Chapter 220: Pfizer’s Trends, Fluid Dynamics Vascular Analysis

Style: Science Author: Chief designerWords: 3252Update Time: 24/01/12 13:34:48
Swiss Biovalley.

The name of Swiss Biovalley is widely spread in the biomedical community.

It's like Silicon Valley in the United States and Optics Valley in China.

Silicon Valley is famous for its semiconductor chip industry, and Optics Valley is famous for its optical devices.

The biological valley naturally lies in biomedicine.

It houses almost 40% of the global pharmaceutical industry's business, including more than 700 life science companies and more than 200 academic or public institutions. Tens of thousands of scientific researchers gather in this area, making it a global biotech center. One of the most prosperous places for medicine.

In addition to the headquarters of Novartis and Roche, companies such as Pfizer and Johnson & Johnson have established important departments here.

It can be said that the development of biomedicine in Switzerland and Europe is closely related to this biological valley.

At the same time, in the Biovalley, Pfizer branch laboratory.

"How's the experiment going?"

Pfizer Vice President, Mike Conn walked into the laboratory and said to Skana Slaoui who was conducting experiments.

"It went pretty well."

"We are now very close to the fourth generation of thrombolytic drugs," Skana Slaoui said with a smile.

"At least as far as we know so far, Novartis and Johnson & Johnson have not been able to find an ingredient that can stably inhibit the increase in PAI-1."

"We discovered such an ingredient just the day before yesterday, and are now trying to prepare it in a targeted manner."

"As long as we complete it, we will be victorious in the fourth generation of thrombolytic drugs!"

Conn immediately smiled and praised: "Well done!"

"After you succeed, the company will definitely hold a celebration party for you."

"Haha, then it seems that this celebration party must be held." Slavi laughed.

Obviously, he is already confident about the development of this new drug.

"I feel relieved after hearing what you said." Conn nodded with satisfaction.

As the chief scientist of Pfizer, Slavi had such confidence in success, so Conn, as the vice president, naturally expressed enough trust in this.

At least Slavi rarely let them down.

But after asking this question, Conn said: "In addition, I am here to tell you another news. Li Mu has arrived in Germany, and he went to the laboratory where Kingsley Weir is."

Upon hearing the news, Slavi was stunned for a moment, and finally snorted coldly and said: "That Chinese guy is really determined to believe that liar."

"It's true that he was so clever that he was mistaken for his cleverness."

He looked disdainful.

But Conn still asked: "Are you sure that Kingsley Weir is really just a liar? After all, he was once a professor at ETH Zurich."

"I have also investigated and found that he was indeed very talented. He studied at ETH Zurich for his undergraduate and graduate studies. He also received a PhD in biology and published several articles in Cell. I heard that he It was not that far away from becoming a professor at that time."

After confirming that the other party is a competitor, Pfizer will naturally investigate the other party thoroughly.

Needless to say, Li Mu, even his achievements in mathematics and physics have nothing to do with Pfizer, and he is even happy to see them, but his data analysis of biological experiments is really influenced by the entire biology. Praise from the medical community.

Therefore, this is first of all a strong enemy, and the other Kingsley Ware, although he has always been said to be a liar by Skarna Slavi, when Kingsley Ware approached Pfizer and wanted to cooperate , also blocked by Skana Slavi.

Although Skana Slaoui was not Pfizer's chief scientist at the time, he had already made a lot of contributions, so their president agreed to his request, even though Kingsley Ware wanted The funding is not much, it is just a drop in the bucket for them.

But now, they have to consider the threat that the other party will bring to them.

However, Skana Slavi still shook his head and said with great certainty: "Even if he is a professor, he is only an associate professor, not to mention that he is just a liar now and is not worth mentioning."

Seeing what Skarna Slavi said, Mike Conn took a deep look at him, and then said: "Okay, you are our chief scientist. I believe you, but I also hope that you will not let yourself go because of yourself." emotions that affect the company."

"The president doesn't have a good temper, you know."

Naturally, they also investigated the conflict between Skarna Slaoui and Kingsley Ware, so it is basically certain that Skarna Slaoui treated Kingsley Ware like this. The disgust is due to the contradictions back then.

Moreover, the contradiction is still very deep and basically cannot be persuaded.

After hearing Conn's words, Skana Slavi didn't say anything, but just said: "It's time for me to continue the experiment."

Conn immediately shook his head. Obviously, Slavi didn't want to hear these words and started to chase people away.

In terms of status in the company, Slavi's status was still higher than that of his vice president, so he left the laboratory without saying anything more.

Slavi did not look back, he just thought of Kingsley Weir in his mind, snorted at the end, and then shouted to other researchers in the laboratory: "Don't think about rest for the next period of time, We must go all out to achieve our goal!”

For a moment, everyone in the laboratory looked sad, but there was nothing they could do. Slavi was the chief scientist and the leader of them, so they could only listen.

In this way, their originally relatively relaxed experimental arrangement immediately became intense.

"Kingsley Weir, I'm not afraid of you, I'm just worried about that Li Mu."

Slavi said in his heart.



Time passed quietly.

Outside Oxford University, the house Li Mu bought for one pound.

After staying in Germany for a few days, he returned here without staying any longer.

The experiments here have made gratifying progress. They have discovered two unknown ingredients again, and it is basically certain that this is one of the ingredients that plays the most critical role.

Their next job is to determine the specific composition of this ingredient and find out how it works.

This will take a lot of effort, but for Kingsley Weir and others, they are very excited to make such progress.

As long as they determine the principle of this ingredient and its synthesis method, and confirm its efficacy on the human body, possible side effects, etc., they can start preparing for clinical use.

And Li Mu doesn't need to care about these things.

He also has to take care of his own affairs...

Of course, strictly speaking, it is not unrelated to this research.

While watching Kingsley Weir and others conduct in vitro thrombolysis experiments, Li Mu had an idea when he looked at the simulated blood flow passing through the simulated blood vessels.

Whether it is possible to directly analyze the thrombus situation in human blood vessels through fluid mechanics analysis.

Of course, it’s not just blood clots, there are many possible problems.

Such as atherosclerosis, blood viscosity, etc.

These problems can all be analyzed directly using fluid mechanics.

As long as he can establish a general model of human blood vessels, and then use fluid mechanics to analyze every place, then it might be possible in the end. He only needs to draw blood once, determine the viscosity of the blood, and measure it again. Blood pressure can analyze various diseases hidden in human blood vessels.

There are too many vascular-related diseases...

"It should be feasible."

"However, this requires a more in-depth analysis of fluid mechanics."

Li Mu touched his chin.

As long as there is fluid, it can be analyzed using fluid mechanics, including blood vessels.

To a certain extent, the analysis of microtubule fluid dynamics is still very exciting for physicists to discuss.

In addition, within biology, there happens to be a branch called biophysics.

Using fluid mechanics to analyze the flow of blood is also a research direction.

However, once it is related to fluid mechanics, it is not a simple problem. As the last piece of the puzzle in classical physics, the study of fluid mechanics has always been a hot topic - because it combines all past physics The whole family was stumped.

The biggest problem left here, and also the most famous problem, is the solution of the Navier-Stokes equation.

Solving the Navier-Stokes equation is an almost impossible task, except under certain specific conditions, such as the simplest parallel flow, where an exact solution can be obtained.

Generally speaking, both the mathematics community and the physics community believe that the exact solution to the Navier-Stokes equation cannot be found.

Therefore, among the famous seven major mathematical problems of the millennium, the question about the Navier-Stokes equation only requires proving the existence and smoothness of its solution, but does not require directly finding its solution.

The existence of the solution is easy to understand, which is to let people know that there is an exact solution, but scientists cannot do it, and smoothness means infinite differentiability.

Proving this issue is of great significance to any practical application issues related to fluid mechanics.

Including the problems Li Mu is facing now.

"Just kidding..." Li Mu curled his lips: "You can't let me prove this thing."

Just kidding, this is a millennium problem.

The difficulty is quite high.

But at this moment, the system's voice rang.

"Reward mission released——"

[Proof: Existence and smoothness of solutions to the Navier-Stokes equation]



Take a day off tomorrow

(End of chapter)