When Kingsley Weir heard Li Mu's words, he was stunned.
After thinking for a moment, he exclaimed again.
"They actually have the ability to develop this kind of medicine?"
Obviously, in Kingsley Ware's view, the side effects of PEFF were intentionally caused by Pfizer.
There are many drugs in the world that treat the symptoms but not the root cause, but there are very few drugs that can treat the symptoms and at the same time aggravate the severity of the root cause.
This kind of drug is simply the favorite of all pharmaceutical companies.
So, the scary thing about this is that if Skana Slavi can come up with this kind of drug, his research and development capabilities are really a bit too abnormal, right?
Actually developed a drug with targeted effects?
Li Mu also guessed the reason why Kingsley Weir was so surprised. He waved his hand and said: "It's not necessarily that they did it on purpose. Maybe they themselves didn't expect PEFF to have such an effect at all."
No matter how you think about it, with the current research methods of mankind, it is still very difficult to develop targeted effect drugs, so it should be that Skana Slavi accidentally created it.
He thought for a moment, then re-entered the simulation space, and then created a bunch of patients suffering from pulmonary embolism and acute myocardial infarction.
Then, he injected PEFF into these simulated patients, and then started to accelerate time to observe their physical changes.
After the injection of PEFF, the blood vessel blockage in these patients was more or less relieved. As the blood circulation became unobstructed, pulmonary embolism and acute myocardial infarction were resolved to a certain extent.
However, as time accelerated, Li Mu discovered that some of the patients showed signs of atherosclerosis in their blood, especially some of the simulated elderly patients. This was the impact of increased platelet activation.
As the accelerated time passed, Li Mu suddenly noticed that one of the elderly patients had a severe cerebral infarction, and then died in less than forty minutes because he did not receive treatment.
Li Mu's brows immediately raised.
interesting.
He only simulated 20 patients here, and one case had such a serious situation.
Moreover, the conditions of the patients he simulated are relatively ideal, and the physical problems they suffer from are relatively simple. The diseases suffered by patients in reality may be more complex.
It means that both cerebral infarction and myocardial infarction can occur together.
However, thrombolytic drugs are specially used to deal with this type of disease.
After all, compared with interventional treatment, interventional treatment has relatively high requirements on doctors' skills, and the cost of surgery is also very high. Thrombolytic drugs only need to be injected into the body, and thrombolysis can be achieved by relying on the circulation mechanism in the body. , and more easily accepted by patients.
Therefore, once Pfizer encounters such a problem during clinical trials, which even directly leads to the death of clinical trial volunteers, whether their new drug can pass the review of the FDA and EMA is a huge problem.
FDA and EMA are the drug regulatory agencies of the United States and Europe. Any drug that wants to enter the market in these two regions needs to pass the review of these two organizations. These two regions are the most developed regions in the world for medicine and are also the most developed in the pharmaceutical industry. In areas with the most developed markets, as long as it passes, it will bring huge profits.
However, it is very difficult to pass the review of these two regulatory organizations, especially the FDA, which can be called the most stringent and authoritative drug regulatory agency in the world.
China, including China, also recognizes FDA certification to a certain extent. Generally speaking, as long as a drug is approved by the FDA, it is relatively easy to pass China's QS certification.
And although Pfizer is well-known around the world and has a lot of power behind it, and they also have people on the FDA committee, if PEFF is found to have such a big hidden danger, whether it can pass the review is a question. After all, , FDA and people from other pharmaceutical companies.
Thinking of this, Li Mu opened his eyes again and looked at Kingsley Weir next to him.
Although he simulated many things just now, the actual time that passed was less than a minute.
He already knows the results of PEFF, so now he no longer cares.
"Okay, we don't need to worry too much about PEFF."
"We have to believe in our RSCA."
Kingsley Ware came to his senses, and then sighed and said: "Of course I believe in RSCA. This is Pfizer after all."
The world's largest pharmaceutical company is an absolute giant. In reality, everyone must be in awe of it.
Li Mu said with a smile: "Don't worry too much about this. There is a poem in China called: Let him be strong, let him be strong, the breeze will blow on the hills. Let him be horizontal, let him be horizontal, the bright moon will shine on the river."
"We just have to do our part."
Hearing Li Mu's words, Kingsley Weir took a deep breath and nodded heavily: "You are right, don't worry about it."
"Well, that's right."
Li Mu nodded.
…
In the next period of time, Li Mu continued to stay in Germany, using the simulation function of the brain computer to help Kingsley Weir and the others in their subsequent research.
Just like any drug requires active ingredients and auxiliary ingredients to work together, the simulation of the real universe environment cannot study issues such as the preparation process because the topic has been determined, but it can directly test the active ingredients. Which ratio with auxiliary ingredients has the best overall effect.
For a time, their research speed also became very fast. Kingsley Weir and the others were all amazed at how Li Mu did it, but Li Mu often only used one reason to explain, and that was data analysis.
And he often gives the process of data analysis - after all, he already knows the answer. It is not too simple for him to follow the answer and give the process of data analysis.
Ever since, Kingsley Weir and the others have come to regard Li Mu as a god, and their data analysis methods have become more and more believed by them to be the guidance brought by the god of biomedicine.
Of course, while Li Mu was helping them analyze, he also did not forget to continue the fluid mechanics analysis of blood vessels.
As time passed, he also sorted out a lot of results.
For now, one of the most outstanding achievements is that after measuring blood pressure and blood viscosity, we can directly determine whether there are any blocked areas in the blood vessels in the human body, and we can directly determine where the blocked areas are located on the human body. The accuracy rate is as high as 90%.
This result alone is of great significance. It means that for doctors, when faced with a patient who is suspected of having vascular disease but does not know where the problem is, they can let the patient first Go get a blood draw, measure your blood pressure, and then use Li Mu's results to calculate which part of the body may have the problem, thereby directly determining where the problem is and whether it is serious.
In addition to this, Li Mu's results also have a high probability of determining whether there are blood circulation problems such as atherosclerosis in the patient's body.
Although these results cannot help cure diseases, they can still save lives. Determining the disease of a patient in a timely manner is of course saving lives!
This is the significance of Li Mu’s research.
In this way, time passed quickly and December came.
[Hk={(f, g)|∑|α|≤κ……]
At the end of the scratch paper I wrote the last line of formula.
Li Mu's brows moved slightly.
"Fluid...fluid..."
After such a long period of analysis and research on vascular fluid mechanics, his understanding of the entire fluid mechanics has reached a level that is beyond the reach of ordinary people.
"A fluid is defined as a material body that cannot resist shear stress. As long as shear stress is applied to a certain fluid, the fluid will continue to deform..."
"So the shape of the fluid is always the same as the container, just like blood in a blood vessel, and obstructions such as blood clots will cause the shape of the fluid, blood, to change."
"However, in the current mathematical community, the analyzes and models are always different for different fluids."
"So is there a fluid analysis method that can describe fluids in all different situations?"
Li Mu thought.
The most complicated point in the study of fluids is that there are too many forms of fluids.
The liquid in a pipe is one kind, the fluid in a river is also one kind, or the fluid between two flat plates is also one kind.
Therefore, researchers often can only discuss fluids under different situations separately.
Therefore, there has never been a unified analysis method to include all these situations.
Therefore, this question made Li Mu think: "This is very uncomfortable."
He studies blood vessels - or pipeline fluids. He has always wanted to expand from pipeline fluids to other fluid patterns to achieve unified analysis, but he always failed in this.
"No...no..."
Suddenly, Li Mu suddenly came to his senses, "I have always thought about how to achieve a unified analysis method for different external environments, but I have not thought about how to unify the fluid!"
"What if I ignore the external shear stress and just consider the shape of the fluid?"
"Consider the external shear stress directly into the internal force of the fluid, and directly consider the fluid as a whole..."
All the research for so long turned into a sudden realization at this moment.
In an instant, Li Mu found a bright road leading to the key.
"It should be like this! Just like the Navier-Stokes equation, it is a unified analysis of all fluids. If I want to prove the existence and smoothness of its solution, then I must first find any fluids in different shapes. , they all have something in common..."
"Differential geometry...smooth manifolds!"
"Yes, it's like Ricci flow or any other manifold. No matter how the fluid changes, it's just a topological space."
Li Mu's eyes gradually brightened.
"Just treat the volume of the fluid as a space!"
Almost as soon as his thoughts were flowing smoothly, Li Mu picked up a pen and started writing on the draft paper.
After only a moment, he burst into laughter.
"This is the most suitable space for studying fluids!"
"Let's call it Li's Space from now on!"
(End of chapter)
