Boom, boom, boom!
There was a knock on the door slowly, and Tang Que and Wen Renlong pushed the door open and entered.
"Sit down, list the pros and cons of your plan, and then debate the pros and cons. Whichever plan has more advantages will be chosen."
Wei Kang sat at his desk and said calmly.
The two of them had straight faces, as if they had just quarreled, and their expressions were serious. They nodded at the same time and sat down.
"Okay, who of you comes first?"
Wei Kang leaned back and looked at the other party with interest.
The first person to tell his plan will definitely face a storm of rebuttals and challenges from the other party, and he must be very confident.
Tang Que crossed his arms and said solemnly: "I'll go first. My gene therapy plan is undoubtedly the best, and no one can deny it."
"Hmph!" Wenrenlong snorted in protest.
Tang Que ignored him and instead talked eloquently, describing his plan in detail.
"I believe you all already know the key role of the ccr5 gene in the treatment of HIV infection. Since the natural deletion of the ccr5 gene can make people immune to HIV infection, then we only need to copy the treatment process of these four 'cured' patients That’s it.”
"Our gene editing technology is already very powerful, and there are many successful cases of gene drugs. Single-gene knockout editing like this couldn't be simpler."
"Just like in the past, we only need to inject genetic medicine into the patient's bone marrow and knock out the ccr5 gene in the new hematopoietic stem cells, which will continuously produce healthy white blood cells, thereby completely curing AIDS."
Wen Renlong sneered and said: "Think simply, you can only replace the patient's infected white blood cells, but there are still HIV virus reservoirs remaining in the cells of the patient's other organs. What if it comes back?"
Tang Que said angrily: "You are just making excuses. As long as the HIV virus is no longer detected in the body after stopping taking antiretroviral drugs, it will be considered cured. There are four ready-made examples that have proven that this approach is feasible." , don’t you even look at it?”
"Haha, you also know that there are four examples, not forty, four hundred, or four thousand?" Wen Renlong said with a strange air.
"You!" Tang Que glared at him angrily. Seeing his playful and unconcerned look, he had no choice but to look at Wei Kang.
"Okay, Tang Que is right, don't make excuses. Since there are actual examples, we can't ignore them."
Wei Kang tapped the table to correct one of the party's incorrect debate methods.
Wen Renlong finally became serious. He held his chin with his left hand and said in deep thought.
"Have you ever considered that the ccr5 gene is not a dispensable junk gene. It is very important to the human immune system. It not only has a protective effect against many viruses, but also protects the lungs of patients with some serious infectious diseases and chronic diseases. , liver and brain and other important organs.”
"The ccr5 gene can produce immune responses in the body to West Nile virus, Flaviviridae viruses, tick-borne viruses, dengue fever and yellow fever viruses. These viruses can cause severe encephalitis."
"At the same time, the ccr5 protein can also mobilize key immune cells to fight against lung viruses. Without this gene, this defense system will collapse. The risk of patients dying from influenza is four times that of ordinary people, and my country has a high incidence of influenza. land."
"As for ccr5 deletion, it may also be harmful in other chronic diseases such as hepatitis C and diabetes, but the specific role is still unclear. In short, ccr5 gene deletion can lead to serious adverse consequences."
"Many genes do not just play a single role, but have complex effects on the human body. Our research and understanding in this area are not deep enough. Gene editing is not a universal solution, so I don't think that for To completely eliminate the HIV virus, we need to adopt such an extreme plan and put patients at such great risk."
"Of course, I know you will say that AIDS is a very serious disease, and the stigma it brings to patients has long been disgraceful. If patients have a choice, they will definitely be willing to knock out ccr5 Gene comes to take off this big hat."
"But that doesn't mean you can ignore these immune risks. Patients can take antiretroviral drugs and maintain a normal life for a long time."
Tang Que frowned and fell into deep thought, but was unable to refute.
Wei Kang asked curiously: "It seems that this solution has great hidden dangers. Can we consider a more thorough solution and directly knock out the inserted HIV gene fragment from the patient's DNA?"
"Excellent!" Tang Que suddenly slapped his thigh and shouted, while looking at Wei Kang in shock.
"Why didn't I think of such a good solution? Yes, why do we need to knock out the original human genes, which will lead to more health risks? Why not just knock out the HIV virus from DNA."
He sighed sadly: "Hey, I was misled by other people's treatment plans and didn't think of this. My fault! I actually lost my independent thinking and followed others. I really shouldn't have."
Wei Kang quickly comforted him: "Don't blame yourself. It's completely normal for insiders to be trapped by their inherent thinking."
Tang Que gave a thumbs up: "Mr. Wei, as an outsider like you, your thinking is more straightforward and you can often think outside the box. I will have more discussions with you in the future."
Later, he began to seriously consider the feasibility of knocking out the HIV virus gene.
"Although our technology can already perform gene editing in many places in the body, after the HIV virus infects the human body, it will multiply in various body cells throughout the body and spread throughout the body."
"It is still very difficult for genetic drugs to knock out viral fragments in cells throughout the body, and treatment needs to be continued continuously, which will take years. This will undoubtedly greatly increase the cost. I am afraid that the selling price will be one Astronomical numbers.”
Wenrenlong stopped making excuses at this moment, but was thinking seriously.
He suddenly interjected: "So, is it possible to fight fire with fire?"
"As we all know, after the virus enters the human body, it will spontaneously infect all human cells. This efficiency is much higher than any genetic drug."
"Then can we take advantage of this characteristic of the virus? Wrap the gene editing drug in the plasmid shell of the virus, so that the virus can still remain infective, but what it injects into the cell will no longer be its own DNA, but the gene Editing Drugs.”
"In this way, we can take advantage of the characteristics of the virus, wrap the good cure in the shell of the virus, use the virus to fight the virus, and completely eliminate the HIV virus."
Wen Renlong became more and more excited as he talked: "At that time, curing AIDS will be like taking a vaccine. With just one shot, the disease will be cured."
"How about this idea? Hahaha~" At the end of his sentence, he couldn't help laughing loudly.
Tang Que was stunned, staring at him for a long time, hesitating to speak, and finally choked out a sentence.
"You're a fucking genius!"
Wen Renlong's thinking has always been unconventional. He can always come up with unexpected solutions from an unusually tricky angle to any problem that leaves people helpless.
Wei Kang has now seen how powerful he is, and understands why many large companies tolerate his wanton and weird personality.
Of course, he just proposed a solution. Whether you can implement it depends on your ability.
So Tang Que quickly said with a grimace: "This plan is good, but it is too difficult and will not yield results in the short term. Aaron, you are deliberately creating problems for me."
Wenren shook his head like a rattle, indicating that he was determined not to take the blame.
"You understand me. I have inspiration, but I don't have a specific solution. The rest is up to you. But with your ability, you can at most spend some time and you will be able to solve it sooner or later."
"Look at Mr. Chen. He sharpens his sword in three years, but without making a sound, he is already a blockbuster. You have to learn from him."
Tang Que glared at him angrily: "You have bad intentions. Don't think I don't know. You looked amazing with this, but you trapped me with a very difficult plan. Then in the short term, the company will only I can use your plan, right?"
Wen Renlong said with a smile, "How is that possible? Which of us is following the other? How can a pure and kind-hearted boy like me, Aaron, have any bad intentions?"
Tang Que shook his head and did not speak any more. Instead, he concentrated on thinking and immersed himself in the solution of the new plan.
In just a few words, Wen Renlong scrapped his opponent's plan, making him unable to compete with him in a short period of time. He couldn't help but smile.
He was so happy at this moment that he came over and said with a smile: "Boss, Brother Que, he has no intention of fighting with me. Why don't you just decide on my plan?"
Wei Kang secretly laughed in his heart, but said with a straight face: "No, the agreed rules cannot be invalidated casually, it's your turn."
"Well, my plan actually starts with the ccr5 gene. There are many new anti-AIDS drugs under development targeting the ccr5 target. The currently popular ones include ccr5 antagonists, monoclonal antibodies, gene therapy and T-cell therapy, etc."
"I chose a less radical CCR5 antagonist program. As long as the antagonist binds to the CCR5 protein, it can reduce the binding of HIV to the cell surface, thus preventing the HIV virus from entering the cell and playing an anti-infective role."
"This is already a very mature treatment option. The only one currently on the market is maraviroc developed by viiv healthcare, a CCR5 antagonist against HIV infection, with sales of US$150 million in 2017."
Wenrenlong had obviously done detailed homework and memorized it, and he continued talking.
"There are currently more than 20 new drug projects under development targeting the CCR5 target in the world, 20 of which are indicated for HIV infection. One of the projects targeting HIV infection has been launched, which is the Maraviroc I just mentioned. 3 models are in the clinical phase III stage, 6 models are in the clinical phase II stage, 2 models are in the clinical phase i/ii clinical stage, 7 models are in the clinical phase i clinical stage, and 1 model is in preclinical research.”
"This target is quite popular, and even many domestic companies are making efforts in this area, but they have not made breakthrough progress yet."
"I feel that with the strength of Sanqing, we must not lag behind others and must participate. I am very confident in this regard. I will definitely be the first to arrive and successfully develop it ahead of them."
Wen Renlong said with confidence: "The most important thing about CCR5 antagonists is that they have good effects and extremely high specificity. The affinity of CCR5 protein needs to be as high as possible, so that it can block as many HIV virus infections as possible." "
"Otherwise, there are so many CCR5 proteins on the cell surface, and your drug can only bind 50% or 60%. How can this work? Then the remaining HIV virus can still invade the cell and infect it. This is the difference between 1 and 0. There is no Median."
"The ccr5 antagonists currently undergoing clinical trials have a maximum drug binding rate of only 80%. This may be satisfactory enough for other pharmaceutical companies, but it is far from enough for Sanqing."
"We need to find a drug that can achieve an inhibition rate of ccr5 protein of more than 95%, preferably 100%, so that the patient can be completely cured."
"Finally, the side effects of such drugs must be low enough. Several antagonists have been discontinued due to serious adverse reactions."
"But there is no need to worry about this. Our AI pharmaceutical technology is no worse than gene editing technology. It can completely modify its structure and obtain drugs with higher antagonistic activity and no toxic or side effects."
"In this regard, biological macromolecule drugs ccr5 peptide antagonists are also a good choice like small molecule antagonists. They are safe and will not produce toxic effects, but they are also unstable and easily digested and degraded. shortcomings, combining the two can achieve the effect of 1+1>2.”
"I have always felt that combined medication is the main direction for the treatment of aids in the future."
"The current first-line treatment option for AIDS patients is cocktail therapy, which requires long-term use of inhibitors of other aspects of the virus life cycle, such as reverse transcriptase inhibitors, protease inhibitors and fusion inhibitors. This is equivalent to a chronic disease. Relief, but not cure, is what makes patients miserable.”
"In order to develop more drug-resistant anti-HIV drugs, combining CCR5 antagonists with these drugs and taking them for a long time can inhibit viral replication to the greatest extent, thus achieving the goal of being close to cure to the greatest extent."
"HIV is a very cunning and cunning virus. We must take a multi-pronged approach to completely kill it. The current popular treatment is cocktail therapy, and patients will only need to take more drugs in the future."
"Before Tang Que's genetic medicine comes out, ccr5 antagonists are the best solution."
"Patients who take ccr5 antagonists for a long time can also achieve the effect of ccr5 gene deletion. Although we don't know what the recurrence rate will be after stopping the drug, at least it can be regarded as a 'cure' solution."
After Wen Renlong finished speaking, he looked at Wei Kang expectantly, almost wagging his tail crazily as if he was waiting for praise.
Wei Kang was deeply pleased. Each of these subordinates was better than the last, which made him feel a little pressure.
He immediately nodded in approval and said, "Well done, it sounds like a great plan, I'm sure."
He glanced at Tang Que, who was still thinking hard, his eyes straight, and the corner of his mouth suddenly twitched.
"You also have a share in Tang Que's plan. Discuss with him more and try your best to help solve any problems."
When Wen Renlong was praised by his boss, he felt comfortable all over, his tail was raised as high as the sky, and he immediately said proudly.
"As soon as Old Tang becomes dazed, he is so distracted. Don't worry about him. He will definitely come to me when he wakes up."
Wei Kang nodded slightly: "It should be so. Sanqing has you as a sleeping dragon and phoenix, so why worry about not being prosperous?"
Wen Renlong's face froze: "Wolong, phoenix and cubs don't seem to be a good word."
"No? I think this word is very good, it suits you two very well!"
Wei Kang said with certainty.
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