Li Mu's question stunned everyone present.
What's the meaning?
Are the ingredients they measured not complete enough?
What really works is the other ingredient hidden inside?
They couldn't help but become confused.
"Boss, why...why do you say that?" Kingsley Weir asked doubtfully.
"Just answer first whether you have measured all the ingredients." Li Mu was not in a hurry to explain.
Kingsley Weir thought for a moment, and then said: "If we talk about the ingredients that have not yet been measured... there may indeed be some ingredients that have not been completely measured. After all, I believe the boss also knows that for this kind of ingredients extracted from nature What comes out will always have some natural ingredient that we can’t quite discover, especially if it’s in such small amounts.”
Li Mu nodded slightly and said directly: "So, the next task is to find these trace components that have not been discovered."
"And I can confirm that what we are looking for now is among these unknown ingredients."
As he spoke, Li Mu found some scratch paper from the side, and then wrote several sets of experimental numbers on it. After writing, he handed it directly to Kingsley Weir.
"Just repeat these sets of experiments and measure the ingredients of the liquid. If my analysis is correct, the content of this unknown ingredient in these sets of experiments is relatively higher, and it should be easier to find. .”
Kingsley Weir quickly took the piece of paper, read it for a long time, and finally asked cautiously: "Among the sets of experiments you wrote, I found that the results of two sets of experiments were not good. , even if it has not reached the average level, are you sure that the content of the unknown ingredient in the medicinal solutions of these two groups of experiments is higher?"
Wouldn’t it be better to have more effective ingredients?
At least in this tiny amount, Kingsley Ware was very clear on this point.
However, Li Mu just shook his head and said: "If you study Chinese medicine, you should also know the properties of medicine. Different combinations of medicines will produce different effects."
"Of course, this is just the experience passed down by traditional Chinese medicine, but if it is reacted to chemistry, different components will have an inhibitory effect on each other."
"It's like a catalyst, and an inhibitor."
"You should understand what I mean, right?"
"Oh, maybe I can provide you with some help in finding that unknown ingredient..."
After thinking about it, Li Mu took the piece of paper from Kingsley Weir again, and then wrote a chemical formula on it again.
【C9H7NO2NH3……】
Then, he drew its molecular structure based on this chemical formula.
In organic chemistry, the chemical formulas of organic molecules may be the same, but once the structures are different, the effects will be completely different.
As the saying goes, structure determines function.
"Basically, if I guess correctly, it is this thing that affects the display of the effect of the unknown ingredient."
Kingsley Weir was immediately shocked when he saw this ingredient.
"This is... 8-hydroxy-2-aminoquinoline?"
Because he also noticed the abnormal performance of this ingredient during the experiment. It was sometimes present and sometimes absent, and it seemed to be irregular.
At first, Kingsley Weir thought it was the effect of this thing. After the experiment, it turned out that this thing was of no use at all, and even seemed to affect the effect of thrombolysis.
But now that Li Mu singled it out and explained that it might be the "culprit" that suppressed the effect of the unknown ingredient, he immediately realized this possibility!
His face was filled with deep surprise.
Of course, the faces of his former students around him were also full of surprise.
After Li Mu's few words of advice, they all thought of this as if they were enlightened.
Looking at the molecular structure diagram drawn on the piece of paper in his hand, after thinking for a long time, Kingsley Weir finally determined that this was the key to their ultimate success!
Taking a deep breath, he looked at Li Mu and said, "Is this what you discovered from data analysis?"
Li Mu nodded slightly.
"This...can I ask how you did it?" Kingsley Weir said with some embarrassment: "I really want to learn it."
Li Mu's scientific and systematic analysis method is much superior to his method of looking at a lot of experimental data and relying on intuition to find the salient points!
Relying on intuition to search, sometimes you can only catch the blind, but Li Mu's analysis can find clues from the clues!
For Kingsley Weir, this method was too greedy for him.
But Li Mu raised his eyebrows and asked, "Are you sure you want to study?"
"I'm sure!" Kingsley Weir nodded repeatedly.
Of course, the assistants around him nodded.
Just kidding, they were confused for several days in front of that huge amount of data. As soon as Li Mu got started, it didn't even take long, and he didn't even do any calculations before he discovered something they had never discovered before.
Are these Thai pants hot?
Seeing their expectant looks, Li Mu smiled and finally said, "Okay, then I will demonstrate it to you."
Naturally, there was no blackboard for them to use in the GMP laboratory, so Li Mu just took paper and pen and started calculating on the table.
Kingsley Weir and others gathered around him and watched.
"It might be a little difficult, so don't be too anxious."
Before starting to write, Li Mu also gave a special reminder.
Kingsley Weir felt good about himself and said: "It's not particularly difficult. Anyway, I've been studying for a while in the past few days, so I should be able to understand it... I still got A+ in the mathematics course during my undergraduate degree. "
Regarding his words, Li Mu just smiled without comment.
"Really? That's good."
Then his demonstration began.
Then, there were several more confused faces in the laboratory.
Kingsley Weir looked at the mathematical formulas written by Li Mu in silence.
"...?"
Everyone has obviously learned general knowledge, why can Li Mu use it so well?
From then on, he deeply understood that when Li Mu said it was a bit difficult, they should pay attention, because it would be very, very difficult for them.
…
In the end, Li Mu gave them a complete demonstration of his analysis process.
Although Kingsley Weir and the others ended up watching it with confused faces.
They finally understood why in the past few months, the entire biomedical community has been discussing Li Mu's data analysis methods with great enthusiasm, but not many people have made any results.
Learn math first!
"Well, I thought I had figured out something, but now it looks like..."
Kingsley Weir sighed helplessly.
It's not on the same level at all.
Li Mu smiled.
In fact, he hasn't said yet, this seemingly complicated process is very simple for him.
Just like at the beginning, he only needed to use the computer in his mind to process the data, and soon he would get the results.
Of course, there is no need to say this, so as not to affect the mentality of Kingsley Weir and others.
Putting away the pen in his hand, he stood up and said, "I'll put this analysis process here, and you can study it on your own."
"Next, it depends on your experiments."
Kingsley Weir recovered from the shock, and then stood still and said: "Regarding this, please rest assured, since we have such a detailed analysis, we will definitely be able to succeed."
"Do you think so?"
He looked at his former students and current assistants and asked with a smile.
"yes!"
These students all nodded.
For their experiments, the biggest worry is not knowing what to do next.
We can only keep repeating experiments, hoping to find undiscovered phenomena.
This is also one of the reasons why a large number of biology papers published in "Science", "Nature", and "Cell" cannot be reproduced by others.
Excluding the possibility of data fraud, the only remaining possibility is that they themselves repeated the experiment many times. If others want to reproduce it, it will of course become more difficult.
And now, with Li Mu's analysis helping them to identify the target and scope, it will naturally be of great help to their research.
This is why the biological community has always been so enthusiastic about Li Mu's data analysis methods.
Ever since, their experiment officially began.
The first step is to reconfigure the medicinal liquids used in the several sets of experiments marked by Li Mu, such as how many grams of rehmannia glutinosa juice should be taken, or the extracted extract that has been boiled, and then proportioned.
It looks like they are making alchemy - in fact, what they are doing is almost the same as alchemy.
That unknown ingredient is the gold they want to refine.
For experiments on drug research, the most critical thing is to find ingredients that are effective for symptoms, and then extract the active ingredients and mix them with other auxiliary ingredients to make drugs.
So generally speaking, a pill may weigh 0.5 grams, but what really works is often only a few tenths of a milligram of the main ingredient, and the remaining components are generally diluents, binders, and colorants. And so on. Another example is flavoring agents, which are ingredients that make the originally bitter medicine taste sweeter.
Of course, no matter what, those active ingredients are used to make money.
This experiment will probably take a while. For those who study biology, it is normal to live directly in the laboratory.
Of course, as the boss, Li Mu could have just left the laboratory, but with a certain interest in the experiments, he stayed and decided to watch their experiments for a few more days.
In this way, time passed quickly.
…
(End of chapter)
