Since Zhao Xin entrusted Lin Ziping with an important task, the old man's body was particularly important.
Historically, after Lin Ziping published "Hai Guo Bing Tan" at his own expense in 1791, it was soon banned by the shogunate. He was also ordered by the shogunate to return to his home in Sendai and "live in seclusion". He died of illness two years later.
So on the next day, Sheng Haizhou, who had received Zhao Xin's order, took Lin Ziping, who had not had breakfast, to the hospital for a physical check-up.
Although Hong Tao hates islanders, he heard that the old man in front of him was the director of the "Surveying and Mapping Bureau" appointed by Zhao Xin, and he also helped Beihai Town draw maps, so he did not dare to neglect him. First there were blood tests, urine tests, and stool tests, then X-rays, echocardiograms, and then Lin Ziping kept complaining.
After that, Sheng Haizhou took Lin Ziping to find Wu Xianhou.
Now the Wu brothers rely more and more on various examination reports for medical treatment. Although the four diagnostic methods of traditional Chinese medicine have been passed down for more than 2,000 years, this method relies too much on consultation experience and personal cultivation ability. Many doctors in this era are only good at one subject throughout their lives, and it is difficult to become a general practitioner. .
Since Beihai Town currently has a shortage of doctors, what it needs most is generalists who can deal with common diseases, frequently-occurring diseases and general emergencies. So in the two years since they came to Beihai Town, the Wu brothers have switched from specialist doctors to general practitioners. What they see most every day are headaches, brain fever and trauma caused by work-related accidents.
Wu Xianhou took Lin Ziping's various examination reports and read them, and after some consultation and pulse checking, he judged that the other party should have the "upper respiratory tract infection" that Dean Hong had mentioned before.
It is very common for wind and cold to turn into pneumonia these days. Sometimes, even if the fever subsides, the inflammation is still latent, and in the end, it will lead to lung infection or even death.
At that time, Yonglian, the son of Qianlong and Empress Fucha next door, caught a cold and a fever because he followed them to the northern suburbs for school review, and finally lost his life.
The ancients' treatment for typhoid fever was either "Guizhi Decoction" or "Ephedra Decoction", which was used to induce sweating and dispel cold, and only rich people could afford it; as for the poor, a bowl of Coptidis Coptidis Decoction would be good. But even the emperor's son couldn't be cured, which shows the effect of this thing.
After coming to Beihai Town for two years, Wu Xianhou had seen a lot of the "magic medicine" in Beihai Town and knew how to deal with it, so with a swipe of a pen, he prescribed a "penicillin injection", one injection a day for three days. .
There are currently three types of penicillin powder in Beihai Town Hospital: 800,000 units for people in this time and space, and 1.6 million and 4 million units for people traveling through time and space. The shelf life of this thing is only three years at most, so there is little point in hoarding it if you buy too much.
Although penicillin powder was not expensive in another time and space, after Zhao Xin returned from Guangzhou, he actually asked Hong Tao to take time to develop penicillin.
This time Hong Tao was stumped. The ethylene salicylic acid mentioned above has not been solved yet. If we try to make synthetic penicillin, it will cost lives!
Don't talk about boiling willow bark. What's purified from willow bark is called "saurin". From the saponin, a fairly strong organic acid is extracted, which is called salicylic acid. And salicylic acid has a big problem, that is, it irritates the gastrointestinal tract and makes it difficult to take. In addition, it is impossible to achieve industrial production simply by extracting it from bark.
The production of modern salicylic acid is made by reacting phenol and sodium to produce sodium phenolate, and then introducing carbon dioxide under normal pressure to perform a hydroxylation reaction to produce salicylate, which is then acidified with sulfuric acid to produce a crude salicylic acid product. It is then refined by sublimation to obtain salicylic acid.
Hong Tao has been waiting for almost a year, but the problem of industrial production of salicylic acid has not yet been solved.
The most important thing here is the high-pressure reactor. Zhao Xin can buy one off-the-shelf, but the problem is not to produce it himself. For more than a year, several workers under Zhao Liang have been processing more than a dozen of them, and now they are finally able to make a qualified tank.
The main material of this thing is not complicated. It uses ordinary stainless steel plates. It cannot be made in Beihai Town at the moment, so all it uses is stock. However, due to the poor craftsmanship of the workers and the high precision and smoothness of the tank contact surface, the first few failed.
During the whole process, Zhao Liang watched coldly and did not interfere at all. If he wants to help, he will definitely do it, but he can't do everything!
Several workers thought about it for a long time, and finally thought, if we can't make a big one, why can't we make a small one first? So when Hong Tao finally saw the high-pressure reactor shell produced in Beihai Town, several months had passed.
Just having a shell isn’t enough! The lid of the kettle must also be equipped with a pressure gauge, a vapor-liquid phase valve, a temperature sensor, and a layer of bursting membrane. In addition, there must be a lot of magnetic couplings and cooling water jackets.
At this point, all the workers were completely blinded. This was really impossible!
But being able to make reactor shells means that people in the workshop can already make old-fashioned boilers. At least Zhao Xin no longer has to buy water boilers in public bathhouses and everywhere.
Hong Tao had been thinking about penicillin for a long time but had no idea. The day after Lin Ziping finished his examination, Zhao Xin called.
"Dean Hong, can we get this penicillin?"
"Mr. Zhao, I am studying clinical practice, not biotechnology. Do you want to know how much the wholesale price of 6-APA is now? It is thirty yuan per kilogram. If you buy a lot, it is cheaper than Chinese cabbage. Let's There’s no need to bother with this yourself!”
On the phone, Hong Tao explained to Zhao Xin, a half-hearted Mongolian doctor, that there was no need to buy penicillin now.
"As far as I know, there are no manufacturers that synthesize penicillin from scratch for production. They are all semi-synthetic or biological fermentation. Moreover, the synthesis of semi-synthetic penicillin uses 6-aminopenicillanic acid (6-APA) as the raw material. It can be obtained by connecting various amide side chains using acid chloride method or acid anhydride method. Moreover, the current domestic production capacity is 40,000 tons, most of which are used for export."
"Oh! So that's it." Zhao Xinyi heard that the production capacity was so excessive, no wonder the price was the same as cabbage.
Didn’t you realize how big a stir was made in "The Good Doctor" to save a man-made penicillin, but it may not be effective in the end. If it is to be industrialized for medical use, safety must come first.
At this time, Hong Tao continued on the phone: "Mr. Zhao, my opinion is that instead of penicillin, it is better to use allicin, which is also good for sterilization and anti-inflammatory. And the process is simple and can be used by both humans and animals. Mr. Zhao, Let’s not mess with the mycelium.”
How could Zhao Xin understand this? He had only heard of allicin before, but didn't really understand the details. After Hong Tao briefly explained the medicinal effects of allicin, he quickly asked: "Isn't this difficult to do?"
Hong Tao smiled and said: "Pounding garlic is nothing difficult. At most, use a blender. Solvent or steam distillation extraction is similar to making perfume."
Hong Tao said it was easy, but when he actually made it, he found that it was really troublesome.
The first is that it tastes too great!
There is no allicin in fresh garlic, only alliin. When garlic is cut or crushed, the alliinase in garlic is activated, catalyzing the decomposition and synthesis of allicin.
What’s so outrageous about this thing is that if a brave woman eats garlic before giving birth, the baby’s first cry will be filled with the smell of garlic! That scene, tsk tsk tsk~~
The second thing is dosage. One kilogram of garlic can only produce up to 8 mg of allicin, so if someone wants to achieve the anti-inflammatory and therapeutic effects of eating garlic, he or she needs at least 160 mg.
As mentioned before, allicin can be produced only when garlic is cut or crushed. In other words, you have to eat twenty kilograms of minced garlic. Whether it can be cured or not is a matter of debate, but it is certain that I will die...
In the afternoon, Hong Tao and his assistant carried a box of equipment to the canteen in Beihai Town. This thing can't be done in a hospital, it can smoke out everyone, and some people will even "YUE"...
The first thing is to pound the garlic.
A kilogram of fresh garlic, several women working in the canteen lined up, each person had a garlic mortar in front of them, and everyone started pounding it.
In order to prevent oxidation, after each portion of garlic paste is pounded, Hong Tao's assistant puts it into a glass container and seals it to wait for enzymatic decomposition. After one kilogram of minced garlic filled two glass bottles, Hong Tao took action.
In order to make the operation simple and convenient, Hong Tao did not choose to use ethanol extraction, but used local distillation.
A group of women watched curiously as Hong Tao took out the glass distillation bottle and alcohol lamp from the box. They were wondering what kind of treasure it was when they saw Hong Tao, who was wearing gloves and a mask, pouring the minced garlic from one of the bottles into the distillation bottle.
In fact, it can be used without a distillation bottle. In ancient times, artificial wine relied on fumigation in a large pot to extract the wine liquid. The principle is the same. Use an iron sheet to make a pot, connect a copper pipe to the lid, wrap the copper pipe several times, use cold water or a damp cloth in the middle to promote condensation, and just put it on the stove to burn.
However, temperature is still very important, and the extraction effect is best below 80 degrees.
Two hours later, two bottles of light yellow and clear allicin were extracted, and a strong smell of garlic floated in the kitchen operation room.
At this time, the kitchen, including everyone's body, was full of the smell of garlic. Even the cooks in the canteen were so smoked that they came in and went out holding their noses.
When Hong Tao returned to the hospital with two bottles of allicin, he found that everyone who came near him would wrinkle their noses. It was not until he met Director Liu Da that he finally broke out.
"Eh! It stinks so much. Did you get into the garlic basket?!"
"Ah?" Hong Tao sniffed himself. His nose had already been numbed by garlic.
"Hurry up and take a shower later! Don't come in unless you wash off this smell!" Director Liu walked away, holding his nose.
Hong Tao was stunned for a while, shook his head and smiled bitterly.
Now it’s time to test the effect of the extracted allicin. Who should we choose as the “guinea pig”? This stuff is too irritating to the gastrointestinal tract. If you take it directly, you might get a gastric perforation. In other time and space, they are all made into capsules and dissolved after entering the small intestine.
Hong Tao thought for a while, and first went to the injection room to get a bottle of glucose wrapped in plastic, and took a disposable syringe and an infusion needle. Then he changed into clothes and went out, stepping on the snow, and strolled to the horse farm.
Ever since Liu Zheng went to Guangzhou, the affairs of the racecourse have been handed over to Yalha. This poor man now has more than 200 refugees under his command, taking care of thousands of Mongolian horses.
Serdan kept asking him to find another wife, but Yalha always shook his head; the death of his family members at the same time before was too irritating to him. Although Yalha looks smiling every day now, the scars in his heart have never been there. heal.
"Lao Ya, what are you busy with?" Hong Tao opened the door and walked into the racecourse's official room (office), and saw Yalha sitting cross-legged on the fire kang and smoking.
"Hey! Doctor Hong, why are you here?" Yalha looked up and saw Hong Tao. He quickly stood up to greet him and boiled water to make tea for Hong Tao. It was Hong Tao who performed the surgery to remove his fingers and toes.
"Don't be busy, don't be busy, Lao Ya, I came here to ask you if any of the horses in the racecourse were injured?"
Yarha hesitated when he heard the words, and immediately replied: "You really asked, the day before yesterday two stallions started to fuck for some reason, and one of them was bitten."
"Bite through?"
Yalha nodded and said, "It's not broken yet. I asked someone to find some herbs and wrap it up."
Hong Tao was overjoyed and said quickly: "Take me to see it quickly."
Yalha is worried that Dr. Hong has changed his profession to become a veterinarian?
The bitten stallion was kept alone in a pen in a shed, with its head drooping and looking listless. The wound at the lower end of the neck was wrapped with a piece of white cloth, and some herbal green liquid oozed faintly.
Hong Tao first asked Yalha to untie the white cloth and then remove the herbs on the paste. Yalha didn't know what he was going to do, but as a doctor, whatever he said was right and he had to listen.
During the process of applying the herbal medicine, the horse must have been touched by the wound. It shook its head in pain and neighed, and its hooves jumped uneasily. Yalha comforted him for a while before he calmed down.
Hong Tao asked Yalha to lead the horse to the fence and get a closer look. Perhaps the worker assigned by Yarha was not careful in his work, or perhaps there was something wrong with the herbs. The wound had not healed at all and had begun to become inflamed.
When Yalha saw it, he was so angry that he cursed at the worker. The worker had only been at the racecourse for more than a month. He knew that he had done something wrong, but he just bowed and couldn't help but admit his mistake.
Hong Tao waited until Yalha had finished teaching him a lesson, then he took out the glucose and allicin from his coat pocket and placed them on a wooden board in the stable. He put on gloves and first took 60 mg of allicin with a syringe. Then inject 500 ml of glucose injection, shake well, and connect the infusion needle.
He had heard Liu Zheng say once before that to give a horse infusion, the needle should be inserted from the jugular groove, which is the long tendon-like area under the horse's neck. Although the horse's jugular groove is very long, only the middle third is safe; the upper part is too close to the brain, and the lower part is too close to the heart, which is not suitable.
Hong Tao asked Yalha and the worker to calm the horse. He first reached out and pinched the lower end of the jugular vein. After the blood vessel was exposed, he quickly inserted a needle sideways.
"It's okay! The craftsmanship is intact!" Hong Tao praised himself in his heart.
The horse was also a little confused and shook its head uneasily. Yalha quickly stroked the horse's head to comfort it. After checking that there was no problem with the blood returning, Hong Tao unscrewed the flow regulator on the infusion tube. Because it was the first time to give an infusion to a horse, Hong Tao couldn't control the flow rate well, so he chose the middle flow rate.
After almost forty minutes, the infusion was completed. Hong Tao pulled out the needle and said to Yalha: "Don't apply the medicine yet, just wrap it with a cloth. I'll come over to take a look at noon tomorrow."
After two consecutive days of infusion, the inflammation in the horse's wound was stopped. However, the horse exuded a garlic smell mixed with sweat, which could make Hong Tao stun.
That’s it! The next step is to detect the allicin content in the extracted allicin solution and improve the extraction rate.
A few days later, when Chen Qingsong heard the news, he immediately issued an order to the civil affairs clerks, informing all residents of Beihai Town and Fuldan City that from now on, every household must grow garlic!
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