Vaccines are mainly divided into five categories: inactivated vaccines (such as rabies vaccines, influenza vaccines, etc.), live attenuated vaccines (such as BCG, polio vaccines, etc.), recombinant protein vaccines, recombinant virus vector vaccines, and nucleic acid vaccines.
Inactivated vaccines and live attenuated vaccines are traditional vaccines; recombinant virus vaccines, recombinant protein vaccines, and nucleic acid vaccines are new vaccines developed by humans using genetic engineering technology, so they are also called second-generation vaccine technologies.
Among them, inactivated vaccines are the classic technical route among traditional vaccines.
The advantages are obvious, the preparation method is simple and fast, and the safety is relatively high. When dealing with the spread of acute diseases, inactivated vaccines are usually used. Commonly used hepatitis B vaccine, inactivated polio vaccine, inactivated Japanese encephalitis vaccine, diphtheria-tetanus pertussis vaccine, etc. are all inactivated vaccines.
The main working principle is to culture them in vitro and then inactivate them to make them non-toxic, but these "corpses" can still stimulate the body to produce antibodies, allowing immune cells to remember the appearance of the virus.
As for the disadvantages, of course there are also the duration of the immune response, the need for multiple vaccinations, the single route of immunity, etc.
As for the mRNA vaccine, it is a nucleic acid vaccine. This is a new type of vaccine. So far, no vaccine developed based on mRNA technology has been approved for marketing in the world.
Its advantages are obvious. Compared with the other four major categories of vaccines, it is faster to develop and easier to mass produce. From the perspective of production capacity and production time, it is theoretically the best to use it to deal with viruses with strong mutations such as masks. Best candidate vaccine route.
Simply put, the principle of the mRNA vaccine is to directly introduce the mRNA (messenger RNA, which is a messenger) encoding the viral antigen protein into the human body. It does not need to be cultured in vitro or through a carrier. This mRNA is directly introduced into the human body. The entire process Very hardcore. After the virus's mRNA is introduced into the human body, human cells are used to synthesize antigenic proteins in the human body, stimulating the body to produce antibodies. When the virus is encountered again, it can directly initiate immune protection.
Of course, the hard-core results, as the vaccinated host, will inevitably be uncomfortable.
Compared with inactivated vaccines, mRNA has a greater risk of toxicity.
Mainly due to the toxicity caused by nucleic acid analogues in artificially synthesized raw materials and the toxicity caused by the packaging materials used for mRNA.
Of course, these are not really important.
In fact, the most important thing is safety.
In the past, it took at least 5-7 years to evaluate the efficacy and safety of a vaccine before it could be initially determined. After all, this is a technology applied to the human body.
No matter how good the security is, it is still just a theory.
Therefore, Liu Gong was so surprised when he heard Wu Zhou say that Miguo was already researching an mRNA vaccine.
In biomedicine, the most important thing is actually safety.
Therefore, if the difference in effectiveness between inactivated vaccines and mRNA vaccines is not too big, inactivated vaccines should actually be used first.
Although this technology is backward, it is safer.
Although the mRNA vaccine is theoretically more effective and the immune response lasts longer. But it is still uncertain.
As the saying goes, don't be afraid of ten thousand, just be afraid of the eventuality.
It's just that Liu Gong is not Wu Zhou after all, and he doesn't know the future harm of masks. Super strong immune evasion, coupled with continuous mutations and soaring transmissibility, result in rounds of widespread reinfections.
And repeated infections again and again will bring about deeper health problems.
In the end, Liu Gong was persuaded by Wu Zhou and left Wu Zhou's chairman's office worriedly.
After returning to the R&D center, the division of labor began immediately.
"I just went to see Mr. Wu. Mr. Wu said that after the vaccine is successfully developed, we will be given additional rewards." Liu Gong looked around and raised a finger.
"One hundred thousand?" Someone was careful when saying this.
In fact, before Wu Zhou came, the actual monthly salary of Sinovac researchers only started at 10,000 yuan.
Then after Wu Zhou came, it doubled to 2w. It can be regarded as catching up with the salary level of the domestic industry leaders.
Now entering this inactivated vaccine team, the salary has doubled again to 40,000.
Who wouldn’t be tempted by such a simple and crude way to increase salary?
However, in order to avoid someone deliberately taking advantage of the situation and delaying the progress of the work, there are of course constraints, such as elimination of the last place, slow task completion, poor task completion, etc.
"One million?" Some people boldly said the number one million.
After saying this, the eyes of many people around him seemed to light up.
Liu Gong smiled and nodded, then shook his head.
"Not only that, one million is a daily project bonus, and everyone's daily salary will be increased by one level."
"Wow."
As soon as Liu Gong finished speaking, everyone in the entire research room became lively, with smiles on their faces. No one has trouble with money.
How many geniuses have to give up their favorite scientific research due to the pressure of life.
After all, life is not a fairy tale, it requires daily necessities.
Scientists want to make money, are they shabby?
"Mr. Wu's atmosphere is bright and open."
"He deserves to be the richest man in China."
"It would have been better if Mr. Wu had come here earlier. I guess I could have bought a house."
"Yeah, if you come earlier, at least I should have enough money for the bride price, alas."
After all, many of the trivial things in life are related to money.
"Come on, boys, this is just the beginning. Come on, get results as soon as possible." Liu Gong looked at the young people around him and recalled some of the very potential students he had led.
In the end, I had to bow my head in front of reality and went to industries where it was easy to make money, such as IT or finance.
"Perhaps the domestic pharmaceutical industry needs laypeople like Mr. Wu."
Aiying Biotechnology is stepping up its research and development of inactivation.
On the other side, there are three medical device companies, and now only the last one has not yet fully negotiated.
But these two medical devices cost Wu Zhou 11.8 billion.
However, when we arrived at the third medical device company, we encountered some twists and turns.
The market's valuation of him was only 2.8 billion, and Wu Zhou was willing to pay a 50% premium for the acquisition. The negotiations were almost complete, and Wu Zhou went over to sign the contract, but this person suddenly changed his mind and raised the price.
"Mr. Wu is the richest man in China. He can donate 14 billion yuan at a time. Although my medical company is not as big as Mr. Wu's company, some of its products are still very recognized by consumers. If Mr. Wu acquires our company , coupled with your company's operational capabilities, Mr. Wu will definitely make a lot of money by then. The market has underestimated our company now, and we can't buy it at this price."
"Mr. Zhao, we have negotiated before and you have already agreed."
"That's how it is in the business world. Things are changing rapidly. Mr. Liu has been in the world for a long time, so he should be clear about it." After Zhao Deqing finished speaking, he looked at Wu Zhou.
But Wu Zhou didn't get used to him and left directly.
Zhao Deqing did not expect that Wu Zhou, a young man, had such a personality.
"Mr. Wu, if you are not satisfied with the price, we can discuss it again."
But when Zhao Deqing finished speaking, Wu Zhou had already left the conference room quickly.
"Young people are still impatient and have no patience at all. I really don't know how to behave." Zhao Deqing said with a slightly ugly face when he saw Wu Zhou leaving without looking back.
Mr. Liu, the broker, was left and took one last look at Zhao Deqing. "Mr. Zhao, we can't do business like this. The price offered by Mr. Wu is not low. It is already the highest price in the industry. If you do this, if word spreads in the future, ugh..." Mr. Liu left quickly before finishing his words.
Wu Zhou left angrily. The reason was not that Zhao Deqing sat on the ground and raised the price, but mainly because he went back on his word and wasted his time.
I was originally in Yuncheng, but I came all the way to Shenzhen City just to get a result.
Looking through the list of Zhao Deqing's medical equipment shares in his hand.
Although Zhao Deqing's medical device company is not large, its products are rich, covering health monitoring, rehabilitation assistive devices, respiratory support, medical care, etc.
But the most important products are actually the four products: oximeter, ventilator, oxygen concentrator, and electric wheelchair.
Although the market share of these four products is average, according to the system, the technical strength can reach the domestic leading level. Although Zhao Deqing is not very good, the company still has certain research and development capabilities.
As for other products, they are actually made for the sake of being made, and most of them are at the domestic second-tier or even third-tier level.
"If you contact these small shareholders, you can get them first at a premium of up to 100%."
"In addition, please help me investigate Zhao Deqing's detailed information, and by the way, his wife's information as well."
(End of chapter)
