We all know that there is a Software Developers Conference. Have you heard of the BioDevelopers Conference? Starting yesterday, the world's first synbiopunk2021 and biological developers conference was held in Shanghai.
This year's conference, with the theme of "Opening Links", aims to promote the linkage of various communities in the entire engineering biology industry, cultivate a better ecological environment, promote the development of biotechnology products, and open new links in the engineering biology ecosystem. Experts gathered at the conference, and representatives from over a hundred companies and many investors also attended.
Using DNA as coding, professional biological developers are here
Synthetic biology is an emerging interdisciplinary science in the 21st century. It can use Escherichia coli to produce bulk chemical materials, getting rid of the constraints of petroleum raw materials; yeast produces artemisinic acid and rare ginsenosides, reducing costs and promoting the development of new drugs; engineering bacteria cannot "accidentally injure" normal cells and specifically attack cancer cells...
"In the era of 'convergence', the R&D capabilities of life sciences and biotechnology are in urgent need of improvement." Zhao Guoping, an academician of the Chinese Academy of Sciences, said at the conference. Synthetic biology adopts the "bottom-up" concept of engineering to break the boundaries between "natural" and "unnatural", from systematically characterizing biological macromolecules with catalytic regulation and other functions in nature to turning them into standardized "components". Create new biological components and cell "chassis" such as "modules" and "circuits" to build artificial life systems for various purposes.
Just as there are software engineers who write codes in the IT industry, biological developers are people who use DNA as "coding" and focus on the source innovation and new product development of biotechnology. Guo Haotian, founder of Red Panda Biotechnology (Shenzhen Xunzhu Biotechnology Co., Ltd.), the sponsor of the synbiopunk2021 conference, said that in recent years, the division of labor in the biotechnology industry has become more and more detailed, and a middle group has appeared in the chain of the biotechnology industry. They neither study basic mechanisms nor engage in clinical trials or scale-up production. Instead, they specialize in strain development of fermentation products, reconstruction of chassis microorganisms, protein drug design, and even molecular breeding, organoid transformation, etc. The industry calls this group of people biodevelopers.
Photo provided by Wenhui: Turning "sugar" into gold has many wonderful uses in biological development
What's the use of a bio developer? Zhao Xinyan, chairman of Fenkai Technology, gave an example of the perfume industry, which has grown rapidly in recent years. Sandalwood is a precious fragrance extracted from the sandalwood tree. The price of sandalwood can reach 2,000 US dollars per kilogram. A technology to biosynthesize sandalwood from sugar can reduce the price to 2,000 yuan per kilogram. In addition to lowering prices, biosynthesis technology can also significantly reduce plant cultivation cycles and improve safety. A spice extract that requires 150,000 acres of flower fields for one year can be synthesized in a petri dish using biosynthesis methods in just 5 days.
Fenkai Technology is researching ways to artificially synthesize ambroxan, the “king of fragrances”, a fixative with a “subtle velvety feel.” Zhao Xinyan said that if this substance is not added to the perfume, the perfume will last for up to 40 minutes, and if it is added, it can last for more than 4 hours. Therefore, ambroxan is added to almost all high-end perfumes.
At present, the company has completed the mass production of sclareol-sclareolide and is in urgent need of developing the next step of synthesis technology.
The conference also held the Sustainable Development Challenge, which aims to release biological potential to promote sustainable development in various fields by providing a variety of biological solutions. Teams from Tsinghua University, East China University of Science and Technology, Jiangnan University, Shanghai University of Science and Technology and other universities participated in the on-site competition.
Provide basic "computing power" for life sciences
Just as IT workers need computing power, biological developers also need high-throughput, low-cost "development tools." The emergence of ultra-high-throughput vector testing platform Red Panda Bio has solved the worries of many biological developers.
“We have encountered many such scenarios in the past. On the one hand, developers working on the front line in the laboratory do not realize that there are already good tools on the market to help them speed up research and development, reduce costs and reduce repetitive labor; On the one hand, it is usually difficult for institutions with platform capabilities to reach customers, and they often need to spend a lot of money on promotion." Guo Haotian said that Red Panda Biotech can provide cloud laboratory services for million-level protein recombination, which is better than international general tools. It is 6 orders of magnitude higher and costs only one percent of ordinary tools.
The reason why it can achieve such "cost-effectiveness" is that Red Panda Bio is based on synthetic biology cell programming technology. This is a brand-new experimental method. Simply put, it is to provide bacteria with a piece of DNA code to allow them to "program in cells" work autonomously.
As a Shenzhen start-up, why come to Shanghai for a meeting? Guo Haotian admitted that he was interested in the high-quality biomedical resources in Shanghai and the Yangtze River Delta. As a "basic computing power" in life sciences, this tool can be linked to almost all biological industries and provide them with high-quality services.
"Ikukawa Floating" talks about several points, but there is a problem in connecting them. What can we see if we look at it from the protagonist’s perspective? The protagonist returns to his hometown. The reason for returning home is that he does not have much time left. Pneumoconiosis is an embarrassing disease. For many people in the country, this is undoubtedly a death sentence. After the protagonist, who is deeply worried about his illness, returns to his hometown, what kind of life test will he face? In the face of various hardships, how should he express his emotions after the illness? This is the first core theme that the author wants to tell everyone. , caring for pneumoconiosis, or starting to pay attention to a group that has been ignored.
When the protagonist returns to his hometown, his mother's experience lingers like a nightmare. The only thing that can comfort his soul is to do something silently, build a monument for his mother, and do anything he can think of silently. . This is a kind of repentance for the long-standing debt to the mother.
For his own brother, no matter what happened before, the first thing he thought of when he was dying was reconciliation, reconciliation with his brother, excusing himself from the past, and bidding farewell to his future. And meet your enemies. The scene with red eyes did not happen, and he even stopped everyone who wanted to help. The exciting scenes were replaced by dullness. Everything has passed. What's the point of mentioning these grievances again for a dying person?
The second core point lies in the relationship between people. The protagonist’s wife divorced him, the protagonist’s brother is not on good terms with him, friends are still friends, but they all have their own lives. Even if they are enemies, the protagonist will not I am willing to look at all this with a vengeful eye. Life is still going on, and everyone is going on. However, many people who have interacted with me before have lost contact at this moment. No one wants to mention the past again, and no one Be willing to completely move on from something. Therefore, everything becomes very awkward. The protagonist wants to find something from it, but ultimately finds that there is no way to do it.
The origin of Qiandao Lake and the impact of changing times on people appear subtly in this film. However, this subtle influence does not become the driving force for the advancement of the film. Most of the time, there is not much intersection between these elements and the film. ,This is where the problem lies. Many times we have expectations, and our expectations for a film, especially a literary film, need to be expressed by the creator. The expression of this film is divided into several aspects. However, these aspects are single independent individuals. How these independent individuals are well connected together through the tragic character of the protagonist is the key to testing the original intention of the creator. If If you cannot handle this well, then no matter how good the film is, it will become independent fragments at best. However, what the film needs is coherence.
In addition to self-expression, how much core do domestic literary films have?
2021-10-1009:27Pearl People’s Information
The second core point lies in the relationship between people. The protagonist’s wife divorced him, the protagonist’s brother is not on good terms with him, friends are still friends, but they all have their own lives. Even if they are enemies, the protagonist will not I am willing to look at all this with a vengeful eye. Life is still going on, and everyone is going on. However, many people who have interacted with me before have lost contact at this moment. No one wants to mention the past again, and no one Be willing to completely move on from something. Therefore, everything becomes very awkward. The protagonist wants to find something from it, but ultimately finds that there is no way to do it.
The origin of Qiandao Lake and the impact of changing times on people appear subtly in this film. However, this subtle influence does not become the driving force for the advancement of the film. Most of the time, there is not much intersection between these elements and the film. ,This is where the problem lies. Many times we have expectations, and our expectations for a film, especially a literary film, need to be expressed by the creator. The expression of this film is divided into several aspects. However, these aspects are single independent individuals. How these independent individuals are well connected together through the tragic character of the protagonist is the key to testing the original intention of the creator. If If you cannot handle this well, then no matter how good the film is, it will become independent fragments at best. However, what the film needs is coherence.
Domestic art film directors are very accustomed to self-expression, but they always ignore the coherence of the story. Even obscure and profound art films should have a theme to connect them. Otherwise, no matter how excellent the fragments are, they can only be fragments, exquisite The facial features are missing, which is embarrassing.
Is "sugar-free" really sugar-free?
According to tests, all milk teas claimed to be "sugar-free" were found to contain sugar, even higher than the amount of sugar in some samples with normal sweetness.
According to a test result from the Shanghai Consumer Rights Protection Committee, among 27 milk tea samples with normal sweetness, the sugar content ranged from 11 to 62 grams per cup, and the average sugar content was 34 grams per cup. Among them, the milk tea with the highest sugar content The amount of sugar is equivalent to 14 sugar cubes.
Among the so-called "less sugar", "low sugar", "sugar-free" or "sugar-free" milk teas, 20 of them all had sugar content measured, with the average sugar content being 2.4g100ml, and the lowest was 1.2g100ml.
The "Healthy China Action (2019-2030)" advocates that the per capita daily intake of added sugar should not exceed 25 grams. Other countries have similar recommendations:
theameriheartassosuggeststhatmehan150calories(about9teasprams)ofaddedsugarperday.forwomen,thenumberislooons(25gramsor100calories)perday.
The American Heart Association recommends that men consume no more than 150 calories (about 9 teaspoons, or 36 grams) of added sugar per day. For women, the number is even lower: 6 teaspoons (25 grams or 100 calories) per day.
Consuming too much sugar is very harmful to the body. In a 2014 study published in JAMA Internal Medicine, there was a link between a high-sugar diet and a higher risk of heart disease.
&hecourseofthe15-yearstudy,peoplewhogot17%to21%oftheiraddedsugarhada38%higherriskofdyingfromcardiovasculardiseaseparedwiththosewhoed8%oftheircaloriesasaddedsugar.
A 15-year study showed that people who ate 17% to 21% of their calories from added sugar had a nearly four-fold higher risk of dying from heart disease than those who ate 8% of their calories from added sugar. become.
Is there really milk in milk tea?
Although there is only one word difference between milk tea and milk, the milk in some milk teas is not milk, but is replaced by non-dairy creamer or creamer.
Research shows that in a test of protein in milk tea, the protein content is low, while the trans fatty acid content is high.
In this regard, experts believe that due to the imbalance of protein and trans fatty acid indicators, it means that the merchants may not be using "real ingredients" and may use products such as creamer instead of milk raw materials.
But what are trans fatty acids?
artifisfats(ortransfattyacids)ydietarysoursfatsinprocessedfoodis"partiallyhydrogenatedoils."
Artificial trans fats (or trans fatty acids) are created in an industrial process where hydrogen gas is added to liquid vegetable oils to make them more solid. The main dietary source of trans fats in processed foods is "partially hydrogenated oils."
Trans fatty acids are commonly used in foods such as cakes, biscuits, frozen pizza, French fries, and popcorn.
The "Dietary Guidelines for Chinese Residents" recommends that the daily intake of trans fatty acids should not exceed 2 grams. After testing the milk tea samples, it was found that the amount of trans fat contained in one cup of milk tea exceeded the human body's intake limit for three days.
Trans fatty acids are as harmful to the human body as sugar is to the human body.
transfatsraiseyourbad(ldl)cholesterollevelsandlood(hdl)fatsincreasesyourriskofdevelopidiseasea'salsoassociatedwithahigherriskofdevelopies.
Trans fats raise your bad cholesterol levels and lower your good cholesterol levels. Eating trans fats not only increases your risk of heart disease and stroke, but also increases your risk of type 2 diabetes.
One cup of milk tea = 8 cans of Red Bull? !
Have you ever been unable to fall asleep after drinking milk tea at night?
That’s because milk tea generally contains a lot of caffeine, and the content exceeds the legal limit several times.
In a test, experts tested 51 samples and found that the average caffeine content of the samples was as high as 270mgl, with the highest reaching 828mgl.
Research shows that a cup of Americano (medium cup) contains 108mg of caffeine and a can of Red Bull has 50mg of caffeine. In comparison, the caffeine content of some milk teas is so high that one cup of milk tea = 4 cups of coffee! =8 cans of Red Bull!
Experts point out that caffeine is generally found in beverages such as coffee and strong tea, and healthy adults should not consume more than 200mg in a single serving. People such as pregnant women and children should not consume caffeine, otherwise it will cause anxiety-like symptoms, such as heart palpitations, tremors, sleep disorders, etc.
And the dangers of excessive caffeine intake don’t end there.
estimulatestheervoussystem, releasesfreefattyaadipose(fatty)tissueahekidneys, ingurination, whileadtodehydration.
Caffeine stimulates the central nervous system, releases free fatty acids from fatty tissue, and affects the kidneys, increasing urination and leading to dehydration.
Shockingly, most milk tea shops don’t have any warning about the caffeine in milk tea.
After reading these research data, does the milk tea in your hands still taste good?
While China's financial technology is booming, it also brings new challenges to supervision. Yi Gang, Governor of the People's Bank of China, recently emphasized the need to establish appropriate firewalls to prevent the spread of financial risks across departments and industries. Disconnect improper connections between financial information and business information to prevent the closed-loop effect of "data-network effect-financial business" from creating monopoly.
China's financial technology continues to develop and innovate, reducing the cost of financial services, improving the efficiency of financial services, and effectively supporting inclusive finance.
"Driven by large technology companies, China's mobile payment has developed rapidly, and the current penetration rate has reached 86%." Yi Gang recently introduced at the Bank for International Settlements (BIS) International Conference on Supervising Large Technology Companies, China's mobile payment and online payment rates Each does not exceed 0.6%. Users can also enjoy customized financial products when using electronic payment tools to collect payments. In addition, with the empowerment of digital technology, the entire credit process such as approval and risk control can be digitized and online, reducing reliance on collateral and better meeting the "small, frequent, and urgent" financing needs of small and micro enterprises. need.
The picture shows consumers scanning QR codes to pay at a convenience market in Handan City, Hebei Province. Photo by Xinhua News Agency reporter Wang Xiao
However, in Yi Gang’s view, the continuous development of financial technology also brings new challenges to supervision. Some platform companies are unlicensed or engage in financial services beyond their scope. They provide financial services such as financial management, credit, and insurance under the same platform, which amplifies the possibility of cross-product and cross-market contagion of financial risks. There are irregularities in the payment business of some platform companies. They illegally invest customers' accumulated deposits in various types of financial assets. Some platform companies embed credit businesses such as "Huabei" and "Jiebei" in the payment link to mislead consumers. . Some platform companies engage in unfair competition through their monopoly position and excessively collect and even abuse consumer information, threatening personal privacy and information security.
"Finance, as a franchised industry, must be operated with a license." Yi Gang said that in order to cope with challenges, China continues to make up for the "shortcomings" of the regulatory system and has successively introduced measures to promote the standardized, healthy and sustainable development of the platform economy.
Yi Gang said that in the next step, he will continue to strengthen support
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