Liu Yurong is Grandma Liu's name when she was young. She is now 72 years old.
When she was young, she joined the army. Although she was thin, she had a straight back and strong eyes. She was a heroic female soldier.
As she gets older, especially after the age of 65, she often suffers from a dull pain in her lower back and frequent cramps in her calves at night. Once an attack occurs, the pain lasts for more than ten minutes and requires a long massage to relieve it, which especially affects her sleep.
Her spine is no longer straight, but bent down. She always lowers her head when walking and moves slowly, but she still moves freely.
She has always thought that this was a normal phenomenon as people get older and didn't pay much attention to it.
Until one time, when she was packing old boxes at home, her legs suddenly weakened, she slipped to the ground, and her back hit the wall hard.
Instantly, she felt a sharp pain in her lower back. She sat on the ground for half an hour before she could get up.
The pain in my lower back worsened from then on and lasted for 2 weeks before slowly relieving.
Since her children all work out of town, she usually lives alone at home so as not to worry her children, she did not go to the hospital for a check-up.
In fact, she herself felt that it was just a fall and a bump on her waist, so it was not a big problem.
She had experienced this kind of pain a lot when she was young, and she really didn't even frown.
But in the following years, the pain in her lower back became more and more frequent, and the pain often made her unable to straighten her back.
So she simply kept bending over and even used crutches.
Slowly, the curvature of her back became more and more pronounced.
Grandma Liu thought that it was normal for people to be stooped when they grow old, so she gradually accepted her hunchback life.
It wasn't until the daughter, whom she hadn't seen for two years, came home to visit relatives that she was surprised to find that her mother had a hunchback. The hunchback was so severe that her daily life was obviously affected.
Under the pressure of her daughter, Grandma Liu finally went to Kunming First People's Hospital on crutches.
At this time, her entire back had been bent into a very unnatural hemispheric shape, and her hunchback was extremely obvious.
The whole person's spine is like a curled shrimp. You have to hold the cane firmly in front of your chest with both hands to stabilize your body.
My lower back was so low that I could hardly raise my head and look straight ahead, and could only look down at the ground.
Grandma Liu walked into the consulting room unusually slowly, like a snail weighed down by a heavy back shell.
Her daughter stood beside her, supporting her like an old and frail camel.
At a glance, people can only see the towering hump, but they cannot look at her.
This scene left a deep impression on the doctor who treated him at the time.
As an orthopedic surgeon, he has treated many similar patients, but such severe osteoporosis is rare even for him.
The doctor first evaluated Grandma Liu's height changes.
The results are shocking!
She was 158 centimeters tall when she was young, but now her height is only 147 centimeters, and she has lost a full 11 centimeters in height.
After a series of examinations, Grandma Liu's bone density had reached -4.1, and she was diagnosed with severe osteoporosis. She also had old compression fractures in her 7th and 8th thoracic vertebrae.
It was precisely because of severe osteoporosis and compression fractures that stole her height, resulting in her obvious hunchback.
After being hospitalized for a period of time, Grandma Liu's pain improved.
Although doctors also prescribe anti-osteoporosis drugs, at this age, considering the adverse reactions after taking the drugs, the choices of drugs are relatively limited.
The most commonly used treatment is bisphosphonate treatment, but no matter what treatment, it cannot significantly restore bone density, but can reduce the risk of fractures as much as possible, which can only allow her to maintain her current condition and not continue to deteriorate.
This is actually enough.
Any treatment for osteoporosis is a long-term and lengthy process. In many cases, doctors can only help, and you can only rely on yourself to ultimately defeat the disease.
As usual, she was discharged after two weeks of stay. Every year when the pain became unbearable, she would stay for another two weeks, and so on.
When he was discharged from the hospital, the doctor couldn't help but be filled with emotion when he saw Grandma Liu bending over.
In fact, there is no particularly effective method for this kind of severe osteoporosis.
He knew there was nothing he could do and could only watch Grandma Liu's condition getting worse and worse.
Thinking of this, a deep sense of powerlessness arose in his heart, and he felt a trace of sadness and helplessness.
In fact, the best age for Grandma Liu to prevent osteoporosis is in her 30s, but going back 40 years, it was the 1980s.
For people of that era, the concept of osteoporosis was almost non-existent.
This also determines that the best time of this generation has actually passed.
This is also the reason why so many elderly people now suffer from osteoporosis.
This is probably the price of time, the doctor shook his head and sighed in his heart.
Grandma Liu’s daughter took her mother’s condition very seriously and went home to take care of her. She also downloaded the most authoritative and popular Longtu APP to record her case and medication status.
One sunny winter day, a notification was sent to Grandma Liu’s daughter’s mobile phone.
She cheered instantly: "Mom, Sanqing has released a drug to treat osteoporosis. Now the quota for the Phase III clinical trial is open. I can help you sign up."
Grandma Liu was sitting on a chair on the balcony. The golden sunlight was shining down, but she could only look at her feet in a daze.
"What kind of test is it? What do you want to sign up for?" She asked with a dull expression and some slurred speech.
My daughter walked over with a smile, knelt down and said, "I'm just going to the hospital to take medicine. I'll take you there in a moment. Sanqing's medicines are very effective, and this one will definitely not disappoint."
"Oh." Grandma Liu responded and said nothing more.
My daughter was very excited and kept talking: "This medicine is very powerful. All the astronauts in the sky are taking it. They take it on the space station and on the earth. It must be very effective. Otherwise, can the country allow them to take it? Mom?" , you will definitely get better if you eat it.”
Grandma Liu suddenly grabbed her hand tightly and said in a trembling voice: "Are all the astronauts eating? That should be very good. I believe in the country."
The daughter looked at her mother, and her cloudy eyes lit up instantly, and there seemed to be a glimmer of hope in her numb eyes.
So he nodded quickly and said: "You can't be wrong, it will definitely work well."
That afternoon, Grandma Liu came to the hospital. After a physical examination, she signed an informed consent form.
She was assigned to the critical care unit and was in the same ward with a group of hunched old men and women.
The youngest of these people is 65 years old.
Next door there is a menopause group, a mild disease group, and even a youth group, with a total of hundreds of people.
The menopausal group is a group of aunts, the mild group is a group of uncles, and as for the youth group, there are also a lot of people. This disease is becoming more and more common among young people.
They get sick because of some bad living habits, such as not spending time in the sun, lack of exercise, frequent drinking of carbonated drinks, and eating junk food, which leads to calcium loss, vitamin D deficiency, and damage to bones.
Each group's situation is different, so the medicine they take is also different.
Like the youth group, because they are young and have strong recovery power, they just need to supplement calcium and vitamin D with medicines.
As for aunts and uncles, aunts need to take sex hormone drugs, but uncles do not. Instead, they take drugs that promote bone formation.
And this time, except for the severe group, all other patients will participate in a double-blind controlled trial.
Because there are many drugs for the treatment of osteoporosis on the market, comparative trials must be conducted with the first-line drugs that are already on the market.
The patients in the severe group are older and have been treated for several years. They have taken all the drugs they should take. The existing drugs on the market are no longer effective, so the treatment plan must be more cautious.
"The Point Guard Is Here"
This group of old men and women can't stand the torment, so naturally they don't need to participate in the double-blind trial.
Grandma Liu could only lie on her side on the hospital bed due to the deformation of her spine. She was in severe pain all over her body and could not stop shaking.
Next, in addition to taking calcium supplements every day, she also took Sanqing's new medicine.
In the first week, she didn't feel much.
In the second week, the bones in my body seemed to be less painful, and my fatigue also improved.
In the third week, the pain in my lower back was not that severe.
In the fourth week, the test results showed that the bone density increased by 7%, reaching -3.8.
Although osteoporosis is still serious, it has been suppressed and is developing in a good direction.
Another month later, Grandma Liu's back pain has been greatly relieved and the pain has become tolerable.
Her bone density value has reached -3.4. Compared with before, the bone density has increased by 18%. The effect can be said to be immediate.
The daughter was in front of the hospital bed, holding her mother's withered hands and bursting into tears with excitement.
"Mom, the anti-osteoporosis treatment has been very successful. The bone density has improved. Next, as long as the deformed ridge is repaired through surgery, you can straighten your waist and walk normally."
After two months of clinical trials, the results are obvious. The mother's condition has been suppressed and is improving continuously.
Next, she will ask a doctor to perform ridge correction surgery on her mother.
The operation is very difficult, requires high technology and equipment and hardware, is invasive, takes a long time, and carries certain risks.
However, my mother's bone density has improved now. If she has surgery as soon as possible, she will be able to walk normally as soon as possible.
At that time, all that is needed is medication and long-term rehabilitation.
With the guidance of the three-dimensional imaging CT system and the assistance of advanced surgical equipment such as ultrasonic osteotome and grinding drill, the operation was carried out smoothly.
After the operation, Grandma Liu's spine was corrected and she could finally lie down on the hospital bed comfortably.
Grandma turned her head with difficulty, looked at the surrounding scenery, and then looked at the ceiling.
Her eyes were moist.
After five years, I can finally look up at the sky and no longer have to stare at my feet.
As long as she continues to take this astronaut-certified medicine in the future, she will definitely recover completely.
In Grandma Liu's gloomy eyes, the fire of hope for the future life was rekindled.
There are many patients like Grandma Liu who are slowly recovering.
As the trial came to an end, the condition of all participants had greatly improved.
****
The clinical phase III trial report of the bone resorption inhibitor quickly reached Wei Kang.
He was very satisfied with the results. Even with a double-blind experiment, the data was still amazing.
Compared with the control drug, patients taking Sanqing bone resorption inhibitors increased their bone density by more than 20%, reduced the risk of new vertebral fractures by 81%, reduced the risk of non-vertebral fractures by 62%, and reduced the risk of hip fractures by 62%. The risk is reduced by 73%.
In terms of adverse events, Sanqing’s new drugs are also fewer, and there are basically no serious adverse reactions.
Wei Kang couldn't help feeling that the drugs produced by the system were always so safe and effective.
Generally speaking, in addition to the side effects of drugs themselves, another important reason is the excipients and impurities in the production process.
To achieve such low adverse reactions, drug molecule purification technology must reach a very high level.
There is no reason why Wei Kang is not envious.
"Dongdongdong!"
There was a sudden knock on the door.
"Come in!" Wei Kang looked at the schedule and remembered that this was a regular work meeting with Chen Yiqing.
Sure enough, Chen Yiqing quickly pushed open the door and sat across from him.
"Mr. Health, the recent scientific research project arrangement of the neuroscience laboratory is as follows..."
Chen Yiqing reported the progress of the laboratory work in a clear and coherent manner, which made Wei Kang nod.
"Your laboratory has a new scientific research goal. This time it is to study the regeneration of motor neurons."
Wei Kang looked at this new project curiously and asked, "Did you discover it? Or is it just an idea?"
Chen Yiqing explained with a smile: "We have made a huge breakthrough in research on brain neuron regeneration, but the human nervous system is not limited to the brain. The nerves in the muscles are also very developed. What I want to study this time is the motor nerves." Rebirth."
"Motor neurons connect the brain and muscles through the spinal cord. They are very potential research objects and are very useful for in-depth understanding of the human nervous system."
"As you know, motor neuron disease, also called ALS, can cause patients to suffer from muscle atrophy and difficulty swallowing, and eventually death from respiratory failure. This disease is very famous and has always been a terminal illness, but in recent years, scientists have discovered It has identified potential treatment targets for the disease and provided some new ideas, which I want to try."
"But this is just a new drug research and development project. I will continue to study the human brain. After all, the brain is my favorite."
Wei Kang was immediately overjoyed. As a boss, he was not afraid of employees being too active, but afraid that employees were not active.
It would be great if Lao Chen can take the initiative to explore new projects and enter new fields.
He immediately patted his chest and agreed: "No problem, tell me what resources you need and how much investment you need."
"Okay, I will study this project with my assistant Zhang Li. She has great potential in neuroscience and I am ready to train her."
Chen Yiqing pondered for a moment and then mentioned another thing.
"That's right. She seemed to be the second author of the paper you published last time. I'm very happy that you can find outstanding talents for the company."
"Yes, she is already a team leader in the laboratory. She is a very talented little girl. Maybe she can take over my class in the future."
"Yes, as long as she shows enough ability, it will be no problem to become the director of the Neuroscience Laboratory in the future." Wei Kang chuckled.
After the meeting, Wei Kang clicked on a list on his computer.
The people on this list are young employees with outstanding performance and worthy of the company's vigorous training.
He also put Zhang Li on this list of key concerns.
A person who can be recommended by Chen Yiqing like this should be good enough and worth paying attention to.
After finishing this, he looked at the table again, where there were clinical trial reports of several other new drugs.
Last time he extracted eight new drugs in one go, and now their experimental results are out.
