops after long-term medication use?
What if the patient has another underlying disease?
Or what should I do if the patient cannot take the medicine continuously for some reason?
There are always various accidents in life. If a patient misses taking medicine for a period of time, he or she will easily become positive again. What if the patient infects others again?
In short, it is impossible to persist in eating for decades without making any mistakes.
He is having a headache about the follow-up measures.
I never expected that joy would fall from the sky.
Sanqing has successfully developed a genetic drug that can completely cure the virus, which can completely kill these existing viruses.
Why didn't this make him surprised and happy, calling God to help me?
So after hearing the news, he rushed over immediately to discuss the specific implementation plan with Wei Kang.
He has also seen the HIV gene drug with his own eyes and is very reassured. The patient seems to be in good condition after the injection.
All this gave him confidence in his plan.
These few months of clinical trials are a good time to prepare in advance.
After returning to Sanqing headquarters, he quickly met Wei Kang.
Both parties exchanged greetings and took their seats.
Director Han was enthusiastic and full of praise for genetic drugs.
“Mr.
Wei Kang smiled slightly: "Director Han, you're welcome. These are the results of the R&D staff."
"Until we see clinical results, it's still too early."
"Mr. Wei is so humble. I saw that the patient was fine after the injection. When we left, he was in good spirits and only had a little fever." Director Han couldn't help but give a thumbs up.
…
"However, this medicine uses a recombinant virus vector, so there will be some difficulties in transportation and storage, right?" Director Han asked.
Wei Kang nodded: "Yes, this may not be friendly to economically underdeveloped areas. Since it is a live virus vector, it requires long-distance cold chain transportation, otherwise there is a risk of failure."
"Due to the particularity of the recombinant genetic virus, large-scale production is also a bit difficult. The virus cannot be cultured in chicken embryo cells, that is, eggs, which are commonly used for vaccines. It is necessary to use a type of cells cultured and isolated from macaque lymph and visceral tissues. , can it continue to reproduce in large numbers, and I’m afraid it will be difficult to popularize it in large numbers in a short period of time.”
"Here," Director Han suddenly became anxious and patted his chest and said, "No, if you have any difficulties in production, just mention them and I will coordinate and resolve them."
Wei Kang pondered: "We have only produced genetic drugs for rare diseases before. The quantity was relatively small and it was not a live virus vector, so there was no problem. But when we have to face millions of AIDS patients in China and even tens of millions of patients abroad, Our Sanqing family may not be able to absorb this production capacity.”
"What's more, there is also the problem of long-distance cold chain transportation, especially cross-border cold chain transportation, which is twice as troublesome."
"So, I want to authorize this drug and let capable pharmaceutical companies produce it on their own. This can solve the problem of remote production areas and insufficient production capacity."
Director Han's eyes lit up: "This is indeed a very good solution."
"So, I may have to hold another press conference to meet with old acquaintances from multinational pharmaceutical companies." Wei Kang said with a smile.
Director Han smiled meaningfully: "That's right. The whole world is trying to find ways to solve the century-old problem of AIDS. Since Sanqing is at the forefront, it is natural that it must take responsibility for all mankind and unite the entire pharmaceutical industry to solve the problem together. this problem."
Wei Kang also smiled: "Governments of all countries also have a duty to do so. In this regard, as a pioneer, China will not mind playing an important role and becoming the world leader."
The two of them looked at each other and smiled, and their tacit understanding was clear.
"Okay, let's talk about the price." Wei Kang coughed lightly and turned to another topic.
"It's still the same as before. Domestic prices will be very favorable. Just treat it as a charity to repay the society. The main income comes from overseas. I know that these rich countries have announced a series of plans to end AIDS. Their wallets are bulging and they are holding coins for purchases. In this case, I won’t be polite.”
"Mr. Wei, don't worry, you will never suffer too much in this regard."
Director Han looked solemn and said: "I heard the news that you are on the list of this year's China Charity Award. This is an affirmation of Sanqing's long-term return to society and its courage to assume social responsibilities."
"Haha, it seems that I will continue to fight and show greater responsibility." Wei Kang laughed.
The ensuing discussion went very smoothly, and the two reached a general agreement.
Director Han returned home satisfied, and he is now waiting for the results of the clinical trial.
As long as the HIV virus does not recur in the body within a few months after an AIDS patient stops taking medication, the HIV Elimination Plan 2.0 will be stable.
****
Two weeks later, Director Fu looked at the test results in front of him and was completely shocked.
…
"Patients will initially show mild cold symptoms, low-grade fever, runny nose, nasal congestion, general fatigue, etc."
"These symptoms will last for four to five days, during which genetic analysis of samples collected from the patient revealed that HIV viral gene fragments will rapidly decrease in tissue cells."
"A week later, HIV gene fragments could no longer be detected in the patient's tissue cells. At the same time, the patient's cold symptoms began to heal on their own. After three days, the symptoms would disappear and he would completely recover."
"Two weeks after stopping the medication, the HIV virus in the body has disappeared, and the patient can be discharged. The follow-up situation needs to be observed again."
"It's really amazing that just one shot can have such an effect."
Director Fu closed the report and sighed: "Sanqing has developed an incredible drug."
"With such genetic medicine, China will no longer have AIDS."
"What a great achievement, great company."
He quickly sent the latest information to Sanqing and the Centers for Disease Control and Prevention.
One month later, the four test results of the patients participating in the clinic after stopping the drug showed no signs of active replication of the HIV virus.
Although the time is still short, doctors are more hopeful that their AIDS is in long-term remission.
Whether it is cured or not requires a long period of observation before a final conclusion can be made.
But it is clear that the dawn of healing, like the morning sun, is unstoppable and will, sooner or later, shine upon the entire world.
After Sanqing received the clinical trial results, it quickly held a formal press conference to announce the successful cure of AIDS.
I can extract side effects
