Just when the doctors in Eagle Country were having lively exchanges in the online community.
The FDA suddenly issued an announcement.
Guidelines for Abuse-Preventing Opioids and Other Analgesics
"To more rationally use opioid analgesics, there are concerns about withdrawal in patients with increasing opioid dependence and concerns about reduced analgesic efficacy in patients already taking opioids."
"The FDA will give the most stringent and careful consideration to marketing applications for such drugs, and will prioritize addressing abuse issues as its highest priority."
"Withdraw the fast-track approval qualifications for all analgesic drugs and extend the clinical phase time. Pharmaceutical companies need to submit complete 3-5 years of long-term clinical data to evaluate the real-world benefit-risk ratio of drugs and reduce addictive drugs as much as possible. Listing possible.”
"At the same time, this type of drug needs to increase patient diversity in clinical trials. The FDA cannot accept clinical data from a single country, such as relying solely on clinical data from China."
"Any negative clinical data and ethical issues will automatically trigger the decision to stop clinical trials and impose a cooling-off period of more than 2 years."
"If a pharmaceutical company cannot self-certify that it is non-addictive and submit sufficient clinical data, the FDA will reject its marketing application and strictly prohibit any promotion and use of the drug in Eagle Country to avoid any possible adverse consequences. "
"Clinical research applications for opioids and other analgesics by foreign pharmaceutical companies will be temporarily suspended, and the use of related authorized patented drugs in the Eagle Country market will be prohibited."
"This guidance plan also applies to foreign pharmaceutical companies regulated by the FDA and related national markets."
This announcement immediately caused shock in the medical circle.
All experts and scholars were in an uproar.
With this announcement, the FDA put the research and development of painkillers in the coffin and nailed the coffin boards tightly with its own hands.
Not only does it impose extremely stringent requirements on the clinical data of analgesics, it also raises the market threshold to an infinitely high level.
Pharmaceutical companies are also required to self-certify that they are non-addictive before they can apply for clinical trials.
That's okay, after all, combating the abuse of painkillers is considered a basic national policy.
Strengthening the supervision of pharmaceutical companies is also the FDA's job.
However, the last two sentences completely exposed the FDA’s true intentions.
Directly ban the sale of painkillers from foreign pharmaceutical companies.
Not only is it banned in Eagle Country, it is also banned in overseas markets regulated by the FDA.
This is no longer just demanding.
Anyone with a discerning eye will understand the purpose of the announcement.
Such an announcement was made when the clinical paper on Sanqing Painkillers was just published.
Its targeted meaning is very obvious.
If you really want to strengthen supervision, there is no need to emphasize foreign pharmaceutical companies.
Even for Eagle Country, this is a very unfair behavior.
"Did Sanqing offend the FDA?"
"Who knows, anyway, I can see that the FDA is retaliating for the trouble caused by Sanqing."
"Then we won't be able to use Sanqing's new painkillers."
"It's such a shame. I thought Sanqing was going to submit a clinical application to the FDA soon? I have patients who are suffering from neuropathic pain and they need strong, non-addictive painkillers."
"The FDA is making unreasonable claims. Why can Chinese pharmaceutical companies sell painkillers, while foreign pharmaceutical companies ban their sales without any reason?"
"It seems that we can only cooperate with hospitals in China and try our best to send patients to China for treatment."
"Shit, do you know why the FDA is going crazy? It's really confusing."
"Shh, I got a piece of news from some friends in China. It may explain why the FDA went crazy."
"Speak quickly, speak quickly!"
"It is said that China has used this painkiller to detoxify. This drug has helped many addicts resist the withdrawal reaction and saved them from tremendous pain. The withdrawal effect is remarkable after using it for a period of time."
"Oh my God, God will send down thunder to kill the FDA bureaucrats. Such a good drug is not allowed to be purchased by the people."
"This is actually very reasonable. As we all know, drugs that can replace addictive drugs for withdrawal treatment are very likely to be addictive themselves. It's just that the time may be too short and we haven't discovered the side effects of this painkiller."
"Did you also accept sponsorship from any pharmaceutical company? You actually told lies with open eyes. This is obviously a painkiller that can cure drug addiction, not an addictive drug."
"The Sanqing Dynasty has not yet published a paper that discusses the principles in detail, so we should be skeptical."
"Such a quarrel is pointless and I will be following this painkiller as a long-term research project."
Just when the authoritative experts in Eagle Country were arguing over this ban on sales announcement.
Sanqing’s new painkillers have been announced in China and officially launched on the market.
The specification is 30mg per pill, 10 pills per box, priced at 158.
The price is not cheap, it is about the same price as imported painkillers, and much more expensive than domestic painkillers that cost a few yuan a pill.
However, the analgesic effect is different, and it is a new and original drug, so it cannot be sold at a too low price.
Wei Kang doesn’t want to do charity either. After all, research and development still requires money.
Besides, this is for patients with severe pain. If it is mild pain, just buy domestic ibuprofen for a few dollars. It is also a waste to use such a good medicine.
This painkiller is designed to replace addictive opioids.
Whether it is pain relief after surgery or other pain relief, the effect is very good.
The global painkiller market is worth hundreds of billions of dollars, 30% of which are opioid prescription painkillers.
Of course, this does not include those that are abused.
Many people are afraid of becoming addicted and refuse to use it even though it hurts. Now with this new painkiller, this problem can be solved.
On the first day that painkillers were launched on the market, many patients went to the hospital to register for prescriptions.
An old man went into the pain clinic and said directly to the doctor: "Please prescribe me some Sanqing painkillers. I have been suffering from arthritis pain for several years. The pain is so bad that I can't sleep every day."
The doctor looked at the old man and taught earnestly: "Uncle, pain cannot be solved by just taking painkillers. You must also see a doctor and prescribe the right medicine to solve the problem."
"Otherwise, it will only temporarily relieve the pain, but it will not be completely cured. The pain will still persist in the future. Treating the symptoms but not the root cause."
The old man sighed and said, "I have rheumatoid arthritis. The doctor prescribed a lot of medicine, but it doesn't work and the pain continues. There's nothing I can do about it."
"Anyway, it's just pain, and it's not life-threatening. I can bear it. I usually take some ibuprofen, but it won't have much impact. Even if I take ibuprofen on rainy days, it won't work. That's why I asked you to prescribe Sanqing." Painkillers.”
The doctor checked the old man's case and started prescribing medicine for him.
"Uncle, this medicine is a bit expensive, 158 per box. Although it has a good sustained-release effect and one tablet can last a day, it can only be taken for 10 days. Moreover, it has just been launched and has not yet been covered by medical insurance. You need to pay for it out of your own pocket. You have to think carefully. "
The uncle said nonchalantly: "No problem, I have enough money, you can open 10 boxes for me first."
The doctor was startled: "Uncle, this is not how this prescription is prescribed. I can give you a month's supply at most."
"The main thing is that you haven't taken this medicine before. I don't know if you are adaptable to it. Although it is said that there are very few adverse reactions, I can't guarantee it, so I have to take one box and see the effect before continuing to take it."
The uncle seemed a little unhappy: "Why, I don't prescribe medicine even if I have money. Isn't this medicine said to be non-addictive? What are you afraid of? I finally hoped for such an effective and harmless painkiller, but in the end You won't let me eat? Are you responsible if something goes wrong?"
After much talk, the doctor finally prescribed three boxes a month and sent the grumbling uncle away.
The next patient came in and turned out to be a young girl in her early twenties, fashionable and youthful.
The doctor was surprised: "You don't look like you have any chronic disease?"
This is the pain department, which mainly diagnoses and treats various chronic pains. Chronic pain lasting more than three months is included in the scope of pain department diagnosis and treatment, such as headaches, neuralgia, low back and leg pain, cervical spondylosis, arthritis, etc.
The girl said with a relaxed face: "It's okay, I just often have dysmenorrhea. Doctor, please prescribe me some Sanqing painkillers. I heard that the effect is very good. I don't have high requirements. Just open a box and I will have dysmenorrhea every time." Just eat it for a few days."
The doctor couldn't laugh or cry: "There are many reasons for dysmenorrhea. If it's severe, you should see a gynecologist and try to make a complete recovery as soon as possible. Just taking painkillers is useless. And generally, for dysmenorrhea, you can just buy some ibuprofen at the drugstore and take it." "
The girl shook her head: "Ibuprofen doesn't work. Doctor, you don't know how painful it is. Oh my god, it hurts more than giving birth. Every time I feel pain, I want to bang my head against the wall." .I beg you."
"And I have pain for several days every time. I can't go to work. I can't get out of bed at all. I have only been working for a month and have already asked for five days of leave. Seeing that this month is coming again, I will ask for leave again." The boss has to fire me."
The girl was so anxious that her eyes were filled with tears, and she almost cried as she spoke.
The doctor was speechless and helpless, so he had to prescribe a box for the girl.
Next, old men and women kept coming in, all asking for Sanqing painkillers.
The doctor was numb. He received more patients that day than he had in the previous half month.
Although many people asked for painkillers in the past, there were not as many as today, and they all asked for the same medicine.
Moreover, patients often ask for three, five, or even ten boxes to be opened, for fear that if they open too little, they will not be able to buy it the next time they come after eating.
After all, Sanqing's medicines are very popular and sell out easily. Everyone is used to it.
Especially when it first comes on the market, it’s best to stock up on a batch to avoid running out of stock.
When the production volume catches up later, we won’t be afraid that we won’t be able to buy it anymore.
These are all words of experience bought by the people.
In one day, apart from two examination orders, the doctor prescribed Sanqing painkillers.
He was confused. I am a doctor. I also know other skills. Can you please stop asking me to just prescribe painkillers?
But he also understood how popular the drug was.
Hundreds of millions of people around the world suffer from pain every day due to various diseases or accidents.
Most of the pain can be relieved by taking various medicines, but the rest cannot be relieved without taking medicine.
Especially for pain caused by diseases, ordinary analgesics are hardly effective, and only opioids can help.
However, overdose of opioid painkillers is not only addictive, but also prone to sudden death. Countless tragedies occur in Eagle Country every year.
Therefore, domestic control over such drugs is very strict, which results in most patients having to cope with the pain on their own, making them even more miserable.
Now that I finally have this painkiller, why not hurry up and open a few boxes to relieve the pain.
They didn't have a choice before, but now they have a choice. They just want to say get out of pain.
After the doctor got off work, he asked other colleagues and found that everyone was doing the same thing and just prescribing painkillers.
Everyone made statistics together and found that the pain department alone dispensed thousands of boxes of painkillers today, completely depleting the hospital's inventory.
This is just their hospital, there are other hospitals across the city.
As for hospitals across the province and across the country?
This sales volume is really terrifying.
In one day, a drug sales record was created.
***
Wei Kang was sitting in the office, looking at the sales report on the table with a smile on his face.
"The sales of painkillers are indeed very good, as I expected."
"And this is just the beginning, with such high sales. When the subsequent production catches up, the reputation is also established, the sales will increase, and then it will completely occupy the market."
"After all, market promotion also takes time. It cannot be rolled out to all hospitals across the country as soon as it is launched. It will first start with hospitals in major cities and slowly develop to city and county-level hospitals."
The main reason is that Sanqing has already established a reputation with a variety of drugs and does not need to invest too much in advertising.
This is the so-called brand effect.
When patients need a certain drug, the first thing they think of is whether Sanqing is available. If Sanqing is not available, they will consider products from other pharmaceutical companies.
They sincerely believe in the quality and efficacy of Sanqing, and will even spontaneously promote Sanqing.
To put it bluntly, Sanqing seems to be a symbol of medicine that can cure diseases.
This fame can now be used as a kind of placebo.
The psychological effect of patients taking Sanqing's medicine is completely different from taking medicine from other manufacturers.
When they take Sanqing's medicine, they have an expectation that they are taking a panacea and will get better soon.
When I take medicines from other manufacturers, I feel calm and calm. I even worry that I will be poisoned before the effects are felt.
This phenomenon of alleviation of illness caused by strong psychological suggestion is called placebo effect in medicine.
Compared with medicines from other manufacturers, Sanqing's medicines are equivalent to adding a placebo buff out of thin air.
Even if it doesn't work, it can get better, not to mention that the effect of Sanqing's medicine is particularly good.
Therefore, the patient experience is very good, so the reputation of Sanqing has been rising steadily.
"But this use is beyond my imagination."
He looked at the clinical trial data from the drug rehabilitation center that Du Cheng sent and nodded.
“I didn’t expect that an unintentional intervention could help drug addicts detoxify.”
"It seems that painkillers can really replace addictive drugs and help them slowly quit their addiction. This is really great."
Wei Kang was a little excited. This effect made him very happy because it could solve a serious social problem.
At the same time he was lost in thought.
"In this case, the reason why the FDA targets painkillers will be found."
"Haha, I'm afraid this is not just the FDA's own idea, there must be other influences at work behind it."
"It may be the officials of Eagle Country, or it may be some related interest group."
"After all, the big pie of addictive drugs is not within the reach of ordinary people."
"If painkillers enter the Eagle Country market, it will not only squeeze the original painkiller market, but also help addicts better quit their drug addiction, and the market for addictive drugs will be greatly reduced."
"Such a huge source of profit is going to be cut off by Sanqing's painkillers. No wonder they are jumping."
Wei Kang couldn't help but sneer.
"You dare to ban the sale of my medicine, you are really impatient."
