Chapter 162: Gene Therapy Starting from Rare Diseases

Style: Science Author: Riding a pig to dig a holeWords: 3512Update Time: 24/01/12 20:04:28
Just after eight o'clock, there was a constant "didi" sound on each floor.

People walked into the R&D building in twos and threes and swiped their cards to enter.

Those youthful faces walked into the offices and laboratories with great interest and started working day after day.

The cafeteria at the Sanqing headquarters serves breakfast at eight o'clock. Employees' badges have a meal card function. They are given a meal subsidy of 600 yuan every month, which is enough for three meals a day in the cafeteria. There are usually dozens of yuan left over to buy some snacks. Milk and snacks to supplement.

Although the company does not encourage overtime work, it encourages everyone to study and improve after get off work, so many people are trying to seize the time after work, reading books, taking online classes, and doing experiments.

Single R&D personnel basically apply for dormitories. They are too lazy to run more than ten kilometers back and forth every day. They simply live in the dormitories and devote themselves to work and study.

Anyway, the conditions of the dormitory are comparable to those of a hotel. They all have standard rooms and suites, and there are aunties to clean the house. Isn’t this better than cooking and doing housework by yourself?

This group of young and energetic young people get up early every day and are more punctual than the master chefs in the cafeteria. They can always rush in as soon as the door opens, howl and eat a tray of food like a whirlwind, and then act like a head-to-head baby. Rushing into the lab like a bull and getting to work.

People with families don’t work so hard. They have built a love nest nearby and drive to and from get off work every day. Occasionally, in order to escape from family chores, they will work overtime in a brightly lit laboratory and experience the fun of middle-aged people. .

The functional departments work the most regularly, with a standard nine-to-five work schedule. The administrative building is dark at night, in sharp contrast to the brightly lit R&D building next to it.

But today, no matter which department the employees were in, they would all let out bursts of exclamations not long after they started working.

"Damn it, why is the computer so fast today? The company system has been upgraded again?"

"I opened the server very quickly today. Copying files felt like flying. I'm not used to it."

"The page seems to have been changed and has become more concise and convenient. What used to take several steps can now be completed in one or two steps."

"The search function of the database has been enriched, and it feels much smarter. The information found using the same keywords before has become more relevant."

Everyone discussed it enthusiastically and found that they were similar to each other, and everyone's work efficiency has improved a lot.

I was instantly surprised and came to the conclusion that the company must have secretly upgraded the system in the middle of the night.

The IT department was even more surprised. When some of them checked their information, they suddenly discovered that there was an additional direct leader.

"Damn it, I seem to have discovered something big. Look at your data cards. Doesn't it show that our IT department has a big leader? He's also a big beauty!"

"Fuck, let me see, yes, the leader's name is Anmei. She is really young. She looks pretty and beautiful at first glance. Tsk! Where did the boss find such a talented person in technology?"

"The leader's information seems to be encrypted. I can't see it. Isn't there always no one in this position? It seems that he is an airborne sect."

"Let me just say, as soon as I got to work today, I felt that the system had changed a lot, and there were a lot less bugs."

"Hey, will President An summon everyone for an introductory meeting today? Do you think I should take time to go back and take a shower at noon? I haven't washed my hair in three days and I feel really embarrassed."

"It's weird, why can't I find Mr. An's office? Isn't it on this floor?"

"Maybe it's with the Director General's office."

Wen Renlong also quickly discovered the existence of this beautiful new colleague.

He immediately clicked on Anmei's profile picture, and his pupils instantly dilated.

An extremely beautiful and perfect face suddenly appeared in front of him.

He was stunned for a while, then he zoomed in on the image and looked at it carefully, not missing a single detail.

After reading it, I reluctantly right-clicked to save it, and couldn't help but utter a curse word.

"Fuck, this face is simply the most perfect face I have ever seen. It perfectly matches the golden ratio. The boss has really found a treasure."

He rested his head on his hands, leaned back on the chair, and couldn't help but talk to himself.

"I really love the company more and more. Not only is my adrenaline soaring, but my dopamine is also secreted like crazy."

After hesitating for a while, he sent a message to Wei Kang.

"Boss, the new CIO is on point. When can we meet him in person?"

As soon as I sent it, the reply came in seconds: "This new colleague has social phobia and is used to working remotely. I'm afraid you can only see her through video conference."

Wenrenlong was stunned for a moment, wasn't it? It's unscientific for such a beautiful woman to have social phobia.

Aren't beautiful women supposed to be socially awkward people who particularly enjoy the feeling of being surrounded by stars?

He thought about it again and again, but couldn't find a similar example.

I can only comfort myself, maybe this is a talented beautiful girl, so she is extra special.

Thinking about it this way, my heart felt even more itchy.

I couldn't help but secretly sent a message to An Mei.

"Hi, new colleague, I'm Wen Renlong, director of the AI ​​Lab. Nice to meet you."

"Your avatar is very beautiful, but I believe you are ten thousand times more beautiful in person than in the photo. By the way, is today your first day at work? If you don't understand anything, you can ask me."

It took a while before I received a reply: "Hello, I'm Anmei. Nice to meet you. I just joined the company today, but I already know everything about it. Thank you for your concern."

Wen Renlong touched a small nail, touched his nose, and suddenly became a little embarrassed.

"Okay, you're welcome."

With a casual polite word, he closed the dialog box and began to work seriously.

At this moment, in the biology laboratory, it was a different scene.

"Wow! Awesome! The first complete and gap-free human genome sequence has been released."

"Damn it, Science magazine published 6 papers in a row, it's crazy!"

"3.055 billion base pairs and 19,969 protein-coding genes, my God, I can't wait to test my own genome."

"Quickly, download the detailed data!"

"bingo! It's done!"

The entire laboratory has been plunged into a sea of ​​enthusiastic cheers.

Everyone looked intently at the computer in front of them, sometimes uttering a few swear words passionately, then having a heated discussion with the colleagues next to them, and then continuing to read the information on the screen.

Today, a piece of news shocked the entire biological world.

Human genome sequencing, hailed as the life sciences' moonshot, has made significant progress again: the international scientific team Telomere to Telomere Consortium (t2t) has published the first complete, gap-free human genome sequence, revealing for the first time highly Identical segmentally repeated genomic regions and their variation in the human genome.

This is a major upgrade to the standard human reference genome sequence released in 2013. "Science" magazine not only published six consecutive papers reporting this achievement, but also published all the genome data.

In 2001, the International Human Genome Project, which involved scientists from six countries, released the human genome map and preliminary analysis results for the first time. In 2003, it released a draft human genome sequence.

However, due to technical limitations, the original human genome project left about 8% "blank" gaps. This part is difficult to sequence and consists of highly repetitive, complex blocks of DNA that contain functional genes as well as centromeres and telomeres located in the middle and ends of chromosomes.

Now, after 20 years of hard work, a new gapless version has been released, and the sequencing of all genes on the 23 pairs of human chromosomes has been completely conquered.

This complete and gap-free sequence will make a crucial contribution to a comprehensive understanding of human genome variation and to uncovering the genetic mutations underlying certain diseases.

Human chromosomes are composed of gene segments one by one. These segments are encoded by the four bases c, g, a, and t. They are like a code library that stores the design drawings and manufacturing methods of the human machine.

Yes, a human being is really like a machine, but a machine assembled from organic chemical molecules.

DNA contains complete design drawing information. When a part needs to be built, a messenger (mrna) will be copied. The messenger produces proteins one by one in the cell factory based on the information it carries. It is these proteins that Like tools, they realize various functions of the human body.

Tools like proteins are composed of 20 amino acid codes. Amino acids are like standard parts of tools. Each amino acid is pieced together according to the order marked on the DNA drawing to form different tools to achieve different functions.

For example, hemoglobin is manufactured in this way. It is a special protein molecule used to transport oxygen in red blood cells. If the gene fragment related to hemoglobin is mutated, it may cause the cells to be unable to synthesize normal hemoglobin and transport oxygen normally, leading to anemia symptoms. die.

There is a kind of sickle-shaped hemoglobin, which is a hereditary disease in African blacks. On the relevant gene fragment, the codon ctt mutated into cat, a difference of one letter (base). The resulting hemoglobin molecule was originally hydrophilic. The glutamic acid is replaced by the hydrophobic valine, causing the red blood cells to twist into a sickle shape, leading to hemolytic anemia.

This inherited genetic mutation originally arose in response to malaria in the tropics.

The intention is good, if the patient lives in the Philippines, where malaria is common, because the sickle-shaped hemoglobin will kill the malaria parasites that invade the blood, thereby preventing malaria infection and transmission.

It’s just that the ancestral genes did not expect African blacks to go to other continents, so this genetic mutation becomes meaningless and even fatal.

All I can say is that fate has its way with people.

After all, human genes are too old and there are too many, like a warehouse filled with countless ancient objects.

Who knows what kind of ancestral treasures are inside. A random ancient genetic mutation may be powerful and beneficial at the time, but it may be highly toxic to modern humans.

Therefore, genetic mutations have always been full of unknowns, just like opening a blind box, you never know what is inside.

It may be a surprise, but more likely it may be a shock.

After all, life is not science fiction. Every genetic mutation in science fiction is like a pile of bones that have been proven wrong in reality.

The genome on each chromosome contains many meaningless repeated segments. These repeated regions include some extremely critical parts in cell division, and also include new genes that may help species adapt.

In the past, these duplications prevented scientists from assembling the genetic fragments in the correct order. They were like a difficult puzzle with nearly every piece being the same, and people didn't know which piece went where. Huge white space.

Now with this latest effort, there are no longer any hidden or unknown pieces, and the entire puzzle has finally been pieced together.

A brand new genetic treasure house is slowly opening up in front of all mankind.