In 2044, Yawgmoth stated that he could not understand why someone would reject Plan A's HIV infection.
Because whether a person chooses Plan A (HIV infection), Plan B (drugs and radiation destruction) during the "immune system offline" stage, or the "189:3 drug to reverse the life cycle of the immune system" that has not yet been developed at the time, , in the second stage of "gene implantation", you have to face a virus cocktail.
The virus cocktail must contain "its prototype" a thing with a much higher fatality rate than HIV, that is, rabies (improved version).
Different viruses have different affinities for different cells.
Rabies virus is a neurotropic virus. It has extremely strong neural affinity. Generally speaking, after rabies enters the body, it can travel reversely along the nerve axons without going through the blood circulation, and violently enter the brain.
Compared with many viruses in the family Herpesviridae and Picornaviridae, which are both neurotropic viruses, rabies virus has a huge advantage, that is, "fast".
It almost specializes in nerves, can invade the brain at the fastest speed, and spread quickly.
From onset to death, the patient rarely disappears for more than 24 days.
As for the "incubation period", that is, the period "from infection to the discovery of symptoms", it actually only depends on the amount and concentration of the virus received by the infected person.
If a sufficient amount of pathogen is artificially injected, the incubation period can be shortened to a relatively short time.
What's more, the incubation period of rabies is already very short - the "ten-year incubation period" promoted in the past, the latest research believes is more likely to be the result of record completion or false positives.
It can enter the neuronal system very quickly.
This is exactly what genetic modification surgery requires.
Due to differences in metabolism, cells in different parts of the human body renew at different speeds.
And nerve cells are undoubtedly the slowest of them all.
The lifespan of nerve cells is almost the same as that of the human body itself. They almost never divide, and damage cannot be easily repaired.
This is entirely to ensure the stability of the neural network structure, so the repair function is abandoned.
Its proto-oncogene is rather inactive.
This is also the reason why there is almost no cancer in the nervous system, and even cancer in glial cells is basically a benign tumor.
This characteristic also causes the transformation rate of the nervous system during metal-based surgery to be much slower than that of other parts of the physical body.
The remedy is rabies virus.
In theory, this is indeed possible. Anyway, no matter what the pathogen is, it is powerless to face the extremely high body temperature of the baseline human and will eliminate it on its own, so as long as it survives this level, Yawgmoth is guaranteed to be fine.
But here's the problem.
The mortality rate of rabies virus is also very high, close to 100%.
The blood-brain barrier protects the brain from external infections, but it also blocks the entry of immune cells.
If immune cells appear near the central nervous system to kill virus-infected cells, then the damage to the neuron network will be greater than the virus - the principle of immune cells is to "kill them if they are likely to be infected."
Only antibodies can enter the brain.
But a small amount of antibodies is not enough to reverse the ravages of the rabies virus.
Once rabies occurs, the mortality rate is close to 100%.
Generally speaking, if you want to avoid death from rabies, you can only produce enough antibodies to suppress the virus before the disease occurs.
But the method proposed by Chen Feng... was undoubtedly going to make it sick.
After all, this requires simultaneous transformation of neurons throughout the brain.
Since the brain controls every aspect of the body, it is easy to die once the brain is damaged. The condition for "fatal onset" of rabies is actually "the proportion of infected (destroyed) cells is sufficient to cause death"
This time is still far from "the entire brain's neurons are infected."
In other words, this is equivalent to asking the person undergoing surgery to live in a "rabies attack" state for several weeks.
On the basis of ensuring the transfer speed of the virus, it is also necessary to ensure that the virus will not damage the brain's neural network, or "cannot cause death before the transformation is completed", in order to hope that after the transformation is completed, the baseline human body temperature will spontaneously clear the virus.
This is undoubtedly a difficult task.
But it's not "impossible".
Others in Superman Enterprises retrieved Yawgmoth's research records. In order to complete the "virus cocktail" and to give an explanation to investors in HIV research, Yawgmoth made many "reduced-power versions" of viruses.
He has a proven method that can be used against most viruses.
Yawgmoth always likes to start from the underlying principles and think deeply.
So, there's only one question left there.
They could only follow that procedure to cultivate the rabies virus with reduced destructive power, but they did not have time to follow the new drug development process and conduct several phases of experiments. As long as they were sure that "primate experimental animals could survive for several days after becoming ill," they had to inject Yawgmoth.
They didn't even have time to confirm "whether it would cause irreversible central nervous system damage" - at that stage, the "Xiao Huandan Project" had only produced signaling factors that could be used in the peripheral nervous system. It would be several years before Yawgmoth would develop an enzyme that could safely act on the central nervous system.
This kind of thing is gambling on the future. Although there is an excuse of "saving people", this is undoubtedly on the edge of ethics.
If you take it outside, you will easily be attacked.
It's good to succeed, but if it fails, the person who implemented the plan will have to bear the burden for a lifetime.
At this time, Niyaguti unexpectedly stepped forward to take on this task. Through her connections, she obtained the bat rabies virus, which is the least destructive of the known rabies viruses. She even excluded most of her assistants from the laboratory, leaving only a few experimentalists - these people had very low positions and were not qualified to "take responsibility".
So does animal testing.
She almost did the entire process alone.
After finding "an improved virus that would not kill the host immediately after getting sick", he immediately rushed to Yawgmoth.
In the end, she personally injected the virus into Yawgmoth's spine using a subarachnoid injection.
Even if Yawgmoth dies, the responsibility will not affect anyone else.
The end result was good.
Although Yawgmoth gained all the glory in the field of biology at that time, Nia Guti could also be called a "genius scientist".
Yawgmoth survived without any sequelae - the only problem he faced was a few holes in his head.
The health care team used two methods to ensure the temperature inside his skull cavity. First, the blood is extracted from the arteries that supply blood to the brain, cooled outside the body, and then infused back.
The second is to directly drill a hole in his skull and pass the cooling fluid tube through.
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