Wei Kang recorded the prescription on the system panel, but he did not synthesize the medicine according to the above method.
Instead, he copied the compound molecules, walked out of the office, and summoned the three generals again.
This company cannot always rely on him alone to develop drugs, since a research and development team has been set up.
They must be allowed to play their due role.
For this new small molecule compound, he did not want to use the synthesis method provided by the system, but asked the three of them to work together to find a new synthesis route.
Even if their synthesis method does not perfectly achieve the goal, in the process of studying the synthesis route, they can also gain a deeper understanding and understanding of drug development.
It is equivalent to three people working together to perform reverse inference based on the known results to find one or more correct synthesis routes.
In this process, the understanding of drug molecules will be greatly deepened, and if the drug needs to be improved in the future, it will be easier to do so.
He always felt that the most important thing about the various prescriptions given to him by the system was not the synthesis method, but the final drug molecule.
These drug molecules achieve treatment perfectly, have no side effects, and must have a very mature and perfect structure. If further analysis can be done, the rules behind this can be thoroughly understood, and more synthesis routes can be found, it will definitely promote the in-depth study of basic chemistry. Research.
It is not enough to know what is happening, but also to know why it is happening.
The basic principles and underlying rules are the greatest value of these drug molecules.
Although he doesn't have enough drugs on hand, as long as he continues to extract them through the system, there will definitely be enough drug molecule libraries for chemists to study and figure out the reason.
There are so many smart people in China. If these three people are not enough, then he will continue to recruit chemists, biologists, and even mathematicians. Hundreds, thousands, ten thousand people, no matter how many people, will work on this drug molecule analysis project. Keep doing it.
If we can really analyze any chemical principle from it, even the slightest, it will be a progress in the history of human science and technology, and it will also be the greatest value of this system.
Soon, he showed the drug molecules of gamma secretase inhibitors on the laboratory computer.
While admiring the flawless structure, I felt good about myself and couldn't help but ask for advice.
"I looked at some of the drug molecules your group had built before, and suddenly I had an idea, and I came up with this."
"How's it going? What do you think?"
The laboratory fell into an eerie silence, and no one made a sound for a long time.
He looked back and saw that the three people behind him were all speechless, their eyes wide open, staring at the screen, their faces flushed, their breathing rapid, and their expressions intoxicated.
He couldn't help being startled, clapped his hands vigorously, and shouted loudly: "Don't just look at it, tell me what you think."
Bang bang bang!
Crisp applause rang out, immediately waking the three of them up.
The three of them came back to their senses as if they were waking up from a dream, and looked at each other for a few times, their eyes full of surprise.
Chen Yiqing opened his mouth, as if he wanted to say something, but no sound came out. He tugged on the collar of his shirt, unbuttoned a button, took a deep breath, and unconsciously reached out with his right hand to touch his face. But he found that his forehead was covered with sweat.
Wen Renlong suddenly clapped his hands vigorously: "You're the boss after all. This drug molecule looks slightly similar to the structure of an anti-cancer drug. It must have been improved based on the same principle. This fantastic idea , we really couldn’t catch up.”
He clicked his tongue in admiration, with an intoxicated look on his face, as if a pervert was looking at a beautiful fruit painting.
Tang Que was the only one who could still remain calm. He kept nodding and waving his hands unconsciously in front of his chest, as if he was secretly deducing something in his mind.
Chen Yiqing took out a paper towel, wiped the sweat from his face, and asked with difficulty: "Mr. Wei, is this, is this really the molecular structure of a gamma secretase inhibitor?"
Wei Kang nodded affirmatively and said: "Yes, I think it will definitely work. Your first task is to study its synthesis pathway, synthesize the new drug in the laboratory, and then conduct follow-up tests. Are there any problems? ?”
Wen Renlong looked excited and waved his fist: "No problem, this is the moment I have dreamed of. Discovering a molecule and developing it to save tens of millions of lives is such a great feeling. I have completely fallen in love with it. this place."
Chen Yiqing recovered from the shock and was already thinking about the next steps: "Yes, because Alzheimer's disease is a brain disease, our subsequent drug administration methods must take into account the issue of breaking through the blood-brain barrier. At the same time, safety and toxicity Physical testing should also be more complete, and the possible effects of some common diseases in the elderly should also be considered."
Tang Que crossed his hands in front of his chest and suddenly asked: "Mr. Wei, where is the second mission?"
Wei Kang glanced at him approvingly, and then said: "For the second task, I will open the authority to you. You must study all the prescriptions developed by Sanqing, especially these drug molecules. I only discovered the anti-antibiotics by luck. Cancer drugs, I don’t know the rationale behind them.”
"So from a scientific point of view, we need you to study the principles in depth together, and it is best to summarize something. This will also be helpful for us to develop drugs in the future."
Tang Que's eyes shone and he exclaimed: "Oh my God, this idea is great and very attractive. Let's get started. I can't wait."
Wei Kang looked at the three of them looking eager to try, and smiled with satisfaction.
Generally speaking, traditional drug design lacks mature and complete discovery methods and is very blind. Generally, more than 10,000 compounds must be screened to obtain a new drug. Therefore, the development efficiency is very low, and it is difficult to quickly obtain suitable new drugs. Treat more and more difficult and complicated diseases.
With the development of computer technology, computational chemistry, molecular biology and medicinal chemistry, drug design has entered a rational stage.
Computer-aided drug design (CADD) is the basis for drug molecule design. It has developed into a complete and emerging research field, greatly improving the efficiency of drug development and providing people with new ideas and hope for success in overcoming some stubborn diseases. .
It is based on the research results of life sciences such as biochemistry, enzymology, molecular biology and genetics. It aims at potential drug design targets including enzymes, receptors, ion channels and nucleic acids revealed in these basic studies, and refers to The chemical structural characteristics of other analogous ligands or natural products can be used to design reasonable drug molecules.
In time, drug design will enter a new period of development, and the ancient dream of mankind - the era of theoretically designing the required substances and then synthesizing them is becoming a reality!
In the drug synthesis process, retrosynthetic analysis is the most basic and commonly used method for designing organic synthesis routes.
The outstanding feature of retrosynthetic analysis is reverse logical thinking. The thinking process of deriving simple starting materials from complex target molecules is exactly the opposite of the actual process of chemical synthesis, so it is called "retro" synthesis, or "reverse" synthesis.
Professor E. Corey of Harvard University, a master of contemporary organic synthetic chemistry, formally proposed the retrosynthetic analysis method in the 1960s. And this was Chen Yiqing’s mentor when he was a Ph.D. student at Harvard.
The process of retrosynthetic analysis can be simply summarized as follows: Based on the structural analysis of the target molecule, the three steps of cutting, determining the synthon, and searching for synthetic equivalents are repeated until a suitable starting material is found.
The more comprehensive knowledge you have about chemical reactions, the broader your ideas for designing synthetic routes will be.
When designing a drug synthesis process route, it is usually desired to keep the route as simple as possible and complete the construction of the drug molecule with the minimum number of reaction steps. But this cannot be at the expense of the quality of the drug, the purity of the drug must be ensured.
This requires designers to fully understand the selectivity of the reaction and try to use highly selective reactions to reduce the generation of by-products to obtain high-quality products.
Fortunately, these three doctors all have rich experience and comprehensive and profound knowledge. With ready-made drug molecules, it is not too difficult to reversely deduce the synthesis method.
A month later, the new drug was finally synthesized in the laboratory.
