Andre browsed this page curiously.
This is a separate ordering website, called ene, which is operated as a global non-profit organization.
There is an entry for 'How to order' at the top, and after clicking it, 'Ordering Instructions' will appear.
The entire page is simple and beautiful, looks very professional, and the ordering process is also very clear.
Any researcher anywhere in the world, as long as they have a computer or mobile phone, can order the samples they need with a few simple clicks.
In the next few days, the product will be delivered to your door, and then the researchers only need to combine it with the guide RNA of the gene they want to cut off.
Even this last step can be ordered through the website.
The whole process is similar to shopping online on Amazon.com.
Andre immediately clicked the mouse and tried to place an order.
In principle, orders can only be completed online. Orders by phone or other methods cannot be accepted, so personal information must be filled in to register.
Andre clicked 'Register'. The first step was to select a country. After selecting the Eagle Country, he entered the second step, 'Select Unit'. There were three options, research institution/non-profit organization, enterprise, or individual.
Out of curiosity, he tried to select the 'research institution' option, and a row of names of Yingguo universities popped up instantly. When he scrolled down, he saw the school where he graduated.
Select the name of the school you graduated from and click OK. A list of college names of the selected university will pop up.
After choosing a college, the names of professors and associate professors working in that college will be further listed.
Andre browsed through it, found the name of his instructor, and clicked to confirm.
Immediately enter the last step, you can enter your name, email and contact number to complete the registration.
The whole process was very smooth, and the most important thing was that the names of so many university teachers could be listed.
He couldn't help but secretly marvel, and returned to the second step, choosing the 'Enterprise' option.
What jumped out this time were Pfizer, Johnson & Johnson, Eli Lilly, AbbVie, Biogen, Genentech, etc., the names of Eagle Country pharmaceutical companies and biotechnology companies.
Andre chose Pfizer without hesitation, and a list of researchers’ names appeared in front of him.
He was very familiar with these names. Most of them were his colleagues, and some were subordinates of his oncology department.
As expected, he also saw his name, and after clicking on it, he went directly to the last step.
After the account is successfully registered, you can enter the order page.
You can choose the version of the original bacilli protein you need, or you can customize the guide RNA you need.
The former is free, but you need to pay postage, while the latter requires you to pay a certain amount depending on your needs, but the price is not expensive, probably within a hundred dollars.
In terms of quantity, there are certain restrictions. Individuals are limited to 10, and institutions and enterprises are limited to 50.
In this way, the website limits orders to academic research and only offers a limited number of free samples.
If you want to use it for large-scale commercial applications, you can only purchase it from Sanqing through formal channels.
If you have any questions during the ordering process, you can provide consultation services through the email and phone numbers provided on the website.
Next, click the 'Add to Cart' button just like you're actually shopping on Amazon.
Then fill in a valid delivery address, pay and settle, and the order is completed. The whole process is very convenient and fast.
Thanks to the highly developed transportation and delivery system in today's society, after receiving the order, the samples packed into small test tubes will be packed into cartons at a certain time of the day and sent to all parts of the world.
These cartons are managed through barcodes, so that researchers in the world who have purchased samples can all be traced.
The business is booming, and the website receives an average of hundreds of orders from all over the world every day, and then delivers samples to 38 countries and regions around the world.
The entire website is equivalent to a 'trial' system, promoting easy-to-use gene editing tools to the world in the form of free gifts.
This way, any researcher can simply make a purchase and get the sample they need.
Andre went to the last step and placed an order smoothly in the name of the company.
After getting the sample, he planned to let the laboratory try it out to see the actual effect.
At the same time, we also need to compare it with the CRISPR-CAS 9 technology of the Broad Institute to see which one is better.
Although there were rumors everywhere that Sanqing's new technology was so awesome that it beat everything else, he still had some doubts in his heart.
I wonder if this new technology is really as good as rumored?
Only seeing is believing can he be completely convinced.
****
A few days later, Andre received the sample at the company.
Then he rushed to the rare disease division and found the head of the laboratory.
"Dr. Duke, good news, I brought you a gift, I believe you will like it."
Andre handed over the cardboard box in his hand.
Dr. Duke has gray hair and is over sixty years old, but he is still energetic and has bright eyes.
He took it with a puzzled look on his face, and when he saw the letters 'Sanqing' on it, his expression suddenly changed.
I immediately opened the carton and saw a neat row of glass test tubes inside.
I casually picked up a glass test tube and saw the English label on it. My eyes suddenly lit up and I was filled with surprise.
"Wow, Andre, your gift won't be Sanqing's arc1 protein sample, right? This is a huge surprise!"
Dr. Duke immediately danced with joy and took Andre straight to the laboratory, introducing him endlessly as he walked.
"We are currently conducting research on gene therapy for hemophilia, and we have some promising results, but there is still a certain distance before clinical trials."
"Our researchers isolated epithelial cells on the surface of the urinary tract from the urine of seven patients with severe hemophilia A and reprogrammed them into induced pluripotent stem cells (iPS cells). The iPS cells were then gene-edited, Multiple copies of the normal gene for factor VIII are inserted."
"After these endothelial cells were implanted into the subcutaneous tissue of hemophilia A mice, they formed a vascular network. The blood vessels directly transported functional factor VIII directly into the blood, and the secreted protein was sufficient to supply the whole body."
"The results are very encouraging. Mice implanted with endothelial cells increased circulating coagulation factor VIII by 600% and restored normal coagulation."
"Currently, this therapy can only be implemented in mouse models of hemophilia A. As for experiments in human cells, due to the complicated steps, the off-target rate is high when using CRISPR-CAS 9 technology for gene editing. , the success rate is not very satisfactory.”
"But since you brought these treasures," Dr. Duke smiled and raised the test tube in his hand, his eyes full of anticipation.
"We hope that Sanqing's new genetic technology can bring us new breakthroughs."
****
Two weeks later, Dr. Duke looked at the experimental results in front of him, dumbfounded and in disbelief.
"Oh My God! Miracle! This must be a miracle!"
There were exclamations and screams from behind him.
The researchers in the laboratory stared at the screen, each one in a daze, as if they had seen a ghost.
Dr. Duke was well-informed and quickly reacted. He coughed slightly and woke everyone up from their gaffe.
"I really can't believe that after so many years of hard research, there was a qualitative breakthrough in just two weeks."
A senior researcher murmured, with a complicated expression on his face, joy and annoyance appearing at the same time, intertwined.
"If only Sanqing's genetic technology could be used earlier, our hemophilia genetic drugs would have been on the market long ago, and patients would have been saved sooner."
Another researcher looked darkly, lowered his head, and sighed, seeming to recall some not-so-pleasant memories.
Dr. Duke burst out with hearty laughter and encouraged everyone: "It's not too late, haha."
"Today is a wonderful day. Our genetic drug for hemophilia has finally made clinical progress, and we deserve to celebrate."
The whole place burst into cheers instantly, and people smiled one after another, delighted with the results achieved.
Dr. Duke arranged the follow-up work, took the experimental results, and turned around and left.
This exciting result must be reported to the company's senior management immediately, and clinical trials must be promoted as soon as possible to strive for an early launch.
He can already imagine that after Sanqing's fourth-generation gene technology is released, Pfizer will not be the only one to use it to achieve breakthroughs.
Bayer, Novartis, Bogen, Roche, these greedy and ambitious colleagues must also be in the laboratory, working day and night with red eyes, trying their best to break through the difficulties of genetic drugs.
With the blessing of new technologies, the time for them to achieve breakthroughs will only become faster and faster, and competition will become increasingly fierce.
Pfizer, as the number one pharmaceutical company in the world, must not lose at the starting line, let alone fall behind its opponents.
****
Pfizer headquarters building in Sinchon City, Yingguo.
In the spacious and bright office, it was noisy at the moment, as noisy as a vegetable market.
Company executives and directors of major laboratories gathered together, chatting and talking.
Pfizer CEO Albert looked around and patted the table: "Gentlemen, be quiet!"
When everyone calmed down, he looked at Dr. Duke with a serious face.
"Today, I want to tell you some good news. The laboratory has successfully developed a genetic drug for hemophilia. The specific situation will be described by Dr. Duke."
Dr. Duke nodded and told the whole story with enthusiasm.
"This drug research and development is inseparable from Sanqing's genetic technology. Our previous research has not made any breakthroughs. It was only after using this brand-new technology that we achieved amazing results."
"After using this brand-new gene editing technology, we conducted experiments on human cells, and the results were astounding. They can be described as perfect. Not only did the off-target rate greatly decrease, but the gene editing time also greatly increased."
"iPS cells can complete gene editing in just a few hours, achieve the desired results, perfectly transform into healthy endothelial cells, and naturally secrete coagulation factor VIII."
"Not only that, I also tried to inject genetic fluid directly into human cells. The effect of gene editing is also very good, which means that we can improve the way patients inject drugs to achieve in vivo gene therapy."
"Mr. Albert, I suggest that this genetic technology be promoted throughout the company. It will definitely promote the research of genetic drugs for rare diseases."
The more Dr. Duke talked, the more excited he became. He directly connected to the projection screen and began to show the experimental results.
The expressions on the faces of other executives and experts ranged from confusion, to surprise, to shock. They all stared at the screen, dumbfounded.
Until Dr. Duke finished speaking, the audience was still in an eerie silence.
Albert spoke slowly: "What do you think?"
