Chapter 5: Working together to accelerate clinical trials

Style: Science Author: Riding a pig to dig a holeWords: 2198Update Time: 24/01/12 20:04:28
Wei Kang stood in front of the window, watching the three people walking out of the company. The corners of his mouth could not help but curl up, and he felt happy in his heart.

The tacit understanding with Lao Sun is still so strong. Thanks to his assistance, a few words broke down the psychological defenses of these people. Otherwise, the price of withdrawing shares would not be so small, and the process would not be so easy.

Maybe it's because I usually don't care about worldly affairs and concentrate on studying, which makes the establishment too successful for people who are silly, stubborn and easy to bully.

Although the prices of houses in the suburbs of Haishi have increased, they were only at a bargain price when I bought them. Now I can exchange them for 20% of the company's shares, so I won't lose money this time.

But in the future, when news of the success of the new drug spreads, these people will definitely make a big fuss again based on their personalities. This is something that must be guarded against and some preparations must be made.

He was gloating in his heart, but the old Sun next to him was hesitant to speak. He seemed to have a lot to say but didn't know where to start.

Finally, he sighed and said, "Xiaokang, this matter of withdrawing shares is already done. I won't say much more, but about the acquisition, could you please give it another thought and leave a way out?"

Wei Kang felt a warmth in his heart, Lao Sun really cared about him and thought about him.

He wanted to tell Lao Sun the news of the successful development of the new drug and share the joy with him. He opened his mouth and swallowed all the words again.

If Lao Sun knew that the drug test was successful, he would not be able to hide the fact that he was suffering from advanced liver cancer. He did not want to make Lao Sun worry about him anymore.

After thinking about it, he felt that he could reveal some good news for the time being, so as to prevent Old Sun from worrying all day long, so he said seriously: "Uncle Sun, don't worry too much. In fact, I have good news to tell you."

"I have recently developed an improved anti-cancer drug that is progressing rapidly. I estimate that the results should be available soon. When clinical trials start in a while, the company can be revived."

The wrinkles on Lao Sun's face suddenly stretched out, like a blooming chrysanthemum, and he asked in disbelief: "Xiaokang, are you comforting me, are you? That's great."

Wei Kang nodded: "It's true. But as soon as this comes out today, don't make it public for the time being, and wait until it reaches the third phase of clinical trials before speaking out."

Lao Sun clapped his hands suddenly and said, "Yes, you are still smart. These old boys will definitely regret it if they know the news."

The gaze he looked at Wei Kang also became pleased, and he praised: "Mr. Wei has really matured now. I haven't seen him for three days, which is impressive."

He immediately began to ponder: "In this case, everything is focused on clinical trials, so we have to squeeze out the funds first. Let's delay the supplier's payment for a while. We have never been in arrears before, and we can't do anything about it this time. But we also act in accordance with industry practices.”

"There are still a few receivables that have been delayed for a long time. I will go on a business trip to collect the payments. They are all old acquaintances. From my perspective, there should be no big problem. As for President Zhang, I will visit him in person and talk to him carefully. He said that he should be able to renew the loan and only pay interest when it expires..."

"Uncle Sun, thank you for your hard work." Wei Kang looked at Old Sun's white temples, moved in his heart, and nodded heavily: "I'll contact Zhang Bo from the CRO. The clinical trial must be accelerated. When the results come out, we won't be afraid of running out of funds. ”

"The company also needs to be reorganized internally. In the past, too many incompetent bastards were brought in by the related parties. We just took this opportunity to lay off employees and let them go to keep the hard-working people."

"Okay, if you have this ambition, of course I will support you. I will make a list of people for you later."

The two of them looked at each other and smiled, and their tacit understanding was clear.

Wei Kang returned to the office, sat on a chair, and called Zhang Bo, the head of the CRO company with whom he had cooperated for many years.

CRO companies, also known as drug R&D contract outsourcing companies, are a key link in the pharmaceutical R&D industry chain and play a significant role in shortening the pharmaceutical R&D cycle and reducing R&D costs. In terms of shortening the R&D cycle, for the same R&D project, generally speaking, the time required by CRO companies is about 20% to 30% shorter than the time required by pharmaceutical companies themselves.

In addition, labor costs account for more than one-third of the general new drug R&D expense structure, and the salary of R&D personnel in CRO companies is 20% to 30% lower than the average salary of R&D personnel in large pharmaceutical companies. This can greatly reduce the cost of drug development. The company’s R&D expenses.

Because the investment in new drug research and development is too large, the success rate is too low, and the research and development cycle is very long, so in order to improve efficiency, reduce research and development costs, and control risks, more and more pharmaceutical companies have adopted the CRO model to integrate part of the new drug research and development business or Outsource it all.

Among other things, an authoritative data released in 2018 showed that the return on investment in new drug R&D dropped to 1.9%, a record low.

It can be seen from this that developing new drugs is really a narrow escape. It is no wonder that most pharmaceutical companies are buying some expired patents to produce generic drugs. Even some ambitious pharmaceutical companies will invest their energy in improving drugs to develop new drugs. They are all the fighters in the pharmaceutical companies who are fighting for death.

Of course, CRO companies will also help with application approval, finding drug testing personnel resources, etc. It can be said to be a one-stop service.

The company Wei Kang found is very professional. We have cooperated with them for many years and have always been very satisfied.

"Mr. Zhang, are you busy? Can you please take a call?"

"Haha, it's Mr. Wei. It's convenient. What's going on with you guys recently? Are there any new drugs going to clinical trials?"

"Mr. Zhang, we have a new anti-cancer drug. It is an improved drug. We need to do the second phase of clinical testing. This needs to be completed as soon as possible, and then continue to the third phase of clinical testing. Is that okay?"

Zhang Bo was stunned: "Ah? Anti-cancer drug? Have you really developed it?"

"of course it's true."

Zhang Bo stood up instantly: "Awesome, Mr. Wei, this will be a big bomb if it becomes true. I need the data report of the first clinical phase, especially the toxicology test. You are in the company, I will go and get it now. material."

Soon, Zhang Bo drove over and got the data prepared by Wei Kang.

"Is this a respiratory anti-inflammatory drug that was abandoned before? Then the treatment direction was changed?"

"The main ingredients have not changed, but some common pharmaceutical auxiliary ingredients have been added, and the effect is so great?"

Common drug auxiliary ingredients are generally considered to have no pharmacological effects, so the first-phase clinical data can still be used. Now only a second-phase clinical test is needed.

The first clinical phase tests the safety and tolerability of the human body, the second phase tests the safety and basic efficacy, and the third phase basically conducts expanded sample testing based on the second phase.

The first and second phases do not require much sample data, so the time can be very fast.

It's just that Zhang Bo has been in this business for a long time, and he has never seen any pharmaceutical company change its drug research direction so drastically.

However, he instantly remembered the miracle drug Viagra.

Well, it’s not unacceptable. After all, Viagra is the first, and heart disease drugs can be used as aphrodisiacs. It seems more likely that anti-inflammatory drugs can be turned into anti-cancer drugs.

He perked up and nodded repeatedly while looking through the data.

"Don't worry, the data from the first phase are very complete. I will start the second clinical phase for you today and give you the data report within a week."