This is why Cao Dong's first impression when observing this pathological section was that of myocardial necrosis. It is true that a characteristic of myocardial fibrosis is the death of myocardial cells.
Dr. Cao Dong's main job is as a clinician, and his speech is relatively straightforward and straightforward.
If scientific researchers want to conduct in-depth academic discussions, they cannot simply talk about myocardial fibrosis in general terms, nor can they give the impression of myocardial necrosis in slices. The accurate statement should be a pathological description. If you want to diagnose the patient on this slice, it cannot simply be said to be a slice of myocardial necrosis.
The first point that needs to be made clear is that myocardial fibrosis is a pathological diagnosis term, not a disease name. It is actually divided into two types. One is reactive fibrosis, which occurs around blood vessels and is a lesion of the myocardium in response to myocardial load and inflammation.
Through this definition, we can know that this pathological lesion usually occurs in patients with myocardial load or inflammation, such as patients with hypertrophic cardiomyopathy, left ventricular hypertrophy, aortic stenosis, myocarditis, etc.
Recalling the cases we mentioned before, it can be roughly inferred that patients with valvular cardiomyopathy are expected to have this pathology. The reason why it was not mentioned in detail before is because pathological anatomy cannot be performed in vivo for this examination, and only myocardial biopsy can be performed. Perivascular myocardial biopsy is not easy to perform and requires consideration of potential risks to the patient.
Now we are talking about the significance of scientific research. Performing pathological analysis after death is like an afterthought, but a thorough study of the pathogenesis can bring good news to other patients. It can be said that every patient is sacrificing himself to benefit future patients. Human medicine is the true meaning of humankind and a community with a shared future.
Another type of myocardial fibrosis is the response to myocardial cell death mentioned above. The formation of repair scars after myocardial fibrosis is called repairing fibrosis. It often occurs not around blood vessels, but in the myocardial interstitium. The corresponding common patient type is patients with myocardial infarction and myocarditis.
In specific clinical cases, the two types are often mixed together in cases of ventricular remodeling. For example, in patients with myocardial infarction, the periphery of the repair scar is composed of reactive fibrosis and hypertrophic cardiomyocytes surrounding the scar area.
Regarding the great harm of myocardial fibrosis, you can directly refer to Xiao Shugang as an example.
Let's talk about this pathological section. It shows large areas of myocardial fibrosis, and almost nothing else is seen. It is really rare. The pathology of patients with myocardial infarction will still show a little granulation tissue at the edge many days later.
"It's possible that the location of it is not right." Teacher Yuan Fang said.
When making pathological sections, appropriate lesions must be selected. If the location is not accurate, it may not represent the pathological characteristics of the entire human organ. What Teacher Yuan Fang said makes sense.
What Cao Yudong needs to correct is: "What you said is possible. But if not, we may need to consider other causes and diagnoses."
All aspects should be taken into consideration when discussing.
In fact, heart disease is mostly pathologically characterized by myocardial fibrosis. Looking back at the examples of myocardial fibrosis patients, it almost covers all types of heart disease patients.
Here’s the trivia: patients including drowning may develop myocardial fibrosis.
Thank you for your support! ! ! Good night, dear friends~ I’m really tired, so I’ll have five updates today.
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