Wei Kang hurried into the office.
"Anmei, help me check all the information on Daxia Zhizao."
"Okay." A sweet female voice sounded in the Bluetooth headset: "Let me first introduce to you the company Daxia Zhizao..."
"Daxia Intelligent Manufacturing is the leader in the research and development of upstream genetic sequencing equipment in China. According to public information, the company's revenue has grown at a compound growth rate of more than 200% in the past three years, accounting for about one-third of the domestic gene sequencer market, with more than 1,100 installed units worldwide. Covering 16 countries and regions, with more than 300 users.”
“Gene sequencing technology has developed from first-generation sequencing to fourth-generation sequencing technology. However, since these four-generation sequencing technologies have their own advantages and disadvantages, and their application fields are also different, the first-generation sequencing technology has not been eliminated. The current sequencing market It is the coexistence of four generations of sequencing technologies, and overall the second generation ngs sequencing technology is dominant."
"Currently Daxia Intelligent Manufacturing and Illumina are competing in the second-generation NGS sequencing technology market. Although Daxia Intelligent Manufacturing is developing well, its profit margin is not comparable to Illumina. The reason is that its sequencing equipment mainly Supplying the sequencing service business needs of parent group Daxia Gene and its related companies.”
"The two are actually two sides of the development of Daxia Group. The former produces sequencing equipment, and the latter undertakes the former to provide sequencing services to the market. Without the support of Daxia Gene, Daxia Intelligent Manufacturing would not be where it is today."
Wei Kang suddenly asked: "What is the biggest risk for this company right now? Are there any scandals? If we want to reach a long-term strategic cooperation, this is something I need to consider carefully."
"There are two main risks. One is the listing issue. Daxia Zhizao has been applying for an IPO on the Science and Technology Innovation Board, but has been unable to achieve it. The main reason is related transactions with Daxia Gene, which has been criticized by many securities practitioners and media raised questions, and several listing applications were suspended by the exchange due to missing materials.”
"If successfully listed, Daxia Intelligent Manufacturing will raise more than 2 billion yuan, which will greatly promote technology and sales. Otherwise, relying solely on the support of Daxia Gene will inevitably make people lack confidence in its future development."
“Secondly, the company is also mired in litigation and has suffered a series of patent lawsuits from its competitor Illumina in recent years.”
"Illumina has initiated protracted patent litigation against Daxia Intelligent Manufacturing and its subsidiaries, dealers and customers overseas. The countries and regions involved include 12 countries and regions including Eagle Country and Europa. In these lawsuits, some Daxia Zhizao lost the lawsuit, related products were banned, some lawsuits were dismissed, and some lawsuits are still pending.”
"It is still unknown when Daxia Intelligent Manufacturing will be able to get out of the litigation quagmire. However, it is foreseeable that if it does not handle these marathon patent litigations as soon as possible, it will definitely bring greater risks to the company in the future."
"In addition, the boss of Daxia Gene controls 53% of the shares of Daxia Intelligent Manufacturing, and the reputation of this boss is a bit extreme. Daxia Gene also has a very bad reputation, and there are endless scandals. And online information shows that the salary of Daxia Group is the whole bank At the lowest level, employees will leave one after another and no real talents will be retained. These are risks that need to be considered."
Wei Kang couldn't help but be curious: "The salary is the lowest in the industry? How low is it?"
"Shenzhen City Headquarters, undergraduate degree 3000."
"This..." Wei Kang couldn't help being shocked: "Good guy, this is lower than a certain Beverly sweatshop."
"Wang Qing, the boss of Daxia Gene, is 69 years old. He graduated from junior high school and started from scratch. He prefers to talk and is good at capital operations. After Daxia Gene was listed, the stock price rose from 20 yuan to 300 yuan, and now it has fallen back."
Anmei is constantly supplementing the information collected.
"Boss Wang reduced his holdings by more than 20% during the ups and downs of the company, making a lot of money, and he also applied for the listing of the company's best asset, Daxia Zhizao, separately. His motives are unclear. "
"In general, Daxia Intelligent Manufacturing's comprehensive rating is b-, and Daxia Gene's comprehensive rating is d."
Wei Kang shook his head: "There must be a generation gap between the 70-year-old leader and me. It's not that I'm biased against him, it's mainly because a boss with a junior high school education is unreasonable to run a high-tech enterprise."
"What you say makes sense. I have some of his deeds here, which may give you some reference for your decision-making."
"Wang Qing claims that the ultimate goal of Daxia Gene is immortality. He once proposed that everyone can live to 100 years old, but he can live to 120 years old. He also insisted that he has achieved significant reverse growth. After the photo was taken, 70 years old is younger than 50 years old, and it has become a hot search."
"He went around urging people to save their lives instead of saving money. It was better to save their own cells than to hide Moutai for 50 years. He tried his best to persuade the country's richest people to invest in the field of 'life-extending' technology."
Wei Kang couldn't help but exclaimed: "Tsk, tsk, Boss Wang is really a master of hype, I am ashamed of myself."
He touched his chin and said thoughtfully: "When you say this, I feel that this company is a bit too showy, and I am a bit doubtful about whether to cooperate with Daxia for a long time."
"However, if you really want to use a domestic sequencer, you have no choice at the moment. Only Daxia Intelligent Manufacturing is the one that has the climate."
"By the way, what do Daxia Intelligent Manufacturing's customers think of its products?"
"The advantage of the sequencer manufactured by Daxia Intelligent Technology is that it can greatly save costs while ensuring the same DNA fragment read length and output."
"Last year, Bangguo's research team published a research article in the Journal of Genetics, analyzing and comparing the performance of sequencers from Daxia Intelligent Manufacturing and Illumina at the whole-gene sequencing level."
"The researchers used a sequencer to sequence normal and tumor tissues from lung cancer patients in China, and made a parallel comparison of the generated data. By evaluating the quality of the raw data from the two platforms, they found that at the quality control level, both performed well. Produce deep reads of similar quality and genome coverage.”
"At the same time, the research team compared the whole genome sequence to the reference genome, and the results showed that the coverage rate of all samples was above 99.9%. The sequencing results of the two sequencers were very similar, and the overlap ratios were quite high, 92.0% and 93.0 for each sample respectively. %."
“Through various data support, the research team believes that both platforms provide high-quality sequencing data and sufficient genome coverage, are suitable for whole-genome sequencing analysis, and the sequencing performance is highly consistent, which shows that the two platforms Its performance has reached the international leading level."
"In addition, Ruiji Hospital and Peking University Cancer Hospital in China have used the sequencing platform made by Daxia Intelligent to sequence the genes of cancer patients and published articles in magazines such as 'Cell'."
"There are dozens of other papers that have been researched and published using Daxia Intelligent sequencers."
"It can be seen that the sequencers manufactured by Daxia Intelligent Technology have been successfully used in research in many fields."
Wei Kang couldn't help but nodded, and said with some hesitation: "Although Daxia Intelligent Manufacturing and Daxia Genetics are in the same group and have the same boss, they are still different after all. How about this, buy a few machines and try them out first. The machines are good. Just use it.”
"Your decision is very wise. However, AMEI still wants to remind you that although second-generation sequencing technology is currently the mainstream, third-generation single-molecule sequencing technology and fourth-generation nanopore sequencing technology are developing rapidly and have begun to be used in clinical and clinical applications. be applied in scientific research.”
"Compared with the second generation, third-generation and fourth-generation sequencers have the advantages of high read length and low cost, which can reduce the cost of a whole-genome sequencing to less than 100 US dollars. At the same time, the gene fragments that can be detected at one time are relatively long, and the sequencing speed is also high. The improvement is rapid, and fourth-generation technology can compress the time to less than 4 hours, while second-generation sequencing takes several days to complete."
"The only disadvantage is that the technology is not mature enough to achieve a satisfactory sequencing accuracy. The accuracy is about 86%. It cannot be used independently. In most cases, it can only be used as a supplement to second-generation sequencing."
Wei Kang was a little surprised and said: "This is really good. We can also buy a batch of fourth-generation sequencers for supplementary use. By the way, are there any companies with fourth-generation sequencers available?"
"The foreign Oxford Nanopore company has relatively mature technology in this area. The company has been listed on the market and has also mass-produced a high-profile handheld nanopore sequencer, which can be used in extreme environments such as space. It has also been used at the fastest speed Deciphering the Ebola virus sequence.”
"In addition, scientists in Antarctica, where there is no network and no laboratory facilities, have completed real-time sequencing with only a mini handheld device and a portable computer."
Wei Kang shook his head: "This is also a foreign company. It's not necessary. Are there any domestic nanopore sequencer companies?"
"Domestically, only one company called Carbon Base has released the first nanopore gene sequencer. This product is about to be mass-produced and launched on the market."
Wei Kang couldn't help but feel a little disappointed: "It's about to be mass-produced, but it's not mass-produced yet, so we'd better wait."
He thought for a while and then said: "Actually, the fourth generation nanopore sequencer is very suitable for shared laboratories. You can still buy a few and try them out."
Subsequently, he sent instructions to Zhao Xiaojie, requiring the two companies to purchase a few sequencers from each and send them to the R&D department for trial use.
After Zhao Xiaojie received the instruction, he wiped the sweat from his forehead and started running non-stop again.
Qi Jun, president of Carbon Based Company, was also very surprised after receiving the inquiry call.
He took his mobile phone and began to introduce his products endlessly.
"Mr. Zhao, thank you very much for your call. We have invested 200 million to establish a production base in Shu City at the end of last year, and plan to put into production a series of products such as nanopore gene sequencers and test kits. The annual output will reach 2,000 units, with supporting detection reagents of 100 Ten thousand people."
"Welcome to Sichuan for inspection. In the past year, we have carried out close cooperation with local institutions such as Sichuan University and Shuxi Hospital in the fields of infection diagnosis, forensic identification, and tumor research."
"You can see all of these cooperation cases in our company. Currently, the best feedback from our customers is in the forensic field."
"DNA testing is widely used by forensic laboratories around the world to solve criminal cases, and our portable nanopore sequencer is very suitable for crime scene analysis, with an accuracy rate of up to 99.8%, and it has gradually emerged in this area recently."
"In the field of scientific research, nanopore testers are mainly used for virus or bacterial sequencing because their genomes are much smaller than humans, but they also have great potential in large-scale whole-genome sequencing of humans."
"In this regard, we also have scientific research cooperation with many hospitals, and the feedback from our customers is very positive."
"Don't worry, our first mass production machine will be launched next week, and we will send it to Sanqing for trial as soon as possible."
The two parties successfully negotiated the first batch of orders.
Handheld sequencers are very cheap. Foreign products only cost 1,000 US dollars each, while domestic prices are less than 5,000 yuan, so Zhao Xiaojie ordered ten units at once, and they will be officially shipped after the contract is signed.
Zhao Xiaojie put down his dead cell phone and rubbed his brows. He felt his mouth was dry and exhausted.
He made phone calls all day long and communicated continuously with the CEOs of the two companies, and finally finalized two orders within one day.
Just wait until Monday to fly over to inspect the factory and sign the contract.
There are two companies, one in Shu City and one in Shenzhen City. He would be exhausted from running to one of them every day.
But there was nothing he could do. He almost messed up the matter because he didn't have risk control and preparation plans in place.
Damn Inmena, damn the Eagle Country people, they are simply despicable, shameless and despicable.
I hope these two domestic detectors can step up and satisfy President Wei.
He thought silently, poured a cup of strong tea, turned on the computer, and prepared to continue fighting.
There is also a comprehensive domestic equipment list to be finalized this week.
****
At a quarter past eight, Huang Qin hurriedly walked into the genetic laboratory on the 11th floor of Pangu Building.
Since the development of several genetic drugs, biological laboratories have established specialized genetic laboratories to mainly develop drugs for single-gene diseases.
Huang Qin is diligent and studious, and has been working with experts like Williams, so he has made rapid progress and has been promoted to a R&D team leader.
His good friend Williams was also promoted and became the deputy team leader, still working with him.
The two of them enjoyed working together and were considered a golden combination, and were well-known throughout the biology laboratory.
After all, it is quite eye-catching for two people with completely opposite appearances to stay together all day long and go out at the same time.
But what surprised him was that a powerful person like Williams was only promoted to deputy team leader and still his assistant.
He felt a little ashamed, because the other party had made greater contributions to daily work and had a higher education than him.
Maybe it's racial discrimination. After all, Sanqing is a Chinese company and likes to train its own people. Foreigners just can't get promoted as fast as me. And Williams is still a postdoctoral fellow, so he may not be able to stay in the future.
This was all he could do to comfort himself.
As soon as he sat down in the office, he heard Williams greeting him.
"Qin, come here quickly. The laboratory has newly installed several China-made gene sequencers. Let's go and try them out. Let's see how they differ from Illumina's sequencing platform."
Williams speaks Chinese fluently and does not have any foreign accent. However, when he pronounces the word "qin", there is still a slight change in the tone, which sounds more like the familiar title "qin".
This title made Huang Qin dumbfounded. After Williams called him that, all the colleagues in the laboratory began to call him 'dear' enthusiastically like a cat looking for a waiter.
The problem is, when this title is spoken by Williams, a 1.8-meter tall man with a stubble on his face, it always feels weird, as if something is wrong, and there is something sexual about it. Even the new beautiful colleague hears it. When I arrived, I looked at him with a strange look.
Huang Qin responded, put on his white coat, followed Williams and walked into the laboratory.
