"To analyze this kind of experimental data, we often need to use statistical principles."
"Of course, statistical principles do not represent everything. Any different experiments will have different experimental data. We do not have a fixed methodology. At this point, analysis needs to be based on the differences in experimental data. "
"I'll give you an example from that paper to illustrate."
"..."
Later, Li Mu cited examples from their paper to explain to the biologists present.
The biologists below also listened with interest. At least for now, Li Mu's explanation was indeed relatively simple and easy to understand.
After Li Mu shared his analysis ideas, the eyes of the biologists below also lit up.
"It turns out that this is the analysis, it's really wonderful!"
"No wonder...he was able to find such differences from so much data..."
People were amazed.
And on the first row of seats.
"Adrian, it's a shame that you didn't invite him over last time."
One person said to another person next to him: "You were even blocked by him."
"Just don't mention this."
The man named Adrian replied angrily.
He is Adrian Kleiner from Cold Spring Harbor Laboratory, winner of this year’s Wolf Prize in Medicine.
He called Li Mu a month ago and was blocked from the matter. However, he was laughed at by other colleagues for a long time, at least it hasn't stopped yet.
Recalling the scene of the original phone call, he reflected and said: "Maybe I was too enthusiastic last time... After this report is over, I have to talk to him again."
"Then I wish you success."
The person next to him said with a smile: "If you can bring Li Mu to our laboratory, I will definitely credit you."
This person is Bruce Stillman, director of Cold Spring Harbor Laboratory.
As the director of the laboratory, helping the laboratory recruit talents is also one of his jobs, so if Li Mu can really come to their laboratory, he would naturally be willing to see it.
…
Of course, they were not the only ones discussing. In a few rows further back, there were also some representatives from large companies and scientific researchers from these companies also discussing.
For people in large companies, all they care about is whether they can make money or whether it can help them save money, and Li Mu's mathematical analysis method, to a certain extent, is of great help to them.
Sitting in the middle of the third row of seats, the vice president of Pfizer turned to look at the person next to him and asked, "Professor Slavi, will this method proposed by Li Mu be helpful to your research?"
Skana Slaoui is Pfizer's chief scientist and pharmaceutical scientist. He has developed several best-selling drugs for Pfizer and is one of Pfizer's most qualified researchers.
After hearing the vice president's question, Slavi was silent for a moment, and then said: "Although I have always disagreed with the role of mathematics in medical research, but as for the role of mathematical analysis in that paper... I cannot What we don’t admit is that it might actually be of great help to us.”
"His mathematical methods can help us analyze very detailed things. For example, in a certain set of experiments, there may be a component with a small proportion that brings about the effect, but because the proportion of this component is very small, Therefore, the effect is not obvious, so it is generally ignored by us, but his analysis can help us find this point."
"This not only avoids repeated experiments and greatly reduces the cost of experiments, but also greatly improves the success rate of our experiments."
“This is an epoch-making change for us.”
After hearing Slavi's words, the vice president's mind was full of "reducing the cost of experiments" and "improving the success rate of experiments."
This is what they most want to hear.
He immediately asked: "Can this method be learned? Apply it to our laboratory."
Slavi pondered for a moment and said: "I can learn, but I can only learn a little bit - at least for now."
"This requires high mathematics, so we'd better ask some mathematics experts to help. There are still relatively few mathematics experts in our laboratory."
The vice president nodded thoughtfully, then turned to Li Munu on the stage and said, "What if we invite him over directly?"
Slavi: "...Well, whether he wants to come or not is another matter. I heard that he didn't even respond to Cold Spring Harbor Laboratory's invitation."
"How much money does Cold Spring Harbor Laboratory have?" The vice president waved his hand: "We are Pfizer."
Slavi said nothing more.
Indeed, to a certain extent, Pfizer lacks everything except money. It earns 100 billion US dollars a year, which is comparable to their company. There are very few companies in this world.
At this time, Li Mu on the stage also finished giving examples, and then said: "Next, I will focus on sharing with you what kind of analytical thinking we should adopt when facing different data. In this aspect, We have to make better use of mathematical thinking..."
"This part requires more mathematical methods to demonstrate, so I will try to make it as simple as possible..."
After hearing Li Mu's words, those who were still discussing began to watch attentively, because they all knew that the next step would be a more critical point.
But as Li Mu's narration began, they became a little confused.
This is called... keeping it as simple as possible?
Looking at the line after line of formulas written by Li Mu on the blackboard, even though he was explaining the meaning of these formulas in his mouth, the various biologists below were confused.
However, Li Mu discovered at this time that it was easier to make a report using mathematics.
What he said just now made his mouth dry and made him feel that it was too fake and empty. Mathematics is more realistic now.
Ever since, he gradually got better.
What followed was that the audience entered a desperate situation.
Adrian and Bruce were both silent.
Until finally, Adrian covered his eyes, then leaned back in his seat with a tactic.
"Oh my god, I really don't want to do math! Math, get out of biology!"
Bruce said quietly: "You have to learn even if you don't want to. I'll leave this matter to you."
"Please spare me."
Adrian looked hopeless.
I still remember what Li Mu told them at the beginning, "Thank you for the high expectations" and "I won't let you down."
Good guy, now I have neither high hopes nor disappointment, just give them despair.
In the third row of seats, the vice president from Pfizer stared at what Li Mu had written, and then said to Slavi next to him: "Although strictly speaking I am not a scientist, I After all, I graduated from MIT with a degree in biology, but I can’t understand it at all. You in the scientific community try to be as simple as possible, is this simple?”
Slavi: "..."
"Don't get me wrong, the scientific world is also divided into ordinary science and genius science. His situation belongs to the genius science world and is not within the scope of our ordinary science world."
Vice President:"……"
After thinking for a while, he asked: "Then can our people still learn these things he talked about?"
"Ah..." Slavi struggled for a long time, and finally said simply: "Forget it, you'd better drag him into our laboratory."
It's better not to torture the researchers in their lab.
You really can’t learn this.
The vice president nodded with deep understanding.
It can only be this way.
Then he took out his cell phone and started reporting the matter to their president.
Soon, John Young, the president of Pfizer, responded with a message: [No problem. 】
After seeing this news, the vice president gave Professor Slavi an OK gesture.
If their president makes the decision himself, probably no one in the world can refuse, right?
…
At the same time, Pfizer headquarters, in the president's office.
After John Yang put down his cell phone, he called for his assistant.
"Evaluate how much it would cost to hire Li Mu as our scientist."
The assistant was stunned for a moment, then asked: "Is it that young mathematician?"
"Well, it should be." John Yang nodded.
He didn't know much about Li Mu, but he had heard that he had solved famous problems in mathematics, and then seemed to have caused a great response in the physics community.
He neither cares about mathematics nor physics. He only cares about how to make their financial reports look better, so his understanding of Li Mu is limited to these. At most, he has recently had a major impact on their biomedical community. It made him pay a little attention.
But since their vice president Conn said that he must recruit this person, then he should recruit him.
He still trusted Conn's vision.
The assistant nodded and left quickly. After a while, he came back and handed a piece of information to John Young.
"President, this is the evaluation result from the human resources department. Please take a look."
John Yang nodded, took it over and took a look, and was stunned.
"The annual salary is at least 30 million US dollars. Are the HR people kidding me!?"
The person Conn wants to poach actually costs him 30 million a year?
In 10 years, that would be 300 million!
It’s enough for them to build another laboratory!
This does not take into account the salary increase. Once the salary increases, it will be even more serious.
The assistant said weakly: "The details of the HR evaluation are at the back. It actually makes sense."
John Yang didn't say anything and turned directly to the next page to read the details of the evaluation.
Companies like theirs have a standard for recruiting talents.
He wanted to see if this Li Mu could afford him $30 million a year.
As a result, the first two keywords caught his eye.
【Li Mu】
【Age: 21】
[Identity: Candidate for Fields Medal and Nobel Prize (the probability of winning both prizes within five years is over 90%)]
"Twenty-one-year-old Fields Medal and Nobel Prize candidate?"
Seeing this, John Yang's understanding of Li Mu deepened in an instant.
The assistant nodded and said with emotion: "This is a veritable super genius. Based on these two points alone, he is already worthy of an eight-figure annual salary."
John Yang did not continue to say anything, but continued to read down with a frown.
"The all-around genius... has recently used experimental data analysis methods in the biomedical community to help Chen Shanping's team in China develop a new recognition mechanism between immune cells and lung cancer cells. It is very ingenious and is considered to be a pioneer. A new direction for biological research..."
Until the end, John Yang directly put down the information in his hand, and then said to his assistant: "Find the live broadcast room of the Max Planck Society Life Sciences Conference. I want to watch Li Mu's report now."
"yes."
The assistant responded immediately, then turned on a large screen in the office and played a live broadcast for John Yang.
But as soon as he entered the live broadcast room, John Yang was confused by the content on the blackboard at the front of the conference hall, and couldn't help but ask: "Are they a life sciences conference? Isn't this a mathematics academic conference?"
He has participated in many reports on biomedicine. How can there be such reports that are all about mathematics?
The assistant looked confused: "I'm... not sure either."
…
Of course, let alone them, the biologists on site have basically given up.
Let’s wait until we get back and study it slowly.
As of now, they still understand it without having to think about it on the spot.
As time passed, the report lasted for an hour, and Li Mu continued for fifty-five minutes.
After writing the last expression happily, Li Mu nodded with satisfaction, finally writing everything he wanted to say.
Then he turned to look at the people present and said: "This is the end of my report. I hope my sharing can bring some help to everyone's future research."
The people present suddenly woke up from a dream.
Is the report...finished?
After everyone reacted, the applause finally started.
Although I don’t know what Li Mu shared, it just looks amazing.
Just applaud and that's it.
It wasn't until the applause ended that Li Mufang smiled and asked, "Then anyone who has questions can ask questions."
There was a moment of silence.
To ask questions, you must first understand the report before asking questions. If you don’t understand, how can you ask questions?
Until the end, Svante Peper, the chairman of the Life Sciences Committee sitting in the first row, finally raised his hand and stood up.
"Li, thank you for sharing, although I have to admit that my math level is not very high, so I don't understand it very well."
"But I still have to ask, will using mathematics to aid biomedical analysis really be of great help?"
"I have always listened to other people's comments before, but now I want to hear your own thoughts."
Hearing this question, Li Mu was silent for a moment, and then said: "I can't give an exact answer to this question, but I am a mathematician, so I also believe in the role of mathematics."
"If I have the opportunity, I will try to verify the role of mathematics in biomedical research again."
"Everyone can look forward to it."
…
(End of chapter)
