Sudhoff is a professor in the Department of Neuroscience at Stanford University, focusing on the study of synaptic transmission. Since winning the Nobel Prize in Physiology or Medicine in 2013, he has become an authority in this field.
It was around 2 o'clock in the morning, in the dead of night, and he was still dealing with some work matters.
Suddenly, a message flashed on the phone, indicating that it had received an email from the editor-in-chief of the cell journal.
"It's another invitation email. The Sweet editor called me last month and asked if I had any latest discoveries."
Anyway, he saw it all, so he opened the email and prepared to browse it.
As soon as I opened it, I was stunned: "Review submission? I haven't received such an email for a long time."
Then he became energetic and said: "Great, read a paper before going to bed and fall asleep in divergent thinking. Is there anything better than this?"
For an authoritative expert like him, there are not many manuscripts in the same field that he can review. It is rare to come across a novel and interesting article in several months.
After all, the object of neuroscience research is the brain, which is a mixture of matter and spirit. As the most complex substance currently known, its research methods must be very complicated and require the use of methods from a variety of basic disciplines.
Although this subject is currently very prosperous, scientists are still facing difficulties in their research. Currently, they are only studying numerous experimental phenomena without rising to the theoretical level, and have not been able to construct a compatible and nearly complete axiomatic system.
Rather, neuroscience has not yet had its 'Newtons' and 'Einsteins'.
Even so, Sudhov is one of the best in his field. Such experts are very busy with their daily work. He is a typical workaholic. It is common for him to work until two or three in the morning.
The editor-in-chief of the journal is aware of his status, so ordinary submissions will not come to him. Only some more important manuscripts, or submissions for which other editorial board members are difficult to come to a conclusion, will be reviewed by him.
So when Sudhof received a submission, he was still very excited. He immediately opened the attachment and read it carefully.
"Hoho, research on the regeneration of neural stem cells in the hippocampus of the brain is very difficult, but he is an interesting guy. He didn't fool me with some old stuff about stem cell transplantation."
"The idea is indeed good. Activating stem cells in the brain is indeed more promising than transplanting foreign stem cells. Let's see how the experiment goes?"
At this sight, I was fascinated.
When the old man reached the end of the article, he felt like he was waking up from a dream.
"It's amazing, it's amazing. This is how science should be. It should use simple experiments to clearly expose scientific principles. This experiment is well designed."
"Immediately do an experiment to verify it and see if the data is true."
Sudhov felt itchy, picked up his cell phone and rushed out of the house.
Although he was an old man in his sixties, his steps were still vigorous and he soon arrived at his laboratory in the school.
It was already four o'clock in the morning, the sky was slightly bright, and the laboratory was pitch dark, making it impossible to see even one's fingers.
If you were an ordinary person, you would probably take a photo and post it on your WeChat Moments: "Have you ever seen the Stanford campus at four in the morning?"
But the old man didn't even look. He had a clear goal and moved like the wind. He pressed the light switch accurately in the dark.
Wow!
The laboratory was suddenly brightly lit, and Sudhoff rushed to the workbench and began to experiment without sleep or food.
****
Chen Yiqing finished his snacks, drank a cup of black tea, and looked at the scenery by the window for a while.
Then he returned to his desk.
When I opened my mailbox, I saw a reply from the cell editor, already waiting quietly in my inbox.
"Oh, so fast! Replied in less than half an hour? The efficiency is really good."
After calculating the time difference skillfully, it was exactly one o'clock in the night in Eagle Country.
Chen Yiqing couldn't help but be surprised by the other party's efficiency.
Click to take a look:
"Dear Mr. Chen, the manuscript has been read and I am very happy to inform you that your manuscript has entered the next editorial review stage and a response is expected within a week."
"PS: I am personally very optimistic about this article and think it has a very high chance of passing."
"Please wait for the good news. - Your sincere friend, Editor-in-Chief Sweet."
Chen Yiqing smiled lightly. It should be so. Such a high-quality submission would definitely pass the review of the editor-in-chief immediately.
Then just wait slowly. He got up and walked slowly to the laboratory.
Three days later, Chen Yiqing received another letter from the editor.
"Dear Dr. Chen, thank you for your letter. I am honored to inform you that your article has passed the review and will be published on the cover of the cell journal early next month. Please provide your detailed address and we will email you several samples. Electronic The edition of the journal will be released online in advance and sent to your email, please stay tuned!”
"ps: I had a cordial conversation with you last time at the Lasker Award Gala. I really benefited a lot. Sansheng is lucky. A great company like Sanqing has a great scientist like you. It is really lucky for mankind. I wonder if you are here recently. Is it Eagle Country’s plan? If so, I hope I can have this Rongqing dinner with you and get together again.”
"—Your devout admirer, John Sweet."
He was shocked again.
"It's so fast. Didn't you say you'll get a reply within a week?"
"Also, the cover article is actually published next month instead of three months later."
Even if he is a top student like Chen Yiqing, he still feels a little flattered by his treatment.
He has never been on the cover of a top issue, and his article has never been published so quickly.
And why does this editor-in-chief’s tone seem a bit flattering?
Is this special treatment for breakthrough innovations?
Is this the treatment President Wei enjoys every day?
Why do you feel so comfortable all over your body?
Every pore of Chen Yiqing felt as comfortable as eating ginseng fruit, and he couldn't help but feel a little elated.
However, he has always been steady, and if he feels like this, he just keeps it in his heart.
He quickly told Wei Kang the news and then went back to work.
It's just that he seems to be more energetic, and his whole body is as if he has taken a tonic, his face is red and he is full of energy.
****
Time flies so fast, two weeks passed by in a flash.
On the 4th, the top international journal "Cell" released its latest issue online.
Experts and scholars from all over the world, as well as related media, have opened the website one after another, ready to take a look.
The first thing that catches the eye is the journal cover. The cover image of each issue is designed according to the cover article.
The brain neural networks connected together like a star map are extremely bright and radiant, shrouding the top.
In the center, the dark deep part of the brain, which is the hippocampus, shows a completely opposite situation.
The withered brain cells and broken synapses were like ruins of ruins, and the silence was shocking.
However, deeper below, there were faint dots of light that were swaying.
Suddenly, white protein molecules jumped in along the invisible channel.
Their jumping figures one after another were like shooting stars, falling on the light spots at the bottom.
There are more and more light spots, like sparks, quickly starting a prairie fire.
The entire brain center, which was like a forest of death, began to glow with life under the light.
Broken synapses regrow, and dead cells are replaced by new neuronal cells.
Everything is so vibrant and shocking.
As expected, everyone who saw the cover fell silent.
Then I didn’t even have time to look at the table of contents, so I frantically flipped through the cover article.
Bull Country, Wudu University.
Professor Duren came to the office early in the morning and turned on the computer, waiting for the release of the latest issue of Cell journal.
This is a habit he has developed over the years. He does not want to miss every article in every issue of the magazine.
By paying attention to the latest research results of your peers, you can learn about the most popular directions as quickly as possible. As long as you have a sharp eye and quick hands, you can follow up immediately and you will soon be able to produce results and publish one paper after another.
Even if you can't use the project for the time being, it would be great for your graduate students to use it.
With this keen sense of smell, he has cultivated many outstanding talents, and he has also published a large number of high-quality papers and has a good reputation.
In fact, he learned the ability to pursue the latest scientific hot spots and work hard on papers from his mentor, a respected Nobel Prize winner. It can be said that it is a long-standing inheritance.
Soon, when the time is up, the new issue of the cell will be refreshed on time.
He clicked in immediately and saw the shocking cover.
"The cover article of this issue looks unusual. Is it an article in the field of neuroscience?"
"This means that the withered nerve cells in the brain are rejuvenated?"
Professor Duren muttered, clicked the mouse frantically, and immediately entered the cover article, reading it eagerly.
A full half hour passed before Professor Duren read the entire article. He was stunned and speechless.
"Definitely the most shocking discovery this year!"
He murmured to himself, and suddenly, as if remembering something, he found the list of authors and started reading.
"The first author and the corresponding author are both yiqing. I have heard of this person. He seems to be the head of the neuroscience laboratory of Sanqing Group. He has contributed a lot to the development of AD specific drugs. My student Lily Zhang went to his experiment room work.”
"The authors behind may be laboratory personnel involved in research and development, and they are all typical Chinese names..."
Professor Duren suddenly saw an extremely familiar name, and his eyes froze for a moment.
"The second author Lily Zhang, is it her?"
He was very excited for a moment: "Oh my god, he can't be my student, he is actually the second author!"
Generally speaking, different authors of sci papers have different contributions.
The corresponding author is usually the boss or supervisor. If it is the former, even if he has not contributed directly, he at least provided instruments and equipment. If it is the latter, he usually chooses the topic of the entire paper.
The first author (the first author) usually does most of the content, with a contribution of 70%+, and the second author is a good helper, with a contribution of 20%+.
The other authors are just soybeans. They may have discussed with the author once or twice, may have helped test a group of samples, they may just have a good relationship, or they may be new friends who want to make a name for themselves, or they may be this This article is very well published, everyone will be touched by the rain and dew, and enjoy it.
The most important thing about the first work and the corresponding author, especially if the tutor is a big shot, and when it is published in a top journal, it basically means that the big shot mentor chose the topic well and designed the experiment well.
As for being a student, the advantage is also very outstanding, that is, strong operational ability.
To put it in layman's terms, if you compare your thesis to a son, the first one is like your biological father and mother, the second one is like your stepfather and stepmother, and the third one is like your second uncle and aunt.
By analogy, Bai Zuo is the dog that lives next door to the aunt's nephew's second cousin's aunt's house.
For communication, he is the godfather.
A breakthrough achievement, a top issue of the cell, or a cover article, even if it is a second work, it is very valuable.
Such qualifications are eye-catching enough even in Wudu University.
"Oh my god, she is just a graduate student, not even a doctor, but she already has such achievements."
"She is indeed better than I thought. It's a pity that I didn't persist and leave her at Wudu University."
While Professor Duren is happy for his students' achievements, he is also saddened by the loss of talent.
He had no idea that if he stayed in Wudu instead of going to Sanqing, his students might not be able to achieve such results in their lifetime.
"I have to congratulate her properly. Maybe during the Christmas vacation, I can consider traveling to China and have a good talk with her."
Professor Du Lun thought of this and immediately started writing an email to his student Zhang Li.
****
Professor Duren was not the only one who was shocked.
And the whole world.
As soon as the article was published, the news spread rapidly like a computer virus, spreading all over the world.
It was also transmitted back to China at the speed of light, instantly igniting heated discussions across the Internet and directly reaching the top of the hot search list.
In just a few hours, the number of views reached 230 million.
#Chinese scientists discover the secret of brain regeneration#
Wow!
Netizens were very excited.
"Am I dazzled? Did you read that right? The brain can be regenerated?"
"Cell cover article, hiss, so terrifying!"
"So you can survive even if your head is shot?"
"I'm really not watching science fiction?"
"Since the brain can regenerate, it makes sense that the body can regenerate. Human immortality is just around the corner."
"Can you please read the text? It says that brain stem cells can activate regeneration. It doesn't mean that a head can grow after you chop it off."
"Wow, it's a new discovery made by scientists from the Sanqing Group. Sanqing is so awesome."
"I suddenly had an idea. Since it was discovered by the Sanqing Group, will we soon be able to use drugs that stimulate brain regeneration?"
"The paper doesn't mention clinical trials. Isn't this still a theory?"
"Are you stupid upstairs? If I had such a magic medicine, how could I tell you the details?"
"I analyzed it with my supervisor. The experimental data in this paper is very detailed. Although it does not mention any clinical trials, according to the development of the idea, the next step should be human clinical trials."
"I just made a shocking discovery, guess what?"
"The Riddler gets off the grid!"
"Okay, okay, I searched the patent office for patents related to Sanqing, but I didn't find anything."
"You think, Sanqing has not been developed yet? Or has it not registered a patent?"
"Hiss, when you say that, I don't dare to think too much about it."
"Perhaps Sanqing is like Coca-Cola, which treats the drugs it develops as trade secrets and locks them in a safe."
"Isn't this stupid? You don't sell medicine anymore?"
"Perhaps it is really not sold to ordinary people. Only the rich can spend a lot of money to buy it."
"Don't say that, I'm really a little panicked, but I believe Mr. Wei is not that kind of person."
"Haha, this is hard to say. Do you really believe in capitalists? Do you really think that getting rich first will lead to getting rich later? I can only say that you are too naive."
"Stop arguing, think on the bright side, maybe Sanqing really hasn't researched it yet."
"Yes, can this miracle drug be developed as soon as it is developed?"
"You may not know that the discoveries made by scientists are just experiments. There is still a long way to go before it can enter clinical practice. It is very rare to make a breakthrough in five or ten years."
"Hearing what you said makes me feel much better."
Netizens felt a mixture of sadness and joy at the same time. They were both afraid that Sanqing would not develop a new drug, and they were also afraid that they would not tell everyone if it did.
The latter undoubtedly worries them even more.
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