Du Cheng and his party came in joy and returned satisfied.
Wei Kang stretched. After a day of talks, he felt a little tired.
However, things are progressing smoothly. Not only have the two drugs been favored by the military and become strategic reserve materials, but they have also reached a preliminary strategic cooperation intention with them, which can be considered fruitful.
The next step is to improve the hemostatic spray and analgesics according to their requirements and divide them into military and civilian versions with different efficacy.
Hemostatic spray is relatively simple, but for painkillers, several versions have to be made according to different concentrations and preparations.
Painkillers generally take three forms: intramuscular injection, subcutaneous injection and oral administration. The simplest and most convenient way is of course oral administration.
But in this case, there are strict requirements on concentration, degree of sustained release, onset of action, metabolism in the body, etc.
Injection methods are generally used in surgeries and first aid to pursue high efficiency and speed.
Once the third clinical phase is completed, it will be approved and officially launched on the market.
Due to the addictive nature of painkillers, the food and drug administrations of various countries are very strict and prudent in their control in this regard. They may also require continued Phase IV clinical trials after they are put on the market to examine the effects and side effects of long-term use.
However, Wei Kang is confident that Sanqing, a new type of painkiller, will definitely soon replace the clinical status of opioid painkillers as long as it does not have the fatal flaw of addiction.
After all, who would use opioid painkillers when there are painkillers with fewer side effects and no dependence?
Perhaps the only thing that affects the sales of this drug is the cost.
If the cost is too high and many patients cannot afford it, they will still choose those opioid painkillers.
Fortunately, in China, if it is included in the medical insurance reimbursement list, at least there will be medical insurance centralized purchasing, which can reduce the price.
Overseas, it is difficult to say, because the painkiller market is now very mature, daily painkillers are very cheap, and even addictive painkillers are not expensive.
If a new drug does not have any cost advantage, its sales and market will inevitably be affected.
You know, painkillers are a market worth nearly 100 billion.
A painkiller with good efficacy and few side effects can become a pharmaceutical company's flagship product and remain evergreen.
Pfizer's pregabalin (lyrica) was once the world's best-selling painkiller, with annual sales reaching US$6 billion, of which sales in the Eagle Country were US$3.5 billion. After its launch, it was named "The Drug of the Year" by Time magazine. One of the top ten medical advances."
This ace analgesic has a wide range of uses and can be used for anti-epileptic, analgesic and anxiolytic activities, as well as a variety of neuropathic pain.
However, it was later discovered that its side effects were extremely terrible and could lead to severe drug addiction. This side effect caused the death of as many as 33 patients in Northern Ireland in 2018.
Studies have confirmed that pregabalin will double the suicidal thoughts and behaviors of patients. Many patients who take pregabalin for pain relief have obvious side effects after taking the drug. Patients with depression should try their best to restrain suicidal thoughts after taking the drug. Pain patients will Having thoughts of suicide.
There are also quite a number of people who said, “They seem to be addicted to it and cannot live without it. They eat more and more often, resulting in a repeated, long-term, compulsive and non-therapeutic continuous medication phenomenon regardless of the consequences.”
The number of deaths related to this prescription drug increased year by year, and later Bull Country directly listed the drug as a Class C controlled drug.
Most opioid analgesics cannot escape the fate of addiction, because after ingestion, the human body will not only relieve pain, but also produce strong pleasure and pleasure. The more ingested, the stronger the pleasure, and this process will greatly damage the body. Neuronal organization.
After long-term use, the nerves in the human brain have been damaged, and only large doses of drugs can maintain normality. If you stop using it, you will have a strong withdrawal reaction, and your nerves will become extremely sensitive. Even if you lie still, you can feel the pain of being bitten by thousands of ants in every inch of your body.
This is why Sanqing, an analgesic, has received so much attention.
Weikang is very confident that its painkiller directly blocks the pain transmission pathway in the nervous system, but does not produce dopamine and will not give patients any pleasure, so it will not create dependence.
Once the pain disappears, you can just stop taking the medicine. It will not stimulate the nervous system and is very safe and effective.
Since there is no pleasure, neither patients nor normal people will become addicted. After all, no one wants to suddenly lose their sense of pain and then be injured due to various accidents in daily life.
It can even be used to help addicts with their withdrawal reactions and eliminate the heart-wrenching pain they experience after stopping the drug.
In short, it is widely used and has great prospects, and it can become Sanqing's third major product after anti-cancer drugs and anti-Alzheimer's drugs.
Moreover, by improving the formulation and crystal form, we might as well seize the market for mild and moderate analgesics such as ibuprofen and aspirin.
According to conservative estimates, it is not a problem to achieve sales of US$6 billion for pregabalin. If other uses are developed, annual sales exceeding tens of billions will be just around the corner.
Wei Kang chuckled, and a glittering golden mountain seemed to appear in front of his eyes.
****
Kunming City, First People's Hospital.
Zhang Chunhua is a retired chief doctor and an honorary professor of Haishi Medical University.
He recently had surgery and is recovering in the hospital.
Lying on the hospital bed, he only felt pain everywhere in his body, and it felt like every piece of flesh was being cut severely with a knife.
I can only take one piece of tramadol every day to relieve pain, but the effect is not particularly good. It can only relieve the pain slightly, and only for a few hours.
He also dared not take painkillers such as morphine for fear that he would become dependent and become addicted.
Even tramadol is addictive to a certain extent. He can only take one pill. After the effect of the drug wears off, he can only endure the pain no matter how painful it is.
Especially at night, he often moaned in pain, couldn't sleep at all, and his mental state was extremely poor.
After finally staying up for half the night, I was so sleepy that I could only squint for two or three hours.
At this moment, he was holding the quilt with both hands, gritting his teeth and enduring, with beads of sweat on his forehead.
The young doctor who came to check the ward couldn't help it anymore and persuaded: "Director, why don't you give me a shot of morphine? It's too uncomfortable for you. You need to rest after the operation. If you keep it up like this, it will not be conducive to recovery." "
This doctor was Zhang Chunhua's former subordinate. When he was an intern in the department, it was Lao Zhang who took care of him. Even after Lao Zhang retired, he always called him the director.
"No! You can't use this kind of thing casually. I can bear it." Zhang Chunhua gritted his teeth and said with a trembling voice.
The young doctor couldn't help but shake his head. He knew that his old boss was stubborn. He pondered for a moment and then said: "Director, how about this? Recently, the hospital has a new Sanqing painkiller that is undergoing clinical phase III trials. I want to see the effect. It’s not bad, it’s not an opioid analgesic, and it won’t cause dependence. Do you want to try the medicine?”
Clinical trials?
Zhang Chunhua was suddenly in a trance. He used to give clinical trials of drugs to patients, but now it was his turn to test drugs?
However, the word Sanqing moved him. Thinking of the reputation of Sanqing Pharmaceutical, he held back the pain and squeezed out two words through his teeth: "Try! Try!"
The young doctor nodded: "Okay, don't worry. I looked at the data of other patients. The pain is reduced very quickly, and the side effects are very small. Adverse reactions such as nausea, drowsiness, and general weakness are not good for your body." What impact will it have?”
Zhang Chunhua hummed a few times, groaned, and was speechless.
At this moment, he could only treat a dead horse as a living doctor. As long as it was not addictive and could relieve pain, he wanted to try it.
A few adverse reactions are nothing. Can they be more painful than the pain he feels when he cuts his flesh with a dull knife?
The young doctor quickly brought a pill, poured a glass of water, and placed it in front of him.
Zhang Chunhua couldn't help but be stunned: "Why is it an oral medicine? It's not an injection? Is this analgesic effect?"
But he was in too much pain now, so he could only rely on the brand effect of Sanqing.
I hope that the products of big companies can be of some use, but if they don’t, just use your spare energy and contribute to medical experiments.
He stretched out his trembling right hand, picked up the pills from the plate, swallowed them in one gulp, and then drank the water.
The young doctor put the water glass aside and took out a clinical trial drug document.
"Director, let's go through the process. I'll ask you questions. Fill out this form and sign it."
Zhang Chunhua nodded. He was familiar with all this, but this time it seemed that it was the other way around. He became the person testing the medicine, not the doctor administering it.
So, the two of them asked and answered questions, filled in some basic information, and Zhang Chunhua signed again, and that was the end.
Suddenly, the young doctor asked: "Director, are you feeling better? It seems that I haven't heard your moans for a while."
Zhang Chunhua was stunned. He looked at his hands. His clenched fists had been stretched out. His legs were no longer curled up, but straightened. Even the most painful pain in his lower back had disappeared. Unknowingly, He has actually returned to his normal sitting position.
He touched his face, and it still felt tactile, indicating that the nerves were not paralyzed.
Just no more pain.
"F*ck!" Zhang Chunhua couldn't help but cursed: "This is wrong. Why does it take effect so quickly? It's only been a few minutes?"
From the time he drank the medicine to the time he filled out the form, it only took about five minutes.
His pain, which was as severe as cutting flesh with an electric knife, has completely disappeared?
Even a shot of morphine won't take effect that quickly!
This is so fucking outrageous.
