"This, is this a patent medicine for gamma secretase inhibitor?"
Chen Yiqing opened his bloodshot eyes wide and looked at the pile of white powder in the glass vessel, feeling as if he was falling into a dream.
He felt that all this was so unreal. The new drug for Alzheimer's disease that he had been thinking about for more than ten years was right in front of him. He couldn't help but think of his deceased grandma, and tears suddenly filled his eyes.
Wenrenlong walked as fast as the wind, pacing back and forth in the spacious laboratory, too excited to stop.
Tang Que remained calm, with his hands folded across his chest, staring at the white medicine, with a faint fire burning in his eyes.
After a month of hard work and sleepless nights, they finally reverse-engineered the synthesis method of the drug and continued to optimize it, finally synthesizing this new drug.
Wei Kang looked at the detailed data in his hand and nodded with satisfaction.
"It's great. Not only did you perfectly synthesize this drug, you also made optimization changes in terms of lipophilicity, making it faster to administer and more effective."
The blood-brain barrier refers to the barrier formed by brain capillary walls and glial cells, which can prevent certain harmful substances from entering the brain tissue from the blood.
Solutes in the blood enter the brain tissue from the endothelial cells of the brain capillaries with difficulty; some pass quickly, some slowly, and some cannot pass at all. The endothelial cell membrane is lipophilic and fat-soluble substances can easily pass through. Therefore, the more lipid-soluble solutes in the blood pass through the barrier and enter the brain tissue faster.
Chen Yiqing and his colleagues used this rule to modify the drug, making it easier for it to pass through the blood-brain barrier and reach the patient's brain faster, thus producing rapid therapeutic effects.
The drug molecules previously provided by Wei Kang did not have this lipophilicity. They were able to make changes independently, indicating that they fully understood the characteristics and structure of this drug molecule.
Chen Yiqing coughed lightly and skillfully spelled out the follow-up work arrangements.
"The next step is safety and toxicology testing. I have already arranged the manpower to conduct animal experiments. At the beginning, white rats and rabbits will be used to record the results of the experimental group and the control group, and then analyze based on the control results."
"After the first phase of small animal experiments is completed, we will continue a round of control experiments with medium-sized animals such as monkeys."
"After the animal experiments are completed and it is confirmed that there are no toxic effects, we can apply to the Food and Drug Administration for clinical trials."
“The first-phase clinical trial observes the human body’s tolerance to the new drug and formulates a dosing regimen. The second-phase clinical trial evaluates the therapeutic effect and safety of the drug on patients and determines the dosage for subsequent clinical trials.”
“At this point, we can almost truly determine the success of the drug.”
"Let's wait and see!" When Chen Yiqing, who had always been mature and prudent, said this, he couldn't help but imitate Wen Renlong and raised his fist and waved it in the air.
A burst of crisp applause rang out in the laboratory.
Another month passed, Wei Kang looked at the experimental report and dosage plan in his hand, and nodded secretly.
Because he did not use the systematic prescription directly, but insisted on letting Chen Yiqing and others reverse the synthesis method by themselves. Although it took an extra two months, the two months were well spent, and his chemists gained a lot. With its growth, we have also gained a wealth of experience, which will be of great benefit to the research and development of other new drugs.
"Very good. The inhibitory effect on γ-secretase is very obvious. After early patients took it, the amyloid protein in their bodies was significantly reduced, and their condition was greatly improved. There was no memory loss anymore, and they basically returned to normal."
"And there are very few side effects. It has no impact on patients with diabetes and hypertension. It does not put a heavy load on metabolic organs such as the liver and kidneys. It will not increase the physical burden on the elderly. This alone is much better than other drugs of the same type. Know how many times more.”
"However, this drug does not treat the root cause like anti-cancer drugs. After all, aging is an irreversible process. As long as you are old enough, amyloid protein in the brain will continue to precipitate, and Alzheimer's disease is almost inevitable."
"It seems that only continuous medication can inhibit and delay the onset of Alzheimer's disease. It can only be said that the effect is obvious for early-stage patients. But for patients in the middle and later stages, their brains have shrunk. Even if the protein deposition is eliminated, their neuronal cells It’s also difficult to grow it back.”
"Unfortunately, it seems that if we want to cure the root cause, we can only develop drugs that stimulate the regeneration of brain cells. Such drugs are not easy to find. This involves the essence of aging, and research on this aspect in the human scientific community is still very superficial."
"No matter what, it should be enough to treat the early stage of Alzheimer's disease in the old aerospace academician. As long as he continues to take it, he can delay the development of Alzheimer's symptoms with a high probability."
He then picked up his cell phone and informed Academician Qi of the good news.
"What? You developed a new drug in two months?"
Academician Qi was basking in the sun and drinking tea in his study. When he heard this, his hands trembled and the whole cup of tea fell to the ground. Unconsciously, he stood up suddenly and shouted loudly: "Quick! Arrange a car for me. I will Going to a nursing home.”
Xishi Aerospace Sanatorium is located by a beautiful lake, with a mountain on its back and a lake on its side. It is built against a mountain and has a unique natural environment. The entire hospital is surrounded by lush bamboos and forests. It is very elegant and quiet, and is very suitable for the elderly to recuperate.
In a small building by the lake, the doctor examined the body of a gray-haired old man and shook his head in a subtle way.
"Mr. Xie, the examination is over, you still need more rest."
The old man lay on the bed, slowly opened his eyes, and looked at the doctor in front of him. He was a little confused for a moment: "Who are you? Where are you? Why am I here?"
He immediately fell into deep thought, but his expression became more and more confused: "Am I not in the research institute?"
Suddenly, he seemed to remember something, got out of bed suddenly, and was about to walk to the door, his expression instantly became extremely anxious.
"The rocket will be launched tomorrow, and I must be there for this manned spacecraft. This year's mission is very important, and the space station will be launched in two months..." He murmured to himself as he walked, as if Read the work schedule.
The doctor hurriedly stepped forward to support him, and persuaded with a smile: "Mr. Contribute. Just take a rest first."
Mr. Xie shook his head: "No, this launch mission must be completed on time. There were still some problems that were not solved last time. I have to go to the site to take a look."
The doctor sighed: "Mr. You should understand.”
Mr. Xie froze, turned around numbly, and lay back on the bed: "The rocket was launched? It was launched when I was not around? Well, okay, I am already old and confused anyway, and I can't do much work if I go back like this. It’s better to stay here.”
The doctor continued to comfort the old man, shook his head, and walked out of the ward.
Several people were waiting outside the door, including family members and staff, and they all looked at the doctor.
The doctor continued to shake his head: "Mr. It’s up to heaven.”
"This state is definitely not able to work properly. Now he can't even distinguish time and place. If it continues to develop, it is very likely that even you and I will not be able to recognize it."
"I still recommend resting here. His condition can only be delayed, not cured. Moreover, he also has high blood pressure and poor kidney function. Many side effects cannot be used at all, otherwise the consequences will be disastrous."
Several people looked disappointed. They all had hope for Mr. Xie's condition and hoped that this respected old man could return to work as soon as possible.
Unfortunately, there has been no progress in the disease, but it is getting worse.
Even if Mr. Xie can't go back to work, they don't want him to get this disease. This is really cruel for a scientist.
This is an old man who has dedicated his life to the aerospace industry of the motherland.
It is admirable that even when he is sick, he is always thinking about his work when he is awake.
The family members suddenly covered their faces and couldn't help sobbing.
Everyone looked at me and I looked at you. They all shook their heads, with sorrow in their eyes.
How they hope that there will be a specific drug to treat Alzheimer's disease at home and abroad. They do not seek a complete cure, even if it can delay the progression of the elderly's disease and make the elderly a little normal, at least they can remember their daily life and act like a normal person. It's okay to live like an old man.
Unfortunately, after so many years of research at home and abroad, no drugs can be found that can significantly improve the condition.
Mr. Xie, I'm sorry, there's really nothing we can do!
Everyone sighed in unison.
At this moment, a loud voice suddenly came from far away.
The voice was full of joy.
"Quick, tell old man Xie that his illness can be cured!"
